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  1. AU="Skelin, Ivan"
  2. AU="Pinarli, Faruk Güçlü"
  3. AU=Carmina E
  4. AU=Abi-Rafeh Jad
  5. AU="Jalil, Yorschua F"
  6. AU="Barber, M"
  7. AU="Ritt, Luiz Eduardo Fonteles"
  8. AU="Qiu, Jiajing"
  9. AU=Wang Heping
  10. AU="Miyazaki, Masashi"
  11. AU="R Kulkarni"
  12. AU="Braga, D."
  13. AU="Mwenda, Mulenga"
  14. AU="Li, Baohua"
  15. AU="Zhang, Nasen Jonathan"
  16. AU="Scotlandi, Katia"
  17. AU="Thomson, M A"
  18. AU=New Sophie E P
  19. AU="Fenrich, Craig A"
  20. AU="Staehelin, Cornelia"
  21. AU="Akhtar, Suraiya"
  22. AU="Georgel, Philippe"
  23. AU="Gruenewald, Leon D"
  24. AU="Charron, Morgane"
  25. AU="Leona S. Alizadeh" AU="Leona S. Alizadeh"
  26. AU="Soriano, Stéphane"
  27. AU="Lin, Pao-Yen"
  28. AU="Mudali, Gayathri"
  29. AU="McElveen, John T"
  30. AU="Kraimps, Jean-Louis"
  31. AU="Patel, Sheila K"
  32. AU="Zian, Zeineb"
  33. AU="Langley, Jonathan"
  34. AU="Bell, Thomas G."
  35. AU="Harris, Charles"
  36. AU="Lai, Renfa"
  37. AU="Sakane, Tatsuya"
  38. AU="Mirza, I."
  39. AU="Beatriz Amorim Beltrão"
  40. AU="Wildman, D"
  41. AU="Manghi, Manoel"
  42. AU="van Dinther, Maarten"
  43. AU="Adams, Ashley L"
  44. AU="Zhang, Er-Bin"
  45. AU="Diuk-Wasser, Maria A"
  46. AU="Chowdhury, Muhtamim"
  47. AU="Rivas, Manuel A"
  48. AU="Mangelis, Anastasios"
  49. AU="Simpson, Tina Y"
  50. AU="Li, Peirang"
  51. AU="Zhang, Zhao-Liang"
  52. AU="Perner, Sven"
  53. AU=Suwanwongse Kulachanya AU=Suwanwongse Kulachanya
  54. AU="Rose, Jacqueline"
  55. AU="E Lostis"

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  1. Artikel ; Online: Neural computations underlying contextual processing in humans.

    Zheng, Jie / Skelin, Ivan / Lin, Jack J

    Cell reports

    2022  Band 40, Heft 12, Seite(n) 111395

    Abstract: Context shapes our perception of facial expressions during everyday social interactions. We interpret a person's face in a hostile situation negatively and judge the same face under pleasant circumstances positively. Critical to our adaptive fitness, ... ...

    Abstract Context shapes our perception of facial expressions during everyday social interactions. We interpret a person's face in a hostile situation negatively and judge the same face under pleasant circumstances positively. Critical to our adaptive fitness, context provides situation-specific framing to resolve ambiguity and guide our interpersonal behavior. This context-specific modulation of facial expression is thought to engage the amygdala, hippocampus, and orbitofrontal cortex; however, the underlying neural computations remain unknown. Here we use human intracranial electroencephalograms (EEGs) directly recorded from these regions and report bidirectional theta-gamma interactions within the amygdala-hippocampal network, facilitating contextual processing. Contextual information is subsequently represented in the orbitofrontal cortex, where a theta phase shift binds context and face associations within theta cycles, endowing faces with contextual meanings at behavioral timescales. Our results identify theta phase shifts as mediating associations between context and face processing, supporting flexible social behavior.
    Mesh-Begriff(e) Amygdala ; Emotions ; Facial Expression ; Facial Recognition ; Humans ; Magnetic Resonance Imaging/methods
    Sprache Englisch
    Erscheinungsdatum 2022-09-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.111395
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  2. Artikel ; Online: Awake ripples enhance emotional memory encoding in the human brain.

    Zhang, Haoxin / Skelin, Ivan / Ma, Shiting / Paff, Michelle / Mnatsakanyan, Lilit / Yassa, Michael A / Knight, Robert T / Lin, Jack J

    Nature communications

    2024  Band 15, Heft 1, Seite(n) 215

    Abstract: Enhanced memory for emotional experiences is hypothesized to depend on amygdala-hippocampal interactions during memory consolidation. Here we show using intracranial recordings from the human amygdala and the hippocampus during an emotional memory ... ...

