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  1. Article ; Online: Cultivating curiosity about our patients can make all the difference to their care.

    Smith, Louise

    BMJ (Clinical research ed.)

    2024  Volume 384, Page(s) q129

    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.q129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: My Induction Into Anesthesiology: Where Words No Longer Work.

    Smith, L Daniela

    Anesthesia and analgesia

    2024  

    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 149: Show issues

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  3. Article ; Online: Should Patients Be Required to Receive COVID Vaccine to Be Listed for Kidney Transplant?: PRO.

    Smith, LaMorgan

    Kidney360

    2024  Volume 5, Issue 2, Page(s) 175–176

    MeSH term(s) Humans ; Kidney Transplantation ; COVID-19 Vaccines ; COVID-19/prevention & control ; Kidney Failure, Chronic ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The marine sponge, Hymeniacidon sinapium, displays allorecognition of siblings during post-larval settling and metamorphosis to juveniles.

    Smith, L Courtney

    Developmental and comparative immunology

    2024  Volume 157, Page(s) 105179

    Abstract: Marine sponges, including the crumb of bread sponge, Hymeniacidon sinapium, display allorejection responses to contact with conspecifics in both experimental and natural settings. These responses have been used to infer immunocompetence in a variety of ... ...

    Abstract Marine sponges, including the crumb of bread sponge, Hymeniacidon sinapium, display allorejection responses to contact with conspecifics in both experimental and natural settings. These responses have been used to infer immunocompetence in a variety of marine invertebrates. However, larvae and juveniles from several marine sponge species fuse and form chimeras. Some of these chimeras persist, whereas others eventually break down, revealing a period of allogeneic non-responsiveness that varies depending on the species. Alternatively, for H. sinapium, most pairs of sibling post-larvae and juveniles that settle in contact initiate immediate allorecognition and show the same morphological response progression as the adults. This indicates that allorecognition and response occurs during early metamorphosis. Results from H. sinapium and other sponge species, in addition to annotations of sponge genomes, suggest that allorecognition and immunocompetence in sponges are mediated by distinct systems and may become functional at different times during or after metamorphosis for different species. Consequently, allorecognition may not be a good proxy for the onset of immunocompetence.
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2024.105179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1327: Show issues Location:
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  5. Article: The saga of James Lucett and the process for curing insanity, Part 1 (1811-14): The rise and fall of Delahoyde and Lucett.

    Smith, Leonard

    History of psychiatry

    2023  , Page(s) 957154X231199352

    Abstract: James Lucett, a London clerk, claimed possession of a secret remedy for curing chronic insanity. In 1813, he and the Irish surgeon Charles Delahoyde secured royal and aristocratic patronage to implement their 'process' and opened a private asylum. They ... ...

    Abstract James Lucett, a London clerk, claimed possession of a secret remedy for curing chronic insanity. In 1813, he and the Irish surgeon Charles Delahoyde secured royal and aristocratic patronage to implement their 'process' and opened a private asylum. They aroused great public interest after apparently remarkable results with hitherto intractable patients from Bethlem and Hoxton. Delahoyde and Lucett attained brief celebrity, but within a year it was evident that the dramatic recoveries were only temporary. Their venture collapsed in disarray and bankruptcy, and the episode was soon largely forgotten. Delahoyde fled to Ireland, but Lucett managed to re-establish himself in practice. This article narrates the origins, operation and failure of the enterprise. A second article will consider Lucett's subsequent career.
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1028145-9
    ISSN 1740-2360 ; 0957-154X
    ISSN (online) 1740-2360
    ISSN 0957-154X
    DOI 10.1177/0957154X231199352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Space station and spacecraft environmental conditions and human mental health: Specific recommendations and guidelines.

    Smith, Logan

    Life sciences in space research

    2023  Volume 40, Page(s) 126–134

    Abstract: The way that a given environment may influence human mental health is widely established, with decades of research linking anxiety, depression, stress, productivity, and general mood with all facets of a given environment, including noise levels, ... ...

    Abstract The way that a given environment may influence human mental health is widely established, with decades of research linking anxiety, depression, stress, productivity, and general mood with all facets of a given environment, including noise levels, lighting, air quality, and other factors. The environmental conditions of a space habitat have far reaching consequences for human mental health and should be carefully managed. This manuscript serves to briefly review what is known about the main components of a space habitat (e.g., noise levels, lighting, air quality, privacy, plant life, etc.), and provide specific and clear recommendations for mission planners and space habitat designers. Where appropriate, opportunities for future research are highlighted.
    MeSH term(s) Humans ; Spacecraft ; Space Flight ; Mental Health
    Language English
    Publishing date 2023-10-11
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2214-5532
    ISSN (online) 2214-5532
    DOI 10.1016/j.lssr.2023.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Relationship Between Gene Expression Networks and Muscle Contractile Physiology Differences in Anolis Lizards.

    Smith, Luke

    South Dakota medicine : the journal of the South Dakota State Medical Association

    2023  Volume 76, Issue 9, Page(s) 404

    Abstract: Introduction: Muscles facilitate most animal behavior, from eating to fleeing. However, to generate the variation in behavior necessary for survival, different muscles must perform differently. For instance, sprinting requires multiple rapid muscle ... ...

