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  1. Article ; Online: Commentary: The arterial switch operation: Is it still all about the coronaries?

    Sinha, Lok / Mery, Carlos M

    The Journal of thoracic and cardiovascular surgery

    2020  Volume 160, Issue 1, Page(s) 201–202

    MeSH term(s) Arterial Switch Operation ; Coronary Vessels ; Heart ; Humans ; Transposition of Great Vessels
    Language English
    Publishing date 2020-01-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2019.12.055
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  2. Article: An Unusual Presentation of Right Atrial Myxoma: A Case Report.

    Saha, Debmalya / Sinha, Lakshmi / Samal, Satyajit / Sharma, Parag / Naqvi, Sayyed Ehtesham Hussain / Geelani, Muhammad Abid

    Oman medical journal

    2023  Volume 38, Issue 1, Page(s) e466

    Abstract: A right atrial myxoma extending to the inferior vena cava with associated right-to-left shunting leading to systemic desaturation is an exceedingly rare clinical entity. The number of cases reported in the literature to date is not more than five. This ... ...

    Abstract A right atrial myxoma extending to the inferior vena cava with associated right-to-left shunting leading to systemic desaturation is an exceedingly rare clinical entity. The number of cases reported in the literature to date is not more than five. This case study presents a 45-year-old female who was referred to our center with symptoms of breathlessness, easy fatigability, generalized weakness, and central cyanosis. On routine blood investigation, polycythemia was detected. On preoperative 2D-transthoracic echocardiography, the diagnosis of right atrial mass was confirmed but the reason for cyanosis was not revealed. A tumor thrombus in a branch of the right lower pulmonary artery with a small locoregional pulmonary infarct along with right atrial myxoma was reported in computed tomography angiography of the heart and great vessels. On-table transesophageal echocardiography showed patent foramen ovale (PFO) with right-to-left shunting because of raised right atrial pressure and dynamic obstruction of the tricuspid valve by the mass. The myxoma was resected completely via right atrial approach along with primary closure of PFO. Postoperative period was uneventful, and the patient was discharged on day seven. At three-month follow-up, the patient was doing well.
    Language English
    Publishing date 2023-01-31
    Publishing country Oman
    Document type Case Reports
    ZDB-ID 2571431-4
    ISSN 2070-5204 ; 1999-768X
    ISSN (online) 2070-5204
    ISSN 1999-768X
    DOI 10.5001/omj.2023.06
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  3. Article ; Online: Identification of novel curcumin derivatives against pancreatic cancer: a comprehensive approach integrating 3D-QSAR pharmacophore modeling, virtual screening, and molecular dynamics simulations.

    Chahbaoui, Narimene / Khamouli, Saida / Alaqarbeh, Marwa / Belaidi, Salah / Sinha, Leena / Chtita, Samir / Bouachrine, Mohammed

    Journal of biomolecular structure & dynamics

    2023  , Page(s) 1–19

    Abstract: Pancreatic cancer, known as the "silent killer," poses a daunting challenge in cancer therapy. The dysregulation of the PI3Kα signaling pathway in pancreatic cancer has attracted considerable interest as a promising target for therapeutic intervention. ... ...

    Abstract Pancreatic cancer, known as the "silent killer," poses a daunting challenge in cancer therapy. The dysregulation of the PI3Kα signaling pathway in pancreatic cancer has attracted considerable interest as a promising target for therapeutic intervention. In this regard, the use of curcumin derivatives as inhibitors of PI3Kα has emerged, providing a novel and promising avenue for developing effective treatments for this devastating disease. Computational approaches were employed to explore this potential and investigate 58 curcumin derivatives with cytotoxic activity against the Panc-1 cell line. Our approach involved ligand-based pharmacophore modeling and atom-based 3D-QSAR analysis. The resulting QSAR model derived from the best-fitted pharmacophore hypothesis (AAHRR_1) demonstrated remarkable performance with high correlation coefficients (R
    Language English
    Publishing date 2023-10-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2266502
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  4. Article ; Online: Commentary: Dream big in every small step.