    Abstract Enhanced memory for emotional experiences is hypothesized to depend on amygdala-hippocampal interactions during memory consolidation. Here we show using intracranial recordings from the human amygdala and the hippocampus during an emotional memory encoding and discrimination task increased awake ripples after encoding of emotional, compared to neutrally-valenced stimuli. Further, post-encoding ripple-locked stimulus similarity is predictive of later memory discrimination. Ripple-locked stimulus similarity appears earlier in the amygdala than in hippocampus and mutual information analysis confirms amygdala influence on hippocampal activity. Finally, the joint ripple-locked stimulus similarity in the amygdala and hippocampus is predictive of correct memory discrimination. These findings provide electrophysiological evidence that post-encoding ripples enhance memory for emotional events.
    Mesh-Begriff(e) Humans ; Wakefulness/physiology ; Hippocampus/physiology ; Amygdala/physiology ; Emotions ; Electrophysiological Phenomena ; Memory Consolidation/physiology
    Sprache Englisch
    Erscheinungsdatum 2024-01-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-44295-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Impaired Hippocampal-Cortical Interactions during Sleep in a Mouse Model of Alzheimer's Disease.

    Cushing, Sarah D / Skelin, Ivan / Moseley, Shawn C / Stimmell, Alina C / Dixon, Jessica R / Melilli, Andreza S / Molina, Leonardo / McNaughton, Bruce L / Wilber, Aaron A

    Current biology : CB

    2024  Band 34, Heft 8, Seite(n) 1817

    Sprache Englisch
    Erscheinungsdatum 2024-03-28
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2024.03.040
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    Zs.A 3208: Hefte anzeigen Standort:
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  4. Artikel ; Online: Single-Channel EEG Based Arousal Level Estimation Using Multitaper Spectrum Estimation at Low-Power Wearable Devices.

    Demirel, Berken Utku / Skelin, Ivan / Zhang, Haoxin / Lin, Jack J / Abdullah Al Faruque, Mohammad

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2021  Band 2021, Seite(n) 542–545

    Abstract: This paper proposes a novel lightweight method using the multitaper power spectrum to estimate arousal levels at wearable devices. We show that the spectral slope (1/f) of the electrophysiological power spectrum reflects the scale-free neural activity. ... ...

    Abstract This paper proposes a novel lightweight method using the multitaper power spectrum to estimate arousal levels at wearable devices. We show that the spectral slope (1/f) of the electrophysiological power spectrum reflects the scale-free neural activity. To evaluate the proposed feature's performance, we used scalp EEG recorded during anesthesia and sleep with technician-scored Hypnogram annotations. It is shown that the proposed methodology discriminates wakefulness from reduced arousal solely based on the neurophysiological brain state with more than 80% accuracy. Therefore, our findings describe a common electrophysiological marker that tracks reduced arousal states, which can be applied to different applications (e.g., emotion detection, driver drowsiness). Evaluation on hardware shows that the proposed methodology can be implemented for devices with a minimum RAM of 512 KB with 55 mJ average energy consumption.
    Mesh-Begriff(e) Arousal ; Electroencephalography ; Sleep ; Wakefulness ; Wearable Electronic Devices
    Sprache Englisch
    Erscheinungsdatum 2021-12-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC46164.2021.9629733
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Hippocampal coupling with cortical and subcortical structures in the context of memory consolidation.

    Skelin, Ivan / Kilianski, Scott / McNaughton, Bruce L

    Neurobiology of learning and memory

    2018  Band 160, Seite(n) 21–31

    Abstract: Memory consolidation is a gradual process through which episodic memories become incorporated into long-term 'semantic' representations. It likely involves reactivation of neural activity encoding the recent experience during non-REM sleep. A critical ... ...

    Abstract Memory consolidation is a gradual process through which episodic memories become incorporated into long-term 'semantic' representations. It likely involves reactivation of neural activity encoding the recent experience during non-REM sleep. A critical prerequisite for memory consolidation is precise coordination of reactivation events between the hippocampus and cortical/subcortical structures, facilitated by the coupling of local field potential (LFP) oscillations (slow oscillations, sleep spindles and sharp wave/ripples) between these structures. We review the rapidly expanding literature on the qualitative and quantitative aspects of hippocampal oscillatory and neuronal coupling with cortical/subcortical structures in the context of memory reactivation. Reactivation in the hippocampus and cortical/subcortical structures is tightly coupled with sharp wave/ripples. Hippocampal-cortical/subcortical coupling is rich in dimensionality and this dimensionality is likely underestimated due to the limitations of the current methodology.
    Mesh-Begriff(e) Animals ; Basal Ganglia/physiology ; Brain Waves/physiology ; Cerebral Cortex/physiology ; Hippocampus/physiology ; Humans ; Memory Consolidation/physiology ; Sleep Stages/physiology
    Sprache Englisch
    Erscheinungsdatum 2018-04-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1223366-3
    ISSN 1095-9564 ; 1074-7427
    ISSN (online) 1095-9564
    ISSN 1074-7427
    DOI 10.1016/j.nlm.2018.04.004
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    Zs.B 2339: Hefte anzeigen Standort:
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  6. Artikel: Comparing rapid rule-learning strategies in humans and monkeys.

