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  1. Artikel: Spot Hydrogen Breath Test for Predicting Response to Low Fermentable Oligo-, Di-, Mono-saccharides, and Polyols Dietary Advice in Patients With Bloating.

    Somvanapanich, Pochara / Pitisuttithum, Panyavee / Sirimongkolkasem, Jarongkorn / Rattanachaisit, Pakkapon / Jangsirikul, Sureeporn / Patcharatrakul, Tanisa / Gonlachanvit, Sutep

    Journal of neurogastroenterology and motility

    2023  Band 29, Heft 4, Seite(n) 513–519

    Abstract: Background/aims: An increase in postprandial intestinal gas plays a role in bloating symptoms. We aim to study the utility of spot breath hydrogen (H: Methods: Patients with functional gastrointestinal disorders diagnosed by Rome IV criteria with ... ...

    Abstract Background/aims: An increase in postprandial intestinal gas plays a role in bloating symptoms. We aim to study the utility of spot breath hydrogen (H
    Methods: Patients with functional gastrointestinal disorders diagnosed by Rome IV criteria with bothersome bloating for > 6 months were prospectively enrolled. Patients completed 7-day food diaries and collected a breath sample 2 hours after their usual lunch at baseline and 4 weeks after low FODMAPs dietary advice by a dietitian. The responder was defined as an improvement of ≥ 30% bloating scores in the fourth week.
    Results: Thirty-eight patients (32 female, 52.6 ± 13.8 years; 22 irritable bowel syndrome) completed the study. Twenty-one patients (55%) were classified as responders. Baseline global gastrointestinal symptoms, bloating, abdominal pain scores, and numbers of high FODMAPs items were similar between responders and non-responders. Both groups significantly decreased high FODMAPs items intake with similar numbers at the follow-up. The area under the curve for predicting low FODMAPs responsiveness using baseline H
    Conclusions: A higher baseline breath hydrogen level was associated with bloating improvement after low FODMAPs dietary advice. A spot breath test after lunch, a simple point-of-care test, is possibly helpful in managing patients with bloating.
    Sprache Englisch
    Erscheinungsdatum 2023-10-09
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2573719-3
    ISSN 2093-0887 ; 2093-0879
    ISSN (online) 2093-0887
    ISSN 2093-0879
    DOI 10.5056/jnm22214
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Diagnostic validity and learning curve of non-NBI expert endoscopists in gastric intestinal metaplasia diagnosis.

    Tiankanon, Kasenee / Pittayanon, Rapat / Faknak, Natee / Sirimongkolkasem, Jarongkorn / Rattanachaisit, Pakkapon / Lerttanatum, Nathawadee / Sanpavat, Anapat / Klaikaew, Naruemon / Rerknimitr, Rungsun

    Surgical endoscopy

    2023  Band 37, Heft 9, Seite(n) 6771–6778

    Abstract: Background: Endoscopists' experience influences narrow-band imaging (NBI)-guided gastric intestinal metaplasia (GIM) diagnostic performance. We aimed to evaluate the general gastroenterologists (GE) performance in NBI-guided GIM diagnosis compared to ... ...