    Sinha, Lok / Yerebakan, Can

    The Journal of thoracic and cardiovascular surgery

    2019  Volume 158, Issue 2, Page(s) 532–533

    MeSH term(s) Humans ; Respiratory Physiological Phenomena
    Language English
    Publishing date 2019-01-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2018.12.086
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  5. Article ; Online: Identification of Potent Acetylcholinesterase Inhibitors as New Candidates for Alzheimer Disease via Virtual Screening, Molecular Docking, Dynamic Simulation, and Molecular Mechanics-Poisson-Boltzmann Surface Area Calculations.

    Chennai, Hind Yassmine / Belaidi, Salah / Bourougaa, Lotfi / Ouassaf, Mebarka / Sinha, Leena / Samadi, Abdelouahid / Chtita, Samir

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 6

    Abstract: Huperzine A (HUP) plays a crucial role in Alzheimer's therapy by enhancing cognitive function through increased cholinergic activity as a reversible acetylcholinesterase (AChE) inhibitor. Despite some limitations being seen in AChE inhibitors, ongoing ... ...

    Abstract Huperzine A (HUP) plays a crucial role in Alzheimer's therapy by enhancing cognitive function through increased cholinergic activity as a reversible acetylcholinesterase (AChE) inhibitor. Despite some limitations being seen in AChE inhibitors, ongoing research remains dedicated to finding innovative and more effective treatments for Alzheimer's disease. To achieve the goal of the discovery of potential HUP analogues with improved physicochemical properties, less toxic properties, and high biological activity, many in silico methods were applied. Based on the acetylcholinesterase-ligand complex, an e-pharmacophore model was developed. Subsequently, a virtual screening involving a collection of 1762 natural compounds, sourced from the PubChem database, was performed. This screening yielded 131 compounds that exhibited compatibility with the established pharmacophoric hypothesis. These selected ligands were then subjected to molecular docking within the active site of the 4EY5 receptor. As a result, we identified four compounds that displayed remarkable docking scores and exhibited low free binding energy to the target. These top four compounds, CID_162895946, CID_44461278, CID_44285285, and CID_81108419, were submitted to ADMET prediction and molecular dynamic simulations, yielding encouraging findings in terms of their pharmacokinetic characteristics and stability. Finally, the molecular dynamic simulation, cross-dynamic correlation matrix, free energy landscape, and MM-PBSA calculations demonstrated that two ligands from the selected ligands formed very resilient complexes with the enzyme acetylcholinesterase, with significant binding affinity. Therefore, these two compounds are recommended for further experimental research as possible (AChE) inhibitors.
    MeSH term(s) Humans ; Cholinesterase Inhibitors/chemistry ; Alzheimer Disease/drug therapy ; Molecular Dynamics Simulation ; Molecular Docking Simulation ; Acetylcholinesterase/metabolism ; Ligands ; Alkaloids ; Sesquiterpenes
    Chemical Substances Cholinesterase Inhibitors ; Acetylcholinesterase (EC 3.1.1.7) ; huperzine A (0111871I23) ; Ligands ; Alkaloids ; Sesquiterpenes
    Language English
    Publishing date 2024-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29061232
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    Zs.MO 81: Show issues

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  6. Article: Quality Characteristics and Functional Properties of Soy Protein Isolate Prepared Using Ultrafiltration

    John, Hima / Sinha, L. K

    Journal of agricultural engineering. 2019 Jan., v. 56, no. 1

    2019  

    Abstract: Soy protein isolate (SPI) were obtained through ultrafiltration using 10 kDa hollow fibre cartridge, 117.21 kPa trans-membrane pressure and 3.5 volume concentration ratio. SPI prepared by ultrafiltration possessed highest protein content (88±0.3%) and 91. ...

