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  1. Book ; Conference proceedings: New vistas in therapeutics

    Skarlatos, Sonia I.

    from drug design to gene therapy

    (Annals of the New York Academy of Sciences ; 953)

    2001  

    Title variant Drug resistant tuberculosis ; Drug-resistant tuberculosis
    Institution Federation of American Societies for Experimental Biology
    Conference Entitled New Vistas in Therapeutics: From Drug Design to Gene Therapy
    Author's details ed. by Sonia I. Skarlatos
    Series title Annals of the New York Academy of Sciences ; 953
    Collection
    Keywords Arzneimittelforschung ; Arzneimittelentwicklung ; Arzneimitteldesign ; Gentherapie ; Tuberkulose ; Therapie ; Arzneimittelresistenz
    Subject Chemoresistenz ; Medikamentös therapierefraktäres Verhalten ; Pharmakoresistenz ; Medizinische Behandlung ; Behandlung ; Krankenbehandlung ; Tbc ; Tuberculosis ; Somatische Gentherapie ; Drug design ; Wirkstoffdesign ; Arzneimittel ; Drug Development ; Pharmaforschung ; Wirkstoffforschung ; Arzneistoffforschung ; Drug discovery
    Language English
    Size 253 S. : Ill., graph. Darst.
    Publishing place New York, N.Y
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT013267572
    ISBN 1-57331-335-1 ; 1-57331-336-X ; 978-1-57331-335-3 ; 978-1-57331-336-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 110 -953- verfügbar in Königswinter Königswinter

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  2. Article ; Online: National Heart, Lung, and Blood Institute resources and programs for gene therapy in heart, lung, and blood diseases.

    Skarlatos, Sonia I

    Circulation research

    2007  Volume 100, Issue 12, Page(s) 1667–1669

    MeSH term(s) Animals ; Biomedical Research/economics ; Biomedical Research/trends ; Cardiovascular Diseases/therapy ; Clinical Trials as Topic/methods ; Clinical Trials as Topic/trends ; Genetic Therapy/economics ; Genetic Therapy/methods ; Genetic Therapy/trends ; Haplorhini ; Hematologic Diseases/therapy ; Humans ; Lung Diseases/therapy ; National Institutes of Health (U.S.) ; Research Support as Topic ; United States
    Language English
    Publishing date 2007-06-22
    Publishing country United States
    Document type Editorial
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.107.101201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Support for cardiovascular cell therapy research at the National Heart, Lung, and Blood Institute.

    Buxton, Denis B / Skarlatos, Sonia I

    Circulation research

    2012  Volume 110, Issue 12, Page(s) 1549–1555

    MeSH term(s) Animals ; Cardiovascular Diseases/economics ; Cardiovascular Diseases/therapy ; Cell Transplantation/economics ; Cell Transplantation/trends ; Cell- and Tissue-Based Therapy ; Clinical Trials as Topic/economics ; Clinical Trials as Topic/trends ; Financial Support ; Humans ; National Heart, Lung, and Blood Institute (U.S.)/economics ; National Heart, Lung, and Blood Institute (U.S.)/trends ; United States
    Language English
    Publishing date 2012-06-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/RES.0b013e31825ec2a3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Center for fetal monkey gene transfer for heart, lung, and blood diseases: an NHLBI resource for the gene therapy community.

    Tarantal, Alice F / Skarlatos, Sonia I

    Human gene therapy

    2012  Volume 23, Issue 11, Page(s) 1130–1135

    Abstract: The goals of the National Heart, Lung, and Blood Institute (NHLBI) Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases are to conduct gene transfer studies in monkeys to evaluate safety and efficiency; and to provide NHLBI-supported ...

