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  1. Article ; Online: Anti-amyloid trials raise scientific and ethical questions.

    Smith, A David

    BMJ (Clinical research ed.)

    2021  Volume 372, Page(s) n805

    MeSH term(s) Cognition ; Ethics Committees, Research ; Humans ; Informed Consent ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2021-03-26
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.n805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Maternal and infant vitamin B12 status and development.

    Smith, A David

    Pediatric research

    2018  Volume 84, Issue 5, Page(s) 591–592

    MeSH term(s) Humans ; Infant ; Maternal Nutritional Physiological Phenomena ; Vitamin B 12 ; Vitamin B 12 Deficiency
    Chemical Substances Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2018-07-02
    Publishing country United States
    Document type News ; Comment
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-018-0110-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Vitamin B-12.

    Sobczyńska-Malefora, Agata / Smith, A David

    Advances in nutrition (Bethesda, Md.)

    2022  Volume 13, Issue 5, Page(s) 2061–2063

    MeSH term(s) Humans ; Vitamin B 12 ; Vitamin B 12 Deficiency/complications ; Vitamins
    Chemical Substances Vitamins ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2022-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2583634-1
    ISSN 2156-5376 ; 2156-5376
    ISSN (online) 2156-5376
    ISSN 2156-5376
    DOI 10.1093/advances/nmac030
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  4. Article ; Online: Hippocampus as a mediator of the role of vitamin B-12 in memory.

    Smith, A David

    The American journal of clinical nutrition

    2016  Volume 103, Issue 4, Page(s) 959–960

    MeSH term(s) Cognitive Dysfunction/blood ; Female ; Hippocampus/drug effects ; Humans ; Male ; Memory/drug effects ; Vitamin B 12/blood
    Chemical Substances Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2016-03-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.3945/ajcn.116.132266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: ω-3 fatty acids and their interactions.

    Smith, A David / Jernerén, Fredrik / Refsum, Helga

    The American journal of clinical nutrition

    2021  Volume 113, Issue 4, Page(s) 775–778

    MeSH term(s) Cognitive Aging ; Dietary Supplements ; Fatty Acids, Omega-3 ; Folic Acid ; Humans ; Nutrition Therapy
    Chemical Substances Fatty Acids, Omega-3 ; Folic Acid (935E97BOY8)
    Language English
    Publishing date 2021-03-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.1093/ajcn/nqab013
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  6. Article ; Online: Mandatory food fortification with folic acid.

    Smith, A David / Sobczyńska-Malefora, Agata / Green, Ralph / Reynolds, Edward H / Refsum, Helga

    The Lancet. Global health

    2022  Volume 10, Issue 10, Page(s) e1389

    MeSH term(s) Folic Acid ; Food, Fortified ; Humans ; Neural Tube Defects/prevention & control
    Chemical Substances Folic Acid (935E97BOY8)
    Language English
    Publishing date 2022-08-30
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(22)00378-3
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  7. Article ; Online: Folic Acid for the Prevention of Neural Tube Defects.

    Refsum, Helga / Smith, A David

    JAMA pediatrics

    2017  Volume 171, Issue 7, Page(s) 710–711

    MeSH term(s) Folic Acid ; Humans ; Neural Tube Defects ; Nutrition Therapy ; Prenatal Care ; Preventive Health Services
    Chemical Substances Folic Acid (935E97BOY8)
    Language English
    Publishing date 2017-05-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2017.0866
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  8. Article ; Online: Dietary Supplements for Brain Health.

    Smith, A David / Refsum, Helga / Miller, Joshua W

    JAMA

    2019  Volume 321, Issue 24, Page(s) 2467

    MeSH term(s) Brain ; Dementia ; Dietary Supplements ; Humans
    Language English
    Publishing date 2019-06-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2019.4963
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  9. Article: B-vitamins are potentially a cost-effective population health strategy to tackle dementia: Too good to be true?

    Tsiachristas, Apostolos / Smith, A David

    Alzheimer's & dementia (New York, N. Y.)

