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Article ; Online: Development: Pubertal Hormones Meet the Adolescent Brain.

Sisk, Cheryl L

2017 Volume 27, Issue 14, Page(s) R706–R708

Abstract: At the onset of puberty, ovarian hormones increase inhibitory tone in the prefrontal cortex. Inhibitory maturation is a hallmark of the initiation of developmental windows of neural plasticity; pubertal hormones may trigger the opening of an adolescent ... ...

Abstract	At the onset of puberty, ovarian hormones increase inhibitory tone in the prefrontal cortex. Inhibitory maturation is a hallmark of the initiation of developmental windows of neural plasticity; pubertal hormones may trigger the opening of an adolescent critical period for experience-dependent rewiring of circuits underlying executive function.
MeSH term(s)	Adolescent ; Animals ; Brain ; Female ; Frontal Lobe ; Gonadal Hormones ; Humans ; Mice ; Sexual Maturation ; Synaptic Transmission
Chemical Substances	Gonadal Hormones
Language	English
Publishing date	2017-07-24
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2017.05.092
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3208: Show issues

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Article: Ovarian Hormones and Binge Eating in Adulthood: Summary of Findings and Implications for Individual Differences in Risk in Women.

Klump, Kelly L / Culbert, Kristen M / Johnson, Alexander W / Sisk, Cheryl L

Current directions in psychological science

2023 Volume 32, Issue 6, Page(s) 471–478

Abstract: Ovarian hormone influences on general food intake have been studied in animals for 60+ years. Yet, extensions of these data to key eating disorder symptoms in humans (e.g., binge eating (BE)) have only recently occurred. In this article, we summarize ... ...

Abstract	Ovarian hormone influences on general food intake have been studied in animals for 60+ years. Yet, extensions of these data to key eating disorder symptoms in humans (e.g., binge eating (BE)) have only recently occurred. In this article, we summarize findings from studies examining the effects of ovarian hormones on BE. Findings suggest ovarian hormones contribute to BE in animals and humans, although studies are few in number, and effects are not present in all women or all animals exposed to high-risk hormonal milieus. Differences in susceptibility may be due to gene x hormone interactions that can explain why some, but not all, women/females develop BE in the presence of risky hormonal environments.
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2026362-4
ISSN	1467-8721 ; 0963-7214
ISSN (online)	1467-8721
ISSN	0963-7214
DOI	10.1177/09637214231192835
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Article ; Online: Hormone-dependent adolescent organization of socio-sexual behaviors in mammals.

Sisk, Cheryl L

Current opinion in neurobiology

2016 Volume 38, Page(s) 63–68

Abstract: The adolescent transition from childhood to adulthood requires both reproductive and behavioral maturation as individuals acquire the ability to procreate. Gonadal steroid hormones are key players in the maturation of behaviors required for reproductive ... ...

Abstract	The adolescent transition from childhood to adulthood requires both reproductive and behavioral maturation as individuals acquire the ability to procreate. Gonadal steroid hormones are key players in the maturation of behaviors required for reproductive success. Beyond activating behavior in adulthood, testicular and ovarian hormones organize the adolescent brain and program adult-typical and sex-typical expression of sociosexual behaviors. Testicular hormones organize sexual and agonistic behaviors, including social proficiency-the ability to adapt behavior as a function of social experience. Ovarian hormones organize behaviors related to energy balance and maternal care. These sex differences in the behaviors that are programmed by gonadal hormones during adolescence suggest that evolution has selected for hormone-dependent sex-specific organization of behaviors that optimize reproductive fitness.
Language	English
Publishing date	2016-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1078046-4
ISSN	1873-6882 ; 0959-4388
ISSN (online)	1873-6882
ISSN	0959-4388
DOI	10.1016/j.conb.2016.02.004
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Zs.A 3260: Show issues

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Article ; Online: The organizational role of ovarian hormones during puberty on risk for binge-like eating in rats

Hildebrandt, Britny A. / Lee, Jenna R. / Culbert, Kristen M. / Sisk, Cheryl L. / Johnson, Alexander W. / Klump, Kelly L.

Physiology & Behavior. 2023 June, v. 265 p.114177-

2023

Abstract: Puberty is a high-risk period for the development of dysregulated eating, including binge eating. While risk for binge eating in animals and humans increases in both males and females during puberty, the increased prevalence is significantly greater in ... ...

