Article ; Online: Intravenous iron to treat anaemia following critical care: a multicentre feasibility randomised trial.
British journal of anaesthesia
2021 Volume 128, Issue 2, Page(s) 272–282
Abstract: Background: Anaemia is common and associated with poor outcomes in survivors of critical illness. However, the optimal treatment strategy is unclear.: Methods: We conducted a multicentre, feasibility RCT to compare either a single dose of ferric ... ...
| Abstract | Background: Anaemia is common and associated with poor outcomes in survivors of critical illness. However, the optimal treatment strategy is unclear. Methods: We conducted a multicentre, feasibility RCT to compare either a single dose of ferric carboxymaltose 1000 mg i.v. or usual care in patients being discharged from the ICU with moderate or severe anaemia (haemoglobin ≤100 g L Results: Ninety-eight participants were randomly allocated (49 in each arm). The overall recruitment rate was 34% with 6.5 participants recruited on average per month. Forty-seven of 49 (96%) participants received the intervention. Patient-reported outcome measures were available for 79/93 (85%) survivors at 90 days. Intravenous iron resulted in a higher mean (standard deviation [sd]) haemoglobin at 28 days (119.8 [13.3] vs 106.7 [14.9] g L Conclusion: A large, multicentre RCT of i.v. iron to treat anaemia in survivors of critical illness appears feasible and is necessary to determine the effects on patient-centred outcomes. Clinical trial registration: ISRCTN13721808 (www.isrctn.com). |
|---|---|
| Language | English |
| Publishing date | 2021-12-03 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 80074-0 |
| ISSN | 1471-6771 ; 0007-0912 |
| ISSN (online) | 1471-6771 |
| ISSN | 0007-0912 |
| DOI | 10.1016/j.bja.2021.11.010 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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