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Article ; Online: Comparative Analysis of Fcγ and Complement Receptors Presence on Monocytes in Pulmonary Sarcoidosis and Tuberculosis.

Typiak, Marlena / Trzonkowski, Piotr / Skotarczak, Monika / Dubaniewicz, Anna

International journal of molecular sciences

2023 Volume 24, Issue 11

Abstract: Sarcoidosis (SA) is a granulomatous disorder, which mostly affects the lungs. Its clinical characteristics resemble tuberculosis (TB), but its treatment is different. The etiology of SA is unknown; however, mycobacterial antigens were proposed as ... ...

Abstract	Sarcoidosis (SA) is a granulomatous disorder, which mostly affects the lungs. Its clinical characteristics resemble tuberculosis (TB), but its treatment is different. The etiology of SA is unknown; however, mycobacterial antigens were proposed as environmental factors in its development. Due to previously revealed immunocomplexemia with mycobacterial antigens in the blood of our SA but not TB patients, and in the search for biomarkers for differential diagnosis of the two disorders, we studied the phagocytic activity of monocytes from both patients' groups with flow cytometry. With the use of this method, we also analyzed the occurrence of receptors for IgG (FcγR) and complement components (CR) at the surface of these monocytes, responsible for phagocytosis of immunocomplexes. We revealed a higher phagocytic activity of monocytes in both disorders, but an increased frequency of monocytes with FcγRIII (CD16) and decreased with CR1 (CD35) receptor in the blood of SA vs. TB patients. With regard to our other genetic study on FcγRIII variants in SA and TB, this may account for the decreased clearance of immunocomplexes and different immune responses in the two diseases. Thus, the presented analysis not only sheds light on the pathomechanisms of SA and TB but may also support their differential diagnosis.
MeSH term(s)	Humans ; Monocytes ; Sarcoidosis, Pulmonary ; Receptors, IgG ; Receptors, Complement ; Tuberculosis ; Sarcoidosis ; Phagocytosis
Chemical Substances	Receptors, IgG ; Receptors, Complement
Language	English
Publishing date	2023-06-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24119713
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Article ; Online: Celiac trunk thrombosis in a patient with antiphospholipid syndrome induced by median arcuate ligament compression: a case presentation and literature review.

Janiak, Paulina / Smoleńska, Żaneta / Skotarczak, Monika / Zdrojewski, Zbigniew

Rheumatology international

2023 Volume 44, Issue 1, Page(s) 197–202

Abstract: Median arcuate ligament syndrome (MALS) is a rare disorder caused by the compression of the celiac axis by the fibrous structure of the diaphragm called the median arcuate ligament. Patients with MALS are usually undiagnosed unless characteristic ... ...

Abstract	Median arcuate ligament syndrome (MALS) is a rare disorder caused by the compression of the celiac axis by the fibrous structure of the diaphragm called the median arcuate ligament. Patients with MALS are usually undiagnosed unless characteristic symptoms such as nausea and vomiting, postprandial pain, and weight loss are presented. We report a case of a 29-year-old patient diagnosed with MALS and secondary antiphospholipid syndrome (APS) that developed celiac trunk, common hepatic artery and splenic artery thrombosis. There is not enough information on MALS as a trigger of thrombosis in predisposed patients such as those with APS. However, the case gives rise to suspicion and highlights the diagnostic processes, especially for patients with APS presenting postprandial abdominal pain and weight loss. This review likewise aims at the importance of Doppler ultrasonography as a screening tool and computer tomography (CT) or magnetic resonance (MR) both in the angiography variant, especially to diagnose confirmation and underlying treatment options.
MeSH term(s)	Humans ; Adult ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Diaphragm ; Constriction, Pathologic/diagnostic imaging ; Constriction, Pathologic/etiology ; Median Arcuate Ligament Syndrome/complications ; Median Arcuate Ligament Syndrome/diagnostic imaging ; Ligaments ; Weight Loss
Language	English
Publishing date	2023-09-27
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-023-05448-6
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Article: Microbiological, Clinical and Radiological Aspects of Diabetic Foot Ulcers Infected with Methicillin-Resistant and -Sensitive Staphylococcus aureus

Stańkowska, Maria / Garbacz, Katarzyna / Korzon-Burakowska, Anna / Bronk, Marek / Skotarczak, Monika / Szymańska-Dubowik, Anna

Pathogens. 2022 June 17, v. 11, no. 6

2022

Abstract: Diabetic foot ulcer (DFU) is one of the most common chronic complications of diabetes. This study aimed to assess the factors with an impact on the infection of diabetic foot ulcers by methicillin-resistant S. aureus and to evaluate the influence of ... ...

