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  1. Article ; Online: RAC-king up Efferocytosis in Atherosclerotic Plaques With Aldehyde Dehydrogenase 2 Deficiency.

    Sluimer, Judith C

    Arteriosclerosis, thrombosis, and vascular biology

    2022  Volume 42, Issue 6, Page(s) 717–718

    MeSH term(s) Aldehyde Dehydrogenase ; Apoptosis ; Atherosclerosis/genetics ; Humans ; Phagocytosis ; Plaque, Atherosclerotic
    Chemical Substances Aldehyde Dehydrogenase (EC 1.2.1.3)
    Language English
    Publishing date 2022-04-21
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.122.317690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1705: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Effective Transfection and Gene Silencing of Primary Murine Macrophages with Small Interfering RNA.

    van Kuijk, Kim / Nagenborg, Jan / Sluimer, Judith C

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2419, Page(s) 125–132

    Abstract: Transfection of murine primary macrophages to silence genes can be a challenging procedure because this cell type has developed mechanisms to evade cellular intrusion. The introduction of small interfering RNA (siRNA) encapsulated in liposomes to the ... ...

    Abstract Transfection of murine primary macrophages to silence genes can be a challenging procedure because this cell type has developed mechanisms to evade cellular intrusion. The introduction of small interfering RNA (siRNA) encapsulated in liposomes to the cell to decrease gene expression is one of the methods that can be used to achieve gene silencing. There are different commercially available compounds to introduce siRNA into the cell, including Lipofectamine RNAiMAX and HiPerfect. The chapter will describe a method for gene silencing in mouse primary macrophages using liposome-based transfection of siRNA.
    MeSH term(s) Animals ; Gene Silencing ; Macrophages/metabolism ; Mice ; RNA Interference ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Transfection
    Chemical Substances RNA, Small Interfering
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1924-7_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Localization of Long Noncoding RNA in Formalin-Fixed, Paraffin-Embedded Vascular Tissue Using In Situ Hybridization.

    Scanlon, Jessica P / Baker, Andrew H / Sluimer, Judith C

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2419, Page(s) 659–670

    Abstract: In situ hybridization (ISH) is a technique for the detection of the location of RNA within a tissue of interest. This process uses oligonucleotides with complementary sequences to bind to the target RNA, and colorimetric detection to allow for the ... ...

    Abstract In situ hybridization (ISH) is a technique for the detection of the location of RNA within a tissue of interest. This process uses oligonucleotides with complementary sequences to bind to the target RNA, and colorimetric detection to allow for the visualization of this binding. The process of ISH means that the specific location of the RNA in question can be detected, including in which cell types it is present, and the intracellular location. In the case of long noncoding RNA (lncRNA), which do not lead to the production of proteins, ISH is essential for tissue localization. Moreover, RNA abundance is often lower than for protein-coding genes, thus necessitating enhanced detection through double-digoxigenin (DIG) labeling of the probes. Here, we describe the theory and practicalities of performing ISH for lncRNA, with particular reference to vascular tissues.
    MeSH term(s) Digoxigenin ; Formaldehyde ; In Situ Hybridization ; Paraffin Embedding ; RNA, Long Noncoding/genetics
    Chemical Substances RNA, Long Noncoding ; Formaldehyde (1HG84L3525) ; Digoxigenin (NQ1SX9LNAU)
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1924-7_41
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Chaperone-mediated autophagy protects against atherosclerosis.

    Madrigal-Matute, Julio / Cuervo, Ana Maria / Sluimer, Judith C

    Autophagy

    2022  Volume 18, Issue 10, Page(s) 2505–2507

    Abstract: Atherosclerosis, the leading cause of cardiovascular death, is driven by hyperlipidemia, inflammation and aggravated by aging. As chaperone-mediated autophagy (CMA), a selective type of lysosomal degradation for intracellular proteins, diminishes with ... ...

    Abstract Atherosclerosis, the leading cause of cardiovascular death, is driven by hyperlipidemia, inflammation and aggravated by aging. As chaperone-mediated autophagy (CMA), a selective type of lysosomal degradation for intracellular proteins, diminishes with age and is inhibited by lipid excess, we studied if the decline in CMA could contribute to atherosclerosis pathogenesis. We found that CMA declines in human and murine vasculature with disease progression. Inhibition and reactivation of CMA using transgenic mouse models establishes a protective effect of CMA against atherogenesis. CMA upregulation ameliorates both systemic metabolic parameters, and vascular cell function. Our work suggests CMA reactivation could be a viable therapeutic strategy to prevent and reduce cardiovascular disease.
    MeSH term(s) Animals ; Atherosclerosis/metabolism ; Autophagy/physiology ; Chaperone-Mediated Autophagy ; Humans ; Lipids ; Lysosomes/metabolism ; Mice ; Mice, Transgenic ; Molecular Chaperones/metabolism
    Chemical Substances Lipids ; Molecular Chaperones
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2022.2096397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6741: Show issues Location:
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  5. Article ; Online: Pleiotropic, Cellular Effects of Rivaroxaban on Autophagy Explain Atheroprotective Effects.

    Posma, Jens J N / Sluimer, Judith C

    JACC. Basic to translational science

    2021  Volume 6, Issue 12, Page(s) 981–983

    Language English
    Publishing date 2021-12-27
    Publishing country United States
    Document type Editorial
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2021.10.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Arterial lymphangiogenesis ReSPONDINg 2 a new cue: the R-spondin2/LRG4 axis limits VEGFR3-mediated lymphangiogenesis and reverse cholesterol transport.

