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  1. Article: Accurate Placement and Revisions for Cervical Pedicle Screws Placed With or Without Navigation: A Systematic Review and Meta-Analysis.

    Bindels, B J J / Dronkers, B E G / Smits, M L J / Verlaan, J J

    Global spine journal

    2023  Volume 14, Issue 3, Page(s) 1018–1037

    Abstract: Study design: Systematic review and meta-analysis.: Objectives: To evaluate the accuracy of placement for cervical pedicle screws with and without the use of spinal navigation.: Methods: A structured search was conducted in electronic databases ... ...

    Abstract Study design: Systematic review and meta-analysis.
    Objectives: To evaluate the accuracy of placement for cervical pedicle screws with and without the use of spinal navigation.
    Methods: A structured search was conducted in electronic databases without any language or date restrictions. Eligible studies reported the proportion of accurately placed cervical pedicle screws measured on intraoperative or postoperative 3D imaging, and reported whether intraoperative navigation was used during screw placement. Randomized Studies (MINORS) criteria were used to evaluate the methodological quality of how accuracy was assessed for cervical pedicle screws.
    Results: After screening and critical appraisal, 4697 cervical pedicle screws from 18 studies were included in the meta-analysis. The pooled proportion for cervical pedicle screws with a breach up to 2 mm was 94% for navigated screws and did not differ from the pooled proportion for non-navigated screws (96%). The pooled proportion for cervical pedicle screws placed completely in the pedicle was 76% for navigated screws and did not differ from the pooled proportion for non-navigated screws (82%). Intraoperative screw reposition rates and screw revision rates as a result of postoperative imaging also did not differ between navigated and non-navigated screw placement.
    Conclusions: This systematic review and meta-analysis found that the use of spinal navigation systems does not significantly improve the accuracy of placement of cervical pedicle screws compared to screws placed without navigation. Future studies evaluating intraoperative navigation for cervical pedicle screw placement should focus on the learning curve, postoperative complications, and the complexity of surgical cases.
    Language English
    Publishing date 2023-08-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2648287-3
    ISSN 2192-5690 ; 2192-5682
    ISSN (online) 2192-5690
    ISSN 2192-5682
    DOI 10.1177/21925682231196456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dose-effect relationships in neuroendocrine tumour liver metastases treated with [

    Ramdhani, K / Beijer-Verduin, J / Ebbers, S C / van Rooij, R / Smits, M L J / Bruijnen, R C G / de Jong, H W A M / Lam, M G E H / Braat, A J A T

    European journal of nuclear medicine and molecular imaging

    2024  

    Abstract: Purpose: Aim of this study was to investigate a dose-response relationship, dose-toxicity relationship, progression free survival (PFS) and overall survival (OS) in neuroendocrine tumour liver metastases (NELM) treated with holmium-166-microspheres ... ...

    Abstract Purpose: Aim of this study was to investigate a dose-response relationship, dose-toxicity relationship, progression free survival (PFS) and overall survival (OS) in neuroendocrine tumour liver metastases (NELM) treated with holmium-166-microspheres radioembolization ([
    Materials and methods: Single center, retrospective study included patients with NELM that received [
    Results: Twenty-seven treatments in 25 patients were included, with a total of 114 tumours. Median follow-up was 14 months (3 - 82 months). Mean D
    Conclusion: This study confirms the safety and efficacy of [
    Language English
    Publishing date 2024-02-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-024-06645-6
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    Zs.A 1227: Show issues Location:
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  3. Article ; Online: Intra-arterial peptide-receptor radionuclide therapy for neuro-endocrine tumour liver metastases: an in-patient randomised controlled trial (LUTIA).

    Ebbers, S C / Barentsz, M W / de Vries-Huizing, D M V / Versleijen, M W J / Klompenhouwer, E G / Tesselaar, M E T / Stokkel, M P M / Brabander, T / Hofland, J / Moelker, A / van Leeuwaarde, R S / Smits, M L J / Braat, A J A T / Lam, M G E H

    European journal of nuclear medicine and molecular imaging

    2023  Volume 51, Issue 4, Page(s) 1121–1132

    Abstract: Purpose: Peptide receptor radionuclide therapy (PRRT) using [: Methods: Twenty-seven patients with grade 1-2 GEP-NET, and bi-lobar liver metastases were randomized to receive intra-arterial PRRT in the left or right liver lobe for four consecutive ... ...

