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  1. Article ; Online: Should Patients Be Required to Receive COVID Vaccine to Be Listed for Kidney Transplant?: PRO.

    Smith, LaMorgan

    Kidney360

    2024  Volume 5, Issue 2, Page(s) 175–176

    MeSH term(s) Humans ; Kidney Transplantation ; COVID-19 Vaccines ; COVID-19/prevention & control ; Kidney Failure, Chronic ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Making the Transplant List: When Weight Weighs In.

    Smith, LaMorgan

    Kidney360

    2023  Volume 4, Issue 12, Page(s) 1770–1771

    MeSH term(s) Liver Transplantation ; Risk Factors ; Transplants ; Waiting Lists
    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The importance of antimicrobial peptides (AMPs) in amphibian skin defense.

    Rollins-Smith, Louise A

    Developmental and comparative immunology

    2023  Volume 142, Page(s) 104657

    Abstract: Antimicrobial peptides (AMPs) are produced for defense in nearly all taxa from simple bacteria to complex mammalian species. Some amphibian families have developed this defensive strategy to a high level of sophistication by loading the AMPs into ... ...

    Abstract Antimicrobial peptides (AMPs) are produced for defense in nearly all taxa from simple bacteria to complex mammalian species. Some amphibian families have developed this defensive strategy to a high level of sophistication by loading the AMPs into specialized granular glands within the dermis. Enervated by the sympathetic nervous system, the granular glands are poised to deliver an array of AMPs to cleanse the wound and facilitate healing. There have been a number of excellent review publications in recent years that describe amphibian AMPs with an emphasis on their possible uses for human medicine. Instead, my aim here is to review what is known about the nature of amphibian AMPs, the diversity of amphibian AMPs, regulation of their production, and to provide the accumulated evidence that they do, indeed, play an important role in the protection of amphibian skin, vital for survival. While much has been learned about amphibian AMPs, there are still important gaps in our understanding of peptide synthesis, storage, and functions.
    MeSH term(s) Animals ; Amphibians ; Antimicrobial Cationic Peptides ; Antimicrobial Peptides ; Mammals ; Skin/microbiology ; Wound Healing
    Chemical Substances Antimicrobial Cationic Peptides ; Antimicrobial Peptides
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2023.104657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Antenatal Optimization of Maternal Anemia Leads to Decreased Risks of Maternal Morbidity.

    Smith, Laura A / Young, Brett C

    Current obstetrics and gynecology reports

    2023  , Page(s) 1–7

    Abstract: Purpose of review: Our review focuses on the appropriate use of intravenous iron to increase the likelihood of achieving target hemoglobin levels prior to delivery to reduce maternal morbidity.: Recent findings: Iron deficiency anemia (IDA) is a ... ...

    Abstract Purpose of review: Our review focuses on the appropriate use of intravenous iron to increase the likelihood of achieving target hemoglobin levels prior to delivery to reduce maternal morbidity.
    Recent findings: Iron deficiency anemia (IDA) is a leading contributor to severe maternal morbidity and mortality. Prenatal treatment of IDA has been demonstrated to reduce the likelihood of adverse maternal outcomes. Recent investigations of intravenous iron supplementation have demonstrated superior efficacy and high tolerability for the treatment of IDA in the third trimester, compared against oral regimens. However, it is unknown whether this treatment is cost-effective, available to clinicians, or acceptable to patients.
    Summary: Intravenous iron is superior to the oral treatment of IDA; however, its use is limited by the lack of implementation data.
    Language English
    Publishing date 2023-06-03
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2161-3303
    ISSN 2161-3303
    DOI 10.1007/s13669-023-00366-7
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  5. Article ; Online: The importance of antimicrobial peptides (AMPs) in amphibian skin defense

    Rollins-Smith, Louise A.

    Developmental and Comparative Immunology. 2023 Feb. 06, p.104657-

    2023  , Page(s) 104657–

    Abstract: Antimicrobial peptides (AMPs) are produced for defense in nearly all taxa from simple bacteria to complex mammalian species. Some amphibian families have developed this defensive strategy to a high level of sophistication by loading the AMPs into ... ...