    Abstract The goals of the National Heart, Lung, and Blood Institute (NHLBI) Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases are to conduct gene transfer studies in monkeys to evaluate safety and efficiency; and to provide NHLBI-supported investigators with expertise, resources, and services to actively pursue gene transfer approaches in monkeys in their research programs. NHLBI-supported projects span investigators throughout the United States and have addressed novel approaches to gene delivery; "proof-of-principle"; assessed whether findings in small-animal models could be demonstrated in a primate species; or were conducted to enable new grant or IND submissions. The Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases successfully aids the gene therapy community in addressing regulatory barriers, and serves as an effective vehicle for advancing the field.
    MeSH term(s) Academies and Institutes ; Animals ; Female ; Gene Transfer Techniques ; Genetic Therapy ; Haplorhini ; Heart Diseases/genetics ; Heart Diseases/therapy ; Hematologic Diseases/genetics ; Hematologic Diseases/therapy ; Humans ; Lung Diseases/genetics ; Lung Diseases/therapy ; Male ; National Heart, Lung, and Blood Institute (U.S.) ; Pregnancy ; United States
    Language English
    Publishing date 2012-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1028152-6
    ISSN 1557-7422 ; 1043-0342
    ISSN (online) 1557-7422
    ISSN 1043-0342
    DOI 10.1089/hum.2012.178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Homocysteine: an emerging risk factor.

    Skarlatos, Sonia I

    Ethnicity & disease

    2002  Volume 12, Issue 1, Page(s) S1–38–40

    MeSH term(s) Biomarkers/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Female ; Homocysteine/analysis ; Homocysteine/blood ; Humans ; Male ; Prognosis ; Risk Factors ; Sensitivity and Specificity
    Chemical Substances Biomarkers ; Homocysteine (0LVT1QZ0BA)
    Language English
    Publishing date 2002
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1274267-3
    ISSN 1945-0826 ; 1049-510X
    ISSN (online) 1945-0826
    ISSN 1049-510X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bone marrow-derived cell therapy after myocardial infarction.

    Moyé, Lemuel A / Simari, Robert D / Skarlatos, Sonia I

    JAMA

    2013  Volume 309, Issue 14, Page(s) 1459

    MeSH term(s) Bone Marrow Transplantation/methods ; Cardiomyopathies/therapy ; Female ; Humans ; Male ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cells/immunology ; Myocardial Infarction/therapy ; Myocardial Ischemia/therapy ; Ventricular Dysfunction, Left/therapy
    Language English
    Publishing date 2013-04-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2013.2601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: National Heart, Lung, and Blood Institute and the translation of cardiovascular discoveries into therapeutic approaches.

    Galis, Zorina S / Black, Jodi B / Skarlatos, Sonia I

    Circulation research

    2013  Volume 112, Issue 9, Page(s) 1212–1218

    Abstract: The molecular causes of ≈4000 medical conditions have been described, yet only 5% have associated therapies. For decades, the average time for drug development through approval has taken 10 to 20 years. In recent years, the serious challenges that ... ...

    Abstract The molecular causes of ≈4000 medical conditions have been described, yet only 5% have associated therapies. For decades, the average time for drug development through approval has taken 10 to 20 years. In recent years, the serious challenges that confront the private sector have made it difficult to capitalize on new opportunities presented by advances in genomics and cellular therapies. Current trends are disturbing. Pharmaceutical companies are reducing their investments in research, and biotechnology companies are struggling to obtain venture funds. To support early-stage translation of the discoveries in basic science, the National Institutes of Health and the National Heart, Lung, and Blood Institute have developed new approaches to facilitating the translation of basic discoveries into clinical applications and will continue to develop a variety of programs that create teams of academic investigators and industry partners. The goal of these programs is to maximize the public benefit of investment of taxpayer dollars in biomedical research and to lessen the risk required for industry partners to make substantial investments. This article highlights several examples of National Heart, Lung, and Blood Institute-initiated translational programs and National Institutes of Health translational resources designed to catalyze and enable the earliest stages of the biomedical product development process. The translation of latest discoveries into therapeutic approaches depends on continued federal funding to enhance the early stages of the product development process and to stimulate and catalyze partnerships between academia, industry, and other sources of capital.
    MeSH term(s) Academies and Institutes ; Animals ; Cardiovascular Diseases/economics ; Cardiovascular Diseases/therapy ; Cooperative Behavior ; Diffusion of Innovation ; Government Regulation ; Health Care Sector ; Humans ; Interdisciplinary Communication ; Interinstitutional Relations ; National Heart, Lung, and Blood Institute (U.S.)/economics ; National Heart, Lung, and Blood Institute (U.S.)/legislation & jurisprudence ; Program Development ; Research Support as Topic ; Translational Medical Research/economics ; Translational Medical Research/legislation & jurisprudence ; United States
    Language English
    Publishing date 2013-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.113.301100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Extramural Division of Cardiovascular Sciences of the National Heart, Lung, and Blood Institute.

