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  1. Article ; Online: Response to: 'Anakinra for palmoplantar pustulosis: results from a randomized, double-blind, multicentre, two-staged, adaptive placebo-controlled trial (APRICOT)': reply from the authors.

    Cro, S / Smith, C H

    The British journal of dermatology

    2022  Volume 186, Issue 5, Page(s) 909–910

    Abstract: We believe that there is significant interest in the role of IL-1 in the pathomechanism of palmoplantar pustulosis. However, the APRICOT study failed to demonstrate a therapeutic effect of the IL-1 receptor antagonist. So, we recommend that the authors ... ...

    Abstract We believe that there is significant interest in the role of IL-1 in the pathomechanism of palmoplantar pustulosis. However, the APRICOT study failed to demonstrate a therapeutic effect of the IL-1 receptor antagonist. So, we recommend that the authors perform an additional subgroup analysis based on the presence or absence of plaque psoriasis.
    MeSH term(s) Acute Disease ; Chronic Disease ; Double-Blind Method ; Exanthema/drug therapy ; Humans ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Prunus armeniaca ; Psoriasis/drug therapy ; Skin Diseases, Vesiculobullous/drug therapy
    Chemical Substances Interleukin 1 Receptor Antagonist Protein
    Language English
    Publishing date 2022-03-02
    Publishing country England
    Document type Letter ; Multicenter Study ; Randomized Controlled Trial ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.20944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Biologics for psoriasis: more drugs, new patient categories, but fresh challenges for clinical dermatologists.

    Pink, A E / Smith, C H

    The British journal of dermatology

    2017  Volume 177, Issue 1, Page(s) 7–8

    MeSH term(s) Biological Products/therapeutic use ; Clinical Trials as Topic ; Dermatologic Agents/therapeutic use ; Forecasting ; Humans ; Psoriasis/drug therapy
    Chemical Substances Biological Products ; Dermatologic Agents
    Language English
    Publishing date 2017
    Publishing country England
    Document type Editorial
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.15645
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  3. Article ; Online: Letter: a physiological dose of lactose and fructose is necessary to demonstrate intolerance--author's response.

    Wilder-Smith, C H

    Alimentary pharmacology & therapeutics

    2014  Volume 39, Issue 8, Page(s) 901–902

    MeSH term(s) Female ; Fructose Intolerance/diagnosis ; Gastrointestinal Diseases/diagnosis ; Humans ; Intestinal Absorption/physiology ; Lactose Intolerance/diagnosis ; Malabsorption Syndromes/diagnosis ; Male
    Language English
    Publishing date 2014-04
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.12697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Commentary: sugar intolerances in functional gastrointestinal disorders - author's reply.

    Wilder-Smith, C H

    Alimentary pharmacology & therapeutics

    2013  Volume 38, Issue 1, Page(s) 73

    MeSH term(s) Female ; Fructose Intolerance/diagnosis ; Gastrointestinal Diseases/diagnosis ; Humans ; Intestinal Absorption/physiology ; Lactose Intolerance/diagnosis ; Malabsorption Syndromes/diagnosis ; Male
    Language English
    Publishing date 2013-07
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.12351
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  5. Article ; Online: Aldara-induced dermatitis is associated with development of liver fibrosis in mice.

    Maybury, C M / Di Meglio, P / Smith, C H

    The British journal of dermatology

    2018  Volume 179, Issue 1, Page(s) 9–10

    MeSH term(s) Aminoquinolines ; Animals ; Disease Models, Animal ; Imiquimod ; Inflammation ; Liver Cirrhosis ; Mice
    Chemical Substances Aminoquinolines ; Imiquimod (P1QW714R7M)
    Language English
    Publishing date 2018-08-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.16693
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  6. Article ; Online: Subcutaneous methotrexate in patients with moderate-to-severe psoriasis: a critical appraisal.

    Tsakok, T / Jabbar-Lopez, Z K / Smith, C H

    The British journal of dermatology

    2018  Volume 179, Issue 1, Page(s) 50–53

    Abstract: Aim: Warren et al. set out to assess the effect of an intensified dosing schedule of subcutaneous methotrexate in patients with moderate-to-severe chronic plaque psoriasis.: Setting and design: This was a prospective, double-blind, randomized (3 : 1), ...

