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Book: Away from the past and to a sustainable future335

Smith, Ian R. / Smith, Stephen K.

how the UK's health and social care systems can be reformed to better align with the needs of today's society

(Health service journal ; [125,6453, Beil.])

2015

Author's details	Ian R. Smith and Stephen K. Smith
Series title	Health service journal ; [125,6453, Beil.]
Collection
Language	English
Size	15 S. : graph. Darst.
Publishing place	S.l.
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT018766820
Database	Catalogue ZB MED Medicine, Health

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Zs B 1112 -[125,6453,Beil.]-	verfügbar in Königswinter	Königswinter

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Article: How to bring the NHS back from the permanent brink of collapse.

Smith, Ian R

The Health service journal

2018 Volume 126, Issue 6501, Page(s) 11

Abstract: Three sets of coordinated actions are required if the health service is to pull back from the edge of the cliff - and stay there. ...

Abstract	Three sets of coordinated actions are required if the health service is to pull back from the edge of the cliff - and stay there.
MeSH term(s)	Delivery of Health Care/organization & administration ; Health Care Reform/organization & administration ; Humans ; Organizational Objectives ; State Medicine/organization & administration ; United Kingdom
Language	English
Publishing date	2018-08-09
Publishing country	England
Document type	Journal Article
ZDB-ID	632799-0
ISSN	0952-2271 ; 0300-8347
ISSN	0952-2271 ; 0300-8347
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Conference proceedings: Philippine tilapia economics

Smith, Ian R.

[proceedings of a PCARRD ICLARM Workshop, Los Baños, Laguna, Philippines, 10 - 13 August 1983]

(ICLARM conference proceedings ; 12 ; ICLARM contribution ; 254)

1985

Author's details	ed. by Ian R. Smith
Series title	ICLARM conference proceedings ; 12 ICLARM contribution ; 254
Collection
Keywords	Philippinen ; Tilapia ; Aquakultur
Subject	Tilapien
Size	V, 261 S. : Ill., graph. Darst., Kt.
Publisher	Philippine Council for Agriculture and Resources Research and Development u.a.
Publishing place	Manila
Publishing country	Philippines
Document type	Book ; Conference proceedings
HBZ-ID	HT004964722
ISBN	971-1022-18-4 ; 978-971-1022-18-1
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

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938/2309	available for loan (reading room)	Freihandmagazin (U1)

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Book ; Conference proceedings: Summary report of the PCARRD ICLARM Workshop on Philippine Tilapia Economics

Smith, Ian R.

[Los Baños, Laguna, 10 - 13 August 1983]

(ICLARM conference proceedings ; 10)

1983

Institution	Workshop on Philippine Tilapia Economics Philippine Council for Agriculture and Resources Research and Development
Author's details	ed. by Ian R. Smith
Series title	ICLARM conference proceedings ; 10
Collection
Keywords	Philippinen ; Tilapia ; Aquakultur ; Marketing
Subject	Tilapien ; Absatzwirtschaft ; Konsumgütermarketing ; Marketingpolitik ; Verbrauchsgut ; Verbrauchsgütermarketing ; Absatzpolitik ; Absatzplanung ; Verkaufsplanung
Size	V, 45 S. : graph. Darst.
Publishing place	Manila
Publishing country	Philippines
Document type	Book ; Conference proceedings
HBZ-ID	HT006452564
ISBN	971-1022-02-8 ; 978-971-1022-02-0
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

Shelf mark	Loan status	Location
948/3069	available for loan (reading room)	Freihandmagazin (U1)

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Book: A research framework for traditional fisheries

Smith, Ian R.

(ICLARM studies and reviews ; 2)

1983

Author's details	Ian R. Smith
Series title	ICLARM studies and reviews ; 2
Collection
Keywords	Entwicklungsländer ; Kleinfischerei ; Lebensstandard ; Entwicklungshilfe
Subject	Auslandshilfe ; Lebensführung ; Lebensniveau
Size	VII, 40 S. : graph. Darst.
Edition	Reprint.
Publishing place	Manila
Publishing country	Philippines
Document type	Book
HBZ-ID	HT006642442
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

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954/566	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Proteome census upon nutrient stress reveals Golgiphagy membrane receptors.

