Article ; Online: Intrathecal synthesis of oligoclonal IgG in patients with Viliuisk encephalomyelitis: The relationship between oligoclonal bands and clinical features.
Journal of the neurological sciences
2018 Volume 384, Page(s) 84–88
Abstract: Viliuisk encephalomyelitis (VE) is a neurodegenerative disease that afflicts aboriginal people of Yakutia in Siberia with unknown etiology. Oligoclonal IgG bands (OCBs) were discovered in the VE patients (Green et al., 2003). In this study we analysed ... ...
Abstract | Viliuisk encephalomyelitis (VE) is a neurodegenerative disease that afflicts aboriginal people of Yakutia in Siberia with unknown etiology. Oligoclonal IgG bands (OCBs) were discovered in the VE patients (Green et al., 2003). In this study we analysed the association of OCBs with clinical symptoms in 58 VE patients. Positive oligoclonal IgG are associated with a shorter duration of disease (p=0.002), older age of onset (p=0.023) and high frequency of main neurological VE symptoms such as dementia, frontal dysbasia, bulbar disorders, muscle atrophy and centrally caused pelvic disorders. Our results show that the OCBs in VE patients are associated with more severe central nervous system (CNS) damage and may cause secondary complications in the course of the disease. |
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MeSH term(s) | Adult ; Age Factors ; Aged ; Brain/diagnostic imaging ; Chronic Disease ; Disease Progression ; Encephalomyelitis/diagnostic imaging ; Encephalomyelitis/physiopathology ; Female ; Humans ; Immunoglobulin G/biosynthesis ; Immunoglobulin G/cerebrospinal fluid ; Magnetic Resonance Imaging ; Male ; Mental Status and Dementia Tests ; Middle Aged ; Oligoclonal Bands/biosynthesis ; Oligoclonal Bands/cerebrospinal fluid ; Severity of Illness Index |
Chemical Substances | Immunoglobulin G ; Oligoclonal Bands |
Language | English |
Publishing date | 2018-01-15 |
Publishing country | Netherlands |
Document type | Journal Article |
ZDB-ID | 80160-4 |
ISSN | 1878-5883 ; 0022-510X ; 0374-8642 |
ISSN (online) | 1878-5883 |
ISSN | 0022-510X ; 0374-8642 |
DOI | 10.1016/j.jns.2017.11.030 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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