    2016  Volume 2, Issue 3, Page(s) 156–161

    Abstract: Introduction: To respond to the threat of dementia to public health and the economy, we need to prioritize research resources on strategies that would be the most effective. In relation to the prevention of dementia, this article considers whether ... ...

    Abstract Introduction: To respond to the threat of dementia to public health and the economy, we need to prioritize research resources on strategies that would be the most effective. In relation to the prevention of dementia, this article considers whether lowering plasma homocysteine by B-vitamin supplementation is one of the top priority and cost-effective treatments.
    Method: A decision model was constructed to calculate the lifetime costs and quality-adjusted life years (QALYs) of providing B-vitamin treatment to people in the United Kingdom over 60 years with high levels (>13 μmol/L) of plasma homocysteine, which was compared to the lifetime costs and outcomes of not providing them with the treatment.
    Results: Treatment with B-vitamins will save £60,021 per QALY gained and so is highly cost-effective.
    Discussion: We anticipate that this provocative finding will be debated by scientists, clinicians, and policy makers and eventually be tested in future clinical trials.
    Language English
    Publishing date 2016-08-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2832891-7
    ISSN 2352-8737
    ISSN 2352-8737
    DOI 10.1016/j.trci.2016.07.002
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  10. Article ; Online: Homocysteine, B Vitamins, and Cognitive Impairment.

    Smith, A David / Refsum, Helga

    Annual review of nutrition

    2016  Volume 36, Page(s) 211–239

    Abstract: Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with cognitive decline, white matter damage, brain atrophy, neurofibrillary ... ...

    Abstract Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with cognitive decline, white matter damage, brain atrophy, neurofibrillary tangles, and dementia. Most homocysteine-lowering trials with folate and vitamins B6 and/or B12 tested as protective agents against cognitive decline were poorly designed by including subjects unlikely to benefit during the trial period. In contrast, trials in high-risk subjects, which have taken into account the baseline B vitamin status, show a slowing of cognitive decline and of atrophy in critical brain regions, results that are consistent with modification of the Alzheimer's disease process. Homocysteine may interact with both risk factors and protective factors, thereby identifying people at risk but also providing potential strategies for early intervention. Public health steps to slow cognitive decline should be promoted in individuals who are at risk of dementia, and more trials are needed to see if simple interventions with nutrients can prevent progression to dementia.
    MeSH term(s) Aging ; Animals ; Biomarkers ; Cerebrovascular Circulation ; Cognition Disorders/epidemiology ; Cognition Disorders/etiology ; Cognition Disorders/prevention & control ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/prevention & control ; Dietary Supplements/adverse effects ; Evidence-Based Medicine ; Folic Acid/adverse effects ; Folic Acid/metabolism ; Folic Acid/therapeutic use ; Homocysteine/blood ; Homocysteine/metabolism ; Humans ; Hyperhomocysteinemia/diet therapy ; Hyperhomocysteinemia/epidemiology ; Hyperhomocysteinemia/metabolism ; Hyperhomocysteinemia/physiopathology ; Neurodegenerative Diseases/epidemiology ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/physiopathology ; Neurodegenerative Diseases/prevention & control ; Nootropic Agents/adverse effects ; Nootropic Agents/metabolism ; Nootropic Agents/therapeutic use ; Nutritional Status ; Practice Guidelines as Topic ; Risk Factors ; Vitamin B 12/adverse effects ; Vitamin B 12/metabolism ; Vitamin B 12/therapeutic use ; Vitamin B 6/adverse effects ; Vitamin B 6/metabolism ; Vitamin B 6/therapeutic use
    Chemical Substances Biomarkers ; Nootropic Agents ; Homocysteine (0LVT1QZ0BA) ; Vitamin B 6 (8059-24-3) ; Folic Acid (935E97BOY8) ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2016-07-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 406980-8
    ISSN 1545-4312 ; 0199-9885
    ISSN (online) 1545-4312
    ISSN 0199-9885
    DOI 10.1146/annurev-nutr-071715-050947
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