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Article ; Online: The Exposome Approach to Decipher the Role of Multiple Environmental and Lifestyle Determinants in Asthma.

Guillien, Alicia / Cadiou, Solène / Slama, Rémy / Siroux, Valérie

International journal of environmental research and public health

2021 Volume 18, Issue 3

Abstract: Asthma is a widespread respiratory disease caused by complex contribution from genetic, environmental and behavioral factors. For several decades, its sensitivity to environmental factors has been investigated in single exposure (or single family of ... ...

Abstract	Asthma is a widespread respiratory disease caused by complex contribution from genetic, environmental and behavioral factors. For several decades, its sensitivity to environmental factors has been investigated in single exposure (or single family of exposures) studies, which might be a narrow approach to tackle the etiology of such a complex multifactorial disease. The emergence of the exposome concept, introduced by C. Wild (2005), offers an alternative to address exposure-health associations. After presenting an overview of the exposome concept, we discuss different statistical approaches used to study the exposome-health associations and review recent studies linking multiple families of exposures to asthma-related outcomes. The few studies published so far on the association between the exposome and asthma-related outcomes showed differences in terms of study design, population, exposome definition and statistical methods used, making their results difficult to compare. Regarding statistical methods, most studies applied successively univariate (Exposome-Wide Association Study (ExWAS)) and multivariate (adjusted for co-exposures) (e.g., Deletion-Substitution-Addition (DSA) algorithm) regression-based models. This latest approach makes it possible to assess associations between a large set of exposures and asthma outcomes. However, it cannot address complex interactions (i.e., of order ≥3) or mixture effects. Other approaches like cluster-based analyses, that lead to the identification of specific profiles of exposure at risk for the studied health-outcome, or mediation analyses, that allow the integration of information from intermediate biological layers, could offer a new avenue in the understanding of the environment-asthma association. European projects focusing on the exposome research have recently been launched and should provide new results to help fill the gap that currently exists in our understanding of the effect of environment on respiratory health.
MeSH term(s)	Asthma/epidemiology ; Asthma/etiology ; Environmental Exposure/adverse effects ; Environmental Pollutants ; Exposome ; Humans ; Life Style
Chemical Substances	Environmental Pollutants
Language	English
Publishing date	2021-01-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph18031138
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Article ; Online: Asthma heterogeneity: the increasing genetic evidence.

Siroux, Valérie / Bouzigon, Emmanuelle

The Lancet. Respiratory medicine

2019 Volume 7, Issue 6, Page(s) 469–471

MeSH term(s)	Adult ; Asthma ; Child ; Humans ; Phenotype ; Risk Factors ; Transcriptome
Language	English
Publishing date	2019-04-27
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2686754-0
ISSN	2213-2619 ; 2213-2600
ISSN (online)	2213-2619
ISSN	2213-2600
DOI	10.1016/S2213-2600(19)30047-5
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Article ; Online: Correction to "Statistical Approaches to Study Exposome-Health Associations in the Context of Repeated Exposure Data: A Simulation Study".

Warembourg, Charline / Anguita-Ruiz, Augusto / Siroux, Valérie / Slama, Rémy / Vrijheid, Martine / Richiardi, Lorenzo / Basagaña, Xavier

Environmental science & technology

2024 Volume 58, Issue 4, Page(s) 2162

Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Published Erratum
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c10626
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Article ; Online: Intra-breath changes in respiratory mechanics are sensitive to history of respiratory illness in preschool children: the SEPAGES cohort.

Siroux, Valérie / Boudier, Anne / Lyon-Caen, Sarah / Quentin, Joane / Gioria, Yoann / Hantos, Zoltán / Slama, Rémy / Pin, Isabelle / Bayat, Sam

Respiratory research

2024 Volume 25, Issue 1, Page(s) 99

Abstract: Background: Intra-breath oscillometry has been proposed as a sensitive means of detecting airway obstruction in young children. We aimed to assess the impact of early life wheezing and lower respiratory tract illness on lung function, using both ... ...