    Abstract Purpose: Peptide receptor radionuclide therapy (PRRT) using [
    Methods: Twenty-seven patients with grade 1-2 GEP-NET, and bi-lobar liver metastases were randomized to receive intra-arterial PRRT in the left or right liver lobe for four consecutive cycles. The contralateral liver lobe and extrahepatic disease were treated via a "second-pass" effect and the contralateral lobe was used as the control lobe. Up to three metastases (> 3 cm) per liver lobe were identified as target lesions at baseline on contrast-enhanced CT. The primary endpoint was the tumour-to-non-tumour (T/N) uptake ratio on the 24 h post-treatment [
    Findings: After the first cycle, a non-significant difference in T/N uptake ratio was observed: T/N
    Conclusion: Intra-arterial [
    MeSH term(s) Humans ; Octreotide/adverse effects ; Organometallic Compounds/therapeutic use ; Liver Neoplasms/radiotherapy ; Liver Neoplasms/secondary ; Neuroendocrine Tumors/radiotherapy ; Neuroendocrine Tumors/pathology ; Radioisotopes
    Chemical Substances Octreotide (RWM8CCW8GP) ; Organometallic Compounds ; Radioisotopes
    Language English
    Publishing date 2023-10-28
    Publishing country Germany
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06467-y
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  4. Article: Systematic review of the safety and efficacy of contrast injection via venous catheters for contrast-enhanced computed tomography.

    Buijs, S B / Barentsz, M W / Smits, M L J / Gratama, J W C / Spronk, P E

    European journal of radiology open

    2017  Volume 4, Page(s) 118–122

    Abstract: Objective: To examine the safety and efficacy of contrast injection through a central venous catheter (CVC) for contrast-enhanced computed tomography (CECT).: Methods: A systematic literature search was performed using PubMed. Studies were deemed ... ...

    Abstract Objective: To examine the safety and efficacy of contrast injection through a central venous catheter (CVC) for contrast-enhanced computed tomography (CECT).
    Methods: A systematic literature search was performed using PubMed. Studies were deemed eligible if they reported on the use of CVCs for contrast administration. Selected articles were assessed for their relevance and risk of bias. Articles with low relevance and high risk of bias or both were excluded. Data from included articles was extracted.
    Results: Seven studies reported on the use of CVCs for contrast administration. Catheter rupture did not occur in any study. The incidence of dislocation ranged from 2.2-15.4%. Quality of scans was described in three studies, with less contrast enhancement of pulmonary arteries and the thoracic aorta in two studies, and average or above average quality in one study. Four other studies used higher flowrates, but did not report quality of scans.
    Conclusion: Contrast injection via CVCs can be performed safely for CECT when using a strict protocol. Quality of scans depended on multiple factors like flow rate, indication of the scan, and cardiac output of the patient. In each patient, an individual evaluation whether to use the CVC as access for contrast media should be made, while bolus tracking may be mandatory in most cases.
    Language English
    Publishing date 2017-09-29
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2352-0477
    ISSN 2352-0477
    DOI 10.1016/j.ejro.2017.09.002
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  5. Article ; Online: Current Status and Future Direction of Hepatic Radioembolisation.

    Alsultan, A A / Braat, A J A T / Smits, M L J / Barentsz, M W / Bastiaannet, R / Bruijnen, R C G / de Keizer, B / de Jong, H W A M / Lam, M G E H / Maccauro, M / Chiesa, C

    Clinical oncology (Royal College of Radiologists (Great Britain))

    2020  Volume 33, Issue 2, Page(s) 106–116

    Abstract: Radioembolisation is a locoregional treatment modality for hepatic malignancies. It consists of several stages that are vital to its success, which include a pre-treatment angiographic simulation followed by nuclear medicine imaging, treatment activity ... ...

