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  1. Article ; Online: Current Oncologic Standards for Surgery of Small Bowel Cancers.

    Vashistha, Nitin / Singhal, Dinesh

    Journal of gastrointestinal cancer

    2021  Volume 53, Issue 2, Page(s) 434–438

    Abstract: Purpose: The last 2 decades has witnessed efforts towards standardization of surgery for small bowel cancers. The proposed recent guidelines/recommendations pertaining to choice of procedure and extent of lymphadenectomy are based on analysis of data ... ...

    Abstract Purpose: The last 2 decades has witnessed efforts towards standardization of surgery for small bowel cancers. The proposed recent guidelines/recommendations pertaining to choice of procedure and extent of lymphadenectomy are based on analysis of data from high volume centres of excellence. We evaluated whether these recently proposed oncologic recommendations can be replicated in the setting of single centre/team.
    Methods: This was a retrospective analysis of consecutive adult patients (age ≥ 18 years) who underwent surgery for tumours of small intestine (duodenum, jejunum, and ileum) by the same team of surgeons from 01/01/2010 to 12/31/2019. The procedure performed and lymph nodes harvested during pathologic examination were compared with recent recommendations.
    Results: Of the 32 patients (20 males and 12 females), mean age was 52.4 (range 31-77) years. Twenty-nine (90.6%) patients underwent surgery for small bowel cancers. Duodenum was the most common site, while NET was the commonest cancer. Whipple's procedure was performed for tumours of II part of duodenum, while for the rest, segmental resection was performed. The median number of lymph nodes examined for duodenal adenocarcinoma and NET was 14 and 9, respectively. For jejunal/ileal adenocarcinoma, median lymph node number examined was 11.
    Conclusion: Our study shows that these recently proposed standards for surgery of small bowel cancers are achievable if basic principles of oncologic surgery are followed.
    MeSH term(s) Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Adolescent ; Adult ; Aged ; Duodenal Neoplasms/pathology ; Duodenal Neoplasms/surgery ; Female ; Humans ; Ileal Neoplasms/pathology ; Intestine, Small/pathology ; Intestine, Small/surgery ; Jejunal Neoplasms/pathology ; Jejunal Neoplasms/surgery ; Male ; Middle Aged ; Reference Standards ; Retrospective Studies
    Language English
    Publishing date 2021-03-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452514-5
    ISSN 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
    ISSN (online) 1941-6636 ; 1559-0739
    ISSN 1941-6628 ; 1537-3649
    DOI 10.1007/s12029-021-00635-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Solid Pseudopapillary Tumor of Pancreas with Sinistral Portal Hypertension: A Rare Presentation.

    Singhal, Siddharth / Vashistha, Nitin / Singhal, Dinesh

    Journal of gastrointestinal cancer

    2022  Volume 54, Issue 1, Page(s) 297–299

    Abstract: An elderly male presented with complaint of dull aching pain in left upper abdomen of 2 months' duration. He was well built, and on abdominal examination, a large lump was palpable in left lumbar region. His biochemical, hematological parameters and ... ...

    Abstract An elderly male presented with complaint of dull aching pain in left upper abdomen of 2 months' duration. He was well built, and on abdominal examination, a large lump was palpable in left lumbar region. His biochemical, hematological parameters and tumor markers including CA 19.9 were within prescribed normal limits. Contrast enhanced computed tomography (CT) of the abdomen revealed large, well-defined, mixed solid, and cystic lesion arising from distal body-tail of the pancreas extending up to splenic hilum. Chronic thrombosis involving retro pancreatic splenic vein with multiple perisplenic, peripancreatic, and perigastric collaterals were noted. Based on characteristic CT abdomen findings, a diagnosis of solid pseudopapillary tumor (SPT) of the pancreas with sinistral portal hypertension (SPH) was made. The patient was planned for open distal pancreatectomy with splenectomy. At surgery, splenic flexure of colon was densely adhered to the tumor, and hence en bloc resection of colon was also performed. Postoperative period was uneventful, and he was discharged from the hospital on postoperative day 6. Histopathology reported solid pseudopapillary tumor of the pancreas, 22 cm in the largest dimension. SPT of the pancreas rarely present with SPH. At 22-cm size, this may be one of the largest SPTs reported in the English literature to date.
    MeSH term(s) Male ; Humans ; Aged ; Sinistral Portal Hypertension ; Pancreatic Neoplasms/complications ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/surgery ; Pancreas/diagnostic imaging ; Pancreas/surgery ; Pancreas/pathology ; Pancreatectomy/methods ; Abdomen/pathology ; Abdomen/surgery
    Language English
    Publishing date 2022-02-24
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2452514-5
    ISSN 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
    ISSN (online) 1941-6636 ; 1559-0739
    ISSN 1941-6628 ; 1537-3649
    DOI 10.1007/s12029-022-00814-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Evaluation of ACS-NSQIP and CR-POSSUM risk calculators for the prediction of mortality after colorectal surgery: A retrospective cohort study.

