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Article ; Online: A comprehensive study of radon in drinking waters of Hanumangarh district and the assessment of resulting dose to local population

Singla, Amit Kumar / Kanse, Sandeep / Kansal, Sandeep / Rani, Supriya / Mehra, Rohit

Environ Geochem Health. 2023 Feb., v. 45, no. 2 p.443-455

2023

Abstract: Study of radon concentration in drinking water from different sources (groundwater and surface water) used across the Hanumangarh district of Rajasthan, India, was done using scintillation-based detector. The concentration of radon in surface water ... ...

Abstract	Study of radon concentration in drinking water from different sources (groundwater and surface water) used across the Hanumangarh district of Rajasthan, India, was done using scintillation-based detector. The concentration of radon in surface water varied from 0.12 to 2.07 Bq/l with an average value of 0.62 Bq/l and a standard deviation of 0.55 Bq/l and in groundwater samples varied from 1.61 to 8.73 Bq/l with an average value of 4.8 Bq/l and a standard deviation of 2.24 Bq/l. The ingestion and inhalation dose were calculated to assess the health risk for infants, children and adults. The resulting average annual effective dose has been found to be considerably lower than the recommended safe limit of 0.1 msv/y (WHO, In: Incorporating first and second addenda, third ed. WHO Press, Geneva. 3rd ed. World Health Organisation, Geneva, Switzerland, 2008). It can be concluded that radon in water does not pose a significant radiological health risk to the population of the studied area.
Keywords	breathing ; groundwater ; ingestion ; radon ; risk ; standard deviation ; surface water ; India
Language	English
Dates of publication	2023-02
Size	p. 443-455.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-022-01304-x
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Article ; Online: Musculoskeletal Tumors.

Singla, Amit / Geller, David S

Pediatric clinics of North America

2019 Volume 67, Issue 1, Page(s) 227–245

Abstract: Pediatric musculoskeletal tumors can arise in both bone and soft tissues. The overwhelming majority of these are benign; however, rarely, malignant neoplasms do occur. These are collectively termed sarcomas, indicating their mesenchymal origin. Sarcoma ... ...

Abstract	Pediatric musculoskeletal tumors can arise in both bone and soft tissues. The overwhelming majority of these are benign; however, rarely, malignant neoplasms do occur. These are collectively termed sarcomas, indicating their mesenchymal origin. Sarcoma management requires careful adherence to the well-described tenets of tumor management. This article summarizes the basic principles and recent advances in the management of soft tissue and bone tumors.
MeSH term(s)	Bone Neoplasms/diagnosis ; Bone Neoplasms/therapy ; Child ; Humans ; Sarcoma/diagnosis ; Sarcoma/therapy ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/therapy
Language	English
Publishing date	2019-11-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	215711-1
ISSN	1557-8240 ; 0031-3955
ISSN (online)	1557-8240
ISSN	0031-3955
DOI	10.1016/j.pcl.2019.09.014
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Article ; Online: Correlation of multiparametric MRI with histopathological grade of peripheral zone prostate carcinoma.

Singla, Amit / Deep, Nerbadyswari / Naik, Suprava / Mohakud, Sudipta / Nayak, Prasant / Sable, Mukund

Journal of cancer research and therapeutics

2023 Volume 19, Issue Suppl 2, Page(s) S569–S576

Abstract: Background: Prostatic cancer is the second most common malignant tumor in men. Preoperative grading of prostate cancer is important for its management. Our objective is to compare individual and combined detection rates of T2-weighted imaging (T2WI), ... ...