Abstract	Puberty is a high-risk period for the development of dysregulated eating, including binge eating. While risk for binge eating in animals and humans increases in both males and females during puberty, the increased prevalence is significantly greater in females. Emerging data suggest that the organizational effects of gonadal hormones may contribute to the female preponderance of binge eating. In this narrative review, we discuss studies conducted in animals that have examined these organizational effects as well as the neural systems that may serve as intermediary mechanisms. Relatively few studies have been conducted, but data thus far suggest that pubertal estrogens may organize risk for binge eating, potentially by altering key circuits in brain reward pathways. These promising results highlight the need for future studies to directly test organizational effects of pubertal hormones using hormone replacement techniques and circuit-level manipulations that can identify pathways contributing to binge eating across development.
Keywords	behavior ; brain ; females ; gonads ; puberty ; risk ; Eating disorders ; Gonadal hormones ; Estrogens ; Palatable food ; Adolescent ; Rodents
Language	English
Dates of publication	2023-06
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2023.114177
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A Narrative Review of Sex Differences in Eating Disorders: Is There a Biological Basis?

Culbert, Kristen M / Sisk, Cheryl L / Klump, Kelly L

Clinical therapeutics

2020 Volume 43, Issue 1, Page(s) 95–111

Abstract: Purpose: Eating disorders and their core symptoms (eg, binge eating, body weight/shape concerns) disproportionately affect females, and these sex-differentiated effects become prominent during and after puberty. Although psychosocial influences such as ... ...

Abstract	Purpose: Eating disorders and their core symptoms (eg, binge eating, body weight/shape concerns) disproportionately affect females, and these sex-differentiated effects become prominent during and after puberty. Although psychosocial influences such as heightened sociocultural pressures for thinness in girls and women contribute to this sex imbalance, biological factors could also play an important role. Methods: This narrative review summarizes evidence of biological factors underlying the sex-differentiated prevalence of eating pathology as well as within-sex variability in risk. Findings: There are sex differences in the pubertal emergence of genetic effects on eating pathology (adrenarche in males; gonadarche in females), and at least some genetic contributions to eating pathology seem to vary between the sexes. Furthermore, sex steroid hormones (eg, testosterone, estradiol, progesterone) are leading contributors to differential risk for eating pathology in males and females across the life span. Emerging data suggest that between-sex and within-sex variability in risk might occur via hormone-driven modulation (activation/deactivation) of genetic influences and neural responsiveness to food-related cues. Implications: There is a biological basis to heightened risk for eating pathology in females, relative to males, as well as unique biological influences within each sex. Findings from this review highlight the importance of studying both sexes and considering sex-specific biological mechanisms that may underlie differential risk for eating pathology.
MeSH term(s)	Animals ; Feeding and Eating Disorders/genetics ; Feeding and Eating Disorders/metabolism ; Gonadal Steroid Hormones/metabolism ; Humans ; Sex Characteristics
Chemical Substances	Gonadal Steroid Hormones
Language	English
Publishing date	2020-12-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	603113-4
ISSN	1879-114X ; 0149-2918
ISSN (online)	1879-114X
ISSN	0149-2918
DOI	10.1016/j.clinthera.2020.12.003
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Zs.A 1435: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 404: Show issues

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Article ; Online: Sex differences in proliferation and attrition of pubertally born cells in the rat posterior dorsal medial amygdala.

Mohr, Margaret A / Michael, Nancy Staffend / DonCarlos, Lydia L / Sisk, Cheryl L

Developmental cognitive neuroscience

2022 Volume 57, Page(s) 101141

Abstract: The rodent posterodorsal medial amygdala (MePD) evaluates and assigns valence to social sensory stimuli. The perception of social stimuli evolves during puberty, when the focus of social interactions shifts from kin to peers. Using the cell birthdate ... ...

