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  1. Article ; Online: A Case of ABPA-CPA Overlap: Fallitur Identitatis….

    Singh Sehgal, Inderpaul / Agarwal, Ritesh

    Internal medicine (Tokyo, Japan)

    2024  

    Language English
    Publishing date 2024-04-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.3387-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 240: Show issues Location:
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  2. Article ; Online: Ibrutinib and tracheal mucormycosis: A case report and systematic review of literature.

    Damaraju, Vikram / Agarwal, Ritesh / Singh Sehgal, Inderpaul / Khadwal, Alka / Bal, Amanjit / Rudramurthy, Shivaprakash Mandya / Muthu, Valliappan

    Journal de mycologie medicale

    2023  Volume 33, Issue 3, Page(s) 101414

    Abstract: Ibrutinib, a Bruton tyrosine kinase (BTK) inhibitor, has been approved for various hematological malignancies. Invasive aspergillosis is a known complication of ibrutinib, but mucormycosis is rare. We describe the case of a 70-year-old man with mantle ... ...

    Abstract Ibrutinib, a Bruton tyrosine kinase (BTK) inhibitor, has been approved for various hematological malignancies. Invasive aspergillosis is a known complication of ibrutinib, but mucormycosis is rare. We describe the case of a 70-year-old man with mantle cell lymphoma infiltrating the trachea, managed with a tracheobronchial stent and ibrutinib. He had improved one month after treatment, and we removed the airway stent. Four months later, he developed tracheal nodules confirmed to be tracheal mucormycosis and responded to liposomal amphotericin B (3.5 g) followed by posaconazole. After transient improvement, the tracheal lesions recurred, the biopsy showed lymphoma (with no evidence of mucormycosis), and he died. A systematic review of the literature identified 20 additional cases of ibrutinib-associated mucormycosis. Most of the 21 patients included were men (95%), and ibrutinib was the only risk factor in 15.7%. The reported mortality was 31.6% (6/19), attributable to mucormycosis in half the cases.
    MeSH term(s) Male ; Humans ; Adult ; Aged ; Female ; Mucormycosis/diagnosis ; Mucormycosis/drug therapy ; Trachea ; Neoplasm Recurrence, Local ; Piperidines
    Chemical Substances ibrutinib (1X70OSD4VX) ; Piperidines
    Language English
    Publishing date 2023-07-23
    Publishing country France
    Document type Systematic Review ; Case Reports
    ZDB-ID 1067006-3
    ISSN 1773-0449 ; 1156-5233
    ISSN (online) 1773-0449
    ISSN 1156-5233
    DOI 10.1016/j.mycmed.2023.101414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3148: Show issues Location:
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  3. Article ; Online: Pulse methylprednisolone in allergic bronchopulmonary aspergillosis exacerbations.

    Singh Sehgal, Inderpaul / Agarwal, Ritesh

    European respiratory review : an official journal of the European Respiratory Society

    2014  Volume 23, Issue 131, Page(s) 149–152

    MeSH term(s) Adult ; Aspergillosis, Allergic Bronchopulmonary/diagnosis ; Aspergillosis, Allergic Bronchopulmonary/drug therapy ; Aspergillosis, Allergic Bronchopulmonary/microbiology ; Asthma/diagnosis ; Asthma/drug therapy ; Asthma/microbiology ; Disease Progression ; Female ; Glucocorticoids/administration & dosage ; Humans ; Male ; Methylprednisolone/administration & dosage ; Middle Aged ; Pulse Therapy, Drug ; Treatment Outcome
    Chemical Substances Glucocorticoids ; Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2014-01-25
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/09059180.00004813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3265: Show issues Location:
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  4. Article ; Online: The Reversed Halo Sign and the Bronchus Sign: The Eyes See Only What the Mind Knows.

    Muthu, Valliappan / Dhooria, Sahajal / Singh Sehgal, Inderpaul / Thurai Prasad, Kuruswamy / Agarwal, Ritesh

    Annals of the American Thoracic Society

    2019  Volume 16, Issue 9, Page(s) 1203

    MeSH term(s) Bronchi ; Diabetes Mellitus ; Humans ; Lung ; Male ; Pneumonia
    Language English
    Publishing date 2019-07-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201905-360LE
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    Zs.A 5828: Show issues Location:
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  5. Article: Bacterial coinfections and secondary infections in COVID-19 patients from a tertiary care hospital of northern India: Time to adhere to culture-based practices.