Abstract	Background: Intra-breath oscillometry has been proposed as a sensitive means of detecting airway obstruction in young children. We aimed to assess the impact of early life wheezing and lower respiratory tract illness on lung function, using both standard and intra-breath oscillometry in 3 year old children. Methods: History of doctor-diagnosed asthma, wheezing, bronchiolitis and bronchitis and hospitalisation for respiratory problems were assessed by questionnaires in 384 population-based children. Association of respiratory history with standard and intra-breath oscillometry parameters, including resistance at 7 Hz (R Results: Among the 320 children who accepted the oscillometry test, 281 (88%) performed 3 technically acceptable and reproducible standard oscillometry measurements and 251 children also performed one intra-breath oscillometry measurement. Asthma was associated with higher R Conclusions: Our findings confirm the good success rate of oscillometry in 3-year-old children and indicate an association between a history of early-life wheezing and lower respiratory tract illness and lower lung function as assessed by both standard and intra-breath oscillometry. Our study supports the relevance of using intra-breath oscillometry parameters as sensitive outcome measures in preschool children in epidemiological cohorts.
MeSH term(s)	Humans ; Child, Preschool ; Respiratory Sounds/diagnosis ; Spirometry ; Respiratory System ; Asthma/diagnosis ; Asthma/epidemiology ; Respiratory Mechanics ; Bronchiolitis ; Bronchitis/diagnosis ; Bronchitis/epidemiology
Language	English
Publishing date	2024-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-993X
ISSN (online)	1465-993X
ISSN	1465-993X
DOI	10.1186/s12931-024-02701-9
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Article ; Online: Is chronic exposure to air pollutants a risk factor for the development of idiopathic pulmonary fibrosis?

Siroux, Valérie / Crestani, Bruno

The European respiratory journal

2018 Volume 51, Issue 1

MeSH term(s)	Air Pollutants/analysis ; Air Pollution/analysis ; Humans ; Idiopathic Pulmonary Fibrosis ; Incidence ; Italy ; Pulmonary Fibrosis ; Risk Factors
Chemical Substances	Air Pollutants
Language	English
Publishing date	2018-01-25
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.02663-2017
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Zs.A 2322: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Rhinitis phenotypes and multimorbidities in the general population: the CONSTANCES cohort.

Savouré, Marine / Bousquet, Jean / Leynaert, Bénédicte / Renuy, Adeline / Siroux, Valérie / Goldberg, Marcel / Zins, Marie / Jacquemin, Bénédicte / Nadif, Rachel

The European respiratory journal

2023 Volume 61, Issue 2

Abstract: Background: Scarce epidemiological studies have characterised allergic rhinitis (AR) and non-allergic rhinitis (NAR) in adults. In a population-based cohort, our aims were to 1) describe rhinitis, AR and NAR, and 2) explore how asthma and conjunctivitis ...

Abstract	Background: Scarce epidemiological studies have characterised allergic rhinitis (AR) and non-allergic rhinitis (NAR) in adults. In a population-based cohort, our aims were to 1) describe rhinitis, AR and NAR, and 2) explore how asthma and conjunctivitis may lead to the identification of novel rhinitis phenotypes. Methods: In this cross-sectional analysis, current rhinitis was defined as present in the last 12 months using a questionnaire from the French CONSTANCES cohort. Participants with current rhinitis reporting nasal allergies were considered as AR, otherwise as NAR. We described AR and NAR phenotypes, and their phenotypes including co-occurrence with ever-asthma and ever-conjunctivitis. Results: Among the 20 772 participants included in this analysis (mean±sd age 52.6±12.6 years; 55.2% female), crude prevalences of AR and NAR were 28.0% and 10.9%. AR participants more frequently reported persistent rhinitis (31.6% Conclusions: In this large population-based cohort, 40% reported current rhinitis, with a lower prevalence of moderate-to-severe rhinitis than in clinical practice. For the first time in a general adult population, we showed that AR and NAR alone or in combination with asthma or in combination with asthma and conjunctivitis are different phenotypes. These results provide new insights on how best to manage rhinitis and its multimorbidities.
MeSH term(s)	Humans ; Female ; Male ; Rhinitis/epidemiology ; Cross-Sectional Studies ; Rhinitis, Allergic/epidemiology ; Asthma/epidemiology ; Social Group
Language	English
Publishing date	2023-02-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.00943-2022
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Zs.A 2322: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Statistical Approaches to Study Exposome-Health Associations in the Context of Repeated Exposure Data: A Simulation Study.

Warembourg, Charline / Anguita-Ruiz, Augusto / Siroux, Valérie / Slama, Rémy / Vrijheid, Martine / Richiardi, Lorenzo / Basagaña, Xavier

Environmental science & technology

2023 Volume 57, Issue 43, Page(s) 16232–16243

Abstract: The exposome concept aims to consider all environmental stressors simultaneously. The dimension of the data and the correlation that may exist between exposures lead to various statistical challenges. Some methodological studies have provided insight ... ...

