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  1. Book: INFECTION CONTROL IN LONG-TERM CARE FACILITIES

    Smith, Philip W.

    1984  

    Author's details ED. BY PHILIP W. SMITH
    Keywords INFECTION / PREVENTION AND CONTROL ; NURSING HOMES ; Pflegeheim ; Infektionsrisiko
    Subject Infektion ; Infektionsgefahr ; Infektiosität
    Size XVI, 341 S.
    Publisher WILEY
    Publishing place NEW YORK (U.A.)
    Document type Book
    HBZ-ID HT002716103
    ISBN 0-471-89520-2 ; 978-0-471-89520-6
    Database Catalogue ZB MED Medicine, Health

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    1984 A 337 order for loan Magazin

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  2. Article ; Online: Comparison of Exponential and Biexponential Models of the Unimolecular Decomposition Probability for the Hinshelwood-Lindemann Mechanism.

    Smith, Philip W / Jayee, Bhumika / Hase, William L

    The journal of physical chemistry letters

    2020  Volume 11, Issue 7, Page(s) 2772–2774

    Abstract: The traditional understanding is that the Hinshelwood-Lindemann mechanism for thermal unimolecular reactions, and the resulting unimolecular rate constant versus temperature and collision frequency ω (i.e., pressure), requires the Rice-Ramsperger-Kassel- ... ...

    Abstract The traditional understanding is that the Hinshelwood-Lindemann mechanism for thermal unimolecular reactions, and the resulting unimolecular rate constant versus temperature and collision frequency ω (i.e., pressure), requires the Rice-Ramsperger-Kassel-Marcus (RRKM) rate constant
    Language English
    Publishing date 2020-03-24
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.0c00075
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  3. Article ; Online: A Novel Thyroid Ultrasound Proficiency Metric Designed Through a Multidisciplinary Delphi Approach.

    Hu, Yinin / Michaels, Alex D / Khot, Rachita / Schenk, Worthington G / Hanks, John B / Smith, Philip W

    The American surgeon

    2021  , Page(s) 31348211011151

    Abstract: Background: Thyroid ultrasounds extend surgeons' outpatient capabilities and are essential for operative planning. However, most residents are not formally trained in thyroid ultrasound. The purpose of this study was to create a novel thyroid ultrasound ...

    Abstract Background: Thyroid ultrasounds extend surgeons' outpatient capabilities and are essential for operative planning. However, most residents are not formally trained in thyroid ultrasound. The purpose of this study was to create a novel thyroid ultrasound proficiency metric through a collaborative Delphi approach.
    Methods: Clinical faculty experienced in thyroid ultrasound participated on a Delphi panel to design the thyroid Ultrasound Proficiency Scale (UPS-Thyroid). Participants proposed items under the categories of Positioning, Technique, Image Capture, Measurement, and Interpretation. In subsequent rounds, participants voted to retain, revise, or exclude each item. The process continued until all items had greater than 70% consensus for retention. The UPS-Thyroid was pilot tested across 5 surgery residents with moderate ultrasound experience. Learning curves were assessed with cumulative sum.
    Results: Three surgeons and 4 radiologists participated on the Delphi panel. Following 3 iterative Delphi rounds, the panel arrived at >70% consensus to retain 14 items without further revisions or additions. The metric included the following items on a 3-point scale for a maximum of 42 points: Positioning (1 item), Technique (4 items), Image Capture (2 items), Measurement (2 items), and Interpretation (5 items). A pilot group of 5 residents was scored against a proficiency threshold of 36 points. Learning curve inflection points were noted at between 4 to 7 repetitions.
    Conclusions: A multidisciplinary Delphi approach generated consensus for a thyroid ultrasound proficiency metric (UPS-Thyroid). Among surgery residents with moderate ultrasound experience, basic proficiency at thyroid ultrasound is feasible within 10 repetitions.
    Language English
    Publishing date 2021-04-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348211011151
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  4. Article ; Online: Stereotactic radiosurgery before bilateral adrenalectomy is associated with lowered risk of Nelson's syndrome in refractory Cushing's disease patients.

    Bunevicius, Adomas / Lavezzo, Karen / Smith, Philip W / Vance, Mary Lee / Sheehan, Jason

    Acta neurochirurgica

    2021  Volume 163, Issue 7, Page(s) 1949–1956

    Abstract: Background: Nelson's syndrome is a rare but challenging sequelae of Cushing's disease (CD) after bilateral adrenalectomy (BLA). We sought to determine if stereotactic radiosurgery (SRS) of residual pituitary adenoma performed before BLA can decrease the ...