    Abstract Radioembolisation is a locoregional treatment modality for hepatic malignancies. It consists of several stages that are vital to its success, which include a pre-treatment angiographic simulation followed by nuclear medicine imaging, treatment activity choice, treatment procedure and post-treatment imaging. All these stages have seen much advancement over the past decade. Here we aim to provide an overview of the practice of radioembolisation, discuss the limitations of currently applied methods and explore promising developments.
    MeSH term(s) Brachytherapy ; Humans ; Liver Neoplasms/radiotherapy
    Language English
    Publishing date 2020-12-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1036844-9
    ISSN 1433-2981 ; 0936-6555
    ISSN (online) 1433-2981
    ISSN 0936-6555
    DOI 10.1016/j.clon.2020.12.003
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    Zs.A 2774: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Technical solutions to ensure safe yttrium-90 radioembolization in patients with initial extrahepatic deposition of (99m)technetium-albumin macroaggregates.

    Barentsz, M W / Vente, M A D / Lam, M G E H / Smits, M L J / Nijsen, J F W / Seinstra, B A / Rosenbaum, C E N M / Verkooijen, H M / Zonnenberg, B A / Van den Bosch, M A A J

    Cardiovascular and interventional radiology

    2010  Volume 34, Issue 5, Page(s) 1074–1079

    Abstract: Purpose: To evaluate the incidence of extrahepatic deposition of technetium-99m-labeled albumin macroaggregates ((99m)Tc-MAA) after pretreatment angiography, before yttrium-90 radioembolizaton ((90)Y-RE), and to report on technical solutions that can be ...

    Abstract Purpose: To evaluate the incidence of extrahepatic deposition of technetium-99m-labeled albumin macroaggregates ((99m)Tc-MAA) after pretreatment angiography, before yttrium-90 radioembolizaton ((90)Y-RE), and to report on technical solutions that can be used to ensure safe delivery of (90)Y-microspheres in patients with initial extrahepatic deposition.
    Materials and methods: A retrospective analysis of 26 patients with primary and secondary liver malignancies, who were scheduled for treatment with (90)Y-RE in our institution in 2009, was performed. The angiograms and single-photon emission computed tomography images of all patients were reviewed by an interventional radiologist and a nuclear medicine physician, respectively, to identify and localize extrahepatic deposition of (99m)Tc-MAA when present. Subsequently, the technical solutions were used to successfully perform (90)Y-RE in these patients were evaluated and described.
    Results: Extrahepatic deposition of (99m)Tc-MAA was observed in 8 of 26 patients (31%). In 7 of 8 patients, a second pretreatment angiography was performed to detect the cause of extrahepatic deposition. The technical solutions to enable safe (90)Y microspheres delivery included more distal placement of the microcatheter in the proper/right hepatic artery in 4 of 7 (57%) patients; (super)selective catheterization of multiple segmental branches in 2 of 7 (29%); and additional coiling of a newly detected branch in the remaining patient (14%). This was confirmed by a second MAA procedure. (90)Y-RE was eventually performed in 25 of 26 (96%) patients. No procedure-related complications (<30 days) were observed.
    Conclusion: Extrahepatic deposition of (99m)Tc-MAA after pretreatment angiography did occur in 8 of 26 (31%) patients. The technical solutions as presented allowed safe (90)Y-RE delivery in 25 of 26 (96%) patients.
    MeSH term(s) Embolization, Therapeutic ; Female ; Hepatic Artery ; Humans ; Injections, Intra-Arterial ; Liver Neoplasms/blood supply ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/radiotherapy ; Male ; Middle Aged ; Radiopharmaceuticals/administration & dosage ; Radiopharmaceuticals/therapeutic use ; Technetium Tc 99m Aggregated Albumin/analysis ; Tomography, Emission-Computed, Single-Photon ; Yttrium Radioisotopes/administration & dosage ; Yttrium Radioisotopes/therapeutic use
    Chemical Substances Radiopharmaceuticals ; Technetium Tc 99m Aggregated Albumin ; Yttrium Radioisotopes
    Language English
    Publishing date 2010-12-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-010-0088-4
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    Zs.A 1378: Show issues Location:
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  7. Article ; Online: Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy.

