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Article ; Online: Rheumatoid nodules in thyroid gland parenchyma as an expression of rheumatoid arthritis: a case report.

Sivridis, Efthimios / Kouroupi, Maria / Koukourakis, Michael Ioannis / Arelaki, Stella / Lyratzopoulos, Nikolaos / Giatromanolaki, Alexandra

Journal of medical case reports

2019 Volume 13, Issue 1, Page(s) 159

Abstract: Background: The rheumatoid nodule is the most common extra-articular manifestation of rheumatoid arthritis. When present, it is readily identified in conventional hematoxylin and eosin sections.: Case presentation: We report a case with several ... ...

Abstract	Background: The rheumatoid nodule is the most common extra-articular manifestation of rheumatoid arthritis. When present, it is readily identified in conventional hematoxylin and eosin sections. Case presentation: We report a case with several rheumatoid nodules in a thyroid gland of a 33-year-old Greek woman with a 3-year history of rheumatoid arthritis treated with methotrexate, after having total thyroidectomy for hypothyroidism. Conclusion: To the best of our knowledge, this is the first time that rheumatoid nodules have been encountered in the thyroid gland.
MeSH term(s)	Adult ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/physiopathology ; Female ; Greece ; Humans ; Rheumatoid Nodule/physiopathology ; Thyroid Gland/physiopathology ; Thyroid Gland/surgery ; Thyroxine/therapeutic use ; Treatment Outcome
Chemical Substances	Antirheumatic Agents ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2019-05-28
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-019-2113-9
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Article ; Online: Patterns of LC3A Autophagy Protein Expression in Keratoacanthomas.

Sivridis, Efthimios / Koukourakis, Ioannis M / Arelaki, Stella / Balaska, Kostantina / Karpouzis, Antonios / Giatromanolaki, Alexandra

Head and neck pathology

2019 Volume 14, Issue 1, Page(s) 150–155

Abstract: To investigate the expression patterns of autophagy marker light chain protein 3 (LC3A) in keratoacanthoma (KA). KAs are generally regarded as benign but malignant behavior, including rare metastases, may occur. 85 KAs were assessed for the LC3A ... ...

Abstract	To investigate the expression patterns of autophagy marker light chain protein 3 (LC3A) in keratoacanthoma (KA). KAs are generally regarded as benign but malignant behavior, including rare metastases, may occur. 85 KAs were assessed for the LC3A autophagic protein by immunohistochemistry. Diffuse cytoplasmic staining and a "stone-like structure" (SLS) characterized positive expression. Thirty-four out of 85 KAs (40%) had diffuse cytoplasmic LC3A immunostaining (percentage of positive cells ranging from 5 to 60%). In contrast, only 4 of the 85 KAs (4.7%) expressed SLSs. Only one SLS was detected per histologic section of each tumor. The p53 oncoprotein was encountered in all cases with expression ranging from 1 to 90% of cells (median 30%). The Ki-67 index was expressed in 63 cases (74% of cases; range 1-50% of cells; median value 5%). Neither of these two parameters nor diffuse cytoplasmic LC3A staining was significantly correlated with SLS expression or lack thereof. Expression of SLSs, a hallmark of malignancy, was found in 4.7% of KAs. Further study is necessary to determine whether this fraction represents the exceptional cases that harbor latent malignant potential.
MeSH term(s)	Aged ; Aged, 80 and over ; Autophagy ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/metabolism ; Female ; Humans ; Keratoacanthoma/metabolism ; Keratoacanthoma/pathology ; Male ; Microtubule-Associated Proteins/biosynthesis ; Middle Aged ; Retrospective Studies ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor ; MAP1LC3A protein, human ; Microtubule-Associated Proteins
Language	English
Publishing date	2019-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2407834-7
ISSN	1936-0568 ; 1936-055X
ISSN (online)	1936-0568
ISSN	1936-055X
DOI	10.1007/s12105-019-01033-1
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Article ; Online: LC3A, LC3B and Beclin-1 Expression in Gastric Cancer.

