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  1. Article ; Online: Efim Liberman toward the comprehension of the phenomenon of life.

    Skulachev, Vladimir P

    Bio Systems

    2022  Volume 215-216, Page(s) 104650

    Abstract: Efim Liberman was a proud scholar of biophysics-a genuine scientific discipline that strives for high accuracy in contrast to descriptive biology. He played a major role at the Pushchino Institute of Biophysics and participated in Gelfand's famous ... ...

    Abstract Efim Liberman was a proud scholar of biophysics-a genuine scientific discipline that strives for high accuracy in contrast to descriptive biology. He played a major role at the Pushchino Institute of Biophysics and participated in Gelfand's famous seminar. He developed a groundbreaking model of neural impulses and discovered the decisive role of cell membranes and membrane channels in neural cell excitation. Efim Liberman studied artificial and biological membranes, and conducted seminal experiments to proof Mitchell's hypothesis of oxidative phosphorylation. He discovered penetrating ions in pioneering studies of mitochondrial electrical energetics. He put forward a trailblazing idea of an intracell analog-digital molecular computer capable of using genetically coded algorithms for processing information. His ideas and research gave impetus to academic studies in various areas, such as a role of small RNАs as universal regulators of life. Efim Liberman was an outstanding, versatile and bright personality whose lifelong journey was to pursue the comprehension of the Universe and to understand the phenomenon of life.
    MeSH term(s) Biophysics ; Comprehension
    Language English
    Publishing date 2022-02-24
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 186234-0
    ISSN 1872-8324 ; 0303-2647
    ISSN (online) 1872-8324
    ISSN 0303-2647
    DOI 10.1016/j.biosystems.2022.104650
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    Zs.A 768: Show issues Location:
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  2. Article ; Online: Sodium Energetic Cycle in the Natronophilic Bacterium

    Muntyan, Maria S / Viryasov, Mikhail B / Sorokin, Dimitry Y / Skulachev, Vladimir P

    International journal of molecular sciences

    2022  Volume 23, Issue 4

    Abstract: As inhabitants of soda lakes, ...

    Abstract As inhabitants of soda lakes,
    MeSH term(s) Amiloride/metabolism ; Cell Membrane/metabolism ; Ectothiorhodospiraceae/metabolism ; Electron Transport Complex IV/metabolism ; Flagella/metabolism ; Lakes/microbiology ; Sodium/metabolism
    Chemical Substances Amiloride (7DZO8EB0Z3) ; Sodium (9NEZ333N27) ; Electron Transport Complex IV (EC 1.9.3.1)
    Language English
    Publishing date 2022-02-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23041965
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  3. Article ; Online: Cationic antioxidants as a powerful tool against mitochondrial oxidative stress.

    Skulachev, Vladimir P

    Biochemical and biophysical research communications

    2013  Volume 441, Issue 2, Page(s) 275–279

    Abstract: This review describes evidence that mitochondrial reactive oxygen species (mROS) are of great importance under many physiological and pathological conditions. The most demonstrative indications favoring this conclusion originate from recent discoveries ... ...

    Abstract This review describes evidence that mitochondrial reactive oxygen species (mROS) are of great importance under many physiological and pathological conditions. The most demonstrative indications favoring this conclusion originate from recent discoveries of the in vivo effects of mitochondria-targeted antioxidants (MitoQ and SkQs). The latter compounds look promising in treating several incurable pathologies as well as aging.
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Cations/pharmacology ; Cells, Cultured ; Humans ; Mitochondria/drug effects ; Mitochondria/metabolism ; Organophosphorus Compounds/pharmacology ; Oxidative Stress/drug effects ; Plastoquinone/analogs & derivatives ; Plastoquinone/pharmacology ; Reactive Oxygen Species/metabolism ; Rhodamines/pharmacology ; Ubiquinone/analogs & derivatives ; Ubiquinone/pharmacology
    Chemical Substances 10-(6'-plastoquinonyl) decylrhodamine 19 ; 10-(6'-plastoquinonyl)decyltriphenylphosphonium ; Antioxidants ; Cations ; Organophosphorus Compounds ; Reactive Oxygen Species ; Rhodamines ; Ubiquinone (1339-63-5) ; mitoquinone (47BYS17IY0) ; Plastoquinone (OAC30J69CN)
    Language English
    Publishing date 2013-10-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2013.10.063
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    Zs.A 116: Show issues Location:
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  4. Article ; Online: Mitochondria-targeted antioxidants as promising drugs for treatment of age-related brain diseases.

