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  1. Article ; Online: The Role of Hospital Inpatient Mental Health Care in Modern Health Care Systems.

    Smith, Thomas E

    Psychiatric services (Washington, D.C.)

    2020  Volume 71, Issue 9, Page(s) 967–968

    MeSH term(s) Community Psychiatry ; Hospitals, Psychiatric ; Humans ; Inpatients ; Mental Health
    Language English
    Publishing date 2020-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/appi.ps.202000091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Yale Textbook of Public Psychiatryedited by Selby C. Jacobs, M.D., and Jeanne L. Steiner, D.O. New York, Oxford University Press, 2016, 312 pp., $125.00 (hardcover).

    Smith, Thomas E

    The American journal of psychiatry

    2017  Volume 174, Issue 9, Page(s) 906–907

    Language English
    Publishing date 2017-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2017.17040431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Workforce Monitoring: Staffing Patterns in the Public Mental Health Workforce in New York State, 2009-2021.

    Tepper, Miriam C / Leckman-Westin, Emily / Sosiak, Roman / Smith, Thomas E

    Psychiatric services (Washington, D.C.)

    2023  Volume 75, Issue 1, Page(s) 81–82

    MeSH term(s) Humans ; New York ; Health Workforce ; Workforce ; Personnel Staffing and Scheduling ; Health Personnel
    Language English
    Publishing date 2023-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/appi.ps.20230308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Biogenetic Relationships of Bioactive Sponge Merotriterpenoids.

    Smith, Thomas E

    Marine drugs

    2017  Volume 15, Issue 9

    Abstract: Hydroquinone meroterpenoids, especially those derived from marine sponges, display a wide range of biological activities. However, use of these compounds is limited by their inaccessibility; there is no sustainable supply of these compounds. Furthermore, ...

    Abstract Hydroquinone meroterpenoids, especially those derived from marine sponges, display a wide range of biological activities. However, use of these compounds is limited by their inaccessibility; there is no sustainable supply of these compounds. Furthermore, our knowledge of their metabolic origin remains completely unstudied. In this review, an in depth structural analysis of sponge merotriterpenoids, including the adociasulfate family of kinesin motor protein inhibitors, provides insight into their biosynthesis. Several key structural features provide clues to the relationships between compounds. All adociasulfates appear to be derived from only four different hydroquinone hexaprenyl diphosphate precursors, each varying in the number and position of epoxidations. Proton-initiated cyclization of these precursors can lead to all carbon skeletons observed amongst sponge merotriterpenoids. Consideration of the enzymes involved in the proposed biosynthetic route suggests a bacterial source, and a hypothetical gene cluster was constructed that may facilitate discovery of the authentic pathway from the sponge metagenome. A similar rationale can be extended to other sponge meroterpenoids, for which no biosynthetic pathways have yet been identified.
    MeSH term(s) Animals ; Hydroquinones/chemistry ; Porifera ; Triterpenes/chemistry
    Chemical Substances Hydroquinones ; Triterpenes
    Language English
    Publishing date 2017-09-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md15090285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Coordination of host and symbiont gene expression reveals a metabolic tug-of-war between aphids and

    Smith, Thomas E / Moran, Nancy A

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 4, Page(s) 2113–2121

    Abstract: Symbioses between animals and microbes are often described as mutualistic, but are subject to tradeoffs that may manifest as shifts in host and symbiont metabolism, cellular processes, or symbiont density. In pea aphids, the bacterial ... ...

    Abstract Symbioses between animals and microbes are often described as mutualistic, but are subject to tradeoffs that may manifest as shifts in host and symbiont metabolism, cellular processes, or symbiont density. In pea aphids, the bacterial symbiont
    MeSH term(s) Amino Acids/metabolism ; Animals ; Aphids/genetics ; Aphids/microbiology ; Aphids/physiology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Buchnera/classification ; Buchnera/genetics ; Buchnera/physiology ; Gene Expression Regulation, Bacterial ; Host Specificity ; Symbiosis
    Chemical Substances Amino Acids ; Bacterial Proteins
    Language English
    Publishing date 2020-01-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1916748117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Unmet Opportunity: Intensive Care Transition Intervention for Individuals With Serious Medical-Psychiatric Illnesses.

    Smith, Thomas E / Marino, Leslie A / Olfson, Mark

    Psychiatric services (Washington, D.C.)