Giatromanolaki, Alexandra / Koukourakis, Michael I / Georgiou, Ioannis / Kouroupi, Maria / Sivridis, Efthimios

Anticancer research

2019 Volume 38, Issue 12, Page(s) 6827–6833

Abstract: Background: The current study examined the key proteins involved in autophagosome formation and their prognostic role in gastric cancer.: Materials and methods: Paraffin-embedded tissues from 121 consecutive patients treated with surgery for gastric ... ...

Abstract	Background: The current study examined the key proteins involved in autophagosome formation and their prognostic role in gastric cancer. Materials and methods: Paraffin-embedded tissues from 121 consecutive patients treated with surgery for gastric cancer were analyzed immunohistochemically for the expression of autophagic proteins microtubule-associated proteins 1A/1B light chain 3A and 3B (LC3A, LC3B) and beclin-1 (encoded by BECN1 gene). Assessment of proliferative index using the MIB1 monoclonal antibody (recognizing an epitope of the Ki-67 antigen, encoded by the MK167 gene) and correlations with histopathological [corrected]. Results: Strong cytoplasmic expression was noted for all studied proteins, although to a varying proportion, the median percentage being 30% for LC3A, and 40% for LC3B and beclin-1. The median score of LC3A Conclusion: Intense autophagic activity, as assessed by LC3A immunostaining and SLS quantification, is a strong prognostic marker in gastric cancer and can be useful for clinical application.
MeSH term(s)	Adult ; Aged ; Autophagy/physiology ; Beclin-1/metabolism ; Biomarkers, Tumor/metabolism ; Female ; Humans ; Immunohistochemistry ; Male ; Microtubule-Associated Proteins/metabolism ; Middle Aged ; Prognosis ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology
Chemical Substances	BECN1 protein, human ; Beclin-1 ; Biomarkers, Tumor ; MAP1LC3A protein, human ; MAP1LC3B protein, human ; Microtubule-Associated Proteins
Language	English
Publishing date	2019-02-03
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.13056
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Zs.A 1642: Show issues

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Article ; Online: Expression of enzymes related to glucose metabolism in non-small cell lung cancer and prognosis.

Giatromanolaki, Alexandra / Sivridis, Efthimios / Arelaki, Stella / Koukourakis, Michael I

Experimental lung research

2017 Volume 43, Issue 4-5, Page(s) 167–174

Abstract: Purpose/Aim: Cancer cells are addicted to glycolytic anaerobic pathways, in presence or in absence of a functional Krebs' cycle (phenomenon Warburg). This metabolic predilection relies on both extracellular (impaired vascularization and oxygenation) and ... ...

Abstract	Purpose/Aim: Cancer cells are addicted to glycolytic anaerobic pathways, in presence or in absence of a functional Krebs' cycle (phenomenon Warburg). This metabolic predilection relies on both extracellular (impaired vascularization and oxygenation) and intracellular (oncogenic activation of genes) causes. Materials and methods: We investigated the expression and prognostic relevance of enzymes involved in the glucose absorption and metabolism, monocarboxylate transporter (MCT) expression, MCT1 and MCT2, pentose pathway (Glucose-6-phospahte dehydrogenase G6PD), glycogene synthesis (glycogene synthase GYS1), glycolysis (Hexokinase HXKII, phosphofructokinase PFK1, fructose biphosphate aldolase), fate of pyruvate (pyruvate dehydrogenase PDH, phosphorylated pPDH, PDH kinase PDK1, lactate dehydrogenase LDH5 and LDH1) and key Kreb's cycle enzymes (citrate synthase CSynth and isocitrate dehydrogenase IDH). Results: A strong overexpression of the above enzymes/proteins was noted in a varying percentage of cases examined. An interesting significant correlation between the enzymes involved in glycolysis and with the LDH5 was noted. Adenocarcinomas expressed higher levels of GLUT1 and MCT2 compared to other subtypes. Stage (p = 0.0001), aldolase (p = 0.004), LDH5 (p = 0.008), GLUT2 (p = 0.008), MCT2 (p = 0.009), GSYS1 (p = 0.04), and GLUT1 (p = 0.05) were significantly related with poor disease specific overall survival. In multivariate analysis stage (p = 0.001), LDH5 (p = 0.04), pPDH (p = 0.04), and aldolase (p = 0.04) were independent prognostic variables. Conclusion: It is concluded that an orchestrated activation of glucose absorption and metabolism towards anaerobic pathways characterize the majority of NSCLC, and this phenotype is strongly linked with an aggressive clinical behavior. This glycolytic addiction of lung cancer cell is revealed as a key therapeutic target.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Anaerobiosis ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/enzymology ; Carcinoma, Non-Small-Cell Lung/metabolism ; Female ; Glucose/metabolism ; Glycolysis ; Humans ; Isoenzymes ; L-Lactate Dehydrogenase ; Male ; Middle Aged ; Prognosis
Chemical Substances	Isoenzymes ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; lactate dehydrogenase 5 (EC 1.1.1.27.-) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2017-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603791-4
ISSN	1521-0499 ; 0190-2148
ISSN (online)	1521-0499
ISSN	0190-2148
DOI	10.1080/01902148.2017.1328714
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Zs.A 1568: Show issues

