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  1. Article ; Online: Physical Activity: A Strategy to Improve Antibody Response to a SARS-CoV-2 Vaccine Booster Dose in Patients With Autoimmune Rheumatic Diseases.

    Gualano, Bruno / Sieczkowska, Sofia M / Lemes, Ítalo Ribeiro / da Silva, Rafael Pires / Pinto, Ana J / Mazzolani, Bruna C / Smaira, Fabiana I / Aikawa, Nadia E / Kupa, Leonard V K / Pasoto, Sandra G / Medeiros-Ribeiro, Ana C / Saad, Carla G S / Yuk, Emily F N / Silva, Clovis A / Swinton, Paul / Hallal, Pedro C / Roschel, Hamilton / Bonfa, Eloisa

    Journal of physical activity & health

    2023  Volume 20, Issue 4, Page(s) 311–316

    Abstract: Background: Physical activity associates with improved immunogenicity following a 2-dose schedule of CoronaVac (Sinovac's inactivated SARS-CoV-2 vaccine) in patients with autoimmune rheumatic diseases (ARD). This study evaluates whether physical ... ...

    Abstract Background: Physical activity associates with improved immunogenicity following a 2-dose schedule of CoronaVac (Sinovac's inactivated SARS-CoV-2 vaccine) in patients with autoimmune rheumatic diseases (ARD). This study evaluates whether physical activity impacts vaccine-induced antibody responses to a booster dose in this population.
    Methods: This was a phase-4 trial conducted in São Paulo, Brazil. Patients with ARD underwent a 3-dose schedule of CoronaVac. One month after the booster, we assessed seroconversion rates of anti-SARS-CoV-2 S1/S2 IgG, geometric mean titers of anti-S1/S2 IgG, frequency of positive neutralizing antibodies, and neutralizing activity. Physical activity was assessed through questionnaire.
    Results: Physically active (n = 362) and inactive (n = 278) patients were comparable for most characteristics; however, physically active patients were younger (P < .01) and had a lower frequency of chronic inflammatory arthritis (P < .01). Adjusted models showed that physically active patients had ∼2 times odds of seroconversion rates (OR: 2.09; 95% confidence interval, 1.22 to 3.61), ∼22% greater geometric mean titers of anti-S1/S2 IgG (22.09%; 95% confidence interval, 3.91 to 65.60), and ∼7% greater neutralizing activity (6.76%; 95% confidence interval, 2.80 to 10.72) than inactive patients.
    Conclusions: Patients with ARD who are physically active have greater odds of experiencing better immunogenicity to a booster dose of CoronaVac. These results support the recommendation of physical activity to improve vaccination responses, particularly for immunocompromised individuals.
    MeSH term(s) Humans ; Antibody Formation ; Brazil ; COVID-19/prevention & control ; COVID-19 Vaccines ; Exercise ; Immunoglobulin G ; Rheumatic Diseases ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines ; Immunoglobulin G ; sinovac COVID-19 vaccine
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Clinical Trial, Phase IV ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1543-5474
    ISSN (online) 1543-5474
    DOI 10.1123/jpah.2022-0332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effect of an exercise bout before the booster dose of an inactivated SARS-CoV-2 vaccine on immunogenicity in immunocompromised patients.

    Gualano, Bruno / Saad, Carla G S / Sieczkowska, Sofia M / Lemes, Ítalo Ribeiro / da Silva, Rafael Pires / Pinto, Ana J / Mazzolani, Bruna C / Smaira, Fabiana I / Gil, Saulo / Oliveira-Junior, Gersiel / Aikawa, Nadia E / Medeiros-Ribeiro, Ana C / Silva, Clovis A / Yuki, Emily F N / Pasoto, Sandra G / Pereira, Rosa Maria R / Shinjo, Samuel K / Andrade, Danieli C O / Sampaio-Barros, Percival D /
    Roschel, Hamilton / Bonfa, Eloisa

    Journal of applied physiology (Bethesda, Md. : 1985)

    2022  Volume 132, Issue 3, Page(s) 682–688

    Abstract: This randomized controlled study aimed to investigate whether a single bout of exercise before the homologous booster dose of a SARS-CoV-2 inactivated vaccine could enhance immunogenicity in patients with spondyloarthritis. We selected 60 consecutive ... ...