    Abstract Antimicrobial peptides (AMPs) are produced for defense in nearly all taxa from simple bacteria to complex mammalian species. Some amphibian families have developed this defensive strategy to a high level of sophistication by loading the AMPs into specialized granular glands within the dermis. Enervated by the sympathetic nervous system, the granular glands are poised to deliver an array of AMPs to cleanse the wound and facilitate healing. There have been a number of excellent review publications in recent years that describe amphibian AMPs with an emphasis on their possible uses for human medicine. Instead, my aim here is to review what is known about the nature of amphibian AMPs, the diversity of amphibian AMPs, regulation of their production, and to provide the accumulated evidence that they do, indeed, play an important role in the protection of amphibian skin, vital for survival. While much has been learned about amphibian AMPs, there are still important gaps in our understanding of peptide synthesis, storage, and functions.
    Keywords amphibians ; antimicrobial peptides ; dermis ; immunology ; mammals ; medicine ; sympathetic nervous system ; Granular glands ; Host defense peptides ; Skin defenses
    Language English
    Dates of publication 2023-0206
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2023.104657
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: AQcalc: A web server that identifies weak molecular interactions in protein structures.

    Afshinpour, Maral / Smith, Logan A / Chakravarty, Suvobrata

    Protein science : a publication of the Protein Society

    2023  Volume 32, Issue 10, Page(s) e4762

    Abstract: Weak molecular interactions play an important role in protein structure and function. Computational tools that identify weak molecular interactions are, therefore, valuable for the study of proteins. Here, we present AQcalc, a web server (https:// ... ...

    Abstract Weak molecular interactions play an important role in protein structure and function. Computational tools that identify weak molecular interactions are, therefore, valuable for the study of proteins. Here, we present AQcalc, a web server (https://aqcalcbiocomputing.com/) that can be used to identify anion-quadrupole (AQ) interactions, which are weak interactions involving aromatic residue (Trp, Tyr, and Phe) ring edges and anions (Asp, Glu, and phosphate ion) both within proteins and at their interfaces (protein-protein, protein-nucleic acids, and protein-lipid bilayer). AQcalc identifies AQ interactions as well as clusters involving AQ, cation-π, and salt bridges, among others. Utilizing AQcalc we analyzed weak interactions in protein models, even in the absence of experimental structures, to understand the contributions of weak interactions to deleterious structural changes, including those associated with oncogenic and germline disease variants. We identified several deleterious variants with disrupted AQ interactions (comparable in frequency to cation-π disruptions). Amyloid fibrils utilize AQ to bury anions at frequencies that far exceed those observed for globular proteins. AQ interactions were detected three and five times more frequently than the hydrogen-bonded AQ (HBAQ) in fibril structures and protein-lipid bilayer interfaces, respectively. By contrast, AQ and HBAQ interactions were detected with similar frequencies in globular proteins. Collectively, these findings suggest AQcalc will be effective in facilitating fine structural analysis. As other web utilities designed to identify protein residue interaction networks do not report AQ interactions, wide use of AQcalc will enrich our understanding of residue interaction networks and facilitate hypothesis testing by identifying and experimentally characterizing these comparably weak but important interactions.
    MeSH term(s) Lipid Bilayers ; Models, Molecular ; Proteins/chemistry ; Anions/chemistry ; Cations/chemistry
    Chemical Substances Lipid Bilayers ; Proteins ; Anions ; Cations
    Language English
    Publishing date 2023-08-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1106283-6
    ISSN 1469-896X ; 0961-8368
    ISSN (online) 1469-896X
    ISSN 0961-8368
    DOI 10.1002/pro.4762
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  7. Article ; Online: The Effect of Multicultural Attitudes and Perceived Intergroup Threat on Attitudes Towards Immigrants in Portugal: A Polynomial Regression With Response Surface Analysis.

