Article ; Online: Accelerated Hemocompatibility Testing of Rotary Blood Pumps.
ASAIO journal (American Society for Artificial Internal Organs : 1992)
2023 Volume 69, Issue 10, Page(s) 918–923
Abstract: Ex vivo hemocompatibility testing is a vital element of preclinical assessment for blood-contacting medical devices. Current approaches are resource intensive; thus, we investigated the feasibility of accelerating hemocompatibility testing by ... ...
Abstract | Ex vivo hemocompatibility testing is a vital element of preclinical assessment for blood-contacting medical devices. Current approaches are resource intensive; thus, we investigated the feasibility of accelerating hemocompatibility testing by standardizing the number of pump exposures in loops of various sizes. Three identical blood loops were constructed, each with a custom-molded reservoir able to facilitate large-volume expansion. Using the HVAD rotary blood pump operating at 5 L·min -1 and 100 mmHg, three test volumes (80, 160, and 320 ml) were circulated for 4000 pump exposures. Blood sampling was performed at individualized intervals every one-sixth of total duration for the assessment of hemolysis and von Willebrand Factor (vWF) degradation. While steady increases in hemolysis (~24 mg·dl -1 ) were identified in all tests at completion, loop volume was not a primary discriminator. The normalized index of hemolysis did not vary significantly between loops (4.2-4.9 mg·100 L -1 ). vWF degradation progressively occurred with duration of testing to a similar extent under all conditions. These data support an accelerated approach to preclinical assessment of ex vivo blood damage. Adopting this approach enables: enhanced efficiency for rapid prototyping; reduced ex vivo blood aging, and; greater utility of blood, which is presently limited if 450 ml loops are desired. |
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MeSH term(s) | Humans ; von Willebrand Factor/metabolism ; Heart-Assist Devices/adverse effects ; Hemolysis ; Materials Testing ; Stress, Mechanical |
Chemical Substances | von Willebrand Factor |
Language | English |
Publishing date | 2023-09-27 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 759982-1 |
ISSN | 1538-943X ; 0162-1432 ; 1058-2916 |
ISSN (online) | 1538-943X |
ISSN | 0162-1432 ; 1058-2916 |
DOI | 10.1097/MAT.0000000000001995 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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