Abstract	The exposome concept aims to consider all environmental stressors simultaneously. The dimension of the data and the correlation that may exist between exposures lead to various statistical challenges. Some methodological studies have provided insight regarding the efficiency of specific modeling approaches in the context of exposome data assessed once for each subject. However, few studies have considered the situation in which environmental exposures are assessed repeatedly. Here, we conduct a simulation study to compare the performance of statistical approaches to assess exposome-health associations in the context of multiple exposure variables. Different scenarios were tested, assuming different types and numbers of exposure-outcome causal relationships. An application study using real data collected within the INMA mother-child cohort (Spain) is also presented. In the simulation experiment, assessed methods showed varying performance across scenarios, making it challenging to recommend a one-size-fits-all strategy. Generally, methods such as sparse partial least-squares and the deletion-substitution-addition algorithm tended to outperform the other tested methods (ExWAS, Elastic-Net, DLNM, or sNPLS). Notably, as the number of true predictors increased, the performance of all methods declined. The absence of a clearly superior approach underscores the additional challenges posed by repeated exposome data, such as the presence of more complex correlation structures and interdependencies between variables, and highlights that careful consideration is essential when selecting the appropriate statistical method. In this regard, we provide recommendations based on the expected scenario. Given the heightened risk of reporting false positive or negative associations when applying these techniques to repeated exposome data, we advise interpreting the results with caution, particularly in compromised contexts such as those with a limited sample size.
MeSH term(s)	Humans ; Exposome ; Environmental Exposure ; Spain ; Algorithms
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c04805
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Article ; Online: Pre-natal exposure to NO2 and PM2.5 and newborn lung function: An approach based on repeated personal exposure measurements

Lepeule, Johanna / Pin, Isabelle / Boudier, Anne / Quentin, Joane / Lyon-Caen, Sarah / Supernant, Karine / Seyve, Emie / Chartier, Ryan / Slama, Remy / Siroux, Valérie

Environmental Research. 2023 June, v. 226 p.115656-

2023

Abstract: While strong evidence supports adverse effects of pre-natal air pollution on child's lung function, previous studies rarely considered fine particulate matter (PM₂.₅) or the potential role of offspring sex and no study examined the effects of pre-natal ... ...

Institution	the SEPAGES study group
Abstract	While strong evidence supports adverse effects of pre-natal air pollution on child's lung function, previous studies rarely considered fine particulate matter (PM₂.₅) or the potential role of offspring sex and no study examined the effects of pre-natal PM₂.₅ on the lung function of the newborn. We examined overall and sex-specific associations of personal pre-natal exposure to PM₂.₅ and nitrogen (NO₂) with newborn lung function measurements. This study relied on 391 mother-child pairs from the French SEPAGES cohort. PM₂.₅ and NO₂ exposure was estimated by the average concentration of pollutants measured by sensors carried by the pregnant women during repeated periods of one week. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple breath washout (N₂MBW) test, performed at 7 weeks. Associations between pre-natal exposure to air pollutants and lung function indicators were estimated by linear regression models adjusted for potential confounders, and then stratified by sex. Mean exposure to NO₂ and PM₂.₅ during pregnancy was 20.2 μg/m³ and 14.3 μg/m³, respectively. A 10 μg/m³ increase in PM₂.₅ maternal personal exposure during pregnancy was associated with an adjusted 2.5 ml (2.3%) decrease in the functional residual capacity of the newborn (p-value = 0.11). In females, functional residual capacity was decreased by 5.2 ml (5.0%) (p = 0.02) and tidal volume by 1.6 ml (p = 0.08) for each 10 μg/m³ increase in PM₂.₅. No association was found between maternal NO₂ exposure and newborns lung function. Personal pre-natal PM₂.₅ exposure was associated with lower lung volumes in female newborns, but not in males. Our results provide evidence that pulmonary effects of air pollution exposure can be initiated in utero. These findings have long term implications for respiratory health and may provide insights into the underlying mechanisms of PM₂.₅ effects.
Keywords	air pollution ; children ; females ; lung function ; lungs ; maternal exposure ; neonates ; nitrogen ; particulates ; pregnancy ; regression analysis ; research ; tidal volume ; Newborn ; Personal exposure
Language	English
Dates of publication	2023-06
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.115656
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: In utero exposure to poly- and perfluoroalkyl substances and children respiratory health in the three first years of life

Philippat, Claire / Coiffier, Ophélie / Lyon-Caen, Sarah / Boudier, Anne / Jovanovic, Nicolas / Quentin, Joane / Gioria, Yoann / Haug, Line Smastuen / Thomsen, Cathrine / Bayat, Sam / Slama, Rémy / Siroux, Valérie

Environmental Research. 2023 Oct., v. 234 p.116544-

2023

Abstract: Poly- and perfluoroalkyl substances (PFAS) are used in a wide range of products. Experimental studies suggested impaired lung development and pro-inflammatory response following exposure to some PFAS. We aimed to assess the associations between prenatal ... ...