    Abstract Background: Nelson's syndrome is a rare but challenging sequelae of Cushing's disease (CD) after bilateral adrenalectomy (BLA). We sought to determine if stereotactic radiosurgery (SRS) of residual pituitary adenoma performed before BLA can decrease the risk of Nelson's syndrome.
    Methods: Consecutive patients with CD who underwent BLA after non-curative resection of ACTH secreting pituitary adenoma and had at least one follow-up visit after BLA were studied. Nelson's syndrome was diagnosed based on the combination of rising ACTH levels, increasing volume of the pituitary adenoma and/or hyperpigmentation.
    Results: Fifty patients underwent BLA for refractory CD, and 43 patients (7 men and 36 women) had at least one follow-up visit after BAL. Median endocrine, imaging, and clinical follow-up were 66 months, 69 months, and 80 months, respectively. Nine patients (22%) were diagnosed with the Nelson's syndrome at median time after BLA at 24 months (range: 0.6-119.4 months). SRS before BLA was associated with reduced risk of the Nelson's syndrome (HR = 0.126; 95%CI [0.022-0.714], p=0.019), while elevated ACTH level within 6 months after BLA was associated with increased risk for the Nelson's syndrome (HR = 9.053; 95%CI [2.076-39.472], p=0.003).
    Conclusions: SRS before BLA can reduce the risk for the Nelson's syndrome in refractory CD patients requiring BLA and should be considered before proceeding to BLA. Elevated ACTH concentration within 6 months after BLA is associated with greater risk of the Nelsons' syndrome. When no prior SRS is administered, those with a high ACTH level shortly after BLA may benefit from early SRS.
    MeSH term(s) Adrenalectomy ; Adrenocorticotropic Hormone ; Female ; Humans ; Male ; Nelson Syndrome/complications ; Nelson Syndrome/surgery ; Pituitary ACTH Hypersecretion/etiology ; Pituitary ACTH Hypersecretion/surgery ; Pituitary Neoplasms/complications ; Pituitary Neoplasms/surgery ; Radiosurgery
    Chemical Substances Adrenocorticotropic Hormone (9002-60-2)
    Language English
    Publishing date 2021-03-24
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-021-04823-1
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  5. Article ; Online: The ups and downs of general surgery resident experience in endocrine surgery: Analysis of 30 years of ACGME graduate case logs.

    Ramirez, Adriana G / Fashandi, Anna Z / Hanks, John B / Smith, Philip W / Potts, John R

    Surgery

    2020  Volume 168, Issue 4, Page(s) 586–593

    Abstract: Background: The aim of this study was to determine trends in the experience of general surgery residents with endocrine surgery cases.: Methods: American Association of Endocrine Surgeons national general surgery case logs from 1989 through 2019 were ...

    Abstract Background: The aim of this study was to determine trends in the experience of general surgery residents with endocrine surgery cases.
    Methods: American Association of Endocrine Surgeons national general surgery case logs from 1989 through 2019 were reviewed. The numbers of individuals completing residency and the mean and median number of endocrine surgery cases by type and by level of operating resident surgeon were abstracted from annual data and analyzed. Descriptive statistics and linear regression analyses were performed modeling endocrine surgery cases over time and stratified by procedure type and resident level.
    Results: The number of individuals completing general surgery residency each year increased from 981 to 1,219 (P < .001). The average total number of endocrine surgery cases performed increased from 17 to 33.2 (P < .001) but has declined since its peak at 36.9 in 2010 to 2011 (P = .014). Thyroid operations increased from 11.4 to 19.8 (P < .001) but peaked at 23.5 in 2010 to 2011 and have since declined (P < .001). Parathyroid operations more than doubled from 4.2 to 9.7 (P < .001). Adrenal operations increased from 1 to 2.2 (P < .001) and pancreatic endocrine operations increased from 0.2 to 1.5 (P < .001). Surgeon Chief endocrine surgery cases peaked at 14.4 in 2003 to 2004 but have since declined by 22.2% (P < .001). Surgeon Junior endocrine surgery cases increased overall (P < .001) but peaked at 22.8 in 2011 to 2012. There was increasing heterogeneity over time in trainee experience (P < .001).
    Conclusion: After having increased for 2 decades, the number of endocrine surgery cases performed by general surgery residents is currently in decline. Possible contributing factors include growth in the number of general surgery residents, variable and narrowed case mix, and encroachment by other learners.
    MeSH term(s) Clinical Competence ; Endocrine Surgical Procedures/education ; Endocrine Surgical Procedures/statistics & numerical data ; Endocrine Surgical Procedures/trends ; General Surgery/education ; Humans ; Internship and Residency/trends ; Longitudinal Studies ; United States
    Language English
    Publishing date 2020-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2020.07.007
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  6. Article ; Online: A meaningful use of the phrase "appropriately selected patients".

