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  1. Article ; Online: Service-Learning in Physician Assistant Education: A Scoping Review.

    Oliveira, Ana L / Smith, Catherine H / Xavier, Neena A

    The journal of physician assistant education : the official journal of the Physician Assistant Education Association

    2023  Volume 34, Issue 1, Page(s) 41–45

    Abstract: Introduction: Service-learning (SL) is a pedagogy that can be used in healthcare education to develop students who are better prepared to address the various social determinants of health and to provide compassionate care to the diverse populations they ...

    Abstract Introduction: Service-learning (SL) is a pedagogy that can be used in healthcare education to develop students who are better prepared to address the various social determinants of health and to provide compassionate care to the diverse populations they will serve. Yet, an assessment of the quality and scope of the SL activities used in physician assistant (PA) education is not available. The purpose of this scoping review is to review the literature and identify and summarize articles about SL courses in PA education.
    Methods: We performed a scoping literature search of 4 databases (CINAHL, PubMed, Embase, and Scopus) to identify peer-reviewed journal articles about SL in PA education. Studies that did not include PA students, were not a service-learning activity (but instead an interprofessional activity, simulation, or volunteerism), or were not a full article were all excluded.
    Results: Nine articles were included in this scoping review after independent evaluation by 2 investigators based on specific inclusion and exclusion criteria. The most common reason for exclusion was lack of distinct learning objectives specific to the service learning and/or a lack of a structured, guided critical reflection that helped realize and demonstrate the desired learning outcomes.
    Discussion: Although service-learning is considered to be a high-impact teaching practice, it is still an underutilized tool in PA education. Training faculty in the implementation of SL to align the hands-on activity with specific course learning objectives and in the effective use of structured critical reflection can create a more impactful and authentic SL educational experience.
    MeSH term(s) Humans ; Physician Assistants/education ; Learning ; Students ; Clinical Competence ; Faculty
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2620682-1
    ISSN 1941-9449 ; 1941-9430
    ISSN (online) 1941-9449
    ISSN 1941-9430
    DOI 10.1097/JPA.0000000000000481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Spesolimab in the treatment of generalized pustular psoriasis: a critically appraised research paper.

    Ali, Fatima / Smith, Catherine H / Mahil, Satveer K

    The British journal of dermatology

    2023  Volume 188, Issue 3, Page(s) 328–329

    MeSH term(s) Humans ; Psoriasis ; Antibodies, Monoclonal, Humanized ; Chronic Disease ; Acute Disease
    Chemical Substances spesolimab (5IB2J79MCX) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljac049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: In chronic plaque psoriasis, roflumilast cream safely increased likelihood of clear or almost clear state at 6 weeks.

    Mahil, Satveer K / Smith, Catherine H

    Annals of internal medicine

    2020  Volume 173, Issue 10, Page(s) JC55

    Abstract: Source citation: Lebwohl MG, Papp KA, Stein Gold L, et al. ...

    Abstract Source citation: Lebwohl MG, Papp KA, Stein Gold L, et al.
    MeSH term(s) Aminopyridines/adverse effects ; Benzamides/adverse effects ; Cyclopropanes ; Humans ; Psoriasis/drug therapy ; Treatment Outcome
    Chemical Substances Aminopyridines ; Benzamides ; Cyclopropanes ; Roflumilast (0P6C6ZOP5U)
    Keywords covid19
    Language English
    Publishing date 2020-11-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJ202011170-055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Impact of Immune-Modifying Treatments for Skin Diseases on the Immune Response to COVID-19 Vaccines: a Narrative Review.

    Liew, Su-Yi / Tree, Timothy / Smith, Catherine H / Mahil, Satveer K

    Current dermatology reports

    2022  , Page(s) 1–26

    Abstract: Purpose of review: SARS-CoV-2 has had a devastating global effect, with vaccinations being paramount in the public health strategy against COVID-19. Vaccinations have uncoupled infection from adverse COVID-19 outcomes worldwide. While immune-modifying ... ...

