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  1. Article ; Online: Aktualitások a sérült immunitású betegek cytomegalovirusinfekcióinak ellátásában. II. Terápiás lehetőségek és ellátási stratégiák.

    Sinkó, János

    Orvosi hetilap

    2019  Volume 160, Issue 10, Page(s) 363–369

    Abstract: Although cytomegalovirus is one of the most prevalent viral pathogens on the globe, in immunocompetent individuals infected with cytomegalovirus usually no specific antiviral therapy is required. In the case of impaired T-cell mediated immunity, however, ...

    Title translation Current treatment modalities of immunocompromised patients with cytomegalovirus infection. II. Therapeutic options and management strategies.
    Abstract Although cytomegalovirus is one of the most prevalent viral pathogens on the globe, in immunocompetent individuals infected with cytomegalovirus usually no specific antiviral therapy is required. In the case of impaired T-cell mediated immunity, however, latent infection can reactivate and occasionally a viral disease with organ involvement develops. The number of actually available anti-cytomegalovirus drugs is low, for prophylaxis or treatment ganciclovir, valganciclovir, foscarnet or cidofovir can be administered. The clinical use of these drugs is primarily hampered by their toxicity. In search for new treatment options, only letermovir, a terminase complex inhibitor compound showed appropriate activity and tolerability. In a placebo-controlled clinical trial on prophylactic letermovir in stem cell transplant patients, administration of the active compound resulted in a significant decrease in human cytomegalovirus reactivations as well as in prolonged survival. No toxicity affecting clinical use has been observed. For management of patients being at high risk for cytomegalovirus reactivation, appropriate antiviral strategy should be followed. Antiviral prophylaxis or diagnostics-guided pre-emptive therapy seem to be the most suitable options. Orv Hetil. 2019; 160(10): 363-369.
    MeSH term(s) Acetates/administration & dosage ; Acetates/therapeutic use ; Acyclovir/therapeutic use ; Antiviral Agents/therapeutic use ; Cytomegalovirus/drug effects ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/physiopathology ; Cytomegalovirus Infections/prevention & control ; Foscarnet/therapeutic use ; Ganciclovir/therapeutic use ; Humans ; Immunocompromised Host ; Quinazolines/administration & dosage ; Quinazolines/therapeutic use ; Stem Cell Transplantation/adverse effects
    Chemical Substances Acetates ; Antiviral Agents ; Quinazolines ; AIC246 (1H09Y5WO1F) ; Foscarnet (364P9RVW4X) ; Ganciclovir (P9G3CKZ4P5) ; Acyclovir (X4HES1O11F)
    Language Hungarian
    Publishing date 2019-03-04
    Publishing country Hungary
    Document type Journal Article ; Review
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2019.31320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Aktualitások a sérült immunitású betegek cytomegalovirusinfekcióinak ellátásában. I. Epidemiológia és klinikai szempontok.

    Sinkó, János

    Orvosi hetilap

    2019  Volume 160, Issue 3, Page(s) 83–92

    Abstract: Human cytomegalovirus is a DNA virus with a global prevalence of 40-100%. In humans, primary infection is followed by a lifelong latent persistent phase. Even in individuals developing adequate specific immunity, interactions with the resident virus do ... ...

