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  1. Article: Dr PK Sen TAI gold medal oration.

    Singla, Rupak

    The Indian journal of tuberculosis

    2021  Volume 68, Issue 2, Page(s) 307–310

    Abstract: The current write-up is for Dr P.K.Sen TAI Gold Medal Oration Award for 2020 conferred to Dr Rupak Singla and delivered on 19 th December 2020. The title chosen for the oration was "Introduction and scale up of new anti-TB drugs in India: role of NITRD.ˮ ...

    Abstract The current write-up is for Dr P.K.Sen TAI Gold Medal Oration Award for 2020 conferred to Dr Rupak Singla and delivered on 19 th December 2020. The title chosen for the oration was "Introduction and scale up of new anti-TB drugs in India: role of NITRD.ˮ However, in the oration the role this institute has played for overall scale up of Drug-resistant TB services in India under National Tuberculosis Elimination Programme (NTEP) at different times from the beginning of national TB programme has also been presented. National Institute of TB and Respiratory Diseases has travelled with our country from beginning of DR-TB care. It demonstrated for the first time use of a Standardized Treatment Regimen with second line drugs for MDR-TB in field conditions. NITRD assisted NTEP for the concept of DST guided treatment. This institute guided NTEP for the management of MDR-TB failure patients with Pre-XDR and XDR-TB. Also, NITRD assisted India for the introduction of newer DR-TB drugs and scale up of newer drugs across the country. The strength of NITRD include clinical expertise, laboratory support and training division. NITRD commitment is strong and will continue to support NTEP for all endeavors in future also.
    MeSH term(s) Awards and Prizes ; Humans ; India ; National Health Programs ; Tuberculosis, Multidrug-Resistant/prevention & control
    Language English
    Publishing date 2021-02-08
    Publishing country India
    Document type Journal Article ; Lecture
    ZDB-ID 603129-8
    ISSN 0019-5707 ; 0019-5705
    ISSN 0019-5707 ; 0019-5705
    DOI 10.1016/j.ijtb.2021.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Highlights of pre-conference workshop on drug resistant TB.

    Singla, Rupak

    The Indian journal of tuberculosis

    2021  Volume 68, Issue 1, Page(s) 154–156

    MeSH term(s) Antitubercular Agents/administration & dosage ; Congresses as Topic ; Curriculum ; Humans ; Societies, Medical ; Tuberculosis, Multidrug-Resistant/diagnosis ; Tuberculosis, Multidrug-Resistant/therapy
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2021-02-05
    Publishing country India
    Document type Letter
    ZDB-ID 603129-8
    ISSN 0019-5707 ; 0019-5705
    ISSN 0019-5707 ; 0019-5705
    DOI 10.1016/j.ijtb.2021.02.005
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  3. Article: Clinical spectrum of TB in elderly in a TB & respiratory institution.

    Singla, Rupak / Gupta, Amitesh / Bhattacherjee, Nilotpal / Choudhary, Madhumita Paul

    The Indian journal of tuberculosis

    2022  Volume 69 Suppl 2, Page(s) S220–S224

    Abstract: Tuberculosis has maximum burden among young population in developing countries like India. However, children and elderly form a special group where TB may have atypical presentation. This presents with epidemiological, diagnostic and treatment challenges ...

    Abstract Tuberculosis has maximum burden among young population in developing countries like India. However, children and elderly form a special group where TB may have atypical presentation. This presents with epidemiological, diagnostic and treatment challenges in these groups which may need special attention in the national programmes for TB. Due to atypical presentation, elderly population is vulnerable to frequent misdiagnosis and disease may already be in advanced stage when correct diagnosis is made. Not only this, adjustment of drug dosages and high chances of adverse drug reaction make the management of TB more complicated in elderly. Mortality due to TB is also higher in this group as compared to young patients of TB. This view point briefly highlights the epidemiological, clinical and disease outcome aspects of TB disease in elderly patients.
    MeSH term(s) Aged ; Child ; Humans ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology ; Health Facilities ; India/epidemiology ; Diagnostic Errors
    Language English
    Publishing date 2022-10-26
    Publishing country India
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 603129-8
    ISSN 0019-5707 ; 0019-5705
    ISSN 0019-5707 ; 0019-5705
    DOI 10.1016/j.ijtb.2022.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Basic spirometry and advanced pulmonary function tests - NATCON 2022.