    Lauer, Michael S / Skarlatos, Sonia I / Bild, Diane E

    Journal of the American College of Cardiology

    2009  Volume 54, Issue 3, Page(s) 265–268

    MeSH term(s) Biomedical Research/organization & administration ; Biomedical Research/trends ; Cardiovascular Diseases ; Government Programs/organization & administration ; Government Programs/trends ; Humans ; Models, Organizational ; National Heart, Lung, and Blood Institute (U.S.)/organization & administration ; Research Support as Topic/economics ; United States
    Language English
    Publishing date 2009-07-06
    Publishing country United States
    Document type News
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2009.04.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 196: Show issues

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  9. Book ; Conference proceedings: New vistas in therapeutics

    Skarlatos, Sonia I / Velletri, Paul A

    from drug design to gene therapy

    (Annals of the New York Academy of Sciences ; 953)

    2001  

    Title variant Drug-resistant tuberculosis
    Event/congress Conference Entitled "New Vistas in Therapeutics: From Drug Design to Gene Therapy" (2000.06.03-04, Boston)
    Author's details ed. by Sonia I. Skarlatos
    Series title Annals of the New York Academy of Sciences ; 953
    Language English
    Size 253 S, Ill., graph. Darst
    Publisher New York Academy of Sciences
    Publishing place New York, NY
    Document type Book ; Conference proceedings
    Note Die Vorlage enth. insgesamt 2 Werke ; Includes bibliographical references and index
    ISBN 1573313351 ; 9781573313353
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article ; Online: Oversight and management of a cell therapy clinical trial network: experience and lessons learned.

    Moyé, Lemuel A / Sayre, Shelly L / Westbrook, Lynette / Jorgenson, Beth C / Handberg, Eileen / Anwaruddin, Saif / Wagner, Kristi A / Skarlatos, Sonia I

    Contemporary clinical trials

    2011  Volume 32, Issue 5, Page(s) 614–619

    Abstract: The Cardiovascular Cell Therapy Research Network (CCTRN), sponsored by the National Heart, Lung, and Blood Institute (NHLBI), was established to develop, coordinate, and conduct multiple collaborative protocols testing the effects of cell therapy on ... ...

    Abstract The Cardiovascular Cell Therapy Research Network (CCTRN), sponsored by the National Heart, Lung, and Blood Institute (NHLBI), was established to develop, coordinate, and conduct multiple collaborative protocols testing the effects of cell therapy on cardiovascular diseases. The Network was born into a difficult political and ethical climate created by the recent removal of a dozen drugs from the US formulary and the temporary halting of 27 gene therapy trials due to safety concerns. This article describes the Network's challenges as it initiated three protocols in a polarized cultural atmosphere at a time when oversight bodies were positioning themselves for the tightest vigilance of promising new therapies. Effective strategies involving ongoing education, open communication, and relationship building with the oversight community are discussed.
    MeSH term(s) Cardiovascular Diseases/therapy ; Cell- and Tissue-Based Therapy/ethics ; Cell- and Tissue-Based Therapy/methods ; Clinical Trials Data Monitoring Committees ; Community Networks ; Ethics Committees, Research ; Ethics, Research ; Humans ; Safety ; United States ; United States Food and Drug Administration
    Language English
    Publishing date 2011-05-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2182176-8
    ISSN 1559-2030 ; 1551-7144
    ISSN (online) 1559-2030
    ISSN 1551-7144
    DOI 10.1016/j.cct.2011.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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