    Abstract Purpose of review: SARS-CoV-2 has had a devastating global effect, with vaccinations being paramount in the public health strategy against COVID-19. Vaccinations have uncoupled infection from adverse COVID-19 outcomes worldwide. While immune-modifying therapies are effective for the management of skin diseases such as psoriasis and atopic dermatitis, these medications also impair protective immune responses. There has been longstanding uncertainty and concern over the impact of immune-modifying therapies on the effectiveness of vaccines; for example, it is well recognised that methotrexate impairs humoral responses to both influenza and pneumococcal vaccines. This narrative review aims to discuss the evidence to date on the impact of immune-modifying therapies on the immune response to COVID-19 vaccines, with a focus on the first two vaccine doses.
    Recent findings: Individuals receiving immune-modifying therapy are more likely to have attenuated humoral responses to a single dose of COVID-19 vaccine compared to healthy controls; however, this may be improved by a complete course of vaccination. B cell targeted biologics such as rituximab markedly impair the humoral response to both the first and second COVID-19 vaccination. There remains a paucity of data on cellular immune responses, with the few available studies indicating lower responses to two vaccine doses in individuals receiving immune-modifying therapies compared to healthy controls, which may impact the durability of immune responses.
    Summary: Inadequate humoral immune responses to a single dose of vaccine in the context of immune-modifying therapy are improved by a complete course of vaccination. Individuals receiving immune-modifying treatments should be encouraged to take up a complete vaccine course to mitigate their risk against COVID-19. Research in large patient populations on the longevity/kinetics of the complex humoral and cellular response to subsequent vaccine doses, including against newer variants of concern, is warranted, in addition to data on immune correlates of vaccine clinical effectiveness.
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2162-4933
    ISSN 2162-4933
    DOI 10.1007/s13671-022-00376-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Psoriasis biologics: a new era of choice.

    Mahil, Satveer K / Smith, Catherine H

    Lancet (London, England)

    2019  Volume 394, Issue 10201, Page(s) 807–808

    MeSH term(s) Antibodies, Monoclonal ; Biological Products ; Humans ; Psoriasis
    Chemical Substances Antibodies, Monoclonal ; Biological Products ; guselkumab (089658A12D) ; secukinumab (DLG4EML025)
    Language English
    Publishing date 2019-08-08
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)31772-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: In chronic plaque psoriasis, roflumilast cream safely increased likelihood of clear or almost clear state at 6 weeks

    Mahil, Satveer K / Smith, Catherine H

    Ann Intern Med

    Abstract: SOURCE CITATION: Lebwohl MG, Papp KA, Stein Gold L, et al. Trial of roflumilast cream for chronic plaque psoriasis. N Engl J Med. 2020;383:229-39. 32668113. ...

    Abstract SOURCE CITATION: Lebwohl MG, Papp KA, Stein Gold L, et al. Trial of roflumilast cream for chronic plaque psoriasis. N Engl J Med. 2020;383:229-39. 32668113.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #33197348
    Database COVID19

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  7. Article ; Online: Are Janus kinase inhibitors an effective treatment for palmoplantar pustulosis? A critically appraised topic.

    Gleeson, David / Barker, Jonathan N W N / Capon, Francesca / Pink, Andrew E / Woolf, Richard T / Smith, Catherine H / Mahil, Satveer K

    The British journal of dermatology

    2023  Volume 188, Issue 4, Page(s) 471–473

    MeSH term(s) Humans ; Janus Kinase Inhibitors/therapeutic use ; Psoriasis/drug therapy ; Exanthema ; Chronic Disease ; Treatment Outcome
    Chemical Substances Janus Kinase Inhibitors
    Language English
    Publishing date 2023-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljac130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Effectiveness and survival of methotrexate versus adalimumab in patients with moderate-to-severe psoriasis: a cohort study from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR).

    Alabas, Oras A / Mason, Kayleigh J / Yiu, Zenas Z N / Warren, Richard B / Lunt, Mark / Smith, Catherine H / Griffiths, Christopher E M

    The British journal of dermatology

    2023  Volume 189, Issue 3, Page(s) 271–278

    Abstract: Background: Most information on the comparative effectiveness and survival of methotrexate (MTX) and adalimumab (ADA) in the treatment of psoriasis is from randomized control trials and may not translate to the everyday clinical setting.: Objectives: ...

