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  1. Article ; Online: Knee pain and swelling.

    Smith, Richard D J / Smith, Katherine Nabel / Shanmugam, Vignesh / Beltran, Luis S

    Skeletal radiology

    2023  Volume 52, Issue 9, Page(s) 1799–1800

    MeSH term(s) Humans ; Knee Joint/diagnostic imaging ; Knee ; Pain ; Treatment Outcome
    Language English
    Publishing date 2023-04-26
    Publishing country Germany
    Document type Editorial
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-023-04345-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Knee pain and swelling.

    Smith, Richard D J / Smith, Katherine Nabel / Shanmugam, Vignesh / Beltran, Luis S

    Skeletal radiology

    2023  Volume 52, Issue 9, Page(s) 1777–1779

    MeSH term(s) Humans ; Knee Joint/diagnostic imaging ; Knee ; Pain ; Treatment Outcome
    Language English
    Publishing date 2023-04-18
    Publishing country Germany
    Document type Editorial
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-023-04344-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Exploring dermatologists' perspectives on vaccines in dermatology: a qualitative study.

    Smith, Katherine Nabel / Algarin, Yanci A / Archila, Marjorie / Barbieri, John S / Goldman, Nathaniel / Perez-Chada, Lourdes M / Noe, Megan H

    Archives of dermatological research

    2023  Volume 316, Issue 1, Page(s) 36

    Abstract: Vaccination rates among adults in the United States, including dermatology patients, remain suboptimal. Previous research has concluded that outpatient specialty offices often have administrative and patient-related barriers to administering vaccines in ... ...

    Abstract Vaccination rates among adults in the United States, including dermatology patients, remain suboptimal. Previous research has concluded that outpatient specialty offices often have administrative and patient-related barriers to administering vaccines in their clinics, however, this has never been examined specifically in dermatology. This study aims to examine dermatologists' perspectives on vaccine education in dermatology clinics, identify facilitators and barriers to vaccine administration in dermatology clinics, and explore strategies to improve vaccination rates in dermatology patients. Virtual, semi-structured interviews were conducted with board-certified dermatologists to explore their perspectives on vaccines in dermatology clinic. The Consolidated Framework for Implementation Research was used to analyze the data. Participating dermatologists were 60% female (n = 9) and 40% male (n = 6) and had a median of 7 years of clinic experience (min-max: 3-39 years). Vaccine education emerged as one of the prominent themes during the interview with dermatologists, who emphasized the importance of comprehensive vaccine education for both healthcare providers and patients. Barriers identified encompassed patient hesitancy, lack of provider knowledge, resource limitations, and logistical challenges. Dermatologists proposed solutions such as standardized protocols, improved patient communication, enhanced coordination with other healthcare providers, and increased clinic resources. These results emphasize that dermatologists can play a crucial role in advocating for and addressing preventative care through vaccine implementation and provide a high-level framework to think about implementation. Additionally, this study highlights the need for comprehensive vaccine education, systematic implementation strategies, and organizational support within dermatology clinics to improve vaccine administration for patients.
    MeSH term(s) Adult ; Humans ; Male ; United States ; Female ; Dermatologists ; Dermatology ; Vaccination ; Health Personnel ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-12-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 130131-7
    ISSN 1432-069X ; 0340-3696
    ISSN (online) 1432-069X
    ISSN 0340-3696
    DOI 10.1007/s00403-023-02777-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Structural basis for VLDLR recognition by eastern equine encephalitis virus.

    Yang, Pan / Li, Wanyu / Fan, Xiaoyi / Pan, Junhua / Mann, Colin J / Varnum, Haley / Clark, Lars E / Clark, Sarah A / Coscia, Adrian / Smith, Katherine Nabel / Brusic, Vesna / Abraham, Jonathan

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Alphaviruses are arthropod-borne enveloped RNA viruses that include several important human pathogens with outbreak potential. Among them, eastern equine encephalitis virus (EEEV) is the most virulent, and many survivors develop neurological sequelae, ... ...

    Abstract Alphaviruses are arthropod-borne enveloped RNA viruses that include several important human pathogens with outbreak potential. Among them, eastern equine encephalitis virus (EEEV) is the most virulent, and many survivors develop neurological sequelae, including paralysis and intellectual disability. The spike proteins of alphaviruses comprise trimers of heterodimers of their envelope glycoproteins E2 and E1 that mediate binding to cellular receptors and fusion of virus and host cell membranes during entry. We recently identified very-low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2), two closely related proteins that are expressed in the brain, as cellular receptors for EEEV and a distantly related alphavirus, Semliki forest virus (SFV)
    Language English
    Publishing date 2023-11-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.14.567065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2.

    Hale, Malika / Netland, Jason / Chen, Yu / Thouvenel, Christopher D / Smith, Katherine Nabel / Rich, Lucille M / Vanderwall, Elizabeth R / Miranda, Marcos C / Eggenberger, Julie / Hao, Linhui / Watson, Michael J / Mundorff, Charles C / Rodda, Lauren B / King, Neil P / Guttman, Miklos / Gale, Michael / Abraham, Jonathan / Debley, Jason S / Pepper, Marion /
    Rawlings, David J

    The Journal of experimental medicine

    2022  Volume 219, Issue 9

    Abstract: Humoral immunity to SARS-CoV-2 can be supplemented with polyclonal sera from convalescent donors or an engineered monoclonal antibody (mAb) product. While pentameric IgM antibodies are responsible for much of convalescent sera's neutralizing capacity, ... ...

    Abstract Humoral immunity to SARS-CoV-2 can be supplemented with polyclonal sera from convalescent donors or an engineered monoclonal antibody (mAb) product. While pentameric IgM antibodies are responsible for much of convalescent sera's neutralizing capacity, all available mAbs are based on the monomeric IgG antibody subtype. We now show that IgM mAbs derived from immune memory B cell receptors are potent neutralizers of SARS-CoV-2. IgM mAbs outperformed clonally identical IgG antibodies across a range of affinities and SARS-CoV-2 receptor-binding domain epitopes. Strikingly, efficacy against SARS-CoV-2 viral variants was retained for IgM but not for clonally identical IgG. To investigate the biological role for IgM memory in SARS-CoV-2, we also generated IgM mAbs from antigen-experienced IgM+ memory B cells in convalescent donors, identifying a potent neutralizing antibody. Our results highlight the therapeutic potential of IgM mAbs and inform our understanding of the role for IgM memory against a rapidly mutating pathogen.
    MeSH term(s) Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/therapy ; Humans ; Immunization, Passive ; Immunoglobulin G ; Immunoglobulin M ; Memory B Cells ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; COVID-19 Serotherapy
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-08-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20220849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correction: IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2.

    Hale, Malika / Netland, Jason / Chen, Yu / Thouvenel, Christopher D / Smith, Katherine Nabel / Rich, Lucille M / Vanderwall, Elizabeth R / Miranda, Marcos C / Eggenberger, Julie / Hao, Linhui / Watson, Michael J / Mundorff, Charles C / Rodda, Lauren B / King, Neil P / Guttman, Miklos / Gale, Michael / Abraham, Jonathan / Debley, Jason S / Pepper, Marion /
    Rawlings, David J

    The Journal of experimental medicine

    2022  Volume 219, Issue 9

    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.2022084908172022c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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