    Abstract This randomized controlled study aimed to investigate whether a single bout of exercise before the homologous booster dose of a SARS-CoV-2 inactivated vaccine could enhance immunogenicity in patients with spondyloarthritis. We selected 60 consecutive patients with spondyloarthritis (SpA). Patients assigned to the intervention group performed an exercise bout comprising three exercises. Then, they remained at rest for 1 h before vaccination. The control group remained at rest before vaccination. Immunogenicity was assessed before (Pre) and 1 mo after (Post) the booster using seropositivity rates of total anti-SARS-CoV-2 S1/S2 IgG, geometric mean titers of anti-S1/S2 IgG (GMT), frequency of neutralizing antibodies (NAb) positivity, and NAb activity. At Pre, 16 patients from the exercise group and 16 patients from the control group exhibited seropositivity for IgG (59% vs. 57.1%), and 1 mo after the booster dose, seropositivity occurred in 96% versus 100% of the cases. Only 10 patients from the exercise group and 12 patients from the control group showed positive NAb serology at Pre (37% vs. 42.8%). One month following the booster, NAb positivity was 96% versus 93%. GMT was comparable between groups at Pre. At Post, GMT increased similarly in both groups. Likewise, NAb activity was similar between groups at Pre and increased similarly in both of them as a result of the booster (47.5% vs. 39.9%). In conclusion, a single bout of exercise did not enhance immunogenicity to a homologous booster dose of an inactivated SARS-CoV-2 vaccine among patients with spondyloarthritis.
    MeSH term(s) Antibodies, Viral ; COVID-19 ; COVID-19 Vaccines ; Humans ; Immunocompromised Host ; SARS-CoV-2 ; Vaccines, Inactivated
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; SARS-CoV-2 inactivated vaccines ; Vaccines, Inactivated
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00015.2022
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  3. Article ; Online: Acute cardiometabolic effects of brief active breaks in sitting for patients with rheumatoid arthritis.

    Pinto, Ana J / Meireles, Kamila / Peçanha, Tiago / Mazzolani, Bruna C / Smaira, Fabiana I / Rezende, Diego / Benatti, Fabiana B / Ribeiro, Ana C M / Pinto, Ana L S / Lima, Fernanda R / Shinjo, Samuel K / Dantas, Wagner S / Mellett, Natalie A / Meikle, Peter J / Owen, Neville / Dunstan, David W / Roschel, Hamilton / Gualano, Bruno

    American journal of physiology. Endocrinology and metabolism

    2021  Volume 321, Issue 6, Page(s) E782–E794

    Abstract: Exercise is a treatment in rheumatoid arthritis, but participation in moderate-to-vigorous exercise is challenging for some patients. Light-intensity breaks in sitting could be a promising alternative. We compared the acute effects of active breaks in ... ...

    Abstract Exercise is a treatment in rheumatoid arthritis, but participation in moderate-to-vigorous exercise is challenging for some patients. Light-intensity breaks in sitting could be a promising alternative. We compared the acute effects of active breaks in sitting with those of moderate-to-vigorous exercise on cardiometabolic risk markers in patients with rheumatoid arthritis. In a crossover fashion, 15 women with rheumatoid arthritis underwent three 8-h experimental conditions: prolonged sitting (SIT), 30-min bout of moderate-to-vigorous exercise followed by prolonged sitting (EX), and 3-min bouts of light-intensity walking every 30 min of sitting (BR). Postprandial glucose, insulin, c-peptide, triglycerides, cytokines, lipid classes/subclasses (lipidomics), and blood pressure responses were assessed. Muscle biopsies were collected following each session to assess targeted proteins/genes. Glucose [-28% in area under the curve (AUC),
    MeSH term(s) Aged ; Arthritis, Rheumatoid/metabolism ; Arthritis, Rheumatoid/physiopathology ; Arthritis, Rheumatoid/therapy ; Blood Glucose/metabolism ; Cardiometabolic Risk Factors ; Cardiovascular System/physiopathology ; Cross-Over Studies ; Energy Metabolism/physiology ; Exercise/physiology ; Female ; Humans ; Insulin/metabolism ; Middle Aged ; Postprandial Period ; Sedentary Behavior ; Walking/physiology
    Chemical Substances Blood Glucose ; Insulin
    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    DOI 10.1152/ajpendo.00259.2021
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  4. Article ; Online: Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases.