Abstract	Diabetic foot ulcer (DFU) is one of the most common chronic complications of diabetes. This study aimed to assess the factors with an impact on the infection of diabetic foot ulcers by methicillin-resistant S. aureus and to evaluate the influence of methicillin resistance on the frequency of osteitis (based on classic X-ray images). A total of 863 patients suffering from DFU were analyzed during the study period. Out of 201 isolated S. aureus cases, 31 (15.4%) were methicillin-resistant (MRSA). MRSA infections were associated with a higher incidence of osteitis compared to MSSA infections (p << 0.0001), both the occurrence of smaller (<50%)) and greater (>50%) inflammatory bone changes (p << 0.0001). Furthermore, MRSA occurred significantly more frequently in men than in women (p < 0.01) and more often among patients with type 2 diabetes than among patients with type 1 diabetes (p < 0.05). MRSA were isolated statistically less often in overweight patients than in patients with normal BMI (p < 0.05). DFUs infected with MRSA were significantly more frequently associated with the presence of Pseudomonas sp. and other non-fermenting bacilli than those infected with MSSA (p < 0.05). To conclude, osteitis incidence is related to MRSA infection in patients with diabetic foot ulcers; thus, patients infected by S. aureus should be closely monitored in the course of using antibiotics and treated with narrow-spectrum antibiotics.
Keywords	Pseudomonas ; X-radiation ; diabetic foot ; insulin-dependent diabetes mellitus ; methicillin ; methicillin-resistant Staphylococcus aureus ; noninsulin-dependent diabetes mellitus ; overweight
Language	English
Dates of publication	2022-0617
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11060701
Database	NAL-Catalogue (AGRICOLA)

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Article: Microbiological, Clinical and Radiological Aspects of Diabetic Foot Ulcers Infected with Methicillin-Resistant and -Sensitive

Stańkowska, Maria / Garbacz, Katarzyna / Korzon-Burakowska, Anna / Bronk, Marek / Skotarczak, Monika / Szymańska-Dubowik, Anna

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 6

Abstract	Diabetic foot ulcer (DFU) is one of the most common chronic complications of diabetes. This study aimed to assess the factors with an impact on the infection of diabetic foot ulcers by methicillin-resistant S. aureus and to evaluate the influence of methicillin resistance on the frequency of osteitis (based on classic X-ray images). A total of 863 patients suffering from DFU were analyzed during the study period. Out of 201 isolated S. aureus cases, 31 (15.4%) were methicillin-resistant (MRSA). MRSA infections were associated with a higher incidence of osteitis compared to MSSA infections (p << 0.0001), both the occurrence of smaller (<50%)) and greater (>50%) inflammatory bone changes (p << 0.0001). Furthermore, MRSA occurred significantly more frequently in men than in women (p < 0.01) and more often among patients with type 2 diabetes than among patients with type 1 diabetes (p < 0.05). MRSA were isolated statistically less often in overweight patients than in patients with normal BMI (p < 0.05). DFUs infected with MRSA were significantly more frequently associated with the presence of Pseudomonas sp. and other non-fermenting bacilli than those infected with MSSA (p < 0.05). To conclude, osteitis incidence is related to MRSA infection in patients with diabetic foot ulcers; thus, patients infected by S. aureus should be closely monitored in the course of using antibiotics and treated with narrow-spectrum antibiotics.
Language	English
Publishing date	2022-06-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11060701
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Article: Diagnostic value of diffusion tensor imaging in patients with clinical signs of cervical spondylotic myelopathy.

