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Book ; Conference proceedings: Workshop on the Implementation of Three Dimensional Conformal Radiotherapy

Smith, Alfred R.

Bethesda, Maryland, April 21 - 22, 1994

(International journal of radiation oncology, biology, physics ; 33,5 : Special issue)

1995

Title variant	The implementation of three dimensional conformal radiotherapy
Event/congress	Workshop on the Implementation of Three-Dimensional Conformal Radiotherapy (1994, BethesdaMd.)
Author's details	eds. Alfred R. Smith
Series title	International journal of radiation oncology, biology, physics ; 33,5 : Special issue
Collection
Keywords	Neoplasms / radiotherapy / congresses ; Radiotherapy, Computer-Assisted / methods / congresses ; Radiotherapy Planning, Computer-Assisted / congresses ; Strahlentherapie
Subject	Bestrahlung ; Radiotherapie ; Strahlenbehandlung ; Radioonkologie
Language	English
Size	XXXI S., S. 977 - 1343 : Ill., graph. Darst.
Publisher	Pergamon
Publishing place	New York, NY
Publishing country	United States
Document type	Book ; Conference proceedings
HBZ-ID	HT006846425
Database	Catalogue ZB MED Medicine, Health

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Zs A 1218 -33-	not available for loan	Zeitschriften-Lesesaal

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Article ; Online: Doxycycline Prophylaxis for Skin and Soft Tissue Infections in Naval Special Warfare Trainees, United States

Spiro, Jeffrey / Wisniewski, Piotr / Schwartz, Julia / Smith, Alfred G / Burger, Sara / Tilley, Drake H / Maves, Ryan C

Emerging infectious diseases

2024 Volume 30, Issue 1, Page(s) 89–95

Abstract: In 2015, several severe cases of skin and soft tissue infection (SSTI) among US Naval Special Warfare trainees prompted the introduction of doxycycline prophylaxis during the highest-risk portion of training, Hell Week. We performed a retrospective ... ...

Abstract	In 2015, several severe cases of skin and soft tissue infection (SSTI) among US Naval Special Warfare trainees prompted the introduction of doxycycline prophylaxis during the highest-risk portion of training, Hell Week. We performed a retrospective analysis of the effect of this intervention on SSTI incidence and resulting hospital admissions during 2013-2020. In total, 3,371 trainees underwent Hell Week training during the study period; 284 SSTIs were diagnosed overall, 29 of which led to hospitalization. After doxycycline prophylaxis was introduced, admission rates for SSTI decreased from 1.37 to 0.64 admissions/100 trainees (p = 0.036). Overall SSTI rates remained stable at 7.42 to 8.86 SSTIs/100 trainees (p = 0.185). Hospitalization rates per diagnosed SSTI decreased from 18.4% to 7.2% (p = 0.009). Average length of hospitalization decreased from 9.01 days to 4.33 days (p = 0.034). Doxycycline prophylaxis was associated with decreased frequency and severity of hospitalization for SSTIs among this population.
MeSH term(s)	United States/epidemiology ; Humans ; Doxycycline/therapeutic use ; Retrospective Studies ; Soft Tissue Infections/epidemiology ; Soft Tissue Infections/prevention & control ; Skin ; Hospitalization
Chemical Substances	Doxycycline (N12000U13O)
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid3001.230890
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Zs.A 4778: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Book: Radiation therapy physics

Altschuler, Martin D. / Smith, Alfred R.

(Medical radiology)

1995

Author's details	contributors M. D. Altschuler ... Ed. by Alfred R. Smith
Series title	Medical radiology
Keywords	Radiotherapy, High-Energy ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy Dosage ; Dose-Response Relationship, Radiation ; Strahlentherapie ; Physik
Subject	Bestrahlung ; Radiotherapie ; Strahlenbehandlung ; Radioonkologie ; Naturlehre
Language	English
Size	X, 465 S. : Ill., graph. Darst.
Publisher	Springer
Publishing place	Berlin u.a.
Document type	Book
HBZ-ID	HT006496516
ISBN	3-540-55430-0 ; 0-387-55430-0 ; 978-3-540-55430-1 ; 978-0-387-55430-3
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2004 A 6841	order for loan	Magazin
1995 A 3756	order for loan	Magazin

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Article ; Online: Intensive Care Unit Preparedness During Pandemics and Other Biological Threats.

