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  1. Article: Selecting the best surgical approach in various cases of prolapsed pedunculated submucosal fibroids: A case series.

    Hidayah, Gita Nurul / Harzif, Achmad Kemal / Noviani, Astri / Tantry, Harry Prawiro / Santoso, Budi Iman / Situmorang, Herbert

    International journal of surgery case reports

    2023  Volume 113, Page(s) 109029

    Abstract: Introduction: The pedunculated fibroid is classically managed through vaginal myomectomy. However, vaginal myomectomy cannot be safely and easily performed in all cases. We reviewed three cases of prolapsed pedunculated submucosal fibroids, each with a ... ...

    Abstract Introduction: The pedunculated fibroid is classically managed through vaginal myomectomy. However, vaginal myomectomy cannot be safely and easily performed in all cases. We reviewed three cases of prolapsed pedunculated submucosal fibroids, each with a specific surgical difficulty.
    Presentation of cases: The first case had a prolapsed pedunculated uterine fibroid in pregnancy and underwent fibroid extirpation during an emergency cesarean section through the lower uterine segment incision. The second case was a nulliparous woman with recurrent abnormal uterine bleeding due to a giant prolapsed pedunculated uterine fibroid who underwent laparotomy fibroid extirpation through posterior colpotomy, preserving the uterus. The third case had a prolapsed pedunculated uterine fibroid in perimenopause with multiple fibroids and underwent fibroid stalk excision through an isthmic incision to facilitate a safe laparotomy hysterectomy procedure.
    Discussion: Vaginal removal has become the standard surgical method for prolapsed pedunculated submucous fibroids. However, some possible consequences of vaginal myomectomy include severe stalk bleeding, infection, and uterus inversion induced by excessive traction. Therefore, specific approaches are needed in some circumstances.
    Conclusion: Customised surgical approaches provided safe and efficient access to the prolapsed pedunculated fibroid stalk during myomectomy or hysterectomy.
    Language English
    Publishing date 2023-11-11
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2023.109029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: IN-SILICO dynamic analysis of Sulawesi propolis as anti-endometriosis drug: Interaction study with TNF alpha receptor, NF-kB, estrogen receptor, progesterone receptor and prostaglandin receptor.

    Situmorang, Herbert / Hestiantoro, Andon / Purbadi, Sigit / Flamandita, Darin / Sahlan, Muhamad

    Annals of medicine and surgery (2012)

    2021  Volume 67, Page(s) 102459

    Abstract: Introduction: Endometriosis is a disease that impacts around 10% of all women in reproductive age, with pelvic pain and infertility as its main clinical features. Current medical treatment targeting lowering estrogen activity has not shown sufficient ... ...

    Abstract Introduction: Endometriosis is a disease that impacts around 10% of all women in reproductive age, with pelvic pain and infertility as its main clinical features. Current medical treatment targeting lowering estrogen activity has not shown sufficient result due its side effects and reproductive function suppression. Propolis has been widely studied, showing anti inflammation and pro-apoptosis property, that could potentially be used in the treatment of endometriosis. This study investigates the interaction between Sulawesi Propolis' active components and receptors and protein related to endometriosis pathogenesis.
    Methods: Active components of Sulawesi Propolis were initially identified with their targeted protein receptors. Lipinski rules were used to screen potential components. The ligands and proteins were tested using Autodock program to predict the most active compound and possible binding sites between propolis and some target proteins associated with inflammatory and apoptotic activity in endometriosis models. Receptor modelling is then performed using Swiss-Model.
    Results: These active components of Sulawesi Propolis showed a strong binding potential towards TNF- α, NF-kb, Estrogen-α, Estrogen-β, progesterone B, PGE2 EP2 and EP3 subtype respectively: Sanggenon C, Sanggenon H, Epicryptoacetalide, Chrysin-7-O-β-D-glucopyranodside, Irilone, Polydatin and Epicryptoacetalide. Compared to its negative ligand, Sulawesi Propolis displayed a stronger binding capacity to TNF-α, Estrogen-α, and Progesterone B receptors.
    Conclusion: Sulawesi Propolis has the ability to interact with receptors related to reproductive function, apoptotic reactions and inflammatory processes, a significant factor associated with the pathogenesis of endometriosis.
    Language English
    Publishing date 2021-06-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2021.102459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: In-vitro antioxidant, in-vivo anti-inflammatory, and acute toxicity study of Indonesian propolis capsule from

    Farida, Siti / Pratami, Diah Kartika / Sahlan, Muhamad / Laksmitawati, Dian Ratih / Rohmatin, Etin / Situmorang, Herbert

    Saudi journal of biological sciences

    2021  Volume 29, Issue 4, Page(s) 2489–2500

    Abstract: Propolis is widely used as traditional medicine since ancient times. It was necessary to conduct the pre-clinical study because of its relevant curative properties. This study aimed to investigate in-vitro antioxidant, standardize quality parameters, ... ...