    Title translation Current treatment modalities of immunocompromised patients with cytomegalovirus infection. I. Epidemiological and clinical perspectives.
    Abstract Human cytomegalovirus is a DNA virus with a global prevalence of 40-100%. In humans, primary infection is followed by a lifelong latent persistent phase. Even in individuals developing adequate specific immunity, interactions with the resident virus do probably occur. Clinically significant problems, however, appear primarily in immunocompromised hosts. As a result of an impaired T-cell mediated immunity, viral reactivation as well as a viral disease resulting in organ damage can develop. Most severely affected are HIV positive persons in AIDS stage and individuals undergoing solid organ or stem cell transplantation. As vital functions and survival may adversely be affected by cytomegalovirus reactivation and disease, it is of paramount significance to evaluate evident risk factors. Viral reactivation and organ specific disease can be detected by several methods based on conventional and molecular biological and histological diagnostic techniques. An up-to-date management of affected patient groups requires a meticulous assessment of the possible risk for cytomegalovirus infection and development of an adequate antiviral strategy. Orv Hetil. 2019; 160(3): 83-92.
    MeSH term(s) Antiviral Agents/therapeutic use ; Cytomegalovirus/drug effects ; Cytomegalovirus/isolation & purification ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/epidemiology ; Cytomegalovirus Infections/immunology ; Humans ; Immunity, Cellular/immunology ; Immunocompromised Host
    Chemical Substances Antiviral Agents
    Language Hungarian
    Publishing date 2019-01-14
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2019.31287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Amphotericin B-deoxycholate as first-line antifungal therapy in critically ill patients: a word of caution.

    Sinkó, János

    Intensive care medicine

    2019  Volume 46, Issue 3, Page(s) 562–563

    MeSH term(s) Amphotericin B ; Antifungal Agents ; Critical Illness ; Deoxycholic Acid ; Drug Combinations ; Humans
    Chemical Substances Antifungal Agents ; Drug Combinations ; Deoxycholic Acid (005990WHZZ) ; Amphotericin B (7XU7A7DROE) ; amphotericin B, deoxycholate drug combination (87687-70-5)
    Language English
    Publishing date 2019-12-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-019-05880-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Antibiotikumokkal szemben ellenálló Gram-negatív baktériumok okozta súlyos fertőzések a klinikus szemével. A Birodalom visszavág?

    Sinkó, János

    Orvosi hetilap

    2017  Volume 158, Issue 39, Page(s) 1528–1534

    Abstract: In our days, growing incidence of antibiotic resistant bacteria has become an eminent public health problem. For survival Gram-negative species possess several different tools to withstand antibiotics: they produce degrading and modifying enzymes, ... ...

    Title translation Clinical aspects of severe infections caused by antibiotic-resistant Gram-negative bacteria. The Empire strikes back?
    Abstract In our days, growing incidence of antibiotic resistant bacteria has become an eminent public health problem. For survival Gram-negative species possess several different tools to withstand antibiotics: they produce degrading and modifying enzymes, decrease their permeability or expel drug molecules. An increasing proportion of severe nosocomial infections are caused by strains resistant to several antimicrobials (multiresistant, extensively resistant or panresistant species). Development of new antibiotic compounds may serve as a possible solution to this problem. Ceftolozane-tazobactam is a new beta-lactam+beta-lactamase-inhibitor combination resistant to most extended spectrum beta-lactamase enzymes showing excellent anti-Pseudomonas activity. It is also effective against strains when beta-lactam resistance is related to porin loss or efflux pump activity. The spectrum of ceftazidime-avibactam also includes carbapenemase-(KPC)-producing Enterobacteriaceae. In addition to novel therapy, an effective infection control system together with the prudent use of antimicrobials (antimicrobial stewardship) is of paramount importance. Orv Hetil. 2017; 158(39): 1528-1534.
    Language Hungarian
    Publishing date 2017-10
    Publishing country Hungary
    Document type English Abstract ; Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2017.30858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Invazív gombafertõzések malignus hematológiai betegségekben.

    Sinkó, János

    Magyar onkologia

    2016  Volume 61, Issue 1, Page(s) 75–80

    Abstract: Invasive fungal diseases represent an ever changing field within infectology, profoundly affecting daily clinical activities of specialists in haematology. The dynamic development seen in oncohaematology creates novel risk groups of patients, ... ...