    Abstract Background: Endoscopists' experience influences narrow-band imaging (NBI)-guided gastric intestinal metaplasia (GIM) diagnostic performance. We aimed to evaluate the general gastroenterologists (GE) performance in NBI-guided GIM diagnosis compared to NBI experts (XP) and assess GEs' learning curve.
    Methods: A cross-sectional study was conducted between 10/2019 and 2/2022. Histology-proven GIM who underwent esophagogastroduodenoscopy (EGD) were randomly assessed by 2XPs or 3GEs. Endoscopists' performance on NBI-guided diagnoses were compared to the pathological diagnosis (gold standard) in five areas of the stomach according to the Sydney protocol. The primary outcome were GIM diagnosis validity scores of GEs compared to XPs. The secondary outcome was the minimum number of lesions required for GEs to achieve an accuracy of GIM diagnosis ≥ 80%.
    Results: One thousand one hundred and fifty-five lesions from 189 patients (51.3% male, mean age 66 ± 10 years) were examined. GEs performed EGD in 128 patients with 690 lesions. the GIM diagnosis sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of GEs compared to the XPs, were 91% vs.93%, 73% vs.83%, 79% vs.83%, 89% vs.93%, and 83% vs.88%, respectively. GEs demonstrated lower specificity (mean difference - 9.4%; 95%CI - 16.3, 1.4; p = 0.008) and accuracy (mean difference - 5.1%; 95%CI - 3.3, 6.3; p = 0.006) compared to XPs. After 100 lesions (50% GIM), GEs achieved an accuracy of ≥ 80% and all diagnostic validity scores were comparable to the XPs (p < 0.05 all).
    Conclusions: Compared to XPs, GEs had lower specificity and accuracy for GIM diagnosis. The learning curve for a GE to achieve comparable performance to XPs would necessitate at least 50 GIM lesions. Created with BioRender.com.
    Mesh-Begriff(e) Humans ; Male ; Middle Aged ; Aged ; Female ; Cross-Sectional Studies ; Learning Curve ; Biopsy/methods ; Prospective Studies ; Stomach Diseases ; Narrow Band Imaging/methods ; Metaplasia/diagnosis ; Precancerous Conditions/diagnosis ; Precancerous Conditions/pathology ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/pathology
    Sprache Englisch
    Erscheinungsdatum 2023-05-24
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-023-10123-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Immunogenicity and safety of heterologous versus homologous prime-boost schedules with inactivated and adenoviral vectored SARS-CoV-2 vaccines - A prospective multi-center study.

    Phuensan, Pawat / Sirimongkolkasem, Jarongkorn / Tantawichien, Terapong / Phannajit, Jeerath / Kerr, Stephen J / Hansasuta, Pokrath / Chantharit, Prawat / Wongsa, Adisorn / Fuengfoo, Pusit / Chittinandana, Anutra / Vareesangthip, Kriengsak / Chayakulkeeree, Methee / Jangsirikul, Sureeporn / Schmidt, Araya / Wanvimonsuk, Kanyika / Winichakoon, Poramed / Kajeekul, Rattagan / Prayoonwiwat, Wichai / Rerknimitr, Rungsun

    Heliyon

    2023  Band 10, Heft 1, Seite(n) e23246

    Abstract: Background: During the peak of Coronavirus disease (COVID-19) pandemic in Thailand when the emergence of delta variant reduced the efficacy of inactivated vaccine, Thailand had abundance of inactivated vaccine but mRNA vaccine was not available and the ... ...

    Abstract Background: During the peak of Coronavirus disease (COVID-19) pandemic in Thailand when the emergence of delta variant reduced the efficacy of inactivated vaccine, Thailand had abundance of inactivated vaccine but mRNA vaccine was not available and the supply of adenoviral-vectored vaccine was limited. The heterologous vaccination using CoronaVac and ChAdOx1-nCoV-19 vaccines was applied. We aim to compare the immunogenicity of immune response of primary vaccination with homologous ChAdOx1 nCoV-19 and heterologous vaccination with CoronaVac and ChAdOx1 nCoV-19.
    Methods: A total of 430 adults, scheduled to receive ChAdOx1-nCoV-19 as their second dose of primary COVID-19 vaccination, were enrolled. Participants were classified into two groups based on the first dose vaccine as CoronaVac (heterologous group) or ChAdOx1 nCoV-19 (homologous group). The primary outcome was antibodies to the SARS-CoV-2 spike protein receptor binding domain (anti-RBD) titres at 28 days after the second dose of vaccination. Secondary outcomes were anti-RBD titres at 90 days, surrogate viral neutralizing test (sVNT) at 28 and 90 days, and adverse events.
    Findings: In 358 participants with correct vaccine interval, the anti-RBD geometric mean titre ratio for the heterologous versus homologous group was 0.55 (95%CI; 0.44-0.067);
    Interpretation: The homologous vaccination resulted in higher anti-RBD titres at 28 days after vaccination, but titres in the homologous group showed more rapid decline at 90 days. In the sVNT assay, median neutralization was similar at 28 days, but was longer-lasting and higher in the heterologous group at 90 days.
    Funding: This research received funding from the Royal College of Physicians of Thailand special grant 2021 for research initiative during COVID-19 pandemic.
    Sprache Englisch
    Erscheinungsdatum 2023-12-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e23246
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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