    Sharma, Bhawna / Sreenivasan, Priya / Biswal, Manisha / Mahajan, Varun / Suri, Vikas / Singh Sehgal, Inderpaul / Ray, Pallab / Dutt Puri, Goverdhan / Bhalla, Ashish / Narayana Yaddanapudi, Lakshmi / Koushal, Vipin / Angrup, Archana

    Qatar medical journal

    2021  Volume 2021, Issue 3, Page(s) 62

    Abstract: Objective: Bacterial co-pathogens are common in various viral respiratory tract infections, leading to increased disease severity and mortality. Still, they are understudied during large outbreaks and pandemics. This study was conducted to highlight the ...

    Abstract Objective: Bacterial co-pathogens are common in various viral respiratory tract infections, leading to increased disease severity and mortality. Still, they are understudied during large outbreaks and pandemics. This study was conducted to highlight the overall burden of these infections in COVID-19 patients admitted to our tertiary care hospital, along with their antibiotic susceptibility patterns.
    Material and methods: During the six-month study period, clinical samples (blood samples, respiratory samples, and sterile body fluids, including cerebrospinal fluid [CSF]) of COVID-19 patients with suspected bacterial coinfections (at presentation) or secondary infections (after 48 hours of hospitalization) were received and processed for the same.
    Results: Clinical samples of 814 COVID-19 patients were received for bacterial culture and susceptibility. Out of the total patient sample, 75% had already received empirical antibiotics before the samples were sent for analysis. Overall, 17.9% of cultures were positive for bacterial infections. Out of the total patients with bacterial infection, 74% (108/146) of patients had secondary bacterial infections (after 48 hours of hospitalization) and 26% (38/146) had bacterial coinfections (at the time of admission). Out of the 143 total isolates obtained, the majority (86%) were gram-negative organisms, of which
    Conclusion: The overall rate of secondary bacterial infections (SBIs) in our study was lower (7.9%) than reported by other studies. A rational approach would be to adhere to the practice of initiating culture-based guidance for antibiotics and to restrict unnecessary empirical antimicrobial therapy.
    Language English
    Publishing date 2021-10-25
    Publishing country Qatar
    Document type Journal Article
    ZDB-ID 3031075-1
    ISSN 2227-0426 ; 0253-8253
    ISSN (online) 2227-0426
    ISSN 0253-8253
    DOI 10.5339/qmj.2021.62
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  6. Article ; Online: A Randomized Trial of Itraconazole vs Prednisolone in Acute-Stage Allergic Bronchopulmonary Aspergillosis Complicating Asthma.

    Agarwal, Ritesh / Dhooria, Sahajal / Singh Sehgal, Inderpaul / Aggarwal, Ashutosh N / Garg, Mandeep / Saikia, Biman / Behera, Digambar / Chakrabarti, Arunaloke

    Chest

    2018  Volume 153, Issue 3, Page(s) 656–664

    Abstract: Objective: Whether itraconazole monotherapy is effective in the acute stage of allergic bronchopulmonary aspergillosis (ABPA) remains unknown. The goal of this study was to compare the efficacy and safety of itraconazole and prednisolone monotherapy in ... ...