Abstract	Background: Prostatic cancer is the second most common malignant tumor in men. Preoperative grading of prostate cancer is important for its management. Our objective is to compare individual and combined detection rates of T2-weighted imaging (T2WI), diffusion weighted imaging (DWI), dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI), and magnetic resonance spectroscopy (MRS) for prostate cancer with histopathological diagnosis as its golden standard. Methods: Forty-four patients with positive digital rectal examination (DRE) findings and elevated prostate specific antigen (PSA), underwent multiparametric MRI (Mp-MRI). T2WI, DWI, DCE-MRI and MRS were done in all the patients. Cognitive magnetic resonance-transrectal ultrasound (MR-TRUS) fusion biopsy was done in all the patients. Sensitivity and specificity of T2WI, DWI, DCE-MRI, and Prostate Imaging - Reporting and Data System PIRADS version 2 was obtained. Apparent diffusion coefficient (ADC) value and choline/citrate ratio were obtained for each lesion and correlated with histopathological grade. Results: The mean age of the patients was 68.7 ± 10.1 years, and the mean serum PSA level was 58.1 ± 22.4 ng/dL. Of the 38 lesions in peripheral zone, 33 (87%) had histopathologically proven prostate cancer. T2WI had a sensitivity and specificity of 75.8% and 80% and DWI had a sensitivity and specificity of 90.9% and 80%, respectively, for detection of malignant prostatic lesion. The mean ADC values for prostate cancer, prostatitis, and normal prostatic parenchyma were 0.702 ± 0.094 × 10-3 mm2/sec, 0.959 ± 0.171 × 10-3 mm2/sec, and 1.31 ± 0.223 × 10-3 mm2/sec, respectively. Type 3 curve has lower sensitivity (45.5%) but high specificity (80%) for diagnosing prostate cancer. Conclusion: DWI can be useful to differentiate benign from malignant prostatic lesions, and low-grade from high-grade prostate carcinoma. ADC value has a positive correlation with histopathological grade of prostate cancer.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Prostate/diagnostic imaging ; Prostate/pathology ; Multiparametric Magnetic Resonance Imaging ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Magnetic Resonance Imaging/methods ; Diffusion Magnetic Resonance Imaging/methods ; Sensitivity and Specificity ; Image-Guided Biopsy ; Carcinoma/pathology ; Retrospective Studies
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2023-04-28
Publishing country	India
Document type	Journal Article
ZDB-ID	2187633-2
ISSN	1998-4138 ; 0973-1482
ISSN (online)	1998-4138
ISSN	0973-1482
DOI	10.4103/jcrt.jcrt_280_22
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Article ; Online: Using Biceps Tendon Autograft as a Patch in the Treatment of Massive Irreparable Rotator Cuff Tears Improves Patient-reported Outcome Scores: A Systematic Review.

Cheppalli, Naga Suresh / Purudappa, Prabhudev Prasad / Metikala, Sreenivasulu / Goel, Akshay / Singla, Amit / Sambandam, Senthil

Arthroscopy, sports medicine, and rehabilitation

2023 Volume 5, Issue 2, Page(s) e529–e536

Abstract: Purpose: To review the clinical studies describing the use of ipsilateral biceps tendon autograft for bridging irreparable massive rotator cuff tears (MRCTs).: Methods: A systematic review was conducted of MEDLINE, Embase, Cochrane, CINAHL, and ... ...

Abstract	Purpose: To review the clinical studies describing the use of ipsilateral biceps tendon autograft for bridging irreparable massive rotator cuff tears (MRCTs). Methods: A systematic review was conducted of MEDLINE, Embase, Cochrane, CINAHL, and Scopus databases using search terms "massive rotator cuff tear," "irreparable rotator cuff tear," and "long head of the biceps tendon." Only clinical human studies in which the biceps tendon was used as a bridging graft in MRCTs were included. All review studies, technique papers, and studies describing the use of biceps tendon as superior capsular reconstruction equivalent or rotator cable were excluded. Results: A total of 45 studies were initially identified, of which only 6 studies met the inclusion criterion. All studies were retrospective in nature, with a total of 176 patients. All studies reported a clinically significant improvement in postoperative functional outcomes, although this was not compared to a control group in all the studies. Pain was assessed using the visual analog scale (VAS) in 4 studies, and all reported an improvement in postoperative VAS ranging from 5 to 6 points. One study reported an improvement in pain scale from Japanese Orthopedic Association from 13.1 to 22.5 (9 points). One study did not report a VAS score as this study was published before the VAS score was developed. All the reported studies saw improvements in range of motion. Conclusions: The use of the long head of the biceps tendon as an interposition/bridging patch to augment the MRCT repair can reduce the VAS score, improve elevation and external rotation, and improve clinical and functional outcomes. Level of evidence: IV, systematic review of Level III and IV studies.
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2666-061X
ISSN (online)	2666-061X
DOI	10.1016/j.asmr.2023.01.016
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Article ; Online: "COVID-19 and cervical artery dissection- A causative association?"