Abstract	Poly- and perfluoroalkyl substances (PFAS) are used in a wide range of products. Experimental studies suggested impaired lung development and pro-inflammatory response following exposure to some PFAS. We aimed to assess the associations between prenatal exposure to PFAS and children respiratory health. The study is based on 433 mother-child pairs. 26 PFAS were measured in maternal serum collected during pregnancy. Lung function parameters were measured at 2 months using tidal breathing flow-volume loops and multiple-breath nitrogen washout and at 36 months using oscillometry. Incidence of respiratory health diseases (asthma, wheeze, bronchitis, bronchiolitis) in the first 36 months of life was assessed by repeated questionnaires. A cluster-based analysis was applied to identify prenatal PFAS exposure patterns. Adjusted linear and logistic regressions were performed to assess the associations between PFAS exposure patterns as well as individual PFAS, and each respiratory health parameter. We excluded 13 PFAS due to low quantification (<5%). Relying on the 13 remaining PFAS, we identified three exposure clusters, characterized by low (N = 163), medium (N = 236) and high (N = 51) pregnancy PFAS concentrations. Compared to children belonging to the low exposure group, children in the moderate exposure group had higher reactance at 7 Hz (X₇) and lower frequency dependence of resistance between 7 Hz and 19 Hz (R₇₋₁₉) at 36 months, suggesting better lung function. No association of any exposure metric was detected with respiratory diseases in the first 3 years of life. Our study relying on both mixture and uni-pollutant analyses, does not provide evidence for a deleterious effect of prenatal PFAS exposure on respiratory health at an early age.
Keywords	asthma ; blood serum ; bronchiolitis ; inflammation ; lung function ; lungs ; maternal exposure ; nitrogen ; perfluorocarbons ; pregnancy ; research ; Perfluoroalkyl substances ; Polyfluoroalkyl substances ; PFAS ; Oscillometry ; Wheeze ; Respiratory health
Language	English
Dates of publication	2023-10
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.116544
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Article ; Online: Plasma thymic stromal lymphopoietin (TSLP) in adults with non-severe asthma: the EGEA study.

Ibrahim, Bakari / Achour, Djamal / Zerimech, Farid / de Nadai, Patricia / Siroux, Valerie / Tsicopoulos, Anne / Matran, Régis / Granger, Vanessa / Nadif, Rachel

Thorax

2022 Volume 78, Issue 2, Page(s) 207–210

Abstract: Thymic stromal lymphopoietin (TSLP), a cytokine involved in severe asthma treatment, was never studied in non-severe asthma.Among 969 adults from a large epidemiological study, cross-sectional analyses showed that plasma TSLP levels were associated with ... ...

Abstract	Thymic stromal lymphopoietin (TSLP), a cytokine involved in severe asthma treatment, was never studied in non-severe asthma.Among 969 adults from a large epidemiological study, cross-sectional analyses showed that plasma TSLP levels were associated with increased age and BMI, male sex, smoking and high TSLP levels (one IQR increase) with current asthma and poor lung function. High TSLP levels were also associated with persistence of asthma attacks (aOR=2.14 (95% CI 1.23 to 3.72)) and dyspnoea (aOR=2.71 (95% CI 1.39 to 5.28)) 10 years later.Our results suggest that TSLP could be a cytokine of interest in non-severe asthma, and its determinants of circulating levels could be considered in asthma management.
MeSH term(s)	Male ; Adult ; Humans ; Thymic Stromal Lymphopoietin ; Cross-Sectional Studies ; Cytokines ; Asthma ; Lung
Chemical Substances	Thymic Stromal Lymphopoietin (GT0IL38SP4) ; Cytokines
Language	English
Publishing date	2022-12-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	204353-1
ISSN	1468-3296 ; 0040-6376
ISSN (online)	1468-3296
ISSN	0040-6376
DOI	10.1136/thorax-2022-219192
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