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  1. Article: Cancers de la sphère ORL : l’immunothérapie donne de la voix !

    Sivade, Aurélie / Bensaid, Djamila / Monnier, Yan / Shabafrouz, Keyvan / Bouchaab, Hanan / Cristina, Valérie

    Revue medicale suisse

    2017  Volume 13, Issue 563, Page(s) 1029–1031

    Abstract: Immunotherapy, especially checkpoint inhibitors such as anti-PD1 and anti-PDL1 antibodies, has changed the standard of care and the prognosis of melanoma, but also more recently of lung cancer, renal cancer and Hodgkin lymphoma. Results of preliminary ... ...

    Title translation Head and neck cancer : promising results of immunotherapy.
    Abstract Immunotherapy, especially checkpoint inhibitors such as anti-PD1 and anti-PDL1 antibodies, has changed the standard of care and the prognosis of melanoma, but also more recently of lung cancer, renal cancer and Hodgkin lymphoma. Results of preliminary studies in head and neck squamous cell carcinoma (HNSCC) as well as in less frequent tumors of the region, such as nasopharyngeal carcinoma and high grade salivary gland carcinoma, are also promising. Indeed, in a recent phase 3 study, the PD1 inhibitor nivolumab has recently demonstrated a significant improvement in overall survival for platin-resistant recurrent and/or metastatic HNSCC.
    MeSH term(s) Carcinoma/pathology ; Carcinoma/therapy ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/therapy ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/therapy ; Humans ; Immunotherapy/methods ; Immunotherapy/trends ; Melanoma/pathology ; Melanoma/therapy ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/therapy ; Squamous Cell Carcinoma of Head and Neck
    Language French
    Publishing date 2017-06-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5998: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Synchronous tumors of the pancreas and the gallbladder: a case report with targeted NGS evaluation.

    Sivade, Aurelie / Sempoux, Christine / Voutsadakis, Ioannis / Brunel, Christophe / Halkic, Nermin / Godat, Sebastian / Duran, Rafael / Digklia, Antonia

    Annals of translational medicine

    2019  Volume 7, Issue 22, Page(s) 696

    Abstract: Synchronous tumors of the pancreas and gallbladder are rare and often attributed to an abnormal pancreato-biliary junction, which results in a persistent reflux of pancreatic secretions leading to chronic biliary inflammation. We present the case of a 73- ...

    Abstract Synchronous tumors of the pancreas and gallbladder are rare and often attributed to an abnormal pancreato-biliary junction, which results in a persistent reflux of pancreatic secretions leading to chronic biliary inflammation. We present the case of a 73-year-old woman with synchronous lesions of the pancreas and gallbladder initially considered as two primary localized cancers and treated with curative intent. At relapse, targeted next generation sequencing (NGS), performed in search of potential therapeutic targets, uncovered the fact that the two lesions appeared to be clonally related. This case illustrates the problem of synchronous lesions of the pancreas and gallbladder. New pathologic assessments with comparative molecular analysis of mutational profiles may be helpful in this context.
    Language English
    Publishing date 2019-11-26
    Publishing country China
    Document type Case Reports
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2019.10.107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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