Skotarczak, Monika / Dzierżanowski, Jarosław / Kaszubowski, Mariusz / Winklewski, Paweł J / Romanowski, Alexander / Szurowska, Edyta / Szarmach, Arkadiusz

Neurologia i neurochirurgia polska

2022 Volume 56, Issue 4, Page(s) 341–348

Abstract: Aim of the study: The aim of this study was to assess the diagnostic value of diffusion tensor imaging (DTI) in patients with symptoms of cervical myelopathy. Detailed goals included determining the diagnostic effectiveness of quantitative parameters, i. ...

Abstract	Aim of the study: The aim of this study was to assess the diagnostic value of diffusion tensor imaging (DTI) in patients with symptoms of cervical myelopathy. Detailed goals included determining the diagnostic effectiveness of quantitative parameters, i.e. fractional anisotropy (FA) and apparent diffusion coefficient (ADC), in the diagnosis of cervical myelopathy, and the correlation between these parameters and clinical symptoms. Clinical rationale for the study: The demonstration of an ischaemic focus in the spinal cord by standard magnetic resonance imaging (MRI) methods is associated with already accomplished spinal cord damage, and of course limited treatment options. Therefore, finding a new examination protocol that allows early diagnosis of myelopathic focus, before the onset of full neurological symptoms, has become a priority in the diagnosis and treatment of spine diseases. Such an examination increases the chances of correctly qualifying the patient for conservative vs. surgical treatment. Material and methods: Between 2013 and 2017, 128 adults with clinical signs of cervical myelopathy were examined, and were divided into four symptomatic subgroups. A control group consisted of 37 healthy volunteers. DTI values were measured at the level of C2/C3, and at the most severe stenosis of the spine. Results: In patients with cervical spondylotic myelopathy (CSM), the ADC values were significantly higher (p < 0.001), and FA values were significantly lower (p < 0.001), than in healthy volunteers at the stenotic level. There were significant differences in DTI parameters between the clinical subgroups (p < 0.001). Conclusions and clinical implications: Changes in DTI parameters indicate a microstructural disorder of the core which is not visible in a structural MRI. FA and ADC values measured at the level of the most severe stenosis of the spinal canal allow the differentiation of patients with myelopathy of varying degrees of clinical severity. Extending standard MRI to include assessment of FA and ADC may be helpful in deciding treatment modalities (conservative vs. surgical) for patients with visible canal stenosis without full neurological symptoms. This may be useful in selecting patients for urgent rehabilitative treatment. This study is a starting point for further research, i.e. an evaluation of the extent of FA and ADC lesion withdrawal after surgical treatment.
MeSH term(s)	Adult ; Cervical Vertebrae/surgery ; Constriction, Pathologic/complications ; Constriction, Pathologic/pathology ; Diffusion Tensor Imaging/methods ; Humans ; Spinal Cord Diseases/diagnostic imaging ; Spinal Cord Diseases/surgery ; Spondylosis/complications ; Spondylosis/diagnostic imaging ; Spondylosis/surgery
Language	English
Publishing date	2022-04-26
Publishing country	Poland
Document type	Journal Article
ZDB-ID	415519-1
ISSN	1897-4260 ; 0028-3843
ISSN (online)	1897-4260
ISSN	0028-3843
DOI	10.5603/PJNNS.a2022.0031
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Article ; Online: Copy number variation of FCGR genes in etiopathogenesis of sarcoidosis.

Typiak, Marlena / Rębała, Krzysztof / Haraś, Agnieszka / Skotarczak, Monika / Słomiński, Jan Marek / Dubaniewicz, Anna

PloS one

2017 Volume 12, Issue 5, Page(s) e0177194

Abstract: We have previously revealed that, in contrast to polymorphism of FCGR2B and FCGR3B, polymorphism of FCGR2A, FCGR2C and FCGR3A genes, encoding receptors for Fc fragment of immunoglobulin G (Fcγ receptors), play a role in increased level of circulating ... ...