    Smith, Philip W / Hanks, John B

    Surgery

    2014  Volume 156, Issue 6, Page(s) 1529–1530

    MeSH term(s) Adrenal Cortex Neoplasms/mortality ; Adrenal Cortex Neoplasms/surgery ; Adrenalectomy/methods ; Adrenocortical Carcinoma/mortality ; Adrenocortical Carcinoma/surgery ; Female ; Humans ; Male
    Language English
    Publishing date 2014-12
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2014.08.048
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  7. Article ; Online: New endocrine fellowship programs do not decrease the endocrine surgery experience of residents in co-located general surgery programs.

    Fashandi, Anna Z / Hanks, John B / Ramirez, Adriana G / Potts, John R / Smith, Philip W

    Surgery

    2020  Volume 169, Issue 1, Page(s) 185–190

    Abstract: Background: New pediatric and vascular surgical fellowship programs decrease resident operative experience in those subspecialties in co-located general surgery programs.After 2 decades of increases, the mean number of endocrine surgery cases performed ... ...

    Abstract Background: New pediatric and vascular surgical fellowship programs decrease resident operative experience in those subspecialties in co-located general surgery programs.After 2 decades of increases, the mean number of endocrine surgery cases performed by general surgery residents nationally has decreased since 2010 to 2011. We hypothesized that new endocrine surgery fellowship programs lead to a decrease in the number of endocrine surgery cases performed by co-located general surgery residents and may be a contributing factor in the recent national decline in endocrine surgery cases performed by general surgery residents.
    Methods: Endocrine surgery fellowship programs associated with a single, Accreditation Council of Graduate Medical Education-accredited general surgery program that have completed training of 1 fellow by the 2014-2015 academic year were identified. Endocrine surgery cases performed by general surgery residents who completed co-located general surgery programs from 2002 to 2003 through 2017 to 2018 were recorded. Descriptive statistics are shown as mean ± standard deviation. Statistical significance was calculated using the Mann-Whitney U Test.
    Results: In the 13 general surgery programs with 5 years of case log data after the matriculation of the first fellow, the mean number of total endocrine surgery cases/resident increased from 47 ± 23 in year 0 to 57 ± 25 in year 5 (z-score = 2.53; P < .05).
    Conclusion: New endocrine surgery fellowship programs do not decrease the endocrine surgery cases performed by general surgery residents and have not contributed to the national decline in endocrine surgery cases by general surgery residents.
    MeSH term(s) Accreditation/statistics & numerical data ; Clinical Competence/statistics & numerical data ; Endocrine Surgical Procedures/education ; Endocrine Surgical Procedures/statistics & numerical data ; Endocrinology/education ; Endocrinology/organization & administration ; General Surgery/education ; General Surgery/organization & administration ; Humans ; Internship and Residency/organization & administration ; Internship and Residency/statistics & numerical data ; Surgeons/education ; Surgeons/statistics & numerical data ; Workload/statistics & numerical data
    Language English
    Publishing date 2020-08-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2020.05.043
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  8. Article ; Online: Laparoscopic surgery for adrenocortical carcinoma: Estimating the risk of margin-positive resection.

    Carlisle, Kendyl / Blackburn, Kyle W / Japp, Emily A / McArdle, Patrick F / Turner, Douglas J / Terhune, Julia H / Englum, Brian R / Smith, Philip W / Hu, Yinin

    Journal of surgical oncology

    2023  Volume 129, Issue 4, Page(s) 691–699

    Abstract: Background: Over recent years, there has been increasing adoption of minimally invasive surgery (MIS) in the treatment of adrenocortical carcinoma (ACC). However, MIS has been associated with noncurative resection and locoregional recurrence. We aimed ... ...