Patel, Pratit / Khandelwal, Priyank / Gupta, Gaurav / Singla, Amit

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2020 Volume 29, Issue 10, Page(s) 105047

Abstract: COVID-19 is a pandemic disease which predominantly affects the respiratory system, however it also causes multi-organ dysfunction in a subset of patients. There is a growing evidence that it increases the propensity of strokes in younger patients. ... ...

Abstract	COVID-19 is a pandemic disease which predominantly affects the respiratory system, however it also causes multi-organ dysfunction in a subset of patients. There is a growing evidence that it increases the propensity of strokes in younger patients. Besides producing a prothrombotic state, arterial dissection could be one of its many manifestations, increasing the risks of stroke. Herein, we report the first case of spontaneous bilateral vertebral artery dissection in a patient with COVID-19. 39-year female presented with spontaneous bilateral vertebral artery dissections without any instigating traumatic events and no history of connective tissue disorders. Whether this patient's vertebral artery dissections were triggered by exaggerated inflammatory response or arteriopathy secondary to COVID-19 remains speculative. Nonetheless, arterial dissection could be one of it's complications. It is important for the physicians to be aware of different clinical manifestations of COVID-19 as we manage these patients with no historical experience, to provide adequate care.
MeSH term(s)	Adult ; Anticoagulants/administration & dosage ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/virology ; Female ; Host Microbial Interactions ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/virology ; Risk Factors ; SARS-CoV-2 ; Stroke/diagnostic imaging ; Stroke/drug therapy ; Stroke/etiology ; Stroke/virology ; Vertebral Artery Dissection/diagnostic imaging ; Vertebral Artery Dissection/drug therapy ; Vertebral Artery Dissection/etiology ; Vertebral Artery Dissection/virology
Chemical Substances	Anticoagulants
Keywords	covid19
Language	English
Publishing date	2020-06-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	1131675-5
ISSN	1532-8511 ; 1052-3057
ISSN (online)	1532-8511
ISSN	1052-3057
DOI	10.1016/j.jstrokecerebrovasdis.2020.105047
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Article ; Online: Lag Screw Trajectory in Supination-External Rotation Fractures: Does the Direction of the Fibula Lag Screw Have an Effect?

Singla, Amit / Sahlstrom, Adam D / Tommasini, Steven M / Yoo, Brad J

Clinics in orthopedic surgery

2021 Volume 13, Issue 4, Page(s) 456–460

Abstract: Background: The fracture obliquity of supination-external rotation injury of the fibula is often amenable to lag screw insertion. The purpose of the study was to determine whether biomechanical differences exist between lag screws inserted from an ... ...

Abstract	Background: The fracture obliquity of supination-external rotation injury of the fibula is often amenable to lag screw insertion. The purpose of the study was to determine whether biomechanical differences exist between lag screws inserted from an anterior to posterior direction and from a posterior to anterior direction and the thickness of the anterior and posterior fibular cortices were correlated with biomechanical testing. Methods: Ten cadaver fibulae were harvested and submitted to material testing following 3.5-mm cortical screw insertion from either an anterior to posterior direction or a posterior to anterior direction. Screw torsional insertion strength and axial pullout strength were measured. Computed tomography images of 40 consecutive patients undergoing preoperative planning for fractures excluding the fibula were examined to define fibular cortical thickness and correlate anatomic findings with the biomechanical testing. Results: The axial pullout strength of lag screws inserted from posterior to anterior was significantly greater than that of lag screws inserted from anterior to posterior ( Conclusions: For oblique fractures of the distal fibula, posterior to anterior lag screw insertion exhibited improved biomechanical properties when compared with a similar screw inserted from anterior to posterior. These results correlated with the thicker cortical bone present along the anterior fibula.
MeSH term(s)	Biomechanical Phenomena ; Bone Screws ; Cadaver ; Fibula/diagnostic imaging ; Fibula/surgery ; Fracture Fixation, Internal ; Humans ; Supination
Language	English
Publishing date	2021-11-15
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2502788-8
ISSN	2005-4408 ; 2005-291X
ISSN (online)	2005-4408
ISSN	2005-291X
DOI	10.4055/cios20304
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Article ; Online: Radiological risk assessment to the public due to the presence of radon in water of Barnala district, Punjab, India.