Maves, Ryan C / Jamros, Christina M / Smith, Alfred G

Critical care clinics

2019 Volume 35, Issue 4, Page(s) 609–618

Abstract: In the twenty-first century, severe acute respiratory syndrome (SARS), 2009 A(H1N1) influenza, and Ebola have all placed strains on critical care systems. In addition to the increased patient needs common to many disasters, epidemics may further degrade ... ...

Abstract	In the twenty-first century, severe acute respiratory syndrome (SARS), 2009 A(H1N1) influenza, and Ebola have all placed strains on critical care systems. In addition to the increased patient needs common to many disasters, epidemics may further degrade ICU capability when staff members fall ill, including in the course of direct patient care. In a large-scale pandemic, shortages of equipment and medications can further limit an ICU's ability to provide the normal standard of care. Hospital preparedness for epidemics must include strategies to maintain staff safety, secure adequate supplies, and have plans for triage and prioritization of care when necessary.
MeSH term(s)	Disaster Planning ; Hemorrhagic Fever, Ebola/epidemiology ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza, Human/epidemiology ; Influenza, Human/therapy ; Intensive Care Units/organization & administration ; Pandemics ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/therapy
Keywords	covid19
Language	English
Publishing date	2019-07-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1006423-0
ISSN	1557-8232 ; 0749-0704
ISSN (online)	1557-8232
ISSN	0749-0704
DOI	10.1016/j.ccc.2019.06.001
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Article: Vision 20/20: proton therapy.

Smith, Alfred R

Medical physics

2009 Volume 36, Issue 2, Page(s) 556–568

Abstract: The first patients were treated with proton beams in 1955 at the Lawrence Berkeley Laboratory in California. In 1970, proton beams began to be used in research facilities to treat cancer patients using fractionated treatment regimens. It was not until ... ...

Abstract	The first patients were treated with proton beams in 1955 at the Lawrence Berkeley Laboratory in California. In 1970, proton beams began to be used in research facilities to treat cancer patients using fractionated treatment regimens. It was not until 1990 that proton treatments were carried out in hospital-based facilities using technology and techniques that were comparable to those for modern photon therapy. Clinical data strongly support the conclusion that proton therapy is superior to conventional radiation therapy in a number of disease sites. Treatment planning studies have shown that proton dose distributions are superior to those for photons in a wide range of disease sites indicating that additional clinical gains can be achieved if these treatment plans can be reliably delivered to patients. Optimum proton dose distributions can be achieved with intensity modulated protons (IMPT), but very few patients have received this advanced form of treatment. It is anticipated widespread implementation of IMPT would provide additional improvements in clinical outcomes. Advances in the last decade have led to an increased interest in proton therapy. Currently, proton therapy is undergoing transitions that will move it into the mainstream of cancer treatment. For example, proton therapy is now reimbursed, there has been rapid development in proton therapy technology, and many new options are available for equipment, facility configuration, and financing. During the next decade, new developments will increase the efficiency and accuracy of proton therapy and enhance our ability to verify treatment planning calculations and perform quality assurance for proton therapy delivery. With the implementation of new multi-institution clinical studies and the routine availability of IMPT, it may be possible, within the next decade, to quantify the clinical gains obtained from optimized proton therapy. During this same period several new proton therapy facilities will be built and the cost of proton therapy is expected to decrease, making proton therapy routinely available to a larger population of cancer patients.
MeSH term(s)	Carbon ; Humans ; Positron-Emission Tomography ; Protons/therapeutic use ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Intensity-Modulated/economics ; Radiotherapy, Intensity-Modulated/instrumentation ; Radiotherapy, Intensity-Modulated/methods ; Radiotherapy, Intensity-Modulated/trends ; Tomography, X-Ray Computed
Chemical Substances	Protons ; Carbon (7440-44-0)
Language	English
Publishing date	2009-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	188780-4
ISSN	0094-2405
ISSN	0094-2405
DOI	10.1118/1.3058485
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Zs.A 1210: Show issues

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Article: Proton therapy.