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Article ; Online: Transcription Factor EB Expression in Early Breast Cancer Relates to Lysosomal/Autophagosomal Markers and Prognosis.

Giatromanolaki, Alexandra / Sivridis, Efthimios / Kalamida, Dimitra / Koukourakis, Michael I

Clinical breast cancer

2017 Volume 17, Issue 3, Page(s) e119–e125

Abstract: Background: Disrupting the autophagic balance to trigger autophagic death may open new strategies for cancer therapy. Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and may play a role in cancer biology and clinical ... ...

Abstract	Background: Disrupting the autophagic balance to trigger autophagic death may open new strategies for cancer therapy. Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and may play a role in cancer biology and clinical behavior. Methods: The expression of TFEB and the lysosomal cancer cell content (expression of lysosomal associated membrane protein 2a [LAMP2a] and cathepsin D) was studied in a series of 100 T1-stage breast carcinomas. Expression patterns were correlated with autophagy/hypoxia-related proteins, angiogenesis, and clinical outcome. The effect of hypoxic/acidic conditions on TFEB kinetics was studied in the MCF-7 cancer cell line. Results: Overexpression of TFEB in cancer cell cytoplasm and the perinuclear/nuclear area was noted in 23 (23%) of 100 cases. High LAMP2a and cathepsin D expression was noted in 30 (30%) of 100 and 28 (28%) of 100 cases, respectively. TFEB expression was directly linked with LAMP2a (P < .0001, r = 0.53), cathepsin D (P = .0002, r = 0.36), light chain 3A (LC3A) (P = .02, r = 0.22), and hypoxia-inducible factor 2-alpha (HIF-2α) (P = .01, r = 0.25) expression and inversely with progesterone receptor (P = .01, r = 0.22). High vascular density was directly linked with LAMP2a (P = .05, r = 0.18) and cathepsin D (P = .005, r = 0.28). In Kaplan-Meier survival analysis, TFEB and cathepsin D expression were related to an ominous prognosis (P = .001 and P = .03, respectively). In multivariate analysis, TFEB expression sustained its independent prognostic significance (P = .05, hazard ratio 2.1). In in vitro experiments, acidity triggered overexpression of TFEB and nuclear translocation. Conclusion: Intense TFEB expression and lysosomal biogenesis, evident in one fourth of early breast carcinomas, define poor prognosis. Tumor acidity is among the microenvironmental conditions that trigger TFEB overactivity. TFEB is a sound target for the development of lysosomal targeting therapies.
Language	English
Publishing date	2017-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2106734-X
ISSN	1938-0666 ; 1526-8209
ISSN (online)	1938-0666
ISSN	1526-8209
DOI	10.1016/j.clbc.2016.11.006
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Zs.A 5800: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 498: Show issues

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Article ; Online: Lipophagy-Related Protein Perilipin-3 and Resistance of Prostate Cancer to Radiation Therapy.

