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  1. Article: The 11th revision of the International Statistical Classification of Disease and Related Health Problems and Cholangiocarcinoma.

    Cai, Shijie / Sivakumar, Shivan

    Hepatobiliary surgery and nutrition

    2022  Volume 11, Issue 2, Page(s) 276–279

    Language English
    Publishing date 2022-04-18
    Publishing country China (Republic : 1949- )
    Document type Editorial
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-22-69
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A New Combination Immunotherapy in Advanced Melanoma.

    Frampton, Adam E / Sivakumar, Shivan

    The New England journal of medicine

    2022  Volume 386, Issue 1, Page(s) 91–92

    MeSH term(s) Humans ; Immunotherapy ; Melanoma/drug therapy
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2116892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial on "

    Sivakumar, Shivan / Rocha, Flavio G / Heij, Lara

    Hepatobiliary surgery and nutrition

    2021  Volume 11, Issue 3, Page(s) 422–424

    Language English
    Publishing date 2021-01-29
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-22-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Improving early diagnosis of pancreatic cancer in symptomatic patients.

    Johnston, Amber J / Sivakumar, Shivan / Zhou, Yin / Funston, Garth / Bradley, Stephen H

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2023  Volume 73, Issue 737, Page(s) 534–535

    MeSH term(s) Humans ; Early Detection of Cancer ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Editorial
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/bjgp23X735585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Healthcare systems must get fair value for their data.

    Bradley, Stephen H / Hemphill, Scott / Markham, Sarah / Sivakumar, Shivan

    BMJ (Clinical research ed.)

    2022  Volume 377, Page(s) e070876

    MeSH term(s) Delivery of Health Care ; Humans
    Language English
    Publishing date 2022-06-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj-2022-070876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Biomarkers of response to PD-1 pathway blockade.

    Li, Hanxiao / van der Merwe, P Anton / Sivakumar, Shivan

    British journal of cancer

    2022  Volume 126, Issue 12, Page(s) 1663–1675

    Abstract: The binding of T cell immune checkpoint proteins programmed death 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) to their ligands allows immune evasion by tumours. The development of therapeutic antibodies, termed checkpoint inhibitors, ...

    Abstract The binding of T cell immune checkpoint proteins programmed death 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) to their ligands allows immune evasion by tumours. The development of therapeutic antibodies, termed checkpoint inhibitors, that bind these molecules or their ligands, has provided a means to release this brake on the host anti-tumour immune response. However, these drugs are costly, are associated with potentially severe side effects, and only benefit a small subset of patients. It is therefore important to identify biomarkers that discriminate between responders and non-responders. This review discusses the determinants for a successful response to antibodies that bind PD-1 or its ligand PD-L1, dividing them into markers found in the tumour biopsy and those in non-tumour samples. It provides an update on the established predictive biomarkers (tumour PD-L1 expression, tumour mismatch repair deficiency and tumour mutational burden) and assesses the evidence for new potential biomarkers.
    MeSH term(s) Animals ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/immunology ; Biomarkers, Tumor/genetics ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/immunology ; Humans ; Ligands ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/immunology
    Chemical Substances B7-H1 Antigen ; Biomarkers, Tumor ; Ligands ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2022-02-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-022-01743-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal-external validation of a clinical risk prediction model.

    Clift, Ash Kieran / Tan, Pui San / Patone, Martina / Liao, Weiqi / Coupland, Carol / Bashford-Rogers, Rachael / Sivakumar, Shivan / Hippisley-Cox, Julia

    British journal of cancer

    2024  

    Abstract: Background: The National Institute for Health and Care Excellence (NICE) recommends that people aged 60+ years with newly diagnosed diabetes and weight loss undergo abdominal imaging to assess for pancreatic cancer. More nuanced stratification could ... ...

    Abstract Background: The National Institute for Health and Care Excellence (NICE) recommends that people aged 60+ years with newly diagnosed diabetes and weight loss undergo abdominal imaging to assess for pancreatic cancer. More nuanced stratification could lead to enrichment of these referral pathways.
    Methods: Population-based cohort study of adults aged 30-85 years at type 2 diabetes diagnosis (2010-2021) using the QResearch primary care database in England linked to secondary care data, the national cancer registry and mortality registers. Clinical prediction models were developed to estimate risks of pancreatic cancer diagnosis within 2 years and evaluated using internal-external cross-validation.
    Results: Seven hundred and sixty-seven of 253,766 individuals were diagnosed with pancreatic cancer within 2 years. Models included age, sex, BMI, prior venous thromboembolism, digoxin prescription, HbA1c, ALT, creatinine, haemoglobin, platelet count; and the presence of abdominal pain, weight loss, jaundice, heartburn, indigestion or nausea (previous 6 months). The Cox model had the highest discrimination (Harrell's C-index 0.802 (95% CI: 0.797-0.817)), the highest clinical utility, and was well calibrated. The model's highest 1% of predicted risks captured 12.51% of pancreatic cancer cases. NICE guidance had 3.95% sensitivity.
    Discussion: A new prediction model could have clinical utility in identifying individuals with recent onset diabetes suitable for fast-track abdominal imaging.
    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-024-02693-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Circulating Cell-Free Tumour DNA for Early Detection of Pancreatic Cancer.

