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  1. Article ; Online: Defining and Promoting Pediatric Pulmonary Health: Leveraging Patient Reported Outcomes.

    Rosas-Salazar, Christian / Bacharier, Leonard / Buckley, Lisa H / Amaral, Sandra / Sirota, Susan / Moore, Paul E

    Pediatrics

    2023  Volume 152, Issue Suppl 2

    Abstract: Patient-reported outcomes are based on patient (or caregiver) descriptions without direct measurement by a health care provider. To capture patient-reported outcomes, various patient-reported outcome measures (PROMs) have been created. Using PROMs has ... ...

    Abstract Patient-reported outcomes are based on patient (or caregiver) descriptions without direct measurement by a health care provider. To capture patient-reported outcomes, various patient-reported outcome measures (PROMs) have been created. Using PROMs has been linked to improved patient satisfaction, patient-provider communication, and clinical outcomes in many pediatric fields. Despite a long-standing history of utilizing PROMs for the evaluation and management of childhood asthma, pediatric pulmonologists lag behind other pediatric subspecialists in the use of PROMs. During the National Heart, Lung, and Blood Institute's "Defining and Promoting Pediatric Pulmonary Health" workshop, critical knowledge gaps and research opportunities in the use of PROMs for childhood respiratory health were reviewed. In particular, PROMs can be employed as screening tools in the general population for the primary or secondary prevention of pediatric lung diseases. Incorporating these PROMs into the pediatric primary care setting would be especially impactful. In addition, the use of PROMs for the evaluation and management of asthma suggests that they can be applied to other childhood respiratory diseases. Ongoing multicenter studies or national consortia that study pediatric lung diseases could be leveraged to conduct research designed to develop, validate, and assess the utility of PROMs to assess childhood respiratory health. Harnessing the electronic health record will be critical for the successful adoption of PROMs in children with lung diseases. Ultimately, an integrative approach to systematically address numerous barriers at the level of the provider, patient, and health care system will be needed to attain this goal and achieve sustainability.
    MeSH term(s) Humans ; Child ; Asthma/diagnosis ; Asthma/therapy ; Communication ; Electronic Health Records ; Health Personnel ; Patient Reported Outcome Measures
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2023-062292F
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Developing Consensus on Clinical Outcomes for Children with Mild Pneumonia: A Delphi Study.

    Florin, Todd A / Melnikow, Joy / Gosdin, Melissa / Ciuffetelli, Ryan / Benedetti, Jillian / Ballard, Dustin / Gausche-Hill, Marianne / Kronman, Matthew P / Martin, Lisa A / Mistry, Rakesh D / Neuman, Mark I / Palazzi, Debra L / Patel, Sameer J / Self, Wesley H / Shah, Samir S / Shah, Sonal N / Sirota, Susan / Cruz, Andrea T / Ruddy, Richard /
    Gerber, Jeffrey S / Kuppermann, Nathan

    Journal of the Pediatric Infectious Diseases Society

    2022  Volume 12, Issue 2, Page(s) 83–88

    Abstract: Background: The absence of consensus for outcomes in pediatric antibiotic trials is a major barrier to research harmonization and clinical translation. We sought to develop expert consensus on study outcomes for clinical trials of children with mild ... ...

    Abstract Background: The absence of consensus for outcomes in pediatric antibiotic trials is a major barrier to research harmonization and clinical translation. We sought to develop expert consensus on study outcomes for clinical trials of children with mild community-acquired pneumonia (CAP).
    Methods: Applying the Delphi method, a multispecialty expert panel ranked the importance of various components of clinical response and treatment failure outcomes in children with mild CAP for use in research. During Round 1, panelists suggested additional outcomes in open-ended responses that were added to subsequent rounds of consensus building. For Rounds 2 and 3, panelists were provided their own prior responses and summary statistics for each item in the previous round. The consensus was defined by >70% agreement.
    Results: The expert panel determined that response to and failure of treatment should be addressed at a median of 3 days after initiation. Complete or substantial improvement in fever, work of breathing, dyspnea, tachypnea when afebrile, oral intake, and activity should be included as components of adequate clinical response outcomes. Clinical signs and symptoms including persistent or worsening fever, work of breathing, and reduced oral intake should be included in treatment failure outcomes. Interventions including receipt of parenteral fluids, supplemental oxygen, need for high-flow nasal cannula oxygen therapy, and change in prescription of antibiotics should also be considered in treatment failure outcomes.
    Conclusions: Clinical response and treatment failure outcomes determined by the consensus of this multidisciplinary expert panel can be used for pediatric CAP studies to provide objective data translatable to clinical practice.
    MeSH term(s) Humans ; Child ; Consensus ; Delphi Technique ; Pneumonia/drug therapy ; Dyspnea ; Community-Acquired Infections/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Oxygen
    Chemical Substances Anti-Bacterial Agents ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-12-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piac123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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