Rani, Supriya / Kansal, Sandeep / Singla, Amit Kumar / Mehra, Rohit

Environmental geochemistry and health

2021 Volume 43, Issue 12, Page(s) 5011–5024

Abstract: Various research studies have shown that exposure to radon gas is a cause of concern for health effects to the public. The present work has been carried out for the radiological risk assessment to the public due to the presence of radon isotopes in ... ...

Abstract	Various research studies have shown that exposure to radon gas is a cause of concern for health effects to the public. The present work has been carried out for the radiological risk assessment to the public due to the presence of radon isotopes in drinking water of Barnala district of Punjab, India, for the first time using scintillation-based radiation detector. A total of 100 samples were collected from different sources of water (canal and underground water) from 25 villages on grid pattern of 6 × 6 km
MeSH term(s)	Adult ; Child ; Drinking Water/analysis ; Humans ; India ; Infant ; Radiation Monitoring ; Radon/analysis ; Radon/toxicity ; Risk Assessment ; Water Pollutants, Radioactive/analysis
Chemical Substances	Drinking Water ; Radon-222 ; Water Pollutants, Radioactive ; Radon (Q74S4N8N1G)
Language	English
Publishing date	2021-06-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-021-01012-y
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Article ; Online: Quality and Variability of Physical Therapy Protocols Varies Widely for Osteochondral Allograft Transplantation of the Femoral Condyles.

Garcia-Mansilla, Ignacio / Trivellas, Myra / Singla, Amit / Kelley, Benjamin / Jones, Kristofer J

Cartilage

2022 Volume 13, Issue 1, Page(s) 19476035221073999

Abstract: Objective: To assess the quality and variability of osteochondral allograft (OCA) transplantation rehabilitation protocols associated with academic orthopedic programs in the United States.: Design: A systematic review was performed to collect all ... ...

Abstract	Objective: To assess the quality and variability of osteochondral allograft (OCA) transplantation rehabilitation protocols associated with academic orthopedic programs in the United States. Design: A systematic review was performed to collect all publicly available online rehabilitation protocols for femoral condyle OCA transplant from US academic orthopedic programs participating in the Electronic Residency Application Service. These protocols were evaluated for inclusion of different rehabilitation components as well as timing of suggested initiation of these activities. Results: A total of 22 protocols were included. Although 91% of protocols recommended bracing, wide variation exists in total time of utilization. Median time for full weight bearing (FWB) was 7 weeks (range 4-8). On average, each protocol mentioned 9 (range 2-18) different strengthening exercises. The median time suggested to return to high-impact activities was 9 months (range 8-12). Only 3 protocols (14%) offered criteria of advancement for each phase as well as criteria for discharge. Conclusion: Very few of the academic orthopedic programs have published online rehabilitation protocols following OCA transplantation. Although there is wide variation between the protocols, it allowed the identification of trends or patterns that are more common. However, there is need for more standardized evidence-based rehabilitation protocols which are easy to understand and follow by patients.
MeSH term(s)	Allografts ; Femur/surgery ; Humans ; Intra-Articular Fractures/rehabilitation ; Intra-Articular Fractures/surgery ; Knee Joint/surgery ; Physical Therapy Modalities ; Systematic Reviews as Topic ; Transplantation, Homologous
Language	English
Publishing date	2022-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2515870-3
ISSN	1947-6043 ; 1947-6035
ISSN (online)	1947-6043
ISSN	1947-6035
DOI	10.1177/19476035221073999
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Article ; Online: A comprehensive study of radon in drinking waters of Hanumangarh district and the assessment of resulting dose to local population.