Hickey, Kelsey L / Swarup, Sharan / Smith, Ian R / Paoli, Julia C / Miguel Whelan, Enya / Paulo, Joao A / Harper, J Wade

Nature

2023 Volume 623, Issue 7985, Page(s) 167–174

Abstract: During nutrient stress, macroautophagy degrades cellular macromolecules, thereby providing biosynthetic building blocks while simultaneously remodelling the ... ...

Abstract	During nutrient stress, macroautophagy degrades cellular macromolecules, thereby providing biosynthetic building blocks while simultaneously remodelling the proteome
MeSH term(s)	Animals ; Autophagy/physiology ; Autophagy-Related Protein 8 Family/metabolism ; Endoplasmic Reticulum ; Golgi Apparatus/metabolism ; Mammals/metabolism ; Membrane Proteins/metabolism ; Nutrients/metabolism ; Proteome/metabolism ; Proteomics
Chemical Substances	Autophagy-Related Protein 8 Family ; Membrane Proteins ; Proteome
Language	English
Publishing date	2023-09-27
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-06657-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

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Article ; Online: Combinatorial selective ER-phagy remodels the ER during neurogenesis.

Hoyer, Melissa J / Capitanio, Cristina / Smith, Ian R / Paoli, Julia C / Bieber, Anna / Jiang, Yizhi / Paulo, Joao A / Gonzalez-Lozano, Miguel A / Baumeister, Wolfgang / Wilfling, Florian / Schulman, Brenda A / Harper, J Wade

Nature cell biology

2024 Volume 26, Issue 3, Page(s) 378–392

Abstract: The endoplasmic reticulum (ER) employs a diverse proteome landscape to orchestrate many cellular functions, ranging from protein and lipid synthesis to calcium ion flux and inter-organelle communication. A case in point concerns the process of ... ...

Abstract	The endoplasmic reticulum (ER) employs a diverse proteome landscape to orchestrate many cellular functions, ranging from protein and lipid synthesis to calcium ion flux and inter-organelle communication. A case in point concerns the process of neurogenesis, where a refined tubular ER network is assembled via ER shaping proteins into the newly formed neuronal projections to create highly polarized dendrites and axons. Previous studies have suggested a role for autophagy in ER remodelling, as autophagy-deficient neurons in vivo display axonal ER accumulation within synaptic boutons, and the membrane-embedded ER-phagy receptor FAM134B has been genetically linked with human sensory and autonomic neuropathy. However, our understanding of the mechanisms underlying selective removal of the ER and the role of individual ER-phagy receptors is limited. Here we combine a genetically tractable induced neuron (iNeuron) system for monitoring ER remodelling during in vitro differentiation with proteomic and computational tools to create a quantitative landscape of ER proteome remodelling via selective autophagy. Through analysis of single and combinatorial ER-phagy receptor mutants, we delineate the extent to which each receptor contributes to both the magnitude and selectivity of ER protein clearance. We define specific subsets of ER membrane or lumenal proteins as preferred clients for distinct receptors. Using spatial sensors and flux reporters, we demonstrate receptor-specific autophagic capture of ER in axons, and directly visualize tubular ER membranes within autophagosomes in neuronal projections by cryo-electron tomography. This molecular inventory of ER proteome remodelling and versatile genetic toolkit provide a quantitative framework for understanding the contributions of individual ER-phagy receptors for reshaping ER during cell state transitions.
MeSH term(s)	Humans ; Proteome ; Proteomics ; Endoplasmic Reticulum/metabolism ; Autophagy/physiology ; Endoplasmic Reticulum Stress ; Carrier Proteins/metabolism ; Neurogenesis
Chemical Substances	Proteome ; Carrier Proteins
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1474722-4
ISSN	1476-4679 ; 1465-7392
ISSN (online)	1476-4679
ISSN	1465-7392
DOI	10.1038/s41556-024-01356-4
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Zs.A 5169: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 12: Show issues

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Article ; Online: The impact of closed-loop electronic medication management on time to first dose: a comparative study between paper and digital hospital environments.