    2021  Volume 72, Issue 7, Page(s) 856–858

    Abstract: Individuals with serious mental illnesses and poorly managed medical conditions known as serious medical-psychiatric illnesses (SMPIs) are vulnerable to disruptions in care, resulting in poor outcomes. Intensive integrated care management approaches are ... ...

    Abstract Individuals with serious mental illnesses and poorly managed medical conditions known as serious medical-psychiatric illnesses (SMPIs) are vulnerable to disruptions in care, resulting in poor outcomes. Intensive integrated care management approaches are indicated when these individuals are hospitalized on medical-surgical inpatient units in order to ensure continuity of medical and psychiatric services. This column describes a manualized intervention for hospitalized individuals with SMPIs that was developed in a National Institute of Mental Health ALACRITY research center. The approach uses a critical time intervention model incorporating motivational interviewing and shared decision making to maximize engagement and continuity of care for individuals with SMPIs.
    MeSH term(s) Humans ; Inpatients ; Mental Disorders/therapy ; Patient Transfer
    Language English
    Publishing date 2021-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/appi.ps.202000286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Elucidation of host and symbiont contributions to peptidoglycan metabolism based on comparative genomics of eight aphid subfamilies and their Buchnera.

    Smith, Thomas E / Li, Yiyuan / Perreau, Julie / Moran, Nancy A

    PLoS genetics

    2022  Volume 18, Issue 5, Page(s) e1010195

    Abstract: Pea aphids (Acyrthosiphon pisum) are insects containing genes of bacterial origin with putative functions in peptidoglycan (PGN) metabolism. Of these, rlpA1-5, amiD, and ldcA are highly expressed in bacteriocytes, specialized aphid cells that harbor the ... ...

    Abstract Pea aphids (Acyrthosiphon pisum) are insects containing genes of bacterial origin with putative functions in peptidoglycan (PGN) metabolism. Of these, rlpA1-5, amiD, and ldcA are highly expressed in bacteriocytes, specialized aphid cells that harbor the obligate bacterial symbiont Buchnera aphidicola, required for amino acid supplementation of the host's nutrient-poor diet. Despite genome reduction associated with endosymbiosis, pea aphid Buchnera retains genes for the synthesis of PGN while Buchnera of many other aphid species partially or completely lack these genes. To explore the evolution of aphid horizontally-transferred genes (HTGs) and to elucidate how host and symbiont genes contribute to PGN production, we sequenced genomes from four deeply branching lineages, such that paired aphid and Buchnera genomes are now available for 17 species representing eight subfamilies. We identified all host and symbiont genes putatively involved in PGN metabolism. Phylogenetic analyses indicate that each HTG family was present in the aphid shared ancestor, but that each underwent a unique pattern of gene loss or duplication in descendant lineages. While four aphid rlpA gene subfamilies show no relation to symbiont PGN gene repertoire, the loss of aphid amiD and ldcA HTGs coincides with the loss of symbiont PGN metabolism genes. In particular, the coincident loss of host amiD and symbiont murCEF in tribe Aphidini, in contrast to tribe Macrosiphini, suggests either 1) functional linkage between these host and symbiont genes, or 2) Aphidini has lost functional PGN synthesis and other retained PGN pathway genes are non-functional. To test these hypotheses experimentally, we used cell-wall labeling methods involving a d-alanine probe and found that both Macrosiphini and Aphidini retain Buchnera PGN synthesis. Our results imply that compensatory adaptations can preserve PGN synthesis despite the loss of some genes considered essential for this pathway, highlighting the importance of the cell wall in these symbioses.
    MeSH term(s) Animals ; Aphids/genetics ; Aphids/microbiology ; Buchnera/genetics ; Buchnera/metabolism ; Genes, Bacterial ; Genomics ; Peptidoglycan/genetics ; Peptidoglycan/metabolism ; Phylogeny ; Symbiosis/genetics
    Chemical Substances Peptidoglycan
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1010195
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  8. Article ; Online: Redesigning Public Mental Health Systems Post-COVID-19.

    Smith, Thomas E / Sullivan, Ann-Marie T / Druss, Benjamin G

    Psychiatric services (Washington, D.C.)