    Abstract Background: Most information on the comparative effectiveness and survival of methotrexate (MTX) and adalimumab (ADA) in the treatment of psoriasis is from randomized control trials and may not translate to the everyday clinical setting.
    Objectives: To determine the real-world effectiveness and survival of MTX and ADA in patients with moderate-to-severe psoriasis registered in the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR).
    Methods: Eligible patients were registered in BADBIR, ≥ 16 years of age and receiving a first course of MTX or ADA between September 2007 and December 2021, with ≥ 6 months of follow-up. Effectiveness was defined as achieving an absolute Psoriasis Area and Severity Index (PASI) ≤ 2 reported ≥ 13 weeks after the treatment start date until the stop date. The average treatment effect (ATE) was estimated using inverse probability of treatment weighting with propensity score, including baseline covariates. ATE results were presented as risk ratios (RR). A flexible parametric model was used to estimate adjusted standardized average survival, defined as treatment discontinuation associated with ineffectiveness or the occurrence of adverse events (AEs) at 6, 12 and 24 months. Restricted mean survival time (RMST) at 2 years of treatment exposure was calculated.
    Results: In total, 6575 patients (median age 44 years; 44% female) were analysed; 2659 (40.4%) were prescribed MTX and 3916 (59.5%) ADA. The proportion of patients achieving PASI ≤ 2 was higher in the ADA cohort (77.4%) than in the MTX cohort (37.4%). ADA was more effective than MTX [RR 2.20, 95% confidence interval (CI) 1.98-2.45]. Overall survival associated with ineffectiveness or AEs was lower in the MTX cohort than in the ADA cohort at 6 months [survival estimate 69.7 (95% CI 67.9-71.5) vs. 90.6 (95% CI 89.8-91.4)], 1 year [survival estimate 52.5 (95% CI 50.4-54.8) vs. 80.6 (95% CI 79.5-81.8)] and 2 years [survival estimate 34.8 (95% CI 32.5-37.2) vs. 68.6 (95% CI 67.2-70.0)]. The difference in RMST (years) overall, or when stratified by ineffectiveness and AEs, was 0.53 (95% CI 0.49-0.58), 0.37 (95% CI 0.33-0.42) and 0.29 (95% CI 0.25-0.33), respectively.
    Conclusions: Patients on ADA were twice as likely to be clear or nearly clear of psoriasis and were less likely to discontinue their medication than patients on MTX. Findings from this real-world cohort provide important information to aid clinicians managing patients with psoriasis.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Adalimumab/adverse effects ; Adjuvants, Immunologic/therapeutic use ; Biological Factors/therapeutic use ; Biological Products/adverse effects ; Cohort Studies ; Dermatologists ; Etanercept/therapeutic use ; Immunologic Factors/therapeutic use ; Methotrexate/adverse effects ; Psoriasis/drug therapy ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Adalimumab (FYS6T7F842) ; Adjuvants, Immunologic ; Biological Factors ; Biological Products ; Etanercept (OP401G7OJC) ; Immunologic Factors ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljad179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Anxiety and Depression in People with Eczema or Psoriasis: A Comparison of Associations in UK Biobank and Linked Primary Care Data.

    Matthewman, Julian / Mansfield, Kathryn E / Hayes, Joseph F / Adesanya, Elizabeth I / Smith, Catherine H / Roberts, Amanda / Langan, Sinéad M / Henderson, Alasdair D

    Clinical epidemiology

    2023  Volume 15, Page(s) 891–899

    Abstract: Introduction: Previous research has shown associations between eczema and psoriasis and anxiety and depression. We investigated whether associations are consistent across different settings of ascertainment for depression and anxiety, including ... ...

    Abstract Introduction: Previous research has shown associations between eczema and psoriasis and anxiety and depression. We investigated whether associations are consistent across different settings of ascertainment for depression and anxiety, including interview and survey responses from UK Biobank (a large longitudinal cohort recruiting individuals aged 40-69 years between 2006-2010), and linked primary care data, with the aim of drawing more reliable conclusions through triangulation.
    Methods: In cross-sectional studies, we estimated associations between eczema or psoriasis and anxiety or depression, defining anxiety or depression as 1) self-reported previous diagnosis at UK Biobank recruitment interview; 2) PHQ-9/GAD-7 score indicating depression or anxiety from a UK Biobank mental health follow-up survey in 2016; and 3) diagnosis in linked primary care electronic health record data.
    Results: We analysed 230,047 people with linked Biobank and primary care data. We found poor agreement between the data sources for eczema, psoriasis, anxiety, and depression. Eg, 9474 had a previous eczema diagnosis in primary care data, 4069 self-reported previous eczema diagnosis at the UK biobank interview, and 1536 had eczema in both data sources (for depression 40,455; 13,320; and 9588 respectively). Having eczema or psoriasis (recorded in primary care or baseline interview) was associated with higher odds of anxiety and depression. Eg, the adjusted odds ratio for depression comparing those with eczema to those without was greater than 1 when defining the outcome from 1) the recruitment interview (1.36, 95% confidence interval 1.27-1.45); 2) the follow-up survey (1.24, 1.09-1.39), and 3) primary care records (1.56, 1.50-1.62).
    Discussion: Our findings support increased prevalence of mental illness in people with psoriasis and eczema across multiple data sources, which should be considered in planning of mental health services. However, we found poor agreement in disease ascertainment between settings, with implications for data interpretation in electronic health records.
    Language English
    Publishing date 2023-08-07
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494772-6
    ISSN 1179-1349
    ISSN 1179-1349
    DOI 10.2147/CLEP.S417176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Neutropenia in patients on dupilumab for atopic dermatitis: a case series and review of trial data.

    Pathmarajah, Pirunthan / Corso, Roberto / Salam, Amr / Shah, Gulnaz / Woolf, Richard / Smith, Catherine H / Pink, Andrew E

    The British journal of dermatology

    2023  Volume 188, Issue 6, Page(s) 803–805

    MeSH term(s) Humans ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal, Humanized/adverse effects ; Dermatitis, Atopic/drug therapy ; Neutropenia/chemically induced ; Neutropenia/drug therapy ; Severity of Illness Index ; Treatment Outcome ; Male ; Adult
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; dupilumab (420K487FSG)
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljad038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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