Singla, Amit Kumar / Kanse, Sandeep / Kansal, Sandeep / Rani, Supriya / Mehra, Rohit

Environmental geochemistry and health

2022 Volume 45, Issue 2, Page(s) 443–455

Abstract	Study of radon concentration in drinking water from different sources (groundwater and surface water) used across the Hanumangarh district of Rajasthan, India, was done using scintillation-based detector. The concentration of radon in surface water varied from 0.12 to 2.07 Bq/l with an average value of 0.62 Bq/l and a standard deviation of 0.55 Bq/l and in groundwater samples varied from 1.61 to 8.73 Bq/l with an average value of 4.8 Bq/l and a standard deviation of 2.24 Bq/l. The ingestion and inhalation dose were calculated to assess the health risk for infants, children and adults. The resulting average annual effective dose has been found to be considerably lower than the recommended safe limit of 0.1 msv/y (WHO, In: Incorporating first and second addenda, third ed. WHO Press, Geneva. 3rd ed. World Health Organisation, Geneva, Switzerland, 2008). It can be concluded that radon in water does not pose a significant radiological health risk to the population of the studied area.
MeSH term(s)	Child ; Infant ; Adult ; Humans ; Drinking Water/analysis ; Radiation Monitoring/methods ; Radon/analysis ; Water Pollutants, Radioactive/analysis ; India ; Groundwater
Chemical Substances	Drinking Water ; Radon (Q74S4N8N1G) ; Water Pollutants, Radioactive
Language	English
Publishing date	2022-06-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-022-01304-x
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Article ; Online: Management paradigms of persistent primitive trigeminal artery aneurysms: A systematic review and analysis of techniques and complications from 1960s to 2022: From conservative to surgical to endovascular, how far along the right path are we?

Sreenivasan, Sanjeev / Agarwal, Neha / Roychowdhury, Sudipta / Khandelwal, Priyank / Sun, Hai / Singla, Amit / Sonig, Ashish / Gupta, Gaurav

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

2023 , Page(s) 15910199221150471

Abstract: Introduction: Aneurysms of persistent primitive trigeminal artery (PPTAAs) are increasingly reported and commonly managed by endovascular (EN) techniques. There are no systematic reviews or meta-analyses which analyse outcomes and complications of ... ...

Abstract	Introduction: Aneurysms of persistent primitive trigeminal artery (PPTAAs) are increasingly reported and commonly managed by endovascular (EN) techniques. There are no systematic reviews or meta-analyses which analyse outcomes and complications of treatment modalities for PPTAAs. We aim to highlight the change in trend of management of PPTAAs and to identify clinical and radiological parameters which may influence management paradigms. Methodology: A systematic search of literature was done in PubMed, Embase, Google Scholar, Cochrane library and Medline using keywords 'persistent primitive trigeminal artery', 'aneurysms', 'embolization', 'surgical clipping', etc. Only cases reporting aneurysms of PPTA were included. Three subgroups, such as conservative, open surgical (OS) and EN interventional, were studied for outcome evaluation. In the EN subgroup, relation of clinical and radiological parameters with outcome (complete/partial occlusion) was analysed using Microsoft Excel Data Analysis ToolPak. Results: Of the 101 articles found eligible for assessment, 54 were analysed quantitatively. Mortality in the conservative group was 12.5% and OS group was 9.09%. After EN treatment, complete angiographic occlusion was seen in 88.89% PPTAAs and 5.5% warranted retreatment. In the EN subgroup, location ( Conclusion: Clinical or radiological parameters do not influence angiographic occlusion outcome. Although EN techniques are successful, meticulous reporting of outcomes and complications is important.
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1354913-3
ISSN	2385-2011 ; 1591-0199 ; 1123-9344
ISSN (online)	2385-2011
ISSN	1591-0199 ; 1123-9344
DOI	10.1177/15910199221150471
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