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  1. Article: Does Combined Access Mandibulotomy, Rim Mandibulectomy and Neck Dissection Compound the Late Effects of Radiotherapy?

    Tatsis, Dimitris / Kowa, Xin-Ying / Sinha, Deepti / Kalavrezos, Nicholas

    Plastic and reconstructive surgery. Global open

    2023  Volume 11, Issue 6, Page(s) e5081

    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000005081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Contemporary management of advanced midface malignancy in the age of Instagram - a parallel surgical and patient's perspective.

    Fullerton, Hannah / Dawood, Andrew / Kalavrezos, Nicholas / Sinha, Deepti

    British dental journal

    2021  Volume 231, Issue 4, Page(s) 233–238

    Abstract: The internet and social media give our patients extraordinary access to information; in these unprecedented times of the COVID-19 pandemic, where so much of life takes place online, patients and professionals alike look to the internet more and more for ... ...

    Abstract The internet and social media give our patients extraordinary access to information; in these unprecedented times of the COVID-19 pandemic, where so much of life takes place online, patients and professionals alike look to the internet more and more for information and (self-)diagnosis. This article details the treatment journey for a patient with a high-grade chondroblastic osteosarcoma of the right maxilla, paranasal area and zygoma, from misdiagnosis through to resection and full rehabilitation with free flap surgery and implant reconstruction. Uniquely, the article details the patient's treatment, in parallel with her own perception of the treatment, as shared on social media.
    MeSH term(s) COVID-19 ; Female ; Humans ; Maxilla ; Neoplasms ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-08-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-021-3320-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Vascularized free fibula flap oral rehabilitation using tissue engineered mucosa: Report of 3 cases.

    Vassiliou, Leandros V / Sinha, Deepti / Dawood, Andrew / Kalavrezos, Nicholas

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

    2022  Volume 50, Issue 6, Page(s) 485–492

    Abstract: The aim of this report is to introduce the use of the dermal substitute Integra® in the context of free fibula flap prelamination for mandibular reconstruction. Three cases of mandibular reconstruction with prefabricated and Integra-prelaminated ... ...

    Abstract The aim of this report is to introduce the use of the dermal substitute Integra® in the context of free fibula flap prelamination for mandibular reconstruction. Three cases of mandibular reconstruction with prefabricated and Integra-prelaminated vascularized fibula flaps are reported in this article. The patients reported in this case series presented with the following tumours: an extensive cemento-ossyfying fibroma, a multicystic ameloblastoma and an extensive calcifying epithelial odontogenic tumour. Virtual three-dimensional (3D) planning and 3D-printed cutting guides were used for the mandibulectomies, the flap harvest and the positioning of the implants. The dermal substitute Integra was used for prelamination instead of skin grafts. Treatment of all 3 patients was performed in two stages; the first consisted of the fibula prefabrication (dental implant insertion) and prelamination, and the second consisted of tumor resection and reconstruction with the vascularized implant-bearing fibula flap. Integra was shown to be able to generate complete mucosa-like tissue over the fibula flaps and in the peri-implant areas. The patients have been followed up for 1, 3 and 7 years, respectively, with satisfactory prosthetic, functional and aesthetic results. None of the patients developed peri-implant disease. It was observed that prelamination with the dermal substitute Integra leads to development of mucosal lining with clinical features similar to oral mucosa. In this report of three cases, use of Integra as part of the prelamination and prefabrication process, instead of skin grafts, appears able to clinically generate mucosal lining with avoidance of skin grafts.
    MeSH term(s) Bone Transplantation/methods ; Dental Implants ; Esthetics, Dental ; Fibula/transplantation ; Free Tissue Flaps/transplantation ; Humans ; Mandibular Reconstruction/methods ; Mouth Mucosa ; Reconstructive Surgical Procedures/methods
    Chemical Substances Dental Implants
    Language English
    Publishing date 2022-05-28
    Publishing country Scotland
    Document type Case Reports
    ZDB-ID 91267-0
    ISSN 1878-4119 ; 1010-5182 ; 0301-0503
    ISSN (online) 1878-4119
    ISSN 1010-5182 ; 0301-0503
    DOI 10.1016/j.jcms.2022.05.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correlation between oral and oropharyngeal resection subsites and impact of reconstruction on speech and swallowing function in head and neck cancer patients: A systematic review.

    Awad, Laura / Langridge, Benjamin J / Noy, Dani / Govender, Roganie / Sinha, Deepti / Butler, Peter Em / Kalavrezos, Nicholas

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

    2024  

    Abstract: This review aims to provide a correlation between oral and oropharyngeal subsites and type of reconstruction used in the management of head and neck cancer patients. A literature search of PubMed, Embase and Web of Science was conducted. All study types ... ...