    2020  Volume 72, Issue 5, Page(s) 602–605

    Abstract: The COVID-19 pandemic has disrupted public mental health systems across the country, nowhere more than in New York State (NYS). The authors describe the NYS public health agency's response to the pandemic and offer ideas for redesigning public mental ... ...

    Abstract The COVID-19 pandemic has disrupted public mental health systems across the country, nowhere more than in New York State (NYS). The authors describe the NYS public health agency's response to the pandemic and offer ideas for redesigning public mental health systems post-COVID-19.
    MeSH term(s) COVID-19/epidemiology ; Health Policy ; Humans ; Mental Health Services/organization & administration ; Mental Health Services/trends ; New York/epidemiology ; Pandemics ; Public Health/trends ; Public Health Administration ; SARS-CoV-2
    Language English
    Publishing date 2020-12-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/appi.ps.202000400
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  9. Article ; Online: Building and Landing the Plane While Flying: How New York State Addressed the Needs of People With Serious Mental Illness During the COVID-19 Pandemic.

    Erlich, Matthew D / Casoy, Flavio / Berezin, Joshua / Hernandez, Yamilette / Smith, Thomas E

    Schizophrenia bulletin open

    2022  Volume 3, Issue 1, Page(s) sgac035

    Abstract: New York State was the epicenter for COVID-19 in Spring 2020 when little was known about the pandemic. Dire circumstances necessitated New York State's (NYS) public mental health system to rapidly pivot, adapt, and innovate its policies and procedures to ...

    Abstract New York State was the epicenter for COVID-19 in Spring 2020 when little was known about the pandemic. Dire circumstances necessitated New York State's (NYS) public mental health system to rapidly pivot, adapt, and innovate its policies and procedures to ensure continuous high-level care to individuals with serious mental illness (SMI), a population especially vulnerable to both the physical and psychosocial sequelae of COVID-19. NYS rapidly adopted emergency measures to support community providers, expanded the capacity of its State-Operated facilities, created policies to promote improved infection control access, collaborated to enhance the public-private continuum of service to support people with SMI, and broadened the use of new technologies to ensure continued engagement of care.
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2632-7899
    ISSN (online) 2632-7899
    DOI 10.1093/schizbullopen/sgac035
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  10. Article ; Online: Mental health service utilization review patterns in a Medicaid managed care program.

    Smith, Thomas E / Pangilinan, Maria / Rodgers, Ian / Li, Xian / Claverie, Genevieve / Katagiri, Joe

    The American journal of managed care

    2022  Volume 28, Issue 2, Page(s) 81–84

    Abstract: Objectives: The current study investigated mental health utilization review (UR) clinical service authorization requests, denials, and reasons for denial in a statewide Medicaid managed care organization (MMCO) program.: Study design: Retrospective ... ...

    Abstract Objectives: The current study investigated mental health utilization review (UR) clinical service authorization requests, denials, and reasons for denial in a statewide Medicaid managed care organization (MMCO) program.
    Study design: Retrospective analysis of utilization review data reported by MMCOs in New York State.
    Methods: Data from the utilization review practices of 15 MMCOs were collected and analyzed for calendar years 2017 and 2018. The data reported are specific to mental health services and include the number of authorization requests, number of clinical denials, and the reasons specified for each denial. Analyses were undertaken to determine the UR denial rates and most common reasons for denials.
    Results: A total of 264,901 requests for inpatient mental health service authorizations and 53,687 requests for outpatient mental health service authorizations were made in 2017 and 2018. Of these, 1.5% of inpatient authorization requests and 0.4% of outpatient authorization requests were denied for reasons related to medical necessity. The most common reason for inpatient mental health service denials was that the patient no longer met the standard for the requested level of care.
    Conclusions: Low UR denial rates warrant further examination of the relationship between UR and both quality of care and patient outcomes in mental health care. With the substantial resources spent on UR, findings could point to areas of potential reforms to the system that may minimize these costs and improve care for patients with mental illness.
    MeSH term(s) Humans ; Managed Care Programs ; Medicaid ; Mental Health Services ; Retrospective Studies ; United States ; Utilization Review
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2035781-3
    ISSN 1936-2692 ; 1088-0224 ; 1096-1860
    ISSN (online) 1936-2692
    ISSN 1088-0224 ; 1096-1860
    DOI 10.37765/ajmc.2022.88824
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