    Abstract Propolis is widely used as traditional medicine since ancient times. It was necessary to conduct the pre-clinical study because of its relevant curative properties. This study aimed to investigate in-vitro antioxidant, standardize quality parameters, study acute toxicity, and determine in-vivo anti-inflammatory. Three spectrophotometric methods were used to determine antioxidant activity. The standardization includes physical, chemical, and microbiological evaluation. Furthermore, an acute toxicity test was conducted using 20 female Sprague Dawley (SD) strain rats divided into 4 groups with different dose of propolis. The in vivo anti-inflammatory test was carried out using the carrageenan induction method on rats' soles. A total of 36 female SD rats were classified into 6 groups as follows, Group normal, negative control, diclofenac sodium, and three propolis groups (72; 144; and 288 mg/kg BW). The results demonstrated the IC
    Language English
    Publishing date 2021-12-16
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2515206-3
    ISSN 2213-7106 ; 1319-562X
    ISSN (online) 2213-7106
    ISSN 1319-562X
    DOI 10.1016/j.sjbs.2021.12.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Body fat percentage is a better marker than body mass index for determining inflammation status in polycystic ovary syndrome.

    Hestiantoro, Andon / Kapnosa Hasani, Rachmat Dediat / Shadrina, Amalia / Situmorang, Herbert / Ilma, Nurul / Muharam, Raden / Sumapraja, Kanadi / Wiweko, Budi

    International journal of reproductive biomedicine

    2019  Volume 16, Issue 10, Page(s) 623–628

    Abstract: Background: Polycystic ovary syndrome (PCOS) is an endocrinopathic disorder most commonly experienced by women of reproductive age, and it is characterized by a low-grade chronic inflammatory condition. Excessive fat deposit has been long considered as ... ...

    Abstract Background: Polycystic ovary syndrome (PCOS) is an endocrinopathic disorder most commonly experienced by women of reproductive age, and it is characterized by a low-grade chronic inflammatory condition. Excessive fat deposit has been long considered as an etiological factor in the pathogenesis of this inflammatory condition. Currently, body mass index (BMI) or percentage of body fat is used as a marker to assess the body fat composition of a person.
    Objective: To determine whether BMI or body fat percentage (BFP) can be used as a better marker for measuring inflammation related to body fat accumulation in polycystic ovary syndrome patients.
    Materials and methods: This study took place at the Center for Reproductive Medicine, Yasmin Clinic, Cipto Mangunkusumo Hospital from January to December 2015. In this cross-sectional study, 32 reproductive age women with PCOS according to the Rotterdam criteria (2003) participated. Women with hyperandrogenism caused by non-classic congenital adrenal hyperplasia, pregnant and lactating women, etc., were excluded. Some variables such as BMI, clinical hyperandrogenism sign, BFP, and inflammatory markers were assessed and statistically analyzed.
    Results: From a total of 32 subjects of the study, BFP had a significant positive correlation with procalcitonin levels (r=0.35; p=0.048), while BMI did not (r=0.27; p=0.131).
    Conclusion: BFP can be used as a better marker for measuring inflammation related to body fat accumulation in PCOS subjects.
    Language English
    Publishing date 2019-01-04
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2898387-7
    ISSN 2476-3772 ; 2476-4108
    ISSN (online) 2476-3772
    ISSN 2476-4108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Anti-inflammatory activity of

    Sahlan, Muhamad / Devina, Andrea / Pratami, Diah Kartika / Situmorang, Herbert / Farida, Siti / Munim, Abdul / Kusumoputro, Benyamin / Yohda, Masafumi / Faried, Ahmad / Gozan, Misri / Ledyawati, Mia

    Saudi journal of biological sciences

    2018  Volume 26, Issue 7, Page(s) 1531–1538

    Abstract: Anti-inflammatory drugs inhibit inflammation, particularly those classified as nonsteroidal anti-inflammatory drugs (NSAIDs). Several studies have reported that propolis has both anti-ulcerogenic and anti-inflammatory effects. In this study, we ... ...

    Abstract Anti-inflammatory drugs inhibit inflammation, particularly those classified as nonsteroidal anti-inflammatory drugs (NSAIDs). Several studies have reported that propolis has both anti-ulcerogenic and anti-inflammatory effects. In this study, we investigated the bioactive compound and
    Language English
    Publishing date 2018-12-17
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2515206-3
    ISSN 2213-7106 ; 1319-562X
    ISSN (online) 2213-7106
    ISSN 1319-562X
    DOI 10.1016/j.sjbs.2018.12.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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