    Abstract This review aims to provide a correlation between oral and oropharyngeal subsites and type of reconstruction used in the management of head and neck cancer patients. A literature search of PubMed, Embase and Web of Science was conducted. All study types describing long-term speech and swallow outcomes of adults following head and neck oncological reconstruction, which used a subsite classification, were included. Risk of bias was assessed using the Robbins-1 tool. A total of 2270 patients were found in 26 studies. The number of subsites/studies ranged from 2 to 18. Subsites were predominantly divided on an anatomical basis. Other classifications included functionally grouped subsites. Seven articles considered combinations, unilateral and bilateral defects. Base of tongue, FOM, and defects crossing the midline are negatively correlated with post-operative speech and swallow. Lateral distributions were associated with superior outcomes. The University of Washington Quality of Life Questionnaire (UW-QOL) was the most prevalent tool for speech and swallow assessment. Other factors that significantly affect speech and swallow outcomes include adjuvant therapy, size, type of reconstruction (free flap compared to pedicled or local). The role of neoadjuvant therapy remains unknown. A consistent and formalised approach including risk stratification for multiple contributing factors would be useful in clinical pre- and post-operative management.
    Language English
    Publishing date 2024-01-18
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 91267-0
    ISSN 1878-4119 ; 1010-5182 ; 0301-0503
    ISSN (online) 1878-4119
    ISSN 1010-5182 ; 0301-0503
    DOI 10.1016/j.jcms.2024.01.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Prognosis of oral epithelial dysplasia in individuals with and without oral lichen planus.

    Pimolbutr, Kununya / Lim, Woei Tatt / Leeson, Rachel / Hopper, Colin / Kalavrezos, Nicholas / Liew, Colin / Schilling, Clare / Sinha, Deepti / Jay, Amrita / Agrawal, Reshma / Porter, Stephen / Fedele, Stefano

    Oral diseases

    2023  Volume 30, Issue 2, Page(s) 504–517

    Abstract: Objectives: To investigate the role of oral lichen planus (OLP) on the long-term prognosis of oral epithelial dysplasia (OED).: Methods: Retrospective single-centre cohort study using the 2007-2019 database of the Head and Neck Cancer and Oral ... ...

    Abstract Objectives: To investigate the role of oral lichen planus (OLP) on the long-term prognosis of oral epithelial dysplasia (OED).
    Methods: Retrospective single-centre cohort study using the 2007-2019 database of the Head and Neck Cancer and Oral Medicine units of University College London Hospital. The exposure of interest was the presence of OLP, and the prognostic outcomes included the development of new primary episodes of OED, progression to malignancy and mortality. Cox proportional hazard and Poisson regression models were performed.
    Results: A total of 299 patients, of whom 144 had OED arising on the background of OLP (OLP/OED) and 155 had OED without underlying OLP (non-OLP/OED), were included. A pre-existing diagnosis of OLP was significantly associated with a twofold increased risk of subsequent primary OED events (HR = 2.02, p = 0.04), which also developed faster (1.46 vs. 2.96 years, p = 0.04) and with more involvement of non-cancer-prone sites (p = 0.001) than in the non-OLP/OED group. There was no difference between groups in the progression to malignancy or mortality.
    Conclusions: Oral lichen planus/OED patients are at higher risk of multiple episodes of primary OED, which can develop faster and at non-cancer-prone sites as compared to non-OLP/OED individuals. Further research is needed to clarify the effects of OLP upon progression to OSCC and mortality.
    MeSH term(s) Humans ; Lichen Planus, Oral/pathology ; Mouth Neoplasms/pathology ; Retrospective Studies ; Cohort Studies ; Carcinoma, Squamous Cell/pathology ; Hyperplasia ; Prognosis
    Language English
    Publishing date 2023-01-26
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Clinical atlas of ENT and head & neck diseases

    Saharia, P. S / Sinha, Deepti

    2013  

    Title variant Clinical atlas of ENT and head and neck diseases ; ENT and head and neck diseases
    Author's details P.S. Saharia, Deepti Sinha ; foreword Prem Kakar
    MeSH term(s) Otorhinolaryngologic Diseases ; Head/pathology ; Neck/pathology
    Language English
    Size 175 pages :, illustrations, portraits +
    Edition First edition.
    Document type Book
    Note Includes index.
    Accompanying material 1 DVD (4 3/4 in.)
    ISBN 9789350251157 ; 9350251159
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Article: An amazing case of working wrist watch in the esophagus.