Abstract	We have previously revealed that, in contrast to polymorphism of FCGR2B and FCGR3B, polymorphism of FCGR2A, FCGR2C and FCGR3A genes, encoding receptors for Fc fragment of immunoglobulin G (Fcγ receptors), play a role in increased level of circulating immune complexes with occurrence of Mycobacterium tuberculosis heat shock proteins in patients with sarcoidosis. However, this immunocomplexemia might also be caused by decreased clearance by immune cells due to a changed copy number of FCGR genes. Thus, the next step of our study was to evaluate copy number variation of FCGR2A, FCGR2B, FCGR2C, FCGR3A and FCGR3B in this disease. The analysis was carried out by real-time quantitative PCR on 104 patients and 110 healthy volunteers. Despite previously detected variation in allele/genotype frequencies of FCGR in sarcoidosis and its particular stages, there was no copy number variation of the tested genes between sarcoidosis or its stages and healthy control, as well as between stages themselves. A relevant increase in copy number of FCGR2C and FCGR3B in Stage IV of sarcoidosis vs. other stages and controls was detected, but this observation was based on a limited number of Stage IV patients. Hence, polymorphism of FCGR genes seems to be more important than their copy number variation in etiopathogenesis of sarcoidosis in patients from the Polish population.
MeSH term(s)	Adult ; Aged ; DNA Copy Number Variations ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Receptors, IgG/genetics ; Sarcoidosis/genetics ; Young Adult
Chemical Substances	Receptors, IgG
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0177194
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Article ; Online: Tuberculosis in the course of sarcoidosis treatment: is genotyping necessary for personalized therapy?

Dubaniewicz, Anna / Zimmermann, Agnieszka / Dudziak, Maria / Typiak, Marlena / Skotarczak, Monika

Expert review of clinical immunology

2013 Volume 9, Issue 4, Page(s) 349–360

Abstract: Pathological similarities between sarcoidosis (SA) and tuberculosis (TB) suggest that mycobacterial antigen(s), in genetically different predisposed hosts, may be a cause of SA. The authors' work and other published comparative analyses of HLA and non- ... ...

Abstract	Pathological similarities between sarcoidosis (SA) and tuberculosis (TB) suggest that mycobacterial antigen(s), in genetically different predisposed hosts, may be a cause of SA. The authors' work and other published comparative analyses of HLA and non-HLA alleles in patients with SA or TB from different ethnic groups in the world revealed that some antigens were connected with high risk of SA or TB development, but others were comparable in both patient populations. The authors also showed a possibility of predominant occurrence of HLA alleles characteristic for TB as a cause of TB in patients with SA on corticosteroid therapy. It is possible that an analysis of SA and TB patient's genetic background may be helpful for protection from TB in SA patients on corticosteroids, especially on anti-TNF-α treatment. The authors suggest that the consideration of an immunosuppressive therapy in SA patients will need more attention and individual therapy based on genotyping study.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Animals ; Ethnic Groups ; Genetic Predisposition to Disease ; Genotype ; HLA Antigens/genetics ; Humans ; Mycobacterium/immunology ; Mycobacterium/pathogenicity ; Polymorphism, Genetic ; Precision Medicine ; Sarcoidosis/complications ; Sarcoidosis/drug therapy ; Sarcoidosis/genetics ; Sarcoidosis/immunology ; Tuberculosis/complications ; Tuberculosis/drug therapy ; Tuberculosis/genetics ; Tuberculosis/immunology ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
Chemical Substances	Adrenal Cortex Hormones ; HLA Antigens ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2013-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2274260-8
ISSN	1744-8409 ; 1744-666X
ISSN (online)	1744-8409
ISSN	1744-666X
DOI	10.1586/eci.13.8
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Article: The "Optimum Volume" of Acrylic Cement Filling for Treating Vertebral Compression Fractures: A Morphometric Study of Thoracolumbar Vertebrae.

Dzierżanowski, Jarosław / Winklewski, Paweł J / Skotarczak, Monika / Baczkowska-Waliszewska, Zuzanna / Szmuda, Tomasz / Zdanowski, Szymon / Radkowski, Marek / Łuczkiewicz, Piotr / Czapiewski, Piotr / Słoniewski, Paweł / Szurowska, Edyta / Demkow, Urszula / Szarmach, Arkadiusz

Advances in experimental medicine and biology

2019 Volume 1211, Page(s) 25–39

Abstract: Percutaneous vertebroplasty is a treatment option in vertebral compression fractures (VCF). The aim of the study was to propose the mathematical calculation of the "optimum volume" of acrylic cement filling of the vertebral body, depending on the ... ...