Lamprou, Ioannis / Kakouratos, Christos / Tsolou, Avgi / Pavlidis, Pavlos / Xanthopoulou, Erasmia T / Nanos, Christos / Tsaroucha, Alexandra / Sivridis, Efthimios / Giatromanolaki, Alexandra / Koukourakis, Michael I

International journal of radiation oncology, biology, physics

2022 Volume 113, Issue 2, Page(s) 401–414

Abstract: Purpose: Radiation therapy is a principal treatment modality for localized and locally advanced prostate cancer (PCa). Metabolic alterations, including lipid metabolism, may reduce treatment efficacy, resulting in tumor relapse and poor therapeutic ... ...

Abstract	Purpose: Radiation therapy is a principal treatment modality for localized and locally advanced prostate cancer (PCa). Metabolic alterations, including lipid metabolism, may reduce treatment efficacy, resulting in tumor relapse and poor therapeutic outcome. In the current study, we investigated the role of the lipophagy-related protein perilipin-3 (PLIN3) and the lysosomal acid lipase (LAL) in PCa response to radiation therapy. Methods and materials: We explored the in vitro and xenograft (in NOD SCID and R2G2 mice) response to radiation of either PLIN3-depleted or LAL-depleted hormone-refractory (DU145, PC3) and hormone-responsive (22Rv1) PCa cell lines. Moreover, we evaluated the clinical role of PLIN3 and LAL protein expression in a series of PCa tissue specimens from patients treated with radical radiation therapy. Results: In vitro and in vivo experiments showed reduced proliferation and strong radiosensitization of all studied PCa cell lines upon PLIN3 depletion. In vivo experiments demonstrated the significantly augmented radiation therapy efficacy upon PLIN3 depletion, resulting in extensive tissue necrosis. Overexpression of PLIN3 in tissue specimens was correlated with an increased MIB1 proliferation index, increased autophagy flux, reduced response to radiation therapy, and poor prognosis. The effect of LAL depletion on radiation therapy was of lesser importance. Conclusions: Assessment of PLIN3 expression may identify subgroups of patients with PCa who are less responsive to radiation therapy and at high risk of relapse after irradiation. Whether radiation therapy efficacy may be enhanced by concurrent autophagy or PLIN3 inhibition in this subgroup of patients demands clinical evaluation.
MeSH term(s)	Animals ; Autophagy ; Cell Line, Tumor ; Humans ; Lipid Metabolism/radiation effects ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; PC-3 Cells ; Perilipin-3/metabolism ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/radiotherapy ; Xenograft Model Antitumor Assays
Chemical Substances	PLIN3 protein, human ; Perilipin-3
Language	English
Publishing date	2022-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2022.01.033
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Zs.A 1218: Show issues

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Article ; Online: The pathogenesis of endometrial carcinomas at menopause: facts and figures.

Sivridis, Efthimios / Giatromanolaki, Alexandra

Journal of clinical pathology

2011 Volume 64, Issue 7, Page(s) 553–560

Abstract: Almost a third of the life of a woman is now postmenopausal, and during this period over 80% of endometrial carcinomas develop. This is by far the most common gynaecological malignancy in the industrialised world and, probably, the less completely ... ...