    Vashistha, Nitin / Singhal, Siddharth / Budhiraja, Sandeep / Singhal, Dinesh

    Journal of minimal access surgery

    2022  Volume 20, Issue 2, Page(s) 142–147

    Abstract: Background: Several risk calculating tools have been introduced into clinical practice to provide patients and clinicians with objective, individualised estimates of procedure-related unfavourable outcomes. The currently available risk calculators (RCs) ...

    Abstract Background: Several risk calculating tools have been introduced into clinical practice to provide patients and clinicians with objective, individualised estimates of procedure-related unfavourable outcomes. The currently available risk calculators (RCs) have been developed by well-endowed health systems in Europe and the USA. Applicability of these RCs in low-middle income country (LMIC) settings with wide disparities in patient population, surgical practice and healthcare infrastructure has not been adequately examined.
    Patients and methods: Through this single tertiary care, LMIC-centre, retrospective cohort study, we investigated the accuracy of the two most widely validated RCs - American College of Surgeons-National Surgical Quality Improvement Program (ACS-NSQIP) RC and ColoRectal Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity (CR-POSSUM) - for the prediction of mortality in patients undergoing elective and emergency colorectal surgery (CRS) from March 2013 to March 2020. Online RCs were used to predict mortality and other outcomes. Accuracy was assessed by Brier score and C statistic.
    Results: Of 105 patients, 69 (65.71%) underwent elective and 36 (34.28%) underwent emergency CRS. The 30-day overall mortality was 12 - elective 1 (1.4%) and emergency 11 (30.5%). ACS-NSQIP RC performed better for the prediction of overall ( C statistic 0.939, Brier score 0.065) and emergency ( C statistic 0.840, Brier score 0.152) mortality. However, for elective CRS mortality, Brier scores were similar for both models (0.014), whereas C statistic (0.934 vs. 0.890) value was better for ACS-NSQIP.
    Conclusions: Both ACS-NSQIP and CR-POSSUM were accurate for the prediction of CRS mortality. However, compared to CR-POSSUM, ACS-NSQIP performed better. The overall performance of both models is indicative of their wider applicability in LMIC centres also.
    Language English
    Publishing date 2022-09-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 2186884-0
    ISSN 1998-3921 ; 0972-9941
    ISSN (online) 1998-3921
    ISSN 0972-9941
    DOI 10.4103/jmas.jmas_187_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Derivation of oocyte-like cells from putative embryonic stem cells and parthenogenetically activated into blastocysts in goat.

    Malik, Hruda Nanda / Singhal, Dinesh Kumar / Saini, Sikander / Malakar, Dhruba

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 10086

    Abstract: Germ cells are responsible for the propagation of live animals from generation to generation, but to surprise, a steep increase in infertile problems among livestock poses great threat for economic development of human race. An alternative and robust ... ...