    Jaworski, Jedrzej J / Morgan, Robert D / Sivakumar, Shivan

    Cancers

    2020  Volume 12, Issue 12

    Abstract: Pancreatic cancer is a lethal disease, with mortality rates negatively associated with the stage at which the disease is detected. Early detection is therefore critical to improving survival outcomes. A recent focus of research for early detection is the ...

    Abstract Pancreatic cancer is a lethal disease, with mortality rates negatively associated with the stage at which the disease is detected. Early detection is therefore critical to improving survival outcomes. A recent focus of research for early detection is the use of circulating cell-free tumour DNA (ctDNA). The detection of ctDNA offers potential as a relatively non-invasive method of diagnosing pancreatic cancer by using genetic sequencing technology to detect tumour-specific mutational signatures in blood samples before symptoms manifest. These technologies are limited by a number of factors that lower sensitivity and specificity, including low levels of detectable ctDNA in early stage disease and contamination with non-cancer circulating cell-free DNA. However, genetic and epigenetic analysis of ctDNA in combination with other standard diagnostic tests may improve early detection rates. In this review, we evaluate the genetic and epigenetic methods under investigation in diagnosing pancreatic cancer and provide a perspective for future developments.
    Language English
    Publishing date 2020-12-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12123704
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  9. Article: The COVID-19 Pandemic Is Associated with Reduced Survival after Pancreatic Ductal Adenocarcinoma Diagnosis: A Single-Centre Retrospective Analysis.

    Madge, Oliver / Brodey, Alexandra / Bowen, Jordan / Nicholson, George / Sivakumar, Shivan / Bottomley, Matthew J

    Journal of clinical medicine

    2022  Volume 11, Issue 9

    Abstract: The COVID-19 pandemic has hugely disrupted healthcare provision, including oncology services. To evaluate the effects of the pandemic on referral routes leading to diagnosis, treatments, and prognosis in patients with pancreatic ductal adenocarcinoma, we ...

    Abstract The COVID-19 pandemic has hugely disrupted healthcare provision, including oncology services. To evaluate the effects of the pandemic on referral routes leading to diagnosis, treatments, and prognosis in patients with pancreatic ductal adenocarcinoma, we performed a retrospective cohort study at a single tertiary centre in the UK. The patients were identified from the weekly hepatopancreatobiliary multidisciplinary team meetings between February 2018 and March 2021. The demographic, referral, and treatment data for each patient and date of death, where applicable, were extracted from the electronic patient record. The patients (
    Language English
    Publishing date 2022-05-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11092574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Gene of the month: T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT).

    Bolm, Louisa / Petruch, Natalie / Sivakumar, Shivan / Annels, Nicola E / Frampton, Adam Enver

    Journal of clinical pathology

    2022  Volume 75, Issue 4, Page(s) 217–221

    Abstract: Immune modulators play a crucial role in carcinogenesis and cancer progression by impairing cancer cell-targeted immune responses. T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT) regulates T- ... ...

    Abstract Immune modulators play a crucial role in carcinogenesis and cancer progression by impairing cancer cell-targeted immune responses. T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT) regulates T-cell function and cancer cell recognition and was therefore identified as a promising target for cancer immunotherapy. TIGIT is expressed in T cells and natural killer (NK) cells and has three ligands: CD155, CD112 and CD113. CD155 binds TIGIT with the highest affinity and promotes direct and indirect downregulation of T-cell response. TIGIT signalling further inhibits NK function and secretion of proinflammatory cytokines. An association between TIGIT expression and poor survival was identified in multiple cancer entities. Blocking TIGIT with monoclonal antibodies, and a combination of TIGIT and programmed cell death protein 1 blockade in particular, prevented tumour progression, distant metastasis and tumour recurrence in in vivo models. Inhibition of TIGIT is currently evaluated in first clinical trials.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Humans ; Immunotherapy ; Neoplasm Recurrence, Local ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism ; T-Lymphocytes/metabolism
    Chemical Substances Antibodies, Monoclonal ; Receptors, Immunologic ; TIGIT protein, human
    Language English
    Publishing date 2022-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jclinpath-2021-207789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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