    Title translation Invasive fungal infections in patients with haematological malignancies.
    Abstract Invasive fungal diseases represent an ever changing field within infectology, profoundly affecting daily clinical activities of specialists in haematology. The dynamic development seen in oncohaematology creates novel risk groups of patients, consequently necessitating a re-evaluation of principles in antifungal therapy from time to time. Not even in 2017 may achievements of fungal diagnostics and therapy become a substitute for clinical thinking and adaptation of general guidelines according to local experience. For antifungal management all centres should elaborate appropriate strategies. By creating and operating a multidisciplinary team, decision making can effectively be supported.
    MeSH term(s) Antifungal Agents/therapeutic use ; Hematologic Neoplasms/complications ; Humans ; Invasive Fungal Infections/complications ; Invasive Fungal Infections/drug therapy
    Chemical Substances Antifungal Agents
    Language Hungarian
    Publishing date 2016-07-04
    Publishing country Hungary
    Document type Journal Article ; Review
    ZDB-ID 414033-3
    ISSN 0025-0244
    ISSN 0025-0244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: EQUAL Candida Score 2018

    Mellinghoff, Sibylle Christiane / Köhler, Philipp / Cornely, Oliver Andreas / Sinkó, János

    az ECMM által létrehozott, aktuális irányelveken alapuló pontrendszer, melynek segítségével mérhetővé válik a candidaemia klinikai ellátásának minősége

    2018  

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details Mellinghoff, S.C., Köhler, P., Cornely, O.A., Sinkó, J. ; Uniklinik Köln
    Subject code 610
    Language Hungarian
    Size 1 Online-Ressource (2 Seiten)
    Edition November 2018
    Publisher Uniklinik Köln
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online
    HBZ-ID HT019865477
    DOI 10.4126/FRL01-006410985
    Database Repository for Life Sciences

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  7. Book ; Online: EQUAL Mucormycosis Score 2018

    Cornely, Oliver Andreas / Köhler, Philipp / Mellinghoff, Sibylle Christiane / Sinkó, János

    az ECMM által létrehozott, aktuális irányelveken alapuló pontrendszer, melynek segítségével mérhetővé válik a mucormycosis klinikai ellátásának minősége

    2018  

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details Cornely, O.A., Köhler, P., Mellinghoff, S.C., Sinkó, J. ; Uniklinik Köln
    Subject code 610
    Language Hungarian
    Size 1 Online-Ressource (2 Seiten)
    Edition November 2018
    Publisher Uniklinik Köln
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online
    HBZ-ID HT019868998
    DOI 10.4126/FRL01-006411048
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  8. Book ; Online: EQUAL Aspergillosis Score 2018

    Cornely, Oliver Andreas / Köhler, Philipp / Mellinghoff, Sibylle Christiane / Sinkó, János

    az ECMM által létrehozott, aktuális irányelveken alapuló pontrendszer, melynek segítségével mérhetővé válik az invazív pulmonalis aspergillosis klinikai ellátásának minősége

    (EQUAL Aspergillosis Scorecard)

    2018  

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details Cornely, O.A., Köhler, P., Mellinghoff, S.C., Sinkó, J. ; Uniklinik Köln
    Series title EQUAL Aspergillosis Scorecard
    Subject code 610
    Language Hungarian
    Size 1 Online-Ressource (2 Seiten)
    Edition November 2018
    Publisher Uniklinik Köln
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online
    HBZ-ID HT019868965
    DOI 10.4126/FRL01-006411047
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  9. Article: Characteristics of Enterococcus species bloodstream infections among adults with and without onco-hematological malignancies: Experiences from the national center of Hungary.

    Marosi, Bence / Kádár, Béla / Bruzsa, Anna / Kocsis, Laura / Kamotsay, Katalin / Sinkó, János / Szabó, Bálint Gergely / Lakatos, Botond

    European journal of microbiology & immunology

    2024  

    Abstract: Introduction: Over the past decade, enterococcal bloodstream infection (BSI) shows increasing incidence globally among the elderly and in patients with comorbidities. In this study, we aimed to assess microbiological and clinical characteristics and ... ...