    Gualano, Bruno / Lemes, Italo R / Silva, Rafael P / Pinto, Ana J / Mazzolani, Bruna C / Smaira, Fabiana I / Sieczkowska, Sofia M / Aikawa, Nadia E / Pasoto, Sandra G / Medeiros-Ribeiro, Ana C / Saad, Carla G S / Yuki, Emily F N / Silva, Clovis A / Swinton, Paul / Hallal, Pedro C / Roschel, Hamilton / Bonfa, Eloisa

    Brain, behavior, and immunity

    2021  Volume 101, Page(s) 49–56

    Abstract: Objectives: To investigate whether physical activity is associated with enhanced immunogenicity of a SARS-CoV-2 inactivated vaccine (Coronavac) in patients with autoimmune rheumatic diseases (ARD) (n = 898) and in non-ARD (n = 197) individuals without ... ...

    Abstract Objectives: To investigate whether physical activity is associated with enhanced immunogenicity of a SARS-CoV-2 inactivated vaccine (Coronavac) in patients with autoimmune rheumatic diseases (ARD) (n = 898) and in non-ARD (n = 197) individuals without pre-existing immunogenicity to SARS-CoV-2.
    Methods: This was a prospective cohort study within an open-label, single-arm, phase 4 vaccination trial. Immunogenicity was assessed after vaccination by measuring seroconversion rates of total anti-SARS-CoV-2 S1/S2 IgG (SC), geometric mean titers of anti-S1/S2 IgG (GMT), factor-increase in GMT (FI-GMT), frequency of neutralizing antibody (NAb), and median neutralizing activity. Physical activity (active being defined as ≥ 150 min/week) and sedentary behavior (>8h/day) were assessed by questionnaire.
    Results: Physically active ARD patients (n = 494) were younger and less frequently used prednisone/biologics than inactive patients (n = 404). After controlling for covariates, active patients exhibited greater SC (OR: 1.4 [95%CI: 1.1-2.0]), GMT (32% [95%CI: 8.8-60) and FI-GMT (33% [95%CI: 9.6-63%]) vs. inactive. Cluster analysis (physical activity/sedentary status) revealed greater GMT (43.0% [95% CI: 11.0-84.0%) and FI-GMT (48.0% [95%CI: 14.0-92.0%]) in active/non-sedentary vs. inactive/sedentary ARD patients. A dose-response was observed, with greater benefits for the group of patients performing ≥ 350 min/week of physical activity (OR: 1.6 [95%CI: 1.1-2.4]; 41% [95%CI: 10-80%]; 35% [95%CI: 4.3-74], for SC, GMT, and FI-GMT, respectively) vs. the least active group (≤30 min/week). Greater SC (OR: 9.9 [95%CI: 1.1-89.0]) and GMT (26% [95%CI: 2.2-56.0%]) were observed in active vs. inactive non-ARD.
    Conclusions: A physically active lifestyle may enhance SARS-CoV-2 vaccine immunogenicity, a finding of particular clinical relevance for immunocompromised patients.
    Trial registration: Clinicaltrials.gov #NCT04754698.
    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Exercise ; Humans ; Prospective Studies ; Rheumatic Diseases ; SARS-CoV-2 ; Vaccines, Inactivated
    Chemical Substances COVID-19 Vaccines ; Vaccines, Inactivated
    Language English
    Publishing date 2021-12-23
    Publishing country Netherlands
    Document type Clinical Trial, Phase IV ; Journal Article
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2021.12.016
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  5. Article ; Online: Poor Sleep quality and health-related quality of life impact in adolescents with and without chronic immunosuppressive conditions during COVID-19 quarantine.