    Goudar, Vishwa / Kim, Jeong-Woo / Liu, Yue / Dede, Adam J O / Jutras, Michael J / Skelin, Ivan / Ruvalcaba, Michael / Chang, William / Fairhall, Adrienne L / Lin, Jack J / Knight, Robert T / Buffalo, Elizabeth A / Wang, Xiao-Jing

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Inter-species comparisons are key to deriving an understanding of the behavioral and neural correlates of human cognition from animal models. We perform a detailed comparison of macaque monkey and human strategies on an analogue of the Wisconsin Card ... ...

    Abstract Inter-species comparisons are key to deriving an understanding of the behavioral and neural correlates of human cognition from animal models. We perform a detailed comparison of macaque monkey and human strategies on an analogue of the Wisconsin Card Sort Test, a widely studied and applied multi-attribute measure of cognitive function, wherein performance requires the inference of a changing rule given ambiguous feedback. We found that well-trained monkeys rapidly infer rules but are three times slower than humans. Model fits to their choices revealed hidden states akin to feature-based attention in both species, and decision processes that resembled a Win-stay lose-shift strategy with key differences. Monkeys and humans test multiple rule hypotheses over a series of rule-search trials and perform inference-like computations to exclude candidates. An attention-set based learning stage categorization revealed that perseveration, random exploration and poor sensitivity to negative feedback explain the under-performance in monkeys.
    Sprache Englisch
    Erscheinungsdatum 2023-01-10
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.01.10.523416
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  7. Buch ; Online: Single-Channel EEG Based Arousal Level Estimation Using Multitaper Spectrum Estimation at Low-Power Wearable Devices

    Demirel, Berken Utku / Skelin, Ivan / Zhang, Haoxin / Lin, Jack J. / Faruque, Mohammad Abdullah Al

    2021  

    Abstract: This paper proposes a novel lightweight method using the multitaper power spectrum to estimate arousal levels at wearable devices. We show that the spectral slope (1/f) of the electrophysiological power spectrum reflects the scale-free neural activity. ... ...

    Abstract This paper proposes a novel lightweight method using the multitaper power spectrum to estimate arousal levels at wearable devices. We show that the spectral slope (1/f) of the electrophysiological power spectrum reflects the scale-free neural activity. To evaluate the proposed feature's performance, we used scalp EEG recorded during anesthesia and sleep with technician-scored Hypnogram annotations. It is shown that the proposed methodology discriminates wakefulness from reduced arousal solely based on the neurophysiological brain state with more than 80% accuracy. Therefore, our findings describe a common electrophysiological marker that tracks reduced arousal states, which can be applied to different applications (e.g., emotion detection, driver drowsiness). Evaluation on hardware shows that the proposed methodology can be implemented for devices with a minimum RAM of 512 KB with 55 mJ average energy consumption.

    Comment: To appear at the 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'21), October 31
    Schlagwörter Electrical Engineering and Systems Science - Signal Processing
    Thema/Rubrik (Code) 621
    Erscheinungsdatum 2021-07-31
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Laminar Organization of Encoding and Memory Reactivation in the Parietal Cortex.

    Wilber, Aaron A / Skelin, Ivan / Wu, Wei / McNaughton, Bruce L

    Neuron

    2017  Band 95, Heft 6, Seite(n) 1406–1419.e5

    Abstract: Egocentric neural coding has been observed in parietal cortex (PC), but its topographical and laminar organization is not well characterized. We used multi-site recording to look for evidence of local clustering and laminar consistency of linear and ... ...

    Abstract Egocentric neural coding has been observed in parietal cortex (PC), but its topographical and laminar organization is not well characterized. We used multi-site recording to look for evidence of local clustering and laminar consistency of linear and angular velocity encoding in multi-neuronal spiking activity (MUA) and in the high-frequency (300-900 Hz) component of the local field potential (HF-LFP), believed to reflect local spiking activity. Rats were trained to run many trials on a large circular platform, either to LED-cued goal locations or as a spatial sequence from memory. Tuning to specific self-motion states was observed and exhibited distinct cortical depth-invariant coding properties. These patterns of collective local and laminar activation during behavior were reactivated in compressed form during post-experience sleep and temporally coupled to cortical delta waves and hippocampal sharp-wave ripples. Thus, PC neuron motion encoding is consistent across cortical laminae, and this consistency is maintained during memory reactivation.
    Mesh-Begriff(e) Animals ; Hippocampus/physiology ; Locomotion/physiology ; Male ; Memory/physiology ; Neurons/physiology ; Parietal Lobe/cytology ; Parietal Lobe/physiology ; Rats ; Self Stimulation ; Sleep/physiology
    Sprache Englisch
    Erscheinungsdatum 2017-09-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2017.08.033
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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2496: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 92: Hefte anzeigen

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  9. Artikel ; Online: Acute NMDA receptor antagonism disrupts synchronization of action potential firing in rat prefrontal cortex.