Smith, Alfred R

Physics in medicine and biology

2006 Volume 51, Issue 13, Page(s) R491–504

Abstract: Proton therapy has become a subject of considerable interest in the radiation oncology community and it is expected that there will be a substantial growth in proton treatment facilities during the next decade. I was asked to write a historical review of ...

Abstract	Proton therapy has become a subject of considerable interest in the radiation oncology community and it is expected that there will be a substantial growth in proton treatment facilities during the next decade. I was asked to write a historical review of proton therapy based on my personal experiences, which have all occurred in the United States, so therefore I have a somewhat parochial point of view. Space requirements did not permit me to mention all of the existing proton therapy facilities or the names of all of those who have contributed to proton therapy.
MeSH term(s)	Health Physics/instrumentation ; Health Physics/methods ; Health Physics/trends ; Particle Accelerators/instrumentation ; Protons/therapeutic use ; Radiotherapy/instrumentation ; Radiotherapy/methods ; Radiotherapy/trends ; Radiotherapy Planning, Computer-Assisted/instrumentation ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy Planning, Computer-Assisted/trends
Chemical Substances	Protons
Language	English
Publishing date	2006-07-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/0031-9155/51/13/R26
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Zs.A 199: Show issues

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Article ; Online: Michael Goitein.

Smith, Alfred / Chen, George T Y / Suit, Herman / Bortfeld, Thomas / Epp, Edward

Medical physics

2017 Volume 44, Issue 3, Page(s) 795–797

MeSH term(s)	History, 20th Century ; History, 21st Century ; Nuclear Physics/history ; Switzerland
Language	English
Publishing date	2017-03-16
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	188780-4
ISSN	2473-4209 ; 0094-2405
ISSN (online)	2473-4209
ISSN	0094-2405
DOI	10.1002/mp.12088
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Article: Technology for proton therapy.

Flanz, Jacob / Smith, Alfred

Cancer journal (Sudbury, Mass.)

2009 Volume 15, Issue 4, Page(s) 292–297

Abstract: The technology that is used for the production and delivery of therapeutic proton beams is reviewed. Increased interest in this treatment modality has inspired a new generation of technology development and research into methods that will make proton ... ...

Abstract	The technology that is used for the production and delivery of therapeutic proton beams is reviewed. Increased interest in this treatment modality has inspired a new generation of technology development and research into methods that will make proton treatment facilities more widely available (less expensive) and more efficient. Proton beam therapy has been in use for more than 40 years; it remains a treatment modality of interest because it provides a highly conformal dose distribution to a wide variety of disease sites and the potential for improving clinical outcomes. Recent advances in beam scanning technology may represent the ultimate in external beam radiotherapy dose conformality and treatment delivery efficiency. We describe how this new technology can be integrated into a proton therapy facility.
MeSH term(s)	Acceleration ; Facility Design and Construction ; Health Facilities ; Humans ; Neoplasms/radiotherapy ; Protons/therapeutic use ; Radiometry/instrumentation ; Radiotherapy, Conformal/instrumentation ; Radiotherapy, Conformal/methods ; Synchrotrons
Chemical Substances	Protons
Language	English
Publishing date	2009-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2018400-1
ISSN	1528-9117 ; 1081-4442
ISSN	1528-9117 ; 1081-4442
DOI	10.1097/PPO.0b013e3181b11dd0
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Zs.A 4470: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 163: Show issues

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Article ; Online: The more important heavy charged particle radiotherapy of the future is more likely to be with heavy ions rather than protons.

Jäkel, Oliver / Smith, Alfred R / Orton, Colin G

Medical physics

2013 Volume 40, Issue 9, Page(s) 90601

MeSH term(s)	Heavy Ion Radiotherapy/trends ; Humans ; Neoplasms/radiotherapy ; Physical Phenomena ; Proton Therapy/trends
Language	English
Publishing date	2013-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	188780-4
ISSN	2473-4209 ; 0094-2405
ISSN (online)	2473-4209
ISSN	0094-2405
DOI	10.1118/1.4798945
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SARS-CoV-2 infection is associated with self-reported post-acute neuropsychological symptoms within six months of follow-up.