Austin, Jodie A / Smith, Ian R / Tariq, Amina

The International journal of pharmacy practice

2018 Volume 26, Issue 6, Page(s) 526–533

Abstract: Closed-loop electronic medication management systems (EMMS) are recognised as an effective intervention to improve medication safety, yet evidence of their effectiveness in hospitals is limited. Few studies have compared medication turnaround time for a ... ...

Abstract	Closed-loop electronic medication management systems (EMMS) are recognised as an effective intervention to improve medication safety, yet evidence of their effectiveness in hospitals is limited. Few studies have compared medication turnaround time for a closed-loop electronic versus paper-based medication management environment. Objective: To compare medication turnaround times in a paper-based hospital environment with a digital hospital equipped with a closed-loop EMMS, consisting of computerised physician order entry, profiled automated dispensing cabinets packaged with unit dose medications and barcode medication administration. Method: Data were collected during 2 weeks at three private hospital sites (one with closed-loop EMMS) within the same organisation network in Queensland, Australia. Time between scheduled and actual administration times was analysed for first dose of time-critical and non-critical medications located on the ward or sourced via pharmacy. Key findings: Medication turnaround times at the EMMS site were less compared to the paper-based sites (median, IQR: 35 min, 8-57 min versus 120 min, 30-180 min, P < 0.001). For time-critical medications, 77% were administered within 60 min of scheduled time at the EMMS site versus 38% for the paper-based sites. Similar difference was observed for non-critical medications, 80% were administered within 60 min of their scheduled time at the EMMS site versus 41% at the paper-based facilities. Conclusion: The study indicates medication turnaround times utilising a closed-loop EMMS are less compared to paper-based systems. This improvement may be attributable to increased accessibility of medications using automated dispensing cabinets and electronic medication administration records flagging tasks to nurses in real time.
MeSH term(s)	Drug Prescriptions ; Electronic Data Processing ; Electronic Prescribing ; Humans ; Medical Order Entry Systems/organization & administration ; Medication Systems, Hospital/organization & administration ; Multi-Institutional Systems ; Pharmacy Service, Hospital/organization & administration ; Queensland ; Time Factors
Language	English
Publishing date	2018-01-22
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	1087040-4
ISSN	2042-7174 ; 0961-7671
ISSN (online)	2042-7174
ISSN	0961-7671
DOI	10.1111/ijpp.12432
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Zs.A 3320: Show issues

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Article ; Online: Long-Term Results Following Repair for Degenerative Mitral Regurgitation - Analysis of Factors Influencing Durability.

Gardner, Michael Anthony / Hossack, Kenneth F / Smith, Ian R

Heart, lung & circulation

2018 Volume 28, Issue 12, Page(s) 1852–1865

Abstract: Background: The majority of patients with degenerative mitral regurgitation (DMR) are amenable to reconstructive procedures. There is debate regarding factors that influence long-term durability with respect to repair technique, valve remodelling and ... ...