    Abstract Introduction: Over the past decade, enterococcal bloodstream infection (BSI) shows increasing incidence globally among the elderly and in patients with comorbidities. In this study, we aimed to assess microbiological and clinical characteristics and long-term outcomes of BSIs caused by Enterococcus spp. in adult patients with and without active onco-hematological malignancies hospitalized at a national referral institute.
    Methods: A prospective analysis of consecutive enterococcal BSI cases was conducted in the National Institute of Hematology and Infectious Diseases (Budapest, Hungary) between December 2019 and April 2022. We compared characteristics and outcomes at 30-days and 1 year after diagnosis among patients with and without onco-hematological malignancies.
    Results: In total, 141 patients were included (median age 68 ± 21 years, female sex 36.9%), 37% (52/141) had active onco-hematological malignancies. The distribution of species was as follows: 50.4% Enterococcus faecalis, 46.1% Enterococcus faecium, 1.4% Enterococcus avium and Enterococcus gallinarum, and 0.7% Enterococcus raffinosus. No statistically significant differences in all-cause mortality rates were observed between patient subgroups at 30 days (32.7 vs. 28.1%; P = 0.57) and 1 year (75.0 vs. 60.7%; P = 0.09).
    Conclusion: Enterococcal bloodstream infections yielded a relevant burden of morbidity, but with no statistical difference in long-term outcomes of adult patients with and without active onco-hematological malignancies.
    Language English
    Publishing date 2024-03-27
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 2652327-9
    ISSN 2062-8633 ; 2062-509X
    ISSN (online) 2062-8633
    ISSN 2062-509X
    DOI 10.1556/1886.2024.00011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A neutropeniás onkológiai beteg infekcióinak kezelése és megelõzése.

    Sinkó, János

    Magyar onkologia

    2011  Volume 55, Issue 3, Page(s) 155–163

    Abstract: Prognosis of malignant diseases is significantly influenced by infectious morbidity and mortality. Thus, up to date management of cancer patients, in addition to other supportive care modalities, should also incorporate diagnostic methods and therapy of ... ...

    Title translation Treatment and prevention of infections in cancer patients with neutropenia.
    Abstract Prognosis of malignant diseases is significantly influenced by infectious morbidity and mortality. Thus, up to date management of cancer patients, in addition to other supportive care modalities, should also incorporate diagnostic methods and therapy of infections. In order to improve outcome, patients developing febrile neutropenia following antitumour treatment should be adequately informed regarding the risk of infections. At the same time, centres responsible for cancer patient care should set up written protocols for basic workup and empirical antibiotic therapy. Here general characteristics of neutropenic infections developing in solid tumour patients are outlined and key points for risk assessment are highlighted. In addition, options and limits of anti-infective therapy as well as prophylaxis of infections are reviewed. Importance of a fully functional institutional infection control system and multidisciplinary patient management is also emphasised.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/administration & dosage ; Anti-Infective Agents/therapeutic use ; Antifungal Agents/therapeutic use ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Bacterial Infections/drug therapy ; Bacterial Infections/etiology ; Ciprofloxacin/administration & dosage ; Clinical Protocols ; Drug Administration Schedule ; Evidence-Based Medicine ; Fever/microbiology ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Humans ; Mycoses/drug therapy ; Mycoses/etiology ; Neoplasms/drug therapy ; Neutropenia/chemically induced ; Neutropenia/complications ; Neutropenia/prevention & control ; Ofloxacin/administration & dosage ; Patient Care Team ; Risk Assessment
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Antifungal Agents ; Antineoplastic Agents ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Ciprofloxacin (5E8K9I0O4U) ; Ofloxacin (A4P49JAZ9H)
    Language Hungarian
    Publishing date 2011-09
    Publishing country Hungary
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 414033-3
    ISSN 0025-0244
    ISSN 0025-0244
    DOI MagyOnkol.2011.55.3.155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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