Andronescu, Liana R / Richard, Stephanie A / Scher, Ann I / Lindholm, David A / Mende, Katrin / Ganesan, Anuradha / Huprikar, Nikhil / Lalani, Tahaniyat / Smith, Alfred / Mody, Rupal M / Jones, Milissa U / Bazan, Samantha E / Colombo, Rhonda E / Colombo, Christopher J / Ewers, Evan / Larson, Derek T / Maves, Ryan C / Berjohn, Catherine M / Maldonado, Carlos J /

English, Caroline / Sanchez Edwards, Margaret / Rozman, Julia S / Rusiecki, Jennifer / Byrne, Celia / Simons, Mark P / Tribble, David / Burgess, Timothy H / Pollett, Simon D / Agan, Brian K

PloS one

2024 Volume 19, Issue 4, Page(s) e0297481

Abstract: Background: Chronic neuropsychological sequelae following SARS-CoV-2 infection, including depression, anxiety, fatigue, and general cognitive difficulties, are a major public health concern. Given the potential impact of long-term neuropsychological ... ...

Abstract	Background: Chronic neuropsychological sequelae following SARS-CoV-2 infection, including depression, anxiety, fatigue, and general cognitive difficulties, are a major public health concern. Given the potential impact of long-term neuropsychological impairment, it is important to characterize the frequency and predictors of this post-infection phenotype. Methods: The Epidemiology, Immunology, and Clinical Characteristics of Emerging Infectious Diseases with Pandemic Potential (EPICC) study is a longitudinal study assessing the impact of SARS-CoV-2 infection in U.S. Military Healthcare System (MHS) beneficiaries, i.e. those eligible for care in the MHS including active duty servicemembers, dependents, and retirees. Four broad areas of neuropsychological symptoms were assessed cross-sectionally among subjects 1-6 months post-infection/enrollment, including: depression (Patient Health Questionnaire-9), anxiety (General Anxiety Disorder-7), fatigue (PROMIS® Fatigue 7a), and cognitive function (PROMIS® Cognitive Function 8a and PROMIS® Cognitive Function abilities 8a). Multivariable Poisson regression models compared participants with and without SARS-CoV-2 infection history on these measures, adjusting for sex, ethnicity, active-duty status, age, and months post-first positive or enrollment of questionnaire completion (MPFP/E); models for fatigue and cognitive function were also adjusted for depression and anxiety scores. Results: The study population included 2383 participants who completed all five instruments within six MPFP/E, of whom 687 (28.8%) had at least one positive SARS-CoV-2 test. Compared to those who had never tested positive for SARS-CoV-2, the positive group was more likely to meet instrument-based criteria for depression (15.4% vs 10.3%, p<0.001), fatigue (20.1% vs 8.0%, p<0.001), impaired cognitive function (15.7% vs 8.6%, p<0.001), and impaired cognitive function abilities (24.3% vs 16.3%, p<0.001). In multivariable models, SARS-CoV-2 positive participants, assessed at an average of 2.7 months after infection, had increased risk of moderate to severe depression (RR: 1.44, 95% CI 1.12-1.84), fatigue (RR: 2.07, 95% CI 1.62-2.65), impaired cognitive function (RR: 1.64, 95% CI 1.27-2.11), and impaired cognitive function abilities (RR: 1.41, 95% CI 1.15-1.71); MPFP/E was not significant. Conclusions: Participants with a history of SARS-CoV-2 infection were up to twice as likely to report cognitive impairment and fatigue as the group without prior SARS-CoV-2 infection. These findings underscore the continued importance of preventing SARS-CoV-2 infection and while time since infection/enrollment was not significant through 6 months of follow-up, this highlights the need for additional research into the long-term impacts of COVID-19 to mitigate and reverse these neuropsychological outcomes.
MeSH term(s)	Humans ; Self Report ; COVID-19/complications ; COVID-19/epidemiology ; SARS-CoV-2 ; Follow-Up Studies ; Longitudinal Studies ; Fatigue/epidemiology ; Fatigue/etiology ; Anxiety Disorders
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0297481
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