    Abstract Objective: Whether itraconazole monotherapy is effective in the acute stage of allergic bronchopulmonary aspergillosis (ABPA) remains unknown. The goal of this study was to compare the efficacy and safety of itraconazole and prednisolone monotherapy in ABPA.
    Methods: Treatment-naive subjects with ABPA complicating asthma (January 2012 to December 2013) were randomized to receive either oral itraconazole or prednisolone for 4 months. The study was not blinded. The primary outcomes were proportion of subjects exhibiting a composite response after 6 weeks, percent decline in IgE after treatment, and numbers of subjects experiencing exacerbation. The secondary outcomes included the time to first exacerbation, change in lung function, and treatment-related adverse effects.
    Results: A total of 131 subjects (prednisolone group, n = 63; itraconazole group, n = 68) were included in the study. The number of subjects exhibiting a composite response was significantly higher in the prednisolone group compared with the itraconazole group (100% vs 88%; P = .007). The percent decline in IgE after 6 weeks and 3 months and the number of subjects with exacerbations after 1 and 2 years of treatment were similar in the two groups. The time to first exacerbation (mean: 437 vs 442 days) and the improvement in lung function after 6 weeks was also similar in the two groups. The occurrence of side effects was significantly higher in the glucocorticoid arm (P < .001).
    Conclusions: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA. However, itraconazole was also effective in a considerable number and, with fewer side effects compared with prednisolone, remains an attractive alternative in the initial treatment of ABPA.
    Trial registry: ClinicalTrials.gov; No.: NCT01321827; URL: www.clinicaltrials.gov).
    MeSH term(s) Administration, Oral ; Adult ; Antifungal Agents/administration & dosage ; Antifungal Agents/therapeutic use ; Aspergillosis, Allergic Bronchopulmonary/complications ; Aspergillosis, Allergic Bronchopulmonary/drug therapy ; Asthma/complications ; Female ; Glucocorticoids/administration & dosage ; Glucocorticoids/therapeutic use ; Humans ; Itraconazole/administration & dosage ; Itraconazole/therapeutic use ; Male ; Prednisolone/administration & dosage ; Prednisolone/therapeutic use ; Respiratory Function Tests ; Treatment Outcome
    Chemical Substances Antifungal Agents ; Glucocorticoids ; Itraconazole (304NUG5GF4) ; Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2018-01-11
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2018.01.005
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    Ui III Zs.45: Show issues Location:
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  7. Article ; Online: A randomised trial of glucocorticoids in acute-stage allergic bronchopulmonary aspergillosis complicating asthma.

    Agarwal, Ritesh / Aggarwal, Ashutosh N / Dhooria, Sahajal / Singh Sehgal, Inderpaul / Garg, Mandeep / Saikia, Biman / Behera, Digambar / Chakrabarti, Arunaloke

    The European respiratory journal

    2016  Volume 47, Issue 2, Page(s) 490–498

    Abstract: Whether use of high-dose steroids in acute-stage allergic bronchopulmonary aspergillosis (ABPA) is associated with superior outcomes is not known. Herein, we compare the efficacy and safety of two glucocorticoid protocols in ABPA.Treatment-naive ABPA ... ...

    Abstract Whether use of high-dose steroids in acute-stage allergic bronchopulmonary aspergillosis (ABPA) is associated with superior outcomes is not known. Herein, we compare the efficacy and safety of two glucocorticoid protocols in ABPA.Treatment-naive ABPA subjects randomly received either high-dose or medium-dose oral prednisolone. The primary outcomes were exacerbation rates and glucocorticoid-dependent ABPA after 1 and 2 years, respectively, of treatment. The secondary end-points were composite response rates after 6 weeks, improvement in lung function, time to first exacerbation, cumulative dose and adverse effects.92 subjects (high-dose n=44, medium-dose n=48) were included in the study. The numbers of subjects with exacerbation after 1 year (high-dose 40.9% versus medium-dose 50%, p=0.59) and glucocorticoid-dependent ABPA after 2 years (high-dose 11.4% versus medium-dose 14.6%, p=0.88) were similar in the two groups. Although composite response rates were significantly higher in the high-dose group, improvement in lung function and time to first exacerbation were similar in the two groups. Cumulative glucocorticoid dose and side-effects were significantly higher in the high-dose group.Medium-dose oral glucocorticoids are as effective and safer than high-dose in treatment of ABPA.
    MeSH term(s) Acute Disease ; Adult ; Aspergillosis, Allergic Bronchopulmonary/complications ; Aspergillosis, Allergic Bronchopulmonary/diagnostic imaging ; Aspergillosis, Allergic Bronchopulmonary/drug therapy ; Aspergillosis, Allergic Bronchopulmonary/physiopathology ; Asthma/complications ; Asthma/diagnostic imaging ; Asthma/drug therapy ; Asthma/physiopathology ; Bronchiectasis/complications ; Bronchiectasis/diagnostic imaging ; Bronchiectasis/drug therapy ; Bronchiectasis/physiopathology ; Disease Progression ; Female ; Forced Expiratory Volume ; Glucocorticoids/administration & dosage ; Humans ; Male ; Prednisolone/administration & dosage ; Severity of Illness Index ; Tomography, X-Ray Computed ; Treatment Outcome ; Vital Capacity ; Young Adult
    Chemical Substances Glucocorticoids ; Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2016-02
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01475-2015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 292: Show issues

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