    Molina, Leonardo A / Skelin, Ivan / Gruber, Aaron J

    PloS one

    2014  Band 9, Heft 1, Seite(n) e85842

    Abstract: Antagonists of N-methyl-D-aspartate receptors (NMDAR) have psychotomimetic effects in humans and are used to model schizophrenia in animals. We used high-density electrophysiological recordings to assess the effects of acute systemic injection of an ... ...

    Abstract Antagonists of N-methyl-D-aspartate receptors (NMDAR) have psychotomimetic effects in humans and are used to model schizophrenia in animals. We used high-density electrophysiological recordings to assess the effects of acute systemic injection of an NMDAR antagonist (MK-801) on ensemble neural processing in the medial prefrontal cortex of freely moving rats. Although MK-801 increased neuron firing rates and the amplitude of gamma-frequency oscillations in field potentials, the synchronization of action potential firing decreased and spike trains became more Poisson-like. This disorganization of action potential firing following MK-801 administration is consistent with changes in simulated cortical networks as the functional connections among pyramidal neurons become less clustered. Such loss of functional heterogeneity of the cortical microcircuit may disrupt information processing dependent on spike timing or the activation of discrete cortical neural ensembles, and thereby contribute to hallucinations and other features of psychosis induced by NMDAR antagonists.
    Mesh-Begriff(e) Action Potentials/drug effects ; Action Potentials/physiology ; Animals ; Behavior, Animal/drug effects ; Dizocilpine Maleate/pharmacology ; Electrodes ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/physiology ; Rats ; Rats, Inbred BN ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/metabolism
    Chemische Substanzen Receptors, N-Methyl-D-Aspartate ; Dizocilpine Maleate (6LR8C1B66Q)
    Sprache Englisch
    Erscheinungsdatum 2014-01-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0085842
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  10. Artikel ; Online: Coupling between slow waves and sharp-wave ripples engages distributed neural activity during sleep in humans.

    Skelin, Ivan / Zhang, Haoxin / Zheng, Jie / Ma, Shiting / Mander, Bryce A / Kim McManus, Olivia / Vadera, Sumeet / Knight, Robert T / McNaughton, Bruce L / Lin, Jack J

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Band 118, Heft 21

    Abstract: Hippocampal-dependent memory consolidation during sleep is hypothesized to depend on the synchronization of distributed neuronal ensembles, organized by the hippocampal sharp-wave ripples (SWRs, 80 to 150 Hz), subcortical/cortical slow-wave activity (SWA, ...

    Abstract Hippocampal-dependent memory consolidation during sleep is hypothesized to depend on the synchronization of distributed neuronal ensembles, organized by the hippocampal sharp-wave ripples (SWRs, 80 to 150 Hz), subcortical/cortical slow-wave activity (SWA, 0.5 to 4 Hz), and sleep spindles (SP, 7 to 15 Hz). However, the precise role of these interactions in synchronizing subcortical/cortical neuronal activity is unclear. Here, we leverage intracranial electrophysiological recordings from the human hippocampus, amygdala, and temporal and frontal cortices to examine activity modulation and cross-regional coordination during SWRs. Hippocampal SWRs are associated with widespread modulation of high-frequency activity (HFA, 70 to 200 Hz), a measure of local neuronal activation. This peri-SWR HFA modulation is predicted by the coupling between hippocampal SWRs and local subcortical/cortical SWA or SP. Finally, local cortical SWA phase offsets and SWR amplitudes predicted functional connectivity between the frontal and temporal cortex during individual SWRs. These findings suggest a selection mechanism wherein hippocampal SWR and cortical slow-wave synchronization governs the transient engagement of distributed neuronal populations supporting hippocampal-dependent memory consolidation.
    Mesh-Begriff(e) Adult ; Amygdala/physiology ; Animals ; Electrocorticography ; Female ; Frontal Lobe/physiology ; Hippocampus/physiology ; Humans ; Male ; Memory Consolidation/physiology ; Middle Aged ; Neurons ; Sleep/physiology ; Temporal Lobe/physiology ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2021-05-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2012075118
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