    Skulachev, Vladimir P

    Journal of Alzheimer's disease : JAD

    2012  Volume 28, Issue 2, Page(s) 283–289

    Abstract: Much experimental evidence suggests that age-related brain pathologies are most often mediated by reactive oxygen species primarily originating from mitochondria (mROS). Two papers with such evidence have been recently published in the Journal of ... ...

    Abstract Much experimental evidence suggests that age-related brain pathologies are most often mediated by reactive oxygen species primarily originating from mitochondria (mROS). Two papers with such evidence have been recently published in the Journal of Alzheimer's Disease (Stefanova et al., J Alzheimers Dis 21, 476-491, 2010; Lloret et al., J Alzheimers Dis, doi: 10.3233/JAD-2011-110890). In the first paper, it was shown that appearance of a typical behavioral trait of aging in rats (that old animals do not enter an open arm in a maze) was completely reversed by ten weeks treatment of the old rats with the mitochondria-targeted antioxidant SkQ1. In the second article, the authors identified molecular mechanisms by which amyloid-β-induced mROS can mediate hyperphosphorylation of the tau protein, a key event in Alzheimer's disease. Conventional antioxidants prevented such hyperphosphorylation. In this article, I will summarize the present state of the art in this field. I conclude that mitochondria-targeted rechargeable antioxidants are promising as tools to treat brain pathologies developing in elderly humans.
    MeSH term(s) Aging ; Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Brain Diseases/drug therapy ; Brain Diseases/pathology ; Humans ; Mitochondria/drug effects ; Mitochondria/metabolism ; Models, Neurological ; Plastoquinone/analogs & derivatives ; Plastoquinone/therapeutic use ; Rats ; Reactive Oxygen Species/metabolism ; Rhodamines/therapeutic use
    Chemical Substances 10-(6'-plastoquinonyl) decylrhodamine 19 ; Antioxidants ; Reactive Oxygen Species ; Rhodamines ; Plastoquinone (OAC30J69CN)
    Language English
    Publishing date 2012
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-2011-111391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Age-Dependent Changes in the Production of Mitochondrial Reactive Oxygen Species in Human Skeletal Muscle.

    Vyssokikh, Mikhail Yu / Vigovskiy, Maksim A / Philippov, Vladislav V / Boroday, Yakov R / Marey, Mariya V / Grigorieva, Olga A / Vepkhvadze, Tatiana F / Kurochkina, Nadezhda S / Manukhova, Ludmila A / Efimenko, Anastasiya Yu / Popov, Daniil V / Skulachev, Vladimir P

    Biochemistry. Biokhimiia

    2024  Volume 89, Issue 2, Page(s) 299–312

    Abstract: A decrease in muscle mass and its functionality (strength, endurance, and insulin sensitivity) is one of the integral signs of aging. One of the triggers of aging is an increase in the production of mitochondrial reactive oxygen species. Our study was ... ...