Abstract	Almost a third of the life of a woman is now postmenopausal, and during this period over 80% of endometrial carcinomas develop. This is by far the most common gynaecological malignancy in the industrialised world and, probably, the less completely understood with regard to its pathogenesis after the menopause. For while it is generally thought that these neoplasms are non-oestrogen-induced, we are, at the same time, informed that oestrogenic stimulation is continuous during menopause through increases to oestrone formation in the adipose tissue from androgens of adrenal and ovarian origin. Furthermore, the postmenopausal endometrium has been typified as atrophic, which is indeed true, but is also implied as being inactive, which in fact it is not; in most cases, the postmenopausal endometrium appears to be weakly proliferative with potential to give rise to an endometrial carcinoma. It is also assumed that postmenopausal endometrial tumours are predominantly of serous papillary and clear cell type, and, in general, they are not well-differentiated endometrioid carcinomas; in reality, no more than 15% are serous papillary and clear cell carcinomas, and no less than 55% are well-differentiated endometrioid neoplasms. The overall prognosis is presumed to be poor, yet postmenopausal patients harbouring well-differentiated endometrioid carcinomas have the same excellent prognosis as those premenopausal women having endometrioid tumours of similar grade and stage. This brief account of endometrial carcinogenesis at menopause re-evaluates these issues and, in the light of new and old evidence, proposes the separation of G1 endometrioid adenocarcinomas (low-grade tumours) from all others (high-grade tumours).
MeSH term(s)	Carcinoma/metabolism ; Carcinoma/pathology ; Endometrial Neoplasms/metabolism ; Endometrial Neoplasms/pathology ; Endometrium/metabolism ; Endometrium/pathology ; Female ; Humans ; Menopause/physiology
Language	English
Publishing date	2011-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80261-x
ISSN	1472-4146 ; 0021-9746
ISSN (online)	1472-4146
ISSN	0021-9746
DOI	10.1136/jcp.2010.085951
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Article ; Online: Mast cells co-expressing CD68 and inorganic polyphosphate are linked with colorectal cancer.

Arelaki, Stella / Arampatzioglou, Athanasios / Kambas, Konstantinos / Sivridis, Efthimios / Giatromanolaki, Alexandra / Ritis, Konstantinos

PloS one

2018 Volume 13, Issue 3, Page(s) e0193089

Abstract: Inflammation is a hallmark of colorectal cancer (CRC). Neutrophils are well-known mediators in tumor biology but their role in solid tumors, including CRC, was redefined by neutrophil extracellular traps (NETs). Given that it was recently demonstrated ... ...

Abstract	Inflammation is a hallmark of colorectal cancer (CRC). Neutrophils are well-known mediators in tumor biology but their role in solid tumors, including CRC, was redefined by neutrophil extracellular traps (NETs). Given that it was recently demonstrated that platelet-derived polyP primes neutrophils to release NETs, we examined surgical specimens from CRC to investigate the presence of polyP, as a possible NET inducer. Biopsies with adenomas, hyperplastic polyps, inflammatory bowel disease and healthy colon tissues were used as controls. In all cases, the presence of polyP was apparent, with the main source of polyP being the mast cells. In all CRC and all adenomas with high-grade dysplasia, a substantial number of mast cells, more than 50%, co-expressed intracellularly polyP with CD68 surface antigen (CD68+), but this was not the case in the other examined disorders. PolyP-expressing mast cells were detected in close proximity with tumor cells and neutrophils, suggesting polyP expression by CD68+ mast cells among the stimuli which prime neutrophils to release NETs, in CRC. Moreover, the detection of CD68+ polyP-expressing mast cells could represent a potential prognostic marker in colorectal adenomas and/or carcinomas.
MeSH term(s)	Adenoma/metabolism ; Adenoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Antigens, CD/biosynthesis ; Antigens, Differentiation, Myelomonocytic/biosynthesis ; Antigens, Neoplasm/biosynthesis ; Biomarkers, Tumor/biosynthesis ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mast Cells/metabolism ; Mast Cells/pathology ; Middle Aged ; Polyphosphates/metabolism
Chemical Substances	Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; Antigens, Neoplasm ; Biomarkers, Tumor ; CD68 antigen, human ; Polyphosphates
Language	English
Publishing date	2018
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0193089
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Article ; Online: Hypoxia Inducible Factor Expression and Angiogenesis - Analysis in the Pituitary Gland and Patterns of Death.