    Abstract Germ cells are responsible for the propagation of live animals from generation to generation, but to surprise, a steep increase in infertile problems among livestock poses great threat for economic development of human race. An alternative and robust approach is essential to combat these ailments. Here, we demonstrate that goat putative embryonic stem cells (ESCs) were successfully in vitro differentiated into primordial germ cells and oocyte-like cells using bone morphogenetic protein-4 (BMP-4) and trans-retinoic acid (RA). Oocyte-like cells having distinct zonapellucida recruited adjacent somatic cells in differentiating culture to form cumulus-oocyte complexes (COCs). The putative COCs were found to express the zonapellucida specific (ZP1 and ZP2) and oocyte-specific markers. Primordial germ cell-specific markers VASA, DAZL, STELLA, and PUM1 were detected at protein and mRNA level. In addition to that, the surface architecture of these putative COCs was thoroughly visualized by the scanning electron microscope. The putative COCs were further parthenogenetically activated to develop into healthy morula, blastocysts and hatched blastocyst stage like embryos. Our findings may contribute to the fundamental understanding of mammalian germ cell biology and may provide clinical insights regarding infertility ailments.
    MeSH term(s) Animals ; Blastomeres/cytology ; Blastomeres/metabolism ; Bone Morphogenetic Protein 4/pharmacology ; Cell Differentiation/physiology ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/metabolism ; Germ Cells/cytology ; Goats ; Oocytes/metabolism ; Parthenogenesis/genetics ; Tretinoin/pharmacology
    Chemical Substances Bone Morphogenetic Protein 4 ; Tretinoin (5688UTC01R)
    Language English
    Publishing date 2020-06-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-66609-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Elderly Woman With Acute Abdomen and Gastric Mass on Imaging.

    Vashistha, Nitin / Singhal, Dinesh

    JAMA surgery

    2016  Volume 151, Issue 5, Page(s) 481–482

    Language English
    Publishing date 2016-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2015.4710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Incidentaloma in the Right Iliac Fossa.

    Vashistha, Nitin / Aggarwal, Bharat / Singhal, Dinesh

    JAMA surgery

    2017  Volume 152, Issue 4, Page(s) 405–406

    MeSH term(s) Aged ; Appendix ; Cecal Diseases/diagnosis ; Diagnosis, Differential ; Female ; Humans ; Ilium ; Incidental Findings ; Intraoperative Period ; Mucocele/diagnosis ; Nephrectomy ; Tomography, X-Ray Computed
    Language English
    Publishing date 2017-02-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2016.5552
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  7. Article ; Online: Cronkhite-Canada syndrome.

    Vashistha, Nitin / Chakravarty, Suneel / Singhal, Dinesh

    Gastrointestinal endoscopy

    2017  Volume 86, Issue 5, Page(s) 922–923

    MeSH term(s) Adult ; Colonoscopy ; Humans ; Intestinal Polyposis/diagnosis ; Intestinal Polyposis/pathology ; Male ; Nail Diseases/diagnosis ; Tongue Diseases/diagnosis
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2017.05.028
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  8. Article ; Online: Young Adult With Abdominal Lump.

    Vashistha, Nitin / Tandon, Rakesh / Singhal, Dinesh

    JAMA surgery

    2016  Volume 151, Issue 9, Page(s) 873–874

    Language English
    Publishing date 2016-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2016.0989
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  9. Article ; Online: Young Adult With Multivisceral Lesions and Hypoglycemia.

    Vashistha, Nitin / Aggarwal, Bharat / Singhal, Dinesh

    Gastroenterology

    2016  Volume 151, Issue 1, Page(s) 43–44

    Language English
    Publishing date 2016-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2016.02.079
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  10. Article: Management of Giant Gastric Ulcer Perforation: Report of a Case and Review of the Literature.

    Vashistha, Nitin / Singhal, Dinesh / Makkar, Gurpreet / Chakravarty, Suneel / Raj, Vivek

    Case reports in surgery

    2016  Volume 2016, Page(s) 4681989

    Abstract: Giant gastric ulcer (GGU) is defined as an ulcer more than 3 cm in diameter. Now infrequent in clinical practice, in the pre-H2 receptor antagonist (H2RA) era, the incidence of GGU varied between 12 and 24% of all gastric ulcers. Proton pump inhibitors ... ...

    Abstract Giant gastric ulcer (GGU) is defined as an ulcer more than 3 cm in diameter. Now infrequent in clinical practice, in the pre-H2 receptor antagonist (H2RA) era, the incidence of GGU varied between 12 and 24% of all gastric ulcers. Proton pump inhibitors reportedly achieve better healing rates and symptom relief in comparison to H2RA. The GGU is associated with high incidence of serious complications such as hemorrhage. A perforated GGU though rare (<2%) offers serious challenges in management. We report one such case wherein the role of multidetector CT scan (MDCT) for diagnosis and treatment planning, surgical options for GGU perforations, and factors affecting outcome are discussed.
    Language English
    Publishing date 2016-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2657697-1
    ISSN 2090-6919 ; 2090-6900
    ISSN (online) 2090-6919
    ISSN 2090-6900
    DOI 10.1155/2016/4681989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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