    Abstract A decrease in muscle mass and its functionality (strength, endurance, and insulin sensitivity) is one of the integral signs of aging. One of the triggers of aging is an increase in the production of mitochondrial reactive oxygen species. Our study was the first to examine age-dependent changes in the production of mitochondrial reactive oxygen species related to a decrease in the proportion of mitochondria-associated hexokinase-2 in human skeletal muscle. For this purpose, a biopsy was taken from m. vastus lateralis in 10 young healthy volunteers and 70 patients (26-85 years old) with long-term primary arthrosis of the knee/hip joint. It turned out that aging (comparing different groups of patients), in contrast to inactivity/chronic inflammation (comparing young healthy people and young patients), causes a pronounced increase in peroxide production by isolated mitochondria. This correlated with the age-dependent distribution of hexokinase-2 between mitochondrial and cytosolic fractions, a decrease in the rate of coupled respiration of isolated mitochondria and respiration when stimulated with glucose (a hexokinase substrate). It is discussed that these changes may be caused by an age-dependent decrease in the content of cardiolipin, a potential regulator of the mitochondrial microcompartment containing hexokinase. The results obtained contribute to a deeper understanding of age-related pathogenetic processes in skeletal muscles and open prospects for the search for pharmacological/physiological approaches to the correction of these pathologies.
    MeSH term(s) Humans ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Reactive Oxygen Species/metabolism ; Hexokinase/metabolism ; Mitochondria ; Muscle, Skeletal/metabolism ; Aging/physiology ; Mitochondria, Muscle/metabolism
    Chemical Substances Reactive Oxygen Species ; Hexokinase (EC 2.7.1.1)
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1109-5
    ISSN 1608-3040 ; 0006-2979 ; 0320-9717
    ISSN (online) 1608-3040
    ISSN 0006-2979 ; 0320-9717
    DOI 10.1134/S0006297924020093
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    Zs.A 220: Show issues Location:
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  6. Book ; Conference proceedings: St. Petersburg special issue

    Skulachev, Vladimir P

    mechanisms in biology : [... 38th Congress of the Federation of European Biochemical Societies (FEBS), which is held in St. Petersburg, Russia this summer]

    (FEBS letters ; 587.2013,13)

    2013  

    Institution Federation of European Biochemical Societies
    Event/congress Congress of the Federation of European Biochemical Societies (38, 2013.07.06-11, St.Petersburg) ; FEBS (38, 2013.07.06-11, St.Petersburg)
    Author's details ed. by: Vladimir P. Skulachev
    Series title FEBS letters ; 587.2013,13
    Language English
    Size S. 1829 - 2082
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Document type Book ; Conference proceedings
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Article ; Online: SkQ1 treatment and food restriction--two ways to retard an aging program of organisms.

    Skulachev, Vladimir P

    Aging

    2011  Volume 3, Issue 11, Page(s) 1045–1050

    Abstract: Effects of the mitochondria-targeted antioxidant SkQ1 and food restriction are compared. In both cases there is a remarkable increase in the median lifespan of organisms belonging to many different taxonomic ranks. Essentially, both SkQ1 treatment and ... ...

    Abstract Effects of the mitochondria-targeted antioxidant SkQ1 and food restriction are compared. In both cases there is a remarkable increase in the median lifespan of organisms belonging to many different taxonomic ranks. Essentially, both SkQ1 treatment and restriction in food intake retard development of numerous adverse traits of senescence. This relationship could be predicted assuming that SkQ1 and food restriction inhibit the execution of an aging program. It is hypothesized that food restriction is perceived by organisms as a signal of starvation, which can be catastrophic for the population. Under these conditions, the organism switches off an aging program that is favorable for evolvability of the species but counterproductive for the individual. Unfortunately, food restriction is accompanied by some other effects, e.g., constant anxiety and attempts to scan as large a space as possible looking for food. Such side effects seem to be absent in the case of inhibition of the aging program by SkQ1.
    MeSH term(s) Aging/drug effects ; Aging/physiology ; Animals ; Antioxidants/pharmacology ; Caloric Restriction ; Humans ; Life Expectancy ; Plastoquinone/analogs & derivatives ; Plastoquinone/pharmacology
    Chemical Substances 10-(6'-plastoquinonyl)decyltriphenylphosphonium ; Antioxidants ; Plastoquinone (OAC30J69CN)
    Language English
    Publishing date 2011-12-14
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.100410
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  8. Article ; Online: Aging as a particular case of phenoptosis, the programmed death of an organism (a response to Kirkwood and Melov "On the programmed/non-programmed nature of ageing within the life history").