Abstract	The rodent posterodorsal medial amygdala (MePD) evaluates and assigns valence to social sensory stimuli. The perception of social stimuli evolves during puberty, when the focus of social interactions shifts from kin to peers. Using the cell birthdate marker bromo-deoxyuridine (BrdU), we previously discovered that more pubertally born cells are added to the rat MePD in males than females. Here we addressed several questions that remained unanswered by our previous work. First, to determine whether there are sex differences in cell proliferation within the MePD, we examined BrdU-immunoreactive (-ir) cells at 2 and 4 h following BrdU administration on postnatal day 30 (P30). The density of BrdU-ir cells was greater in males than in females, indicating greater proliferation in males. Proliferation was substantiated by double-label immunohistochemistry showing that MePD BrdU-ir cells colocalize proliferating cell nuclear antigen, but not the cell death marker Caspase3. We next studied longer time points (2-21 days) following BrdU administration on P30 and found that the rate of cell attrition is higher in males. Finally, triple-label immunohistochemistry of P30-born MePD cells revealed that some of these cells differentiate into neurons or astrocytes within three weeks of cell birth, with no discernable sex differences. The demonstration of pubertal neuro- and glio-genesis in the MePD of male and female rats adds a new dimension to developmental plasticity of the MePD that may contribute to pubertal changes in the perception of social stimuli in both sexes.
Language	English
Publishing date	2022-07-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2572271-2
ISSN	1878-9307 ; 1878-9307
ISSN (online)	1878-9307
ISSN	1878-9307
DOI	10.1016/j.dcn.2022.101141
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Article ; Online: The organizational role of ovarian hormones during puberty on risk for binge-like eating in rats.

Hildebrandt, Britny A / Lee, Jenna R / Culbert, Kristen M / Sisk, Cheryl L / Johnson, Alexander W / Klump, Kelly L

Physiology & behavior

2023 Volume 265, Page(s) 114177

Abstract	Puberty is a high-risk period for the development of dysregulated eating, including binge eating. While risk for binge eating in animals and humans increases in both males and females during puberty, the increased prevalence is significantly greater in females. Emerging data suggest that the organizational effects of gonadal hormones may contribute to the female preponderance of binge eating. In this narrative review, we discuss studies conducted in animals that have examined these organizational effects as well as the neural systems that may serve as intermediary mechanisms. Relatively few studies have been conducted, but data thus far suggest that pubertal estrogens may organize risk for binge eating, potentially by altering key circuits in brain reward pathways. These promising results highlight the need for future studies to directly test organizational effects of pubertal hormones using hormone replacement techniques and circuit-level manipulations that can identify pathways contributing to binge eating across development.
MeSH term(s)	Humans ; Male ; Rats ; Female ; Animals ; Sexual Maturation ; Binge-Eating Disorder ; Bulimia ; Estrogens/metabolism ; Gonadal Hormones ; Puberty
Chemical Substances	Estrogens ; Gonadal Hormones
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2023.114177
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Zs.A 747: Show issues

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Article: Reduced Medial Prefrontal Control of Palatable Food Consumption Is Associated With Binge Eating Proneness in Female Rats.

Sinclair, Elaine B / Klump, Kelly L / Sisk, Cheryl L

Frontiers in behavioral neuroscience

2019 Volume 13, Page(s) 252

Abstract: Binge eating is the core, maladaptive eating behavior that cuts across several major types of eating disorders. Binge eating is associated with a significant loss of control over palatable food (PF) intake, and deficits in behavioral control mechanisms, ... ...

Abstract	Binge eating is the core, maladaptive eating behavior that cuts across several major types of eating disorders. Binge eating is associated with a significant loss of control over palatable food (PF) intake, and deficits in behavioral control mechanisms, subserved by the prefrontal cortex (PFC), may underlie binge eating. Few studies, to date, have examined whether the PFC is directly involved in the expression of binge eating. As such, the present study investigated the functional role of the medial PFC (mPFC) in PF consumption, using an individual differences rat model of binge eating proneness. Here, we tested the hypothesis that binge eating proneness (i.e., high levels of PF consumption) is associated with reduced mPFC-mediated behavioral control over PF intake. In experiment 1, we quantified PF-induced Fos expression in both excitatory and inhibitory neurons within the mPFC in binge eating prone (BEP) and binge eating resistant (BER) female rats. In experiment 2, we pharmacologically inactivated the mPFC of BEP and BER female rats, just prior to PF exposure, and subsequently quantified PF intake and scores of feeding behavior. While most Fos-expressing neurons of the mPFC in both BEPs and BERs were of the excitatory phenotype, fewer excitatory neurons were engaged by PF in BEPs than in BERs. Moreover, pharmacological inactivation of the mPFC led to a significant increase in PF intake in both BEPs and BERs, but the rise in PF consumption was stronger in BEPs than in BERs. Thus, these data suggest that lower, PF-induced excitatory tone in the mPFC of BEP rats may lead to a weaker, mPFC-mediated behavioral "brake" over excessive PF intake.
Language	English
Publishing date	2019-10-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452960-6
ISSN	1662-5153
ISSN	1662-5153
DOI	10.3389/fnbeh.2019.00252
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Article ; Online: Low testosterone is associated with dysregulated eating symptoms in young adult men.