    Abstract Introduction: Muscles facilitate most animal behavior, from eating to fleeing. However, to generate the variation in behavior necessary for survival, different muscles must perform differently. For instance, sprinting requires multiple rapid muscle contractions, whereas biting may require fewer contractions but greater force.
    Methods: Here, a transcriptomic approach was utilized to identify genes associated with variation in muscle contractile physiology among different muscles from the same individual. Differential gene expression was measured between a leg and jaw muscle of Anolis lizards (A. chlorocyanus, A. cybotes, A. osa, A. sagrei) known to differ in muscle contractile physiology and performance. For each individual, one muscle was used to measure muscle contractile physiology, including Vmax (the muscle contraction velocity at zero force), V40 (the muscle contraction velocity at 40% force), power ratio (a measure of the trade-off between force and velocity), and twitch time (the amount of time it takes to create and dissipate tension at 50% force). The contralateral muscle was used to extract RNA for transcriptomic sequencing. Weighted Gene Co-Expression Analysis (WGCNA) was performed to cluster differentially expressed genes into groups, or modules with color designations, based on an eigengene. Modules were correlated to physiologic metrics and analyzed for function with gene ontology (GO term) analysis.
    Results: Using the transcriptomic data, clear clustering of muscle type was found indicating there were no specific differences among the four species. Several contractile metrics were significantly different between the jaw and leg: twitch time, V40, and power ratio. Expression of genes clustered in GO terms related to muscle contraction and extracellular matrix was negatively correlated with slower twitch times but positively correlated to power ratio and V40. Conversely, genes related to the GO terms related to aerobic respiration were downregulated in muscles with higher power ratio and V40 and over-expressed with slower twitch times.
    Conclusions: Determining the molecular mechanisms that underlie variation in muscle contractile physiology can begin to explain how organisms are able to optimize behavior under variable conditions. Key areas of difference between gene expression of the jaw and leg included muscle contraction, energy synthesis, and extracellular structures. Modules relating to aerobic respiration are strongly correlated with slower twitch time likely due to slower utilization of ATP. Modules relating to muscle contraction and extracellular structure are negatively correlated with slower twitch time and positively correlated with V40 and power ratio indicating the increased need for structural components to increase and transmit force for greater power.
    MeSH term(s) Animals ; Lizards/genetics ; Muscle Contraction/genetics ; Muscles ; Gene Expression
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2278073-7
    ISSN 0038-3317
    ISSN 0038-3317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 205: Show issues Location:
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  8. Article: Regulation and the scope of practice of the RNA role.

    Smith, Laura

    British journal of nursing (Mark Allen Publishing)

    2023  Volume 32, Issue 8, Page(s) 368–370

    Abstract: The nursing associate role was introduced in in 2017, and is now registered with the Nursing and Midwifery Council. This article looks at the importance of understanding the registered nursing associate (RNA) scope of practice. In some areas, the roles ... ...

    Abstract The nursing associate role was introduced in in 2017, and is now registered with the Nursing and Midwifery Council. This article looks at the importance of understanding the registered nursing associate (RNA) scope of practice. In some areas, the roles of the RNA and registered nurse have become interchangeable with detriment to patient safety. The author explores the differences between the role of a registered nurse and an RNA, the training completed by RNAs and ways in which they can free the time of the registered nurse to provide more complex nursing care. As a registrant, nursing associates are accountable for their own practice and responsible for accepting tasks, as well as delegating tasks. Again, it is important that RNAs themselves and members of the multidisciplinary team understand what this means in practice and for maintaining patient safety.
    MeSH term(s) Humans ; Scope of Practice ; Nursing Care ; Nurse's Role
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1119191-0
    ISSN 0966-0461
    ISSN 0966-0461
    DOI 10.12968/bjon.2023.32.8.368
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    Zs.A 3449: Show issues Location:
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  9. Article: The saga of James Lucett and the process for curing insanity, Part 2 (1814-38): 'Insanity cured'.

    Smith, Leonard

    History of psychiatry

    2023  , Page(s) 957154X231211727

    Abstract: Following the collapse of the Delahoyde and Lucett joint enterprise, James Lucett resumed practice on his own account. He continued to implement his 'process', promoting it as a unique cure for intractable cases of insanity. For two decades he pursued ... ...

    Abstract Following the collapse of the Delahoyde and Lucett joint enterprise, James Lucett resumed practice on his own account. He continued to implement his 'process', promoting it as a unique cure for intractable cases of insanity. For two decades he pursued his activities, with varying success, at different locations in the London area. He maintained his public profile by extensive advertising, letters to newspapers and published pamphlets, extolling his unique 'discovery' and recounting claims of successful cures achieved. Accusations of quackery persisted along with other hostile criticism, particularly from medical men, which Lucett strongly challenged. Periodically he faced more serious difficulties due to legal infractions or financial hardships, but somehow Lucett survived most of these and persevered with his endeavours.
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1028145-9
    ISSN 1740-2360 ; 0957-154X
    ISSN (online) 1740-2360
    ISSN 0957-154X
    DOI 10.1177/0957154X231211727
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  10. Article ; Online: Failure to attend or fear to attend?

    Smith, L

    British dental journal

    2020  Volume 229, Issue 11, Page(s) 700

    MeSH term(s) Fear
    Language English
    Publishing date 2020-12-09
    Publishing country England
    Document type Letter
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-020-2461-2
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    Zs.MO 447: Show issues

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