    Gonçalves, Gabriela / Sousa, Cátia / Arasaratnam-Smith, Lily A

    Psychological reports

    2023  , Page(s) 332941221149182

    Abstract: Supported by the Intergroup Threat Theory (ITT), this study analyzes the effect of multicultural ideology on attitudes towards immigrants mediated by realistic, symbolic, and zero-sum threats. With a sample of Portuguese participants ( ...

    Abstract Supported by the Intergroup Threat Theory (ITT), this study analyzes the effect of multicultural ideology on attitudes towards immigrants mediated by realistic, symbolic, and zero-sum threats. With a sample of Portuguese participants (
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205658-6
    ISSN 1558-691X ; 0033-2941
    ISSN (online) 1558-691X
    ISSN 0033-2941
    DOI 10.1177/00332941221149182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 668: Show issues Location:
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  8. Article: Equitable machine learning counteracts ancestral bias in precision medicine, improving outcomes for all.

    Smith, Leslie A / Cahill, James A / Graim, Kiley

    Research square

    2023  

    Abstract: Gold standard genomic datasets severely under-represent non-European populations, leading to inequities and a limited understanding of human disease [1-8]. Therapeutics and outcomes remain hidden because we lack insights that we could gain from analyzing ...

    Abstract Gold standard genomic datasets severely under-represent non-European populations, leading to inequities and a limited understanding of human disease [1-8]. Therapeutics and outcomes remain hidden because we lack insights that we could gain from analyzing ancestry-unbiased genomic data. To address this significant gap, we present PhyloFrame, the first-ever machine learning method for equitable genomic precision medicine. PhyloFrame corrects for ancestral bias by integrating big data tissue-specific functional interaction networks, global population variation data, and disease-relevant transcriptomic data. Application of PhyloFrame to breast, thyroid, and uterine cancers shows marked improvements in predictive power across all ancestries, less model overfitting, and a higher likelihood of identifying known cancer-related genes. The ability to provide accurate predictions for underrepresented groups, in particular, is substantially increased. These results demonstrate how AI can mitigate ancestral bias in training data and contribute to equitable representation in medical research.
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3168446/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Uncovering the fascinating world of amphibian immunity.

    Katzenback, Barbara A / Rollins-Smith, Louise A

    Developmental and comparative immunology

    2023  Volume 142, Page(s) 104655

    MeSH term(s) Animals ; Amphibians ; Ranavirus
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2023.104655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Heat stress and amphibian immunity in a time of climate change.

    Rollins-Smith, Louise A / Le Sage, Emily H

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2023  Volume 378, Issue 1882, Page(s) 20220132

    Abstract: As a class of vertebrates, amphibians, are at greater risk for declines or extinctions than any other vertebrate group, including birds and mammals. There are many threats, including habitat destruction, invasive species, overuse by humans, toxic ... ...

    Abstract As a class of vertebrates, amphibians, are at greater risk for declines or extinctions than any other vertebrate group, including birds and mammals. There are many threats, including habitat destruction, invasive species, overuse by humans, toxic chemicals and emerging diseases. Climate change which brings unpredictable temperature changes and rainfall constitutes an additional threat. Survival of amphibians depends on immune defences functioning well under these combined threats. Here, we review the current state of knowledge of how amphibians respond to some natural stressors, including heat and desiccation stress, and the limited studies of the immune defences under these stressful conditions. In general, the current studies suggest that desiccation and heat stress can activate the hypothalamus pituitary-interrenal axis, with possible suppression of some innate and lymphocyte-mediated responses. Elevated temperatures can alter microbial communities in amphibian skin and gut, resulting in possible dysbiosis that fosters reduced resistance to pathogens. This article is part of the theme issue 'Amphibian immunity: stress, disease and ecoimmunology'.
    MeSH term(s) Animals ; Amphibians ; Climate Change ; Heat-Shock Response ; Introduced Species ; Knowledge ; Mammals
    Language English
    Publishing date 2023-06-12
    Publishing country England
    Document type Review ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2022.0132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Show issues

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