    Helito, Alberto C / Lindoso, Livia / Sieczkowska, Sofia M / Astley, Camilla / Queiroz, Ligia B / Rose, Natalia / Santos, Claudia Renata P / Bolzan, Thalis / Peralta, Rita María I A / Franco, Ruth R / Cominato, Louise / Pereira, Rosa Maria R / Tannuri, Uenis / Campos, Lucia Maria A / Lourenço, Benito / Toma, Ricardo K / Medeiros, Karina / Watanabe, Andréia / Grangeiro, Patricia Moreno /
    Farhat, Sylvia C / Casella, Caio B / Polanczyk, Guilherme V / Gualano, Bruno / Silva, Clovis A / Sallum, Adriana M E / Iraha, Amanda Y / Ihara, Bianca P / Mazzolani, Bruna C / Martinez, Claudia A / Strabelli, Claudia A A / Fonseca, Claudia B / Lima, Dandara C C / Setoue, Debora N D / Roz, Deborah F P / Smaira, Fabiana I / Roschel, Hamilton / Miyatani, Helena T / Marques, Isabela G / Oba, Jane / Ferreira, Juliana C O / Simon, Juliana R / Kozu, Katia / Saccani, Ligia P / Martiniano, Lorena V M / Miranda, Luana C A / Silva, Luiz E V / Laurentino, Moisés F / Aikawa, Nadia E / Sakita, Neusa K / Tanigava, Nicolas Y / Pereira, Paulo R A / Palmeira, Patrícia / Angelo, Simone S / Lavorato, Sofia S M / Bernardes, Tamires M / Franco, Tathiane C / Viana, Vivianne S L / Barros, Vera P M F R / Zheng, Yingying

    Clinics (Sao Paulo, Brazil)

    2021  Volume 76, Page(s) e3501

    Abstract: Objective: To assess the possible factors that influence sleep quality in adolescents with and without chronic immunosuppressive conditions quarantined during the coronavirus disease 2019 (COVID-19) pandemic.: Methods: This cross-sectional study ... ...

    Abstract Objective: To assess the possible factors that influence sleep quality in adolescents with and without chronic immunosuppressive conditions quarantined during the coronavirus disease 2019 (COVID-19) pandemic.
    Methods: This cross-sectional study included 305 adolescents with chronic immunocompromised conditions and 82 healthy adolescents. Online surveys were completed, which included questions on socio-demographic data and self-rated healthcare routine during COVID-19 quarantine and the following validated questionnaires: the Pittsburgh Sleep Quality Index (PSQI), Pediatric Quality of Life Inventory 4.0 (PedsQL4.0), and Pediatric Outcome Data Collection Instrument (PODCI).
    Results: The median current age [14 (10-18) vs. 15 (10-18) years, p=0.847] and frequency of female sex (62% vs. 58%, p=0.571) were similar in adolescents with chronic conditions compared with healthy adolescents. The frequency of poor sleep quality was similar in both groups (38% vs. 48%, p=0.118). Logistic regression analysis, including both healthy adolescents and adolescents with chronic conditions (n=387), demonstrated that self-reported increase in screen time (odds ratio [OR] 3.0; 95% confidence interval [CI] 1.3-6.8; p=0.008) and intrafamilial violence report (OR 2.1; 95% CI 1.2-3.5; p=0.008) were independently associated with poor sleep quality in these adolescents. However, the PODCI global function score was associated with a lower OR for poor sleep quality (OR 0.97; 95% CI 0.94-0.99; p=0.001). Further logistic regression, including only adolescents with chronic conditions (n=305), demonstrated that self-reported increase in screen time (OR 3.1; 95% CI 1.4-6.8; p=0.006) and intrafamilial violence report (OR 2.0; 95% CI 1.2-3.4; p=0.011) remained independently associated with poor quality of sleep, whereas a lower PODCI global function score was associated with a lower OR for sleep quality (OR 0.96; 95% CI 0.94-0.98; p<0.001).
    Conclusion: Self-reported increases in screen time and intrafamilial violence report impacted sleep quality in both healthy adolescents and those with chronic conditions. Decreased health-related quality of life was observed in adolescents with poor sleep quality.
    MeSH term(s) Adolescent ; COVID-19 ; Child ; Chronic Disease ; Cross-Sectional Studies ; Female ; Humans ; Quality of Life ; Quarantine ; SARS-CoV-2 ; Sleep ; Surveys and Questionnaires
    Language English
    Publishing date 2021-11-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2182801-5
    ISSN 1980-5322 ; 1807-5932
    ISSN (online) 1980-5322
    ISSN 1807-5932
    DOI 10.6061/clinics/2021/e3501
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