Abstract	Background: The majority of patients with degenerative mitral regurgitation (DMR) are amenable to reconstructive procedures. There is debate regarding factors that influence long-term durability with respect to repair technique, valve remodelling and progressive myxomatous change. Methods: A total of 685 patients with DMR underwent mitral valve repair by a single surgeon between 1991 and 2011 with follow-up completed at 31 December 2016. Repair rate for patients undergoing surgery for DMR was over 90%. Mean age was 64 years (18-89) with 66.2% male, 47% NYHA class III-IV, and 20% had permanent atrial fibrillation (PAF). Major associated procedures were performed in 28% of patients (189); including coronary artery bypass graft (CABG) (127), aortic valve replacement (15), aortic root surgery (3) and tricuspid valve annuloplasty (61). Results: Operative mortality (≤30 days) occurred in four patients (0.58%). At 20 years, survival was 58%, freedom from reoperation was 90% and freedom from reoperation and non-operated recurrent MR >2+ (relapse) was 78%. Factors influencing survival were advancing age, left ventricular (LV) dysfunction (ejection fraction <60% or end systolic dimension >40mm), New York Heart Association (NYHA) III-IV and PAF. Predictors of relapse were the degree of residual intraoperative mitral regurgitation (p<0.001), anterior leaflet prolapse (p<0.001) and the addition of a sliding annuloplasty in isolated posterior leaflet repair (p=0.023). The majority of reoperations were for technical issues related to the original repair. A competent valve at 6 months to 3 years postoperatively predicted an excellent long-term result. Conclusion: The great majority of degenerative mitral valves are repairable regardless of age with excellent long-term results achievable following surgery. Survival is reduced by significant symptoms, LV dysfunction and preoperative PAF. Repair is best performed before these features develop. Durability is largely dependent on the technical performance of the repair and degree of residual MR on the post-pump transoesophageal echocardiogram. We recommend surgery should be performed by surgeons specialising and skilled in mitral valve repair.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/etiology ; Atrial Fibrillation/mortality ; Atrial Fibrillation/physiopathology ; Disease-Free Survival ; Echocardiography, Transesophageal ; Female ; Follow-Up Studies ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Male ; Middle Aged ; Mitral Valve/diagnostic imaging ; Mitral Valve/physiopathology ; Mitral Valve/surgery ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/mortality ; Mitral Valve Insufficiency/physiopathology ; Mitral Valve Insufficiency/surgery ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/mortality ; Postoperative Complications/physiopathology ; Risk Factors ; Survival Rate ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/physiopathology ; Tricuspid Valve/surgery
Language	English
Publishing date	2018-10-17
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2020980-0
ISSN	1444-2892 ; 1443-9506
ISSN (online)	1444-2892
ISSN	1443-9506
DOI	10.1016/j.hlc.2018.10.011
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Article ; Online: Coisolation of Peptide Pairs for Peptide Identification and MS/MS-Based Quantification.

Smith, Ian R / Eng, Jimmy K / Barente, Anthony S / Hogrebe, Alexander / Llovet, Ariadna / Rodriguez-Mias, Ricard A / Villén, Judit

Analytical chemistry

2022 Volume 94, Issue 44, Page(s) 15198–15206

Abstract: Stable-isotope labeling with amino acids in cell culture (SILAC)-based metabolic labeling is a widely adopted proteomics approach that enables quantitative comparisons among a variety of experimental conditions. Despite its quantitative capacity, SILAC ... ...

Abstract	Stable-isotope labeling with amino acids in cell culture (SILAC)-based metabolic labeling is a widely adopted proteomics approach that enables quantitative comparisons among a variety of experimental conditions. Despite its quantitative capacity, SILAC experiments analyzed with data-dependent acquisition (DDA) do not fully leverage peptide pair information for identification and suffer from undersampling compared to label-free proteomic experiments. Herein, we developed a DDA strategy that coisolates and fragments SILAC peptide pairs and uses y-ions for their relative quantification. To facilitate the analysis of this type of data, we adapted the Comet sequence database search engine to make use of SILAC peptide paired fragments and developed a tool to annotate and quantify MS/MS spectra of coisolated SILAC pairs. This peptide pair coisolation approach generally improved expectation scores compared to the traditional DDA approach. Fragment ion quantification performed similarly well to precursor quantification in the MS1 and achieved more quantifications. Lastly, our method enables reliable MS/MS quantification of SILAC proteome mixtures with overlapping isotopic distributions. This study shows the feasibility of the coisolation approach. Coupling this approach with intelligent acquisition strategies has the potential to improve SILAC peptide sampling and quantification.
MeSH term(s)	Isotope Labeling/methods ; Peptide Fragments ; Peptides ; Proteome/analysis ; Proteomics/methods ; Tandem Mass Spectrometry/methods
Chemical Substances	Peptide Fragments ; Peptides ; Proteome
Language	English
Publishing date	2022-10-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c01711
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