    Skulachev, Vladimir P

    Aging

    2011  Volume 3, Issue 11, Page(s) 1120–1123

    MeSH term(s) Adaptation, Physiological ; Aging/physiology ; Animals ; Humans
    Language English
    Publishing date 2011-12-02
    Publishing country United States
    Document type Letter ; Comment
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.100403
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  9. Article ; Online: Cellular and Molecular Mechanisms of Action of Mitochondria-Targeted Antioxidants.

    Feniouk, Boris A / Skulachev, Vladimir P

    Current aging science

    2016  Volume 10, Issue 1, Page(s) 41–48

    Abstract: Reactive oxygen species generated in mitochondria are an important factor contributing to mitochondrial and cellular dysfunction underlying many degenerative diseases, chronic pathologies and aging. The idea of delivering antioxidant molecules to ... ...

    Abstract Reactive oxygen species generated in mitochondria are an important factor contributing to mitochondrial and cellular dysfunction underlying many degenerative diseases, chronic pathologies and aging. The idea of delivering antioxidant molecules to mitochondria in vivo to treat these diseases and slow aging intensively developed in the last 20 years. Derivatives of quinones covalently conjugated to a lipophilic cation (e.g., MitoQ and SkQ) were the most extensively studied mitochondria-targeted antioxidants. These compounds have now been used in a wide range of in vitro and in vivo studies, as well as in clinical trials in humans. Here, we review recent progress in this field with a special attention on molecular mechanisms of rechargeable mitochondria-targeted antioxidants. A simple hypothesis that aging results from gradual accumulation of occasional damage inflicted by ROS to DNA, proteins and lipids is apparently insufficient. More and more pieces of evidence indicate that the damage in question is programmed. Moreover, the imbalance in ROS-dependent regulatory mechanisms and compromised ROS signaling are underlying many pathologies and aging. Chain reactions of cardiolipin peroxidation initiated by mitochondrial ROS seem to play a key role in these degenerative processes. Such reactions are specifically abolished by mitochondriatargeted antioxidants.
    MeSH term(s) Aging/metabolism ; Animals ; Antioxidants/administration & dosage ; Cardiolipins/metabolism ; Cardiolipins/pharmacology ; Cytoprotection/drug effects ; Free Radical Scavengers/pharmacology ; Humans ; Mitochondria/drug effects ; Mitochondria/metabolism ; Nitrogen Oxides/pharmacology ; Reactive Oxygen Species/metabolism
    Chemical Substances Antioxidants ; Cardiolipins ; Free Radical Scavengers ; Nitrogen Oxides ; Reactive Oxygen Species
    Language English
    Publishing date 2016-09-22
    Publishing country United Arab Emirates
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1874-6128
    ISSN (online) 1874-6128
    DOI 10.2174/1874609809666160921113706
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  10. Article: Cationic antioxidants as a powerful tool against mitochondrial oxidative stress

    Skulachev, Vladimir P

    Biochemical and biophysical research communications. 2013 Nov. 15, v. 441, no. 2

    2013  

    Abstract: This review describes evidence that mitochondrial reactive oxygen species (mROS) are of great importance under many physiological and pathological conditions. The most demonstrative indications favoring this conclusion originate from recent discoveries ... ...

    Abstract This review describes evidence that mitochondrial reactive oxygen species (mROS) are of great importance under many physiological and pathological conditions. The most demonstrative indications favoring this conclusion originate from recent discoveries of the in vivo effects of mitochondria-targeted antioxidants (MitoQ and SkQs). The latter compounds look promising in treating several incurable pathologies as well as aging.
    Keywords antioxidants ; oxidative stress ; reactive oxygen species
    Language English
    Dates of publication 2013-1115
    Size p. 275-279.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2013.10.063
    Database NAL-Catalogue (AGRICOLA)

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