    Abstract Soy protein isolate (SPI) were obtained through ultrafiltration using 10 kDa hollow fibre cartridge, 117.21 kPa trans-membrane pressure and 3.5 volume concentration ratio. SPI prepared by ultrafiltration possessed highest protein content (88±0.3%) and 91.09±0.84% nitrogen solubility index (NSI) as compared to 84±0.5% protein content and 19.29±0.74% NSI for acid precipitated and 85±0.5% protein content for commercially available SPI. Ultra filtered SPI also possessed highest value of emulsion stability (ES) of 51.96±1.42%, whereas commercially available SPI exhibited the least value of 48.38±0.015 per cent. Highest value of oil absorption capacity (OAC) was 2.15±0.04 g.g⁻¹ of protein for ultra-filtered, followed by 1.94±0.01 g.g⁻¹ of protein for commercially available, and 1.73±0.04g.g⁻¹ of protein for acid precipitated SPI. The hydrophilic lipophilic index (HLI) values for both ultra-filtrated and commercial SPIs were more than 2, indicating hydrophilic-lipophilic balance of proteins. However, water absorption capacity (WAC) and emulsion capacity were less for ultra-filtered sample as compared to commercially available counterpart. Commercially available SPI had highest value of 6.84±0.08 ml.g⁻¹ of protein, whereas it was least at 1.67±0.016 ml.g⁻¹ of protein for acid precipitated SPI.
    Keywords absorption ; emulsions ; hydrophilicity ; lipophilicity ; nitrogen ; oils ; protein content ; solubility ; soy protein isolate ; ultrafiltration ; water binding capacity
    Language English
    Dates of publication 2019-01
    Size p. 16-28.
    Publishing place Indian Society of Agricultural Engineers
    Document type Article
    Note NAL-AP-2-clean
    ISSN 0976-2418
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: The first integrated aortic turbine venous-assist system is born.

    Sinha, Lok / Yerebakan, Can

    The Journal of thoracic and cardiovascular surgery

    2018  Volume 156, Issue 1, Page(s) 304–305

    MeSH term(s) Aorta ; Humans ; Veins
    Language English
    Publishing date 2018-04-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2018.04.007
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  8. Article ; Online: Modified Damus-Kaye-Stansel Connection for Systemic Outflow Tract Obstruction After Fontan Operation.

    Sinha, Lok / Klein, Katherine / Ramakrishnan, Karthik / Jonas, Richard

    World journal for pediatric & congenital heart surgery

    2020  Volume 11, Issue 2, Page(s) 220–221

    Abstract: Late systemic outflow tract obstruction following completion of the Fontan palliation is rarely seen and is a difficult problem to treat. Absence of the main pulmonary trunk and pulmonary valve at this stage makes a conventional Damus-Kaye-Stansel ... ...

    Abstract Late systemic outflow tract obstruction following completion of the Fontan palliation is rarely seen and is a difficult problem to treat. Absence of the main pulmonary trunk and pulmonary valve at this stage makes a conventional Damus-Kaye-Stansel connection difficult to achieve. We report the case of a 37-year-old female who underwent Fontan completion as an adult and subsequently presented with systemic outflow tract obstruction. A valved conduit was interposed between the native pulmonary annulus and the ascending aorta to create a modified Damus-Kaye-Stansel type connection.
    MeSH term(s) Adult ; Anastomosis, Surgical ; Anticoagulants ; Aorta/surgery ; Female ; Fontan Procedure/adverse effects ; Heart Defects, Congenital/surgery ; Heart Valve Prosthesis ; Humans ; Pulmonary Artery/surgery ; Pulmonary Valve/surgery ; Transposition of Great Vessels/surgery
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2020-02-24
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2550261-X
    ISSN 2150-136X ; 2150-1351
    ISSN (online) 2150-136X
    ISSN 2150-1351
    DOI 10.1177/2150135119888142
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  9. Article ; Online: Interposition Technique for Pulmonary Valve Replacement.