    Abstract Background: Over recent years, there has been increasing adoption of minimally invasive surgery (MIS) in the treatment of adrenocortical carcinoma (ACC). However, MIS has been associated with noncurative resection and locoregional recurrence. We aimed to identify risk factors for margin-positivity among patients who undergo MIS resection for ACC. We hypothesized that a simple nomogram can accurately identify patients most suitable for curative MIS resection.
    Methods: Curative-intent resections for ACC were identified through the National Cancer Database spanning 2010-2018. Trends in MIS utilization were reported using Pearson correlation coefficients. Factors associated with margin-positive resection were identified among preoperatively available variables using multivariable logistic regression, then incorporated into a predictive model. Model quality was cross validated using an 80% training data set and 20% test data set.
    Results: Among 1260 ACC cases, 38.6% (486) underwent MIS resection. MIS utilization increased over time at nonacademic centers (R = 0.818, p = 0.007), but not at academic centers (R = 0.009, p = 0.982). Factors associated with margin-positive MIS resection were increasing age, nonacademic center (odds ratio [OR]: 1.8, p = 0.006), cT3 (OR: 4.7, p < 0.001) or cT4 tumors (OR: 14.6, p < 0.001), and right-sided tumors (OR: 2.0, p = 0.006). A predictive model incorporating these four factors produced favorable c-statistics of 0.75 in the training data set and 0.72 in the test data set. A pragmatic nomogram was created to enable bedside risk stratification.
    Conclusions: An increasing proportion of ACC are resected via minimally invasive operations, particularly at nonacademic centers. Patient selection based on a few key factors can minimize the risk of noncurative surgery.
    MeSH term(s) Humans ; Adrenocortical Carcinoma/surgery ; Adrenocortical Carcinoma/pathology ; Laparoscopy ; Nomograms ; Minimally Invasive Surgical Procedures/adverse effects ; Adrenal Cortex Neoplasms/surgery ; Adrenal Cortex Neoplasms/pathology ; Retrospective Studies
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82063-5
    ISSN 1096-9098 ; 0022-4790
    ISSN (online) 1096-9098
    ISSN 0022-4790
    DOI 10.1002/jso.27544
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  9. Article: Preoperative Molecular Markers in Thyroid Nodules.

    Sahli, Zeyad T / Smith, Philip W / Umbricht, Christopher B / Zeiger, Martha A

    Frontiers in endocrinology

    2018  Volume 9, Page(s) 179

    Abstract: The need for distinguishing benign from malignant thyroid nodules has led to the pursuit of differentiating molecular markers. The most common molecular tests in clinical use are ... ...

    Abstract The need for distinguishing benign from malignant thyroid nodules has led to the pursuit of differentiating molecular markers. The most common molecular tests in clinical use are Afirma
    Language English
    Publishing date 2018-04-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2018.00179
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  10. Article ; Online: The Psychosocial Challenges of Caring for Patients with Ebola Virus Disease.

    Smith, Matthew W / Smith, Philip W / Kratochvil, Christopher J / Schwedhelm, Shelly

    Health security

    2017  Volume 15, Issue 1, Page(s) 104–109

    Abstract: Caring for highly infectious patients in biocontainment units is a new phenomenon, and little is known about the behavioral health of workers in this setting. This is a qualitative study exploring the unique experiences of workers involved in the care of ...

    Abstract Caring for highly infectious patients in biocontainment units is a new phenomenon, and little is known about the behavioral health of workers in this setting. This is a qualitative study exploring the unique experiences of workers involved in the care of patients with Ebola virus disease (EVD) at Nebraska Medicine during the 2014 Ebola outbreak. Twenty-one in-depth interviews were conducted focused on topics of personal memories, interpersonal experiences, stress response, and patient management. Five themes were identified: (1) positive experiences were emotional while challenges were technical; (2) a significant percentage of workers encountered interpersonal stressors, with 29% of respondents having feelings of isolation, 33% having alterations in home life, and 25% experiencing at least 1 episode of discrimination; (3) physicians and nurses had stressors primarily related to patient care; (4) mental health was an important supportive service, with 45% of respondents using behavioral health counseling; and (5) working in the biocontainment unit during activation was more stressful than everyday work for 60% of respondents. Differences were also noted based on employee occupation and leadership level: nurses, physicians, and members of the leadership team tended to focus on emotional experiences and were more likely to utilize behavioral health counseling services than support staff and nonleadership personnel. These findings provide a framework for thinking about the unique aspects of caring for highly infectious patients, and understanding these issues will improve training, enable management to better support staff, and provide insights to those establishing biocontainment units.
    MeSH term(s) Civil Defense/methods ; Disease Outbreaks/prevention & control ; Health Personnel/psychology ; Hemorrhagic Fever, Ebola/prevention & control ; Hemorrhagic Fever, Ebola/transmission ; Humans ; Infection Control/methods ; Nebraska ; Nursing Care/psychology ; Patients ; Qualitative Research
    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2823049-8
    ISSN 2326-5108 ; 2326-5094
    ISSN (online) 2326-5108
    ISSN 2326-5094
    DOI 10.1089/hs.2016.0068
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