Kouroupi, Maria / Sivridis, Efthimios / Papazoglou, Dimitrios / Koukourakis, Michael I / Giatromanolaki, Alexandra

In vivo (Athens, Greece)

2018 Volume 32, Issue 1, Page(s) 185–190

Abstract: Background/aim: We investigated the expression of angiogenesis and hypoxia markers in the adenohypophysis and neurohypophysis of patients who died from various acute or chronic diseases.: Materials and methods: Paraffin-embedded material of pituitary ...

Abstract	Background/aim: We investigated the expression of angiogenesis and hypoxia markers in the adenohypophysis and neurohypophysis of patients who died from various acute or chronic diseases. Materials and methods: Paraffin-embedded material of pituitary glands (97 patients) was investigated immunohistochemically for vascular density (CD31) and the expression of vascular endothelial growth factor (VEGF) and of hypoxia inducible factors HIF1α and HIF2α. Results: Vascular density, and HIF1α/HIF2α reactivity is directly related with VEGF expression in the pituitary gland, suggesting that the HIF pathway may regulate the vascular density and blood flow in the gland under hypoxic conditions. HIF2α appears to be a key regulator in neurohypophysis, whilst in adenohypophysis HIF1α and HIF2α are equally expressed. Chronic conditions, including alcoholism and substance abuse, seem to activate the HIF pathway in both neuro- and adeno-hypophysis. Conclusion: The HIF pathway has an important role in regulating vascular density and blood flow in the pituitary gland.
MeSH term(s)	Adult ; Aged ; Angiogenic Proteins/biosynthesis ; Basic Helix-Loop-Helix Transcription Factors/biosynthesis ; Cadaver ; Cause of Death ; Female ; Humans ; Hypoxia ; Hypoxia-Inducible Factor 1, alpha Subunit/biosynthesis ; Immunohistochemistry ; Male ; Middle Aged ; Neovascularization, Pathologic/metabolism ; Pituitary Gland/blood supply ; Pituitary Gland/metabolism ; Platelet Endothelial Cell Adhesion Molecule-1/biosynthesis ; Signal Transduction ; Vascular Endothelial Growth Factor A/biosynthesis
Chemical Substances	Angiogenic Proteins ; Basic Helix-Loop-Helix Transcription Factors ; Hypoxia-Inducible Factor 1, alpha Subunit ; Platelet Endothelial Cell Adhesion Molecule-1 ; Vascular Endothelial Growth Factor A ; endothelial PAS domain-containing protein 1
Language	English
Publishing date	2018-01
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.11223
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Zs.A 2288: Show issues

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Article: Thermogenic protein UCP1 and UCP3 expression in non-small cell lung cancer: relation with glycolysis and anaerobic metabolism.

Giatromanolaki, Alexandra / Balaska, Konstantina / Kalamida, Dimitra / Kakouratos, Christos / Sivridis, Efthimios / Koukourakis, Michael I

Cancer biology & medicine

2018 Volume 14, Issue 4, Page(s) 396–404

Abstract: Uncoupling protein 1 (UCP1) is a proton transporter/channel residing on the inner mitochondrial membrane and is involved in cellular heat production. Using immunohistochemistry, we investigated the expression of UCP1 and UCP3 in a series of 98 patients ... ...

Abstract	Uncoupling protein 1 (UCP1) is a proton transporter/channel residing on the inner mitochondrial membrane and is involved in cellular heat production. Using immunohistochemistry, we investigated the expression of UCP1 and UCP3 in a series of 98 patients with non-small cell lung cancer (NSCLC) treated with surgery. Expression patterns were correlated with histopathological variables, prognosis, and the expression of enzymes/proteins related to cell metabolism. Bronchial epithelium did not express UCP1 or UCP3, while alveolar cells strongly expressed UCP1. In tumors, strong expression of UCP1 and UCP3 was recorded in 43/98 (43.8%) and 27/98 (27.6%) cases, respectively. UCP1 was significantly associated with squamous cell histology (
Language	English
Publishing date	2018-01-17
Publishing country	China
Document type	Journal Article
ZDB-ID	2676322-9
ISSN	2095-3941
ISSN	2095-3941
DOI	10.20892/j.issn.2095-3941.2017.0089
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