    Sinha, Lok / Chery, Josue / Jonas, Richard A / Sinha, Pranava

    World journal for pediatric & congenital heart surgery

    2021  Volume 12, Issue 3, Page(s) 411–413

    Abstract: Background: Stented bioprosthesis implant at surgical pulmonary valve replacement (PVR) ideally should be 25 to 27 mm to facilitate future percutaneous PVR. This often requires accommodating 35 to 37 mm diameter sewing ring in the pulmonary position and ...

    Abstract Background: Stented bioprosthesis implant at surgical pulmonary valve replacement (PVR) ideally should be 25 to 27 mm to facilitate future percutaneous PVR. This often requires accommodating 35 to 37 mm diameter sewing ring in the pulmonary position and requires anterior patch augmentation of the right ventricular outflow tract (RVOT). We present a novel "interposition" technique of PVR that allows upsizing the valve without RVOT patch augmentation.
    Methods: Using standard cardiopulmonary bypass, the main pulmonary artery (MPA) is dissected and transected at an appropriate level. The remnants of pulmonary valve leaflets are excised. The valve stent posts are telescoped into distal MPA, the MPA continuity is restored by end-to-end anastomosis of the proximal and distal MPA, with the interposed prosthetic valve sewing ring in the suture line between the two edges of the MPA with the bulk of the sewing ring extravascular.
    Result: A total of seven patients (tetralogy of Fallot, three; congenital pulmonary stenosis, four; age range: 15-33 years) underwent the procedure. No patient required RVOT patch augmentation, all patients were extubated in the operating room and were fast-tracked to recovery. Our proposed technique of PVR has the following advantages: accommodate larger size valve, eliminates risk of a paravalvar leak, coronary compression, and anterior tilting of the prosthesis.
    Conclusion: The valve interposition technique avoids the need for RVOT patch, allows implantation of an adequate sized prosthetic valve, maintains native geometry of the pulmonary artery without the risk of tilting of the prosthesis, and eliminates the risk of paravalvular regurgitation and left coronary compression.
    MeSH term(s) Adolescent ; Adult ; Cardiac Catheterization ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation ; Humans ; Pulmonary Valve/surgery ; Pulmonary Valve Insufficiency/etiology ; Pulmonary Valve Insufficiency/surgery ; Retrospective Studies ; Tetralogy of Fallot/surgery ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2550261-X
    ISSN 2150-136X ; 2150-1351
    ISSN (online) 2150-136X
    ISSN 2150-1351
    DOI 10.1177/21501351211000283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Comparison of time- and angular-domain scatter rejection in mesoscopic optical projection tomography: a simulation study.

    Sinha, L / Massanes, F / Torres, V C / Li, C / Tichauer, K M / Brankov, J G

    Biomedical optics express

    2019  Volume 10, Issue 2, Page(s) 747–760

    Abstract: Optical imaging offers exquisite sensitivity and resolution for assessing biological tissue in microscopy applications; however, for samples that are greater than a few hundred microns in thickness (such as whole tissue biopsies), spatial resolution is ... ...

    Abstract Optical imaging offers exquisite sensitivity and resolution for assessing biological tissue in microscopy applications; however, for samples that are greater than a few hundred microns in thickness (such as whole tissue biopsies), spatial resolution is substantially limited by the effects of light scattering. To improve resolution, time- and angular-domain methods have been developed to reject detection of highly scattered light. This work utilizes a modified version of a commonly used Monte Carlo light propagation software package (MCML) to present the first comparison of time- and angular-domain improvements in spatial resolution with respect to varying sample thickness and optical properties (absorption and scattering). Specific comparisons were made at various tissue thicknesses (1-6 mm) assuming either typical (average) soft tissue scattering properties,
    Language English
    Publishing date 2019-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.10.000747
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