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  1. Article ; Online: Immunoediting of cancer metastasis by NK cells.

    Nakamura, Kyohei / Smyth, Mark J

    Nature cancer

    2021  Volume 1, Issue 7, Page(s) 670–671

    MeSH term(s) Humans ; Killer Cells, Natural/pathology ; Neoplasms/therapy
    Language English
    Publishing date 2021-07-22
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-020-0081-z
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  2. Article ; Online: Innate myeloid cells in the tumor microenvironment.

    Duhan, Vikas / Smyth, Mark J

    Current opinion in immunology

    2021  Volume 69, Page(s) 18–28

    Abstract: Cancer immunotherapies are receiving increasing approval in the clinic, but still only a fraction of patients benefit long-term. Understanding the most important mechanisms of immunotherapeutic resistance is critical for broader utility and benefit of ... ...

    Abstract Cancer immunotherapies are receiving increasing approval in the clinic, but still only a fraction of patients benefit long-term. Understanding the most important mechanisms of immunotherapeutic resistance is critical for broader utility and benefit of cancer immunotherapy. While the tumor microenvironment (TME) is made up of many cell types, immunosuppressive monocytes/macrophages, granulocytes and myeloid derived suppressor cells interact with, and play a critical role in regulating the anti-tumor lymphocyte effector cells that mediate effective immunotherapies. Herein, we discuss the latest research that has identified and compared the importance of pro-tumor and immunosuppressive mechanisms that tumor infiltrating myeloid cells employ. Exploiting this new information may help to develop totally novel therapies to boost contemporary cancer immunotherapy.
    MeSH term(s) Animals ; Humans ; Immunity, Innate ; Immunotherapy/methods ; Lymphocytes, Tumor-Infiltrating/immunology ; Myeloid-Derived Suppressor Cells/immunology ; Neoplasms/immunology ; Neoplasms/therapy ; Tumor Microenvironment
    Language English
    Publishing date 2021-02-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2021.01.001
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    Zs.A 2773: Show issues Location:
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  3. Article ; Online: Multiple approaches to immunotherapy - the new pillar of cancer treatment.

    Smyth, Mark J

    Immunology and cell biology

    2017  Volume 95, Issue 4, Page(s) 323–324

    MeSH term(s) Adenosine/metabolism ; Animals ; Antibodies/genetics ; Cancer Vaccines/immunology ; Extracellular Space/metabolism ; Genetic Engineering ; Humans ; Immunotherapy/methods ; Neoplasms/immunology ; Neoplasms/therapy ; Tumor Microenvironment
    Chemical Substances Antibodies ; Cancer Vaccines ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2017-02-04
    Publishing country United States
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1038/icb.2017.9
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  4. Article ; Online: TREM2 marks tumor-associated macrophages.

    Nakamura, Kyohei / Smyth, Mark J

    Signal transduction and targeted therapy

    2020  Volume 5, Issue 1, Page(s) 233

    MeSH term(s) Animals ; Antigens, Differentiation/genetics ; Antigens, Differentiation/immunology ; Humans ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/immunology ; Receptors, Immunologic/genetics ; Receptors, Immunologic/immunology ; Tumor-Associated Macrophages/immunology
    Chemical Substances Antigens, Differentiation ; Membrane Glycoproteins ; Receptors, Immunologic ; TREM2 protein, human
    Language English
    Publishing date 2020-10-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-020-00356-8
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  5. Article ; Online: Innate Cancer Immunoediting.

    Bald, Tobias / Smyth, Mark J

    The Journal of investigative dermatology

    2020  Volume 140, Issue 4, Page(s) 745–747

    Abstract: Immune cells detect and destroy cancer cells; however, very early changes in cancer genome and phenotype coupled with immune system selection cause escape variant survival in a process called cancer immunoediting. Although adaptive immunity is important ... ...

    Abstract Immune cells detect and destroy cancer cells; however, very early changes in cancer genome and phenotype coupled with immune system selection cause escape variant survival in a process called cancer immunoediting. Although adaptive immunity is important for this process, the report by Kubick et al. provides novel insights into the role of innate immune cells for immunoediting of early transformed epithelial cells.
    MeSH term(s) Adaptive Immunity ; Humans ; Intravital Microscopy ; Neoplasms/genetics ; Phenotype
    Language English
    Publishing date 2020-03-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2019.09.015
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  6. Article ; Online: Natural Killers out of Thin Air.

    Nakamura, Kyohei / Smyth, Mark J

    Immunity

    2020  Volume 52, Issue 6, Page(s) 895–897

    Abstract: The regulatory mechanisms controlling natural killer (NK) cells in the tumor microenvironment remain unknown. In this issue, Ni. et al. provide evidence that the transcription factor HIF-1α acts as a key negative regulator of NK cell metabolic fitness in ...

    Abstract The regulatory mechanisms controlling natural killer (NK) cells in the tumor microenvironment remain unknown. In this issue, Ni. et al. provide evidence that the transcription factor HIF-1α acts as a key negative regulator of NK cell metabolic fitness in the tumor microenvironment that critically impedes NK cell anti-tumor immune responses.
    MeSH term(s) Humans ; Killer Cells, Natural ; Neoplasms ; Sequence Analysis, RNA ; Transcription Factors ; Tumor Microenvironment
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2020-06-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2020.05.007
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    Zs.A 4227: Show issues Location:
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  7. Article ; Online: Myeloid immunosuppression and immune checkpoints in the tumor microenvironment.

    Nakamura, Kyohei / Smyth, Mark J

    Cellular & molecular immunology

    2019  Volume 17, Issue 1, Page(s) 1–12

    Abstract: Tumor-promoting inflammation and the avoidance of immune destruction are hallmarks of cancer. While innate immune cells, such as neutrophils, monocytes, and macrophages, are critical mediators for sterile and nonsterile inflammation, persistent ... ...

    Abstract Tumor-promoting inflammation and the avoidance of immune destruction are hallmarks of cancer. While innate immune cells, such as neutrophils, monocytes, and macrophages, are critical mediators for sterile and nonsterile inflammation, persistent inflammation, such as that which occurs in cancer, is known to disturb normal myelopoiesis. This disturbance leads to the generation of immunosuppressive myeloid cells, such as myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs). Due to their potent suppressive activities against effector lymphocytes and their abundance in the tumor microenvironment, immunosuppressive myeloid cells act as a major barrier to cancer immunotherapy. Indeed, various therapeutic approaches directed toward immunosuppressive myeloid cells are actively being tested in preclinical and clinical studies. These include anti-