    Sluimer, Judith C / Biessen, Erik A L

    Cardiovascular research

    2021  Volume 117, Issue 6, Page(s) 1417–1419

    MeSH term(s) Cholesterol ; Cues ; Lymphangiogenesis ; Vascular Endothelial Growth Factor Receptor-3
    Chemical Substances Cholesterol (97C5T2UQ7J) ; Vascular Endothelial Growth Factor Receptor-3 (EC 2.7.10.1)
    Language English
    Publishing date 2021-03-12
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvab050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Culture density influences the functional phenotype of human macrophages.

    Ruder, Adele V / Temmerman, Lieve / van Dommelen, Joep M A / Nagenborg, Jan / Lu, Chang / Sluimer, Judith C / Goossens, Pieter / Biessen, Erik A L

    Frontiers in immunology

    2023  Volume 14, Page(s) 1078591

    Abstract: Macrophages (MΦ) are commonly ... ...

    Abstract Macrophages (MΦ) are commonly cultured
    MeSH term(s) Humans ; Inflammasomes/metabolism ; Macrophages/metabolism ; Cytokines/metabolism ; Phenotype ; Lipids
    Chemical Substances Inflammasomes ; Cytokines ; Lipids
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1078591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Clonal Expansion in Cardiovascular Pathology.

    Lin, Alexander / Brittan, Mairi / Baker, Andrew H / Dimmeler, Stefanie / Fisher, Edward A / Sluimer, Judith C / Misra, Ashish

    JACC. Basic to translational science

    2023  Volume 9, Issue 1, Page(s) 120–144

    Abstract: Clonal expansion refers to the proliferation and selection of advantageous "clones" that are better suited for survival in a Darwinian manner. In recent years, we have greatly enhanced our understanding of cell clonality in the cardiovascular context. ... ...

    Abstract Clonal expansion refers to the proliferation and selection of advantageous "clones" that are better suited for survival in a Darwinian manner. In recent years, we have greatly enhanced our understanding of cell clonality in the cardiovascular context. However, our knowledge of the underlying mechanisms behind this clonal selection is still severely limited. There is a transpiring pattern of clonal expansion of smooth muscle cells and endothelial cells-and, in some cases, macrophages-in numerous cardiovascular diseases irrespective of their differing microenvironments. These findings indirectly suggest the possible existence of stem-like vascular cells which are primed to respond during disease. Subsequent clones may undergo further phenotypic changes to adopt either protective or detrimental roles. By investigating these clone-forming vascular cells, we may be able to harness this inherent clonal nature for future therapeutic intervention. This review comprehensively discusses what is currently known about clonal expansion across the cardiovascular field. Comparisons of the clonal nature of vascular cells in atherosclerosis (including clonal hematopoiesis of indeterminate potential), pulmonary hypertension, aneurysm, blood vessel injury, ischemia- and tumor-induced angiogenesis, and cerebral cavernous malformations are evaluated. Finally, we discuss the potential clinical implications of these findings and propose that proper understanding and specific targeting of these clonal cells may provide unique therapeutic options for the treatment of these cardiovascular conditions.
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2023.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Single-cell transcriptomics reveals subtype-specific molecular profiles in Nrf2-deficient macrophages from murine atherosclerotic aortas.

    Sarad, Katarzyna / Stefańska, Monika / Kraszewska, Izabela / Szade, Krzysztof / Sluimer, Judith C / Błyszczuk, Przemysław / Dulak, Józef / Jaźwa-Kusior, Agnieszka

    Frontiers in immunology

    2023  Volume 14, Page(s) 1249379

    Abstract: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcriptional regulator of antioxidant and anti-inflammatory response in all cell types. It also activates the transcription of genes important for macrophage function. Nrf2 activity declines with ...

    Abstract Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcriptional regulator of antioxidant and anti-inflammatory response in all cell types. It also activates the transcription of genes important for macrophage function. Nrf2 activity declines with age and has been closely linked to atherosclerosis, but its specific role in this vascular pathology is not clear. Atherosclerotic plaques contain several macrophage subsets with distinct, yet not completely understood, functions in the lesion development. The aim of this study was to analyze the transcriptome of diverse Nrf2-deficient macrophage subpopulations from murine atherosclerotic aortas. Mice with transcriptionally inactive Nrf2 in Cdh5-expressing cells (
    MeSH term(s) Animals ; Mice ; Aorta/pathology ; Atherosclerosis/metabolism ; Endothelial Cells/metabolism ; Gene Expression Profiling ; Macrophages/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Proprotein Convertase 9/metabolism ; Transcriptome
    Chemical Substances NF-E2-Related Factor 2 ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Nfe2l2 protein, mouse
    Language English
    Publishing date 2023-10-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1249379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Joint ESM-EVBO meetings: past, present, and future.

    Sluimer, Judith C / Houben, Alfons J H M

    Cardiovascular research

    2019  Volume 115, Issue 4, Page(s) e46–e48

    MeSH term(s) Biomedical Research/history ; Biomedical Research/trends ; Blood Vessels/metabolism ; Blood Vessels/pathology ; Blood Vessels/physiopathology ; Congresses as Topic/history ; Congresses as Topic/trends ; Cooperative Behavior ; Diffusion of Innovation ; Forecasting ; History, 20th Century ; History, 21st Century ; Humans ; Interdisciplinary Communication ; Microcirculation ; Societies, Scientific/history ; Societies, Scientific/trends ; Vascular Diseases/metabolism ; Vascular Diseases/pathology ; Vascular Diseases/physiopathology ; Vascular Diseases/therapy
    Language English
    Publishing date 2019-02-12
    Publishing country England
    Document type Editorial ; Historical Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvz041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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