    Korenblik, R / Olij, B / Aldrighetti, L A / Hilal, M Abu / Ahle, M / Arslan, B / van Baardewijk, L J / Baclija, I / Bent, C / Bertrand, C L / Björnsson, B / de Boer, M T / de Boer, S W / Bokkers, R P H / Rinkes, I H M Borel / Breitenstein, S / Bruijnen, R C G / Bruners, P / Büchler, M W /
    Camacho, J C / Cappelli, A / Carling, U / Chan, B K Y / Chang, D H / Choi, J / Font, J Codina / Crawford, M / Croagh, D / Cugat, E / Davis, R / De Boo, D W / De Cobelli, F / De Wispelaere, J F / van Delden, O M / Delle, M / Detry, O / Díaz-Nieto, R / Dili, A / Erdmann, J I / Fisher, O / Fondevila, C / Fretland, Å / Borobia, F Garcia / Gelabert, A / Gérard, L / Giuliante, F / Gobardhan, P D / Gómez, F / Grünberger, T / Grünhagen, D J / Guitart, J / Hagendoorn, J / Heil, J / Heise, D / Herrero, E / Hess, G F / Hoffmann, M H / Iezzi, R / Imani, F / Nguyen, J / Jovine, E / Kalff, J C / Kazemier, G / Kingham, T P / Kleeff, J / Kollmar, O / Leclercq, W K G / Ben, S Lopez / Lucidi, V / MacDonald, A / Madoff, D C / Manekeller, S / Martel, G / Mehrabi, A / Mehrzad, H / Meijerink, M R / Menon, K / Metrakos, P / Meyer, C / Moelker, A / Modi, S / Montanari, N / Navines, J / Neumann, U P / Peddu, P / Primrose, J N / Qu, X / Raptis, D / Ratti, F / Ridouani, F / Rogan, C / Ronellenfitsch, U / Ryan, S / Sallemi, C / Moragues, J Sampere / Sandström, P / Sarriá, L / Schnitzbauer, A / Serenari, M / Serrablo, A / Smits, M L J / Sparrelid, E / Spüntrup, E / Stavrou, G A / Sutcliffe, R P / Tancredi, I / Tasse, J C / Udupa, V / Valenti, D / Fundora, Y / Vogl, T J / Wang, X / White, S A / Wohlgemuth, W A / Yu, D / Zijlstra, I A J / Binkert, C A / Bemelmans, M H A / van der Leij, C / Schadde, E / van Dam, R M

    Cardiovascular and interventional radiology

    2022  Volume 45, Issue 9, Page(s) 1391–1398

    Abstract: Study purpose: The DRAGON 1 trial aims to assess training, implementation, safety and feasibility of combined portal- and hepatic-vein embolization (PVE/HVE) to accelerate future liver remnant (FLR) hypertrophy in patients with borderline resectable ... ...

    Abstract Study purpose: The DRAGON 1 trial aims to assess training, implementation, safety and feasibility of combined portal- and hepatic-vein embolization (PVE/HVE) to accelerate future liver remnant (FLR) hypertrophy in patients with borderline resectable colorectal cancer liver metastases.
    Methods: The DRAGON 1 trial is a worldwide multicenter prospective single arm trial. The primary endpoint is a composite of the safety of PVE/HVE, 90-day mortality, and one year accrual monitoring of each participating center. Secondary endpoints include: feasibility of resection, the used PVE and HVE techniques, FLR-hypertrophy, liver function (subset of centers), overall survival, and disease-free survival. All complications after the PVE/HVE procedure are documented. Liver volumes will be measured at week 1 and if applicable at week 3 and 6 after PVE/HVE and follow-up visits will be held at 1, 3, 6, and 12 months after the resection.
    Results: Not applicable.
    Conclusion: DRAGON 1 is a prospective trial to assess the safety and feasibility of PVE/HVE. Participating study centers will be trained, and procedures standardized using Work Instructions (WI) to prepare for the DRAGON 2 randomized controlled trial. Outcomes should reveal the accrual potential of centers, safety profile of combined PVE/HVE and the effect of FLR-hypertrophy induction by PVE/HVE in patients with CRLM and a small FLR.
    Trial registration: Clinicaltrials.gov: NCT04272931 (February 17, 2020). Toestingonline.nl: NL71535.068.19 (September 20, 2019).
    MeSH term(s) Accreditation ; Embolization, Therapeutic/methods ; Hepatectomy/methods ; Hepatic Veins/pathology ; Hepatomegaly ; Humans ; Hypertrophy/etiology ; Hypertrophy/pathology ; Hypertrophy/surgery ; Liver/surgery ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Multicenter Studies as Topic ; Portal Vein/pathology ; Prospective Studies ; Treatment Outcome
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-022-03176-1
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    Zs.A 1378: Show issues Location:
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