    Aggarwal, Nitin / Sinha, Deepti

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2012  Volume 58, Issue 1, Page(s) 105–106

    Abstract: Foreign bodies in the esophagus are commonly seen in otolaryngologic practice. We report the successful removal of a working wrist watch dial lodged for one month in the esophagus of an adult schizophrenic patient, which is a rare incident. ...

    Abstract Foreign bodies in the esophagus are commonly seen in otolaryngologic practice. We report the successful removal of a working wrist watch dial lodged for one month in the esophagus of an adult schizophrenic patient, which is a rare incident.
    Language English
    Publishing date 2012-10-05
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/BF02907760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Retrospective Analysis of Dental Implants Placed Between 2012 and 2014: Indications, Risk Factors, and Early Survival.

    Grisar, Koenraad / Sinha, Deepti / Schoenaers, Joseph / Dormaar, Titiaan / Politis, Constantinus

    The International journal of oral & maxillofacial implants

    2017  Volume 32, Issue 3, Page(s) 649–654

    Abstract: Purpose: The aim of this study was to review the indications for implant placement, early outcomes, and associated risk factors.: Materials and methods: A retrospective cohort study design was used. The study was composed of a group of 509 ... ...

    Abstract Purpose: The aim of this study was to review the indications for implant placement, early outcomes, and associated risk factors.
    Materials and methods: A retrospective cohort study design was used. The study was composed of a group of 509 consecutive patients, which represented the total number of patients treated from 2012 to 2014 in the Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, Belgium. The authors analyzed the indications for implant placement and the potential risk factors for early implant failure.
    Results: A total of 509 patients received 1,139 dental implants. The group consisted of 240 men and 269 women, with a median age of 58 years. The most frequent indication for implant placement was restoration of a partially edentulous arch (80.1%, n = 408). For 152 implants (13.3%), additional bone-augmentation or sinus elevation procedures were required. Early failures were recorded for 52 (4.6%) implants in 33 patients (6.5%). Smoking, male gender, total edentulism, implant diameter, and bone augmentation surgery were found to be associated with early implant failure.
    Conclusion: Patients referred for implant placement were more likely to be partially edentulous and older than 50 years. Singletooth replacement in the posterior mandible was the most frequent indication (24.4%) for treatment. This study found an early success rate of 95.4% and identified risk factors for early failures.
    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632880-5
    ISSN 1942-4434 ; 0882-2786
    ISSN (online) 1942-4434
    ISSN 0882-2786
    DOI 10.11607/jomi.5332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Sleep disordered breathing in children.

    Sinha, Deepti / Guilleminault, Christian

    The Indian journal of medical research

    2010  Volume 131, Page(s) 311–320

    Abstract: Sleep disordered breathing (SDB) is increasingly being recognised as a cause of morbidity even in young children. With an estimated prevalence of 1 to 4 per cent, SDB results from having a structurally narrow airway combined with reduced neuromuscular ... ...

    Abstract Sleep disordered breathing (SDB) is increasingly being recognised as a cause of morbidity even in young children. With an estimated prevalence of 1 to 4 per cent, SDB results from having a structurally narrow airway combined with reduced neuromuscular tone and increased airway collapsibility. SDB in children differs from adults in a number of ways, including presenting symptoms and treatment. Presentation may differ according to the age of the child. Children have a more varied presentation from snoring and frequent arousals to enuresis to hyperactivity. Those with Down syndrome, midface hypoplasia or neuromuscular disorders are at higher risk for developing SDB. First line definitive treatment in children involves tonsillectomy and adenoidectomy. Rapid maxillary expansion, allergy treatment and continuous positive airway pressure (CPAP) are other options. As untreated SDB results in complications as learning difficulties, memory loss and a long term increase in risk of hypertension, depression and poor growth, it is important to diagnose SDB.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Hypertension ; Infant ; Male ; Risk ; Risk Factors ; Sleep ; Sleep Apnea Syndromes/diagnosis ; Sleep Apnea Syndromes/epidemiology ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/epidemiology ; Snoring ; Trachea/anatomy & histology
    Language English
    Publishing date 2010-02
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: Personal growth and training & development

    Sinha, Deepti / Sinha, Sachin

    2009  

    Abstract: Includes bibliographical references and ... ...

    Title variant Personal growth and training and development
    Institution ebrary, Inc
    Author's details Deepti Sinha, Sachin Sinha
    Abstract Includes bibliographical references and index
    Keywords Identity (Psychology) ; Self-actualization (Psychology) ; Self-perception
    Language English
    Size Online-Ressource
    Publisher Word-press
    Publishing place Lucknow, India
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 9789380257143 ; 9380257147
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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