Culbert, Kristen M / Shope, Megan M / Sisk, Cheryl L / Klump, Kelly L

The International journal of eating disorders

2020 Volume 53, Issue 9, Page(s) 1469–1479

Abstract: Objective: Extant animal and human data indicate that natural variation in circulating levels of testosterone may contribute to differential risk for dysregulated eating among males. Indeed, testosterone ablation in postpubertal male rodents results in ... ...

Abstract	Objective: Extant animal and human data indicate that natural variation in circulating levels of testosterone may contribute to differential risk for dysregulated eating among males. Indeed, testosterone ablation in postpubertal male rodents results in stimulatory effects on sweet-taste preferences, and lower levels of circulating testosterone in adolescent boys have been found to predict dysregulated eating symptoms during mid-to-late puberty. Nonetheless, no prior study has examined whether lower testosterone is associated with dysregulated eating in adulthood. The current study examined this possibility. Method: Participants were 154 young adult men (ages = 18-33) from a large Southwestern University. The Eating Disorder Examination Questionnaire, Eating Pathology Symptoms Inventory, and Loss of Control Over Eating Scale were used to assess three types of dysregulated eating symptoms: eating concerns, binge eating, and loss-of-control eating. Afternoon saliva samples were assayed for testosterone using high-sensitive enzyme immunoassays. Results: Consistent with animal data and prior research in adolescent boys, men with lower testosterone reported significantly higher levels of dysregulated eating symptoms even after controlling for depressive symptoms, body mass index, and age. Discussion: Lower testosterone concentrations might serve as a sex-specific biological factor that contributes to dysregulated eating among men.
MeSH term(s)	Adolescent ; Adult ; Feeding and Eating Disorders/blood ; Humans ; Male ; Testosterone/deficiency ; Young Adult
Chemical Substances	Testosterone (3XMK78S47O)
Language	English
Publishing date	2020-07-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	603170-5
ISSN	1098-108X ; 0276-3478
ISSN (online)	1098-108X
ISSN	0276-3478
DOI	10.1002/eat.23320
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Article ; Online: The organizing actions of adolescent gonadal steroid hormones on brain and behavioral development.

Schulz, Kalynn M / Sisk, Cheryl L

Neuroscience and biobehavioral reviews

2016 Volume 70, Page(s) 148–158

Abstract: Adolescence is a developmental period characterized by dramatic changes in cognition, risk-taking and social behavior. Although gonadal steroid hormones are well-known mediators of these behaviors in adulthood, the role gonadal steroid hormones play in ... ...

Abstract	Adolescence is a developmental period characterized by dramatic changes in cognition, risk-taking and social behavior. Although gonadal steroid hormones are well-known mediators of these behaviors in adulthood, the role gonadal steroid hormones play in shaping the adolescent brain and behavioral development has only come to light in recent years. Here we discuss the sex-specific impact of gonadal steroid hormones on the developing adolescent brain. Indeed, the effects of gonadal steroid hormones during adolescence on brain structure and behavioral outcomes differs markedly between the sexes. Research findings suggest that adolescence, like the perinatal period, is a sensitive period for the sex-specific effects of gonadal steroid hormones on brain and behavioral development. Furthermore, evidence from studies on male sexual behavior suggests that adolescence is part of a protracted postnatal sensitive period that begins perinatally and ends following adolescence. As such, the perinatal and peripubertal periods of brain and behavioral organization likely do not represent two discrete sensitive periods, but instead are the consequence of normative developmental timing of gonadal hormone secretions in males and females.
MeSH term(s)	Adolescent ; Adolescent Behavior ; Adolescent Development ; Brain ; Gonadal Steroid Hormones ; Humans ; Risk-Taking ; Social Behavior
Chemical Substances	Gonadal Steroid Hormones
Language	English
Publishing date	2016-08-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	282464-4
ISSN	1873-7528 ; 0149-7634
ISSN (online)	1873-7528
ISSN	0149-7634
DOI	10.1016/j.neubiorev.2016.07.036
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