Article ; Online: Psyllium is a natural nonfermented gel-forming fiber that is effective for weight loss: A comprehensive review and meta-analysis.
Journal of the American Association of Nurse Practitioners
2023 Volume 35, Issue 8, Page(s) 468–476
Abstract: Background: Psyllium is a natural, predominantly soluble fiber that forms a viscous gel when hydrated and is not digested or fermented. In the small intestine, psyllium gel increases chyme viscosity, slowing the degradation and absorption of nutrients. ... ...
| Abstract | Background: Psyllium is a natural, predominantly soluble fiber that forms a viscous gel when hydrated and is not digested or fermented. In the small intestine, psyllium gel increases chyme viscosity, slowing the degradation and absorption of nutrients. Psyllium has a significant effect in patients with metabolic syndrome and type-2 diabetes on glycemic control, while lowering serum cholesterol in hypercholesterolemic patients. Some randomized controlled studies have shown that psyllium also facilitates weight loss in overweight and obese participants. Objectives: A comprehensive review and meta-analysis assessing psyllium's impact on body weight, body mass index (BMI), and waist circumference in overweight and obese participants. Data sources: A comprehensive search was performed (Medline, Scopus, Cochrane Database) through March 21, 2022, using search terms to identify randomized, controlled, clinical studies designed to assess weight loss in overweight and obese participants over at least 2 months. Data were analyzed using the inverse variance method with random effects models. Conclusions: Six studies meeting inclusion criteria were identified (total n = 354). The meta-analysis showed that psyllium, dosed just before meals (mean dose 10.8 g/day, mean duration 4.8 months), was effective for decreasing body weight (MD = -2.1 kg [95% confidence interval [CI]: -2.6 to -1.6]; p < .001), BMI (MD = -0.8 kg/m 2 [95% CI: -1.0 to -0.6]; p < .001) and waist circumference (MD = -2.2 cm [95% CI: -2.9 to -1.4]; p < .001) in overweight and obese populations. Implications for practice: Gel-forming nonfermented psyllium fiber, dosed just before meals, is effective in facilitating weight loss in overweight and obese participants. |
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| MeSH term(s) | Humans ; Body Weight ; Obesity ; Overweight ; Psyllium/pharmacology ; Psyllium/therapeutic use ; Weight Loss | |||||
| Chemical Substances | Psyllium (8063-16-9) | |||||
| Language | English | |||||
| Publishing date | 2023-08-01 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Meta-Analysis ; Review ; Systematic Review | |||||
| ZDB-ID | 2716317-9 | |||||
| ISSN | 2327-6924 ; 1745-7599 ; 2327-6886 ; 1041-2972 | |||||
| ISSN (online) | 2327-6924 ; 1745-7599 | |||||
| ISSN | 2327-6886 ; 1041-2972 | |||||
| DOI | 10.1097/JXX.0000000000000882 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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