Abstract	Percutaneous vertebroplasty is a treatment option in vertebral compression fractures (VCF). The aim of the study was to propose the mathematical calculation of the "optimum volume" of acrylic cement filling of the vertebral body, depending on the severity of a fracture. Two hundred computed tomography (CT) scans of vertebral columns in healthy adult Caucasians were analyzed. Vertebral body width (VBW), vertebral body depth (VBD), vertebral body height (VBH), and vertebral body volume (VBV) were measured. The "optimum volume" of cement injections in mild (25% collapse) and moderate (40% collapse) VCF were calculated. We found that moving caudally from Th
MeSH term(s)	Adult ; Bone Cements ; Fractures, Compression/surgery ; Humans ; Spinal Fractures/surgery ; Spine/diagnostic imaging ; Tomography, X-Ray Computed ; Treatment Outcome ; Vertebroplasty
Chemical Substances	Bone Cements
Language	English
Publishing date	2019-08-19
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/5584_2019_417
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Article ; Online: Assessment of the Relationship between the Shape of the Lateral Meniscus and the Risk of Extrusion Based on MRI Examination of the Knee Joint.

Szarmach, Arkadiusz / Luczkiewicz, Piotr / Skotarczak, Monika / Kaszubowski, Mariusz / Winklewski, Pawel J / Dzierzanowski, Jaroslaw / Piskunowicz, Maciej / Szurowska, Edyta / Baczkowski, Bogusław

PloS one

2016 Volume 11, Issue 7, Page(s) e0159156

Abstract: Background: Meniscus extrusion is a serious and relatively frequent clinical problem. For this reason the role of different risk factors for this pathology is still the subject of debate. The goal of this study was to verify the results of previous ... ...

Abstract	Background: Meniscus extrusion is a serious and relatively frequent clinical problem. For this reason the role of different risk factors for this pathology is still the subject of debate. The goal of this study was to verify the results of previous theoretical work, based on the mathematical models, regarding a relationship between the cross-section shape of the meniscus and the risk of its extrusion. Materials and methods: Knee MRI examination was performed in 77 subjects (43 men and 34 women), mean age 34.99 years (range: 18-49 years), complaining of knee pain. Patients with osteoarthritic changes (grade 3 and 4 to Kellgren classification), varus or valgus deformity and past injuries of the knee were excluded from the study. A 3-Tesla MR device was used to study the relationship between the shape of the lateral meniscus (using slope angle, meniscus-cartilage height and meniscus-bone angle) and the risk of extrusion. Results: Analysis revealed that with values of slope angle and meniscus-bone angle increasing by one degree, the risk of meniscus extrusion raises by 1.157 and 1.078 respectively. Also, an increase in meniscus-cartilage height by 1 mm significantly elevates the risk of extrusion. At the same time it was demonstrated that for meniscus-bone angle values over 42 degrees and slope angle over 37 degrees the risk of extrusion increases significantly. Conclusions: This was the first study to demonstrate a tight correlation between slope angle, meniscus-bone angle and meniscus-cartilage height values in the assessment of the risk of lateral meniscus extrusion. Insertion of the above parameters to the radiological assessment of the knee joint allows identification of patients characterized by an elevated risk of development of this pathology.
MeSH term(s)	Adolescent ; Adult ; Biomechanical Phenomena ; Female ; Humans ; Knee Joint/diagnostic imaging ; Knee Joint/pathology ; Knee Joint/physiopathology ; Logistic Models ; Magnetic Resonance Imaging ; Male ; Menisci, Tibial/diagnostic imaging ; Menisci, Tibial/pathology ; Menisci, Tibial/physiopathology ; Middle Aged ; Models, Biological ; Risk Factors ; Tibial Meniscus Injuries/diagnostic imaging ; Tibial Meniscus Injuries/etiology ; Tibial Meniscus Injuries/pathology ; Young Adult
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0159156
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