    Abstract Aim: Warren et al. set out to assess the effect of an intensified dosing schedule of subcutaneous methotrexate in patients with moderate-to-severe chronic plaque psoriasis.
    Setting and design: This was a prospective, double-blind, randomized (3 : 1), placebo-controlled study, conducted across 16 centres in Germany, France, the Netherlands and the U.K.
    Study exposure: Methotrexate-naive adults with a diagnosis of moderate-to-severe chronic plaque psoriasis for at least 6 months before baseline were randomly assigned to receive weekly subcutaneous injections of either methotrexate at a starting dose of 17·5 mg, or placebo for 16 weeks (first phase). Dose escalation to 22·5 mg per week was implemented after 8 weeks if patients did not achieve ≥ 50% improvement in Psoriasis Area and Severity Index (PASI 50). Treatment was combined with folic acid 5 mg per week. The first phase of the study was followed by an open-label period from 16 to 52 weeks (second phase), in which both groups received weekly methotrexate injections. At week 24, dose escalation to 22·5 mg per week was possible in patients not achieving PASI 50.
    Outcomes: Psoriasis severity was measured using PASI. The authors also used two other psoriasis severity measures and two quality-of-life measures, looked at safety indices and performed a substudy analysing paired skin biopsies at baseline and week 16 (histopathology, immunohistochemistry and expression of interleukin-17A, interferon-γ and tumour necrosis factor-α).
    Primary outcome measures: The primary outcome was the proportion of patients reaching PASI 75 at week 16.
    Results: In total 120 patients were included in this trial, most of whom were middle-aged white men with long-standing psoriasis, and the mean body mass index was 30·1 kg m
    Conclusion: Warren et al. conclude that the 52-week risk-benefit profile of subcutaneous methotrexate is favourable in patients with psoriasis.
    MeSH term(s) Adult ; Double-Blind Method ; France ; Germany ; Humans ; Male ; Methotrexate ; Middle Aged ; Netherlands ; Prospective Studies ; Psoriasis ; Treatment Outcome
    Chemical Substances Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2018-05-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.16424
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  7. Article: Bone marrow examination in blood disorders of infants and children.

    SMITH, C H

    The Medical clinics of North America

    2009  Volume 31, Page(s) 525–536

    MeSH term(s) Blood ; Bone Marrow ; Bone Marrow Examination ; Child ; Hematologic Diseases ; Humans ; Infant
    Language English
    Publishing date 2009-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 215710-x
    ISSN 1557-9859 ; 0025-7125
    ISSN (online) 1557-9859
    ISSN 0025-7125
    DOI 10.1016/s0025-7125(16)35809-6
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  8. Article: Diagnosis of anemias in infancy and childhood.

    SMITH, C H

    Journal of the American Medical Association

    2009  Volume 134, Issue 12, Page(s) 992–997

    MeSH term(s) Anemia ; Child ; Humans ; Infant ; Tracheophyta
    Language English
    Publishing date 2009-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0002-9955 ; 0254-9077 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0002-9955 ; 0254-9077 ; 0098-7484
    DOI 10.1001/jama.1947.02880290006002
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  9. Article ; Online: Developing an online patient education resource for topical therapy: a pilot study.

    Tull, T J / Jackson, K / Smith, C H / Pink, A E

    The British journal of dermatology

    2019  Volume 182, Issue 2, Page(s) 508–509

    MeSH term(s) Education, Distance ; Humans ; Internet ; Patient Education as Topic ; Pilot Projects
    Language English
    Publishing date 2019-11-06
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.18443
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  10. Article: Management of the Anemias in Infancy and Childhood.

    Smith, C H

    Bulletin of the New York Academy of Medicine

    2009  Volume 16, Issue 8, Page(s) 525–545

    Language English
    Publishing date 2009-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1314-6
    ISSN 0028-7091
    ISSN 0028-7091
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