    Singla, Rupak / Gupta, Amitesh / Gothi, Dipti / Mittal, Saurabh / Meena, Saroj / Gupta, Neeraj

    The Indian journal of tuberculosis

    2023  Volume 70, Issue 3, Page(s) 370–371

    Abstract: At the 77th National Conference on Tuberculosis and Chest Diseases, which took place on February 27, 2023, a pre-conference workshop on Basic Spirometry and Advanced Pulmonary Function Tests was held under the auspices of NATCON-2022. With the assistance ...

    Abstract At the 77th National Conference on Tuberculosis and Chest Diseases, which took place on February 27, 2023, a pre-conference workshop on Basic Spirometry and Advanced Pulmonary Function Tests was held under the auspices of NATCON-2022. With the assistance of highly experienced faculty who are national and international level experts in their fields, the workshop covered all important aspects of basic spirometry and advanced Pulmonary Function Tests.
    MeSH term(s) Humans ; Forced Expiratory Volume ; Respiratory Function Tests ; Spirometry ; Lung
    Language English
    Publishing date 2023-04-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 603129-8
    ISSN 0019-5707 ; 0019-5705
    ISSN 0019-5707 ; 0019-5705
    DOI 10.1016/j.ijtb.2023.04.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: FACTORS AFFECTING BALANCE IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

    Mohd Umar Mukhtar Qurashi / Singla Rupak / Mitra Shambhovi

    International Journal of Physiotherapy (2019)

    2019  

    Abstract: ... ...

    Abstract anstract
    Keywords COPD ; Balance ; Peripheral muscle strength ; respiratory muscle strength ; functional capacity ; BODE index ; Medicine (General) ; R5-920
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher IJPHY
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Adverse drug reactions & drug interactions in MDR-TB patients.

    Gupta, Amitesh / Kumar, Vikas / Natarajan, Sekar / Singla, Rupak

    The Indian journal of tuberculosis

    2020  Volume 67, Issue 4S, Page(s) S69–S78

    Abstract: Multiple drugs taken for long duration in tuberculosis (TB) treatment, especially drug resistant TB (DR-TB), may produce adverse drug reactions (ADRs). Although any anti-TB drug can cause ADRs, but these are more common with drugs used for treatment of ... ...

    Abstract Multiple drugs taken for long duration in tuberculosis (TB) treatment, especially drug resistant TB (DR-TB), may produce adverse drug reactions (ADRs). Although any anti-TB drug can cause ADRs, but these are more common with drugs used for treatment of DR-TB. However, most of ADRs with these drugs are mild or moderate and can be managed if adequate supervision and monitoring is done. However, few ADRs can be severe or potentially life-threatening and may require removal of the offending drug(s). TB patients having comorbidities and on treatment for them may experience drug interaction with anti TB drugs and may require dose modification or change of drug. For a good TB treatment outcome patient's compliance should be ensured, and adverse events and drug interactions should be appropriately addressed by the clinicians. This article outlines the majority of the possible ADRs to anti-TB drugs used for management of DR-TB and their common drug interactions with practical recommendations to identify the possible drug(s) responsible and the most adequate management in each situation.
    MeSH term(s) Antitubercular Agents/adverse effects ; Drug Interactions ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Tuberculosis, Multidrug-Resistant/drug therapy
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2020-10-03
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 603129-8
    ISSN 0019-5707 ; 0019-5705
    ISSN 0019-5707 ; 0019-5705
    DOI 10.1016/j.ijtb.2020.09.027
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  7. Article: Pulmonary function testing during the COVID-19 pandemicin.

    Christopher, Devasahayam Jesudas / Mohan, B V Murali / Singla, Rupak / Koul, Parvaiz A

    Lung India : official organ of Indian Chest Society

    2021  Volume 38, Issue Supplement, Page(s) S92–S96

    Language English
    Publishing date 2021-03-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/lungindia.lungindia_738_20
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  8. Article: Tobacco use, tuberculosis and Covid-19: A lethal triad.

    Mrigpuri, Parul / Gupta, Amitesh / Jha, Ritika / Singla, Pranjal / Singla, Rupak

    The Indian journal of tuberculosis

    2021  Volume 68S, Page(s) S86–S88

    Abstract: Smoking, TB and Covid-19 are high prevalence entities with public health consequences. All three of them have a possible complex interaction at cellular level. Smoking behavior makes it difficult to maintain infection control measures. Smoking is known ... ...

    Abstract Smoking, TB and Covid-19 are high prevalence entities with public health consequences. All three of them have a possible complex interaction at cellular level. Smoking behavior makes it difficult to maintain infection control measures. Smoking is known to increase TB infection and also adversely affect treatment outcomes in TB. There is also upcoming evidence which suggests that smoking and TB increase the risk of severe Covid-19 symptoms. Simple infection control measures like, social distancing, cough etiquette, isolation, hand hygiene, quarantine, use of masks etc. play a pivotal role in prevention of these diseases. There is need of strengthening of the public health policies and incorporation of the Covid-19 safety awareness measures into the various national programmes.
    MeSH term(s) COVID-19/complications ; COVID-19/prevention & control ; Humans ; Pneumonia, Viral/complications ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; Risk Factors ; SARS-CoV-2 ; Smoking/adverse effects ; Tuberculosis/complications ; Tuberculosis/prevention & control
    Language English
    Publishing date 2021-08-12
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 603129-8
    ISSN 0019-5707 ; 0019-5705
    ISSN 0019-5707 ; 0019-5705
    DOI 10.1016/j.ijtb.2021.08.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Chronic pulmonary aspergillosis in a tertiary tuberculosis institute: A common entity missed commonly.

    Singhal, Ritu / Gupta, Amitesh / Singla, Neeta / Singla, Rupak / Jha, Ritika / Raina, Shweta / Choudhary, Madhumita Paul / Bhattacherjee, Nilotpal

    The Indian journal of tuberculosis

    2023  Volume 70, Issue 3, Page(s) 276–285

    Abstract: The disease chronic pulmonary aspergillosis (CPA), which has 3 million cases globally, has a substantial impact on global health. The morbidity and mortality it cause are also rather severe. Patients with modest immune suppression or those with ... ...

    Abstract The disease chronic pulmonary aspergillosis (CPA), which has 3 million cases globally, has a substantial impact on global health. The morbidity and mortality it cause are also rather severe. Patients with modest immune suppression or those with underlying structural and chronic lung illnesses are more likely to develop this condition. CPA pose a diagnostic and management challenge to clinicians. The condition causes patients to have persistent respiratory difficulties, which lowers their quality of life, and the therapy is lengthy and offers few choices. Particularly in a nation like India, where tuberculosis (TB) is prevalent and patients exhibit identical signs and symptoms, a strong index of suspicion is required. Treated pulmonary TB patients, presenting with symptoms or chest x-ray abnormalities, especially those with presence of cavity are also more prone to develop CPA. The constellation of symptoms together with presence of microbiological criteria and suggestive radiology can help to reach at the diagnosis. The field of mycology has made major developments, but there is still much to understand about this illness and to establish timely diagnoses and make the best use of the existing treatment choices. The burden of CPA in patients with treated TB is highlighted in this article along with the most recent research and clinical guidelines.
    MeSH term(s) Humans ; Quality of Life ; Pulmonary Aspergillosis/complications ; Pulmonary Aspergillosis/diagnosis ; Lung ; Tuberculosis ; Tuberculosis, Pulmonary/complications ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/drug therapy ; Chronic Disease
    Language English
    Publishing date 2023-04-01
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 603129-8
    ISSN 0019-5707 ; 0019-5705
    ISSN 0019-5707 ; 0019-5705
    DOI 10.1016/j.ijtb.2023.03.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A new role of extracorporeal membrane oxygenation in the management of tuberculosis with acute respiratory distress syndrome: A case report and review of literature.

    Anand, Shweta / Singla, Rupak / Kumar, Vikas / Dewan, Sandeep / Faye, Abhishek / Gupta, Amitesh

    Lung India : official organ of Indian Chest Society

    2021  Volume 39, Issue 1, Page(s) 77–79

    Abstract: Pulmonary tuberculosis (PTB) can lead to acute respiratory distress syndrome (ARDS), which can be at times fatal. Venovenous extracorporeal membrane oxygenation (VV-ECMO) ensures adequate oxygenation and carbon dioxide removal, avoiding ventilator- ... ...

    Abstract Pulmonary tuberculosis (PTB) can lead to acute respiratory distress syndrome (ARDS), which can be at times fatal. Venovenous extracorporeal membrane oxygenation (VV-ECMO) ensures adequate oxygenation and carbon dioxide removal, avoiding ventilator-induced lung injury. We present a case where a young woman with refractory respiratory failure caused by PTB, unresponsive to conventional mechanical ventilation, but was successfully managed with prolonged VV-ECMO support. The patient diagnosed with PTB was started on antitubercular treatment but went into respiratory failure and ARDS. The patient was put on mechanical ventilation, on which she was not improving. The patient was then put on ECMO. On the 9
    Language English
    Publishing date 2021-12-17
    Publishing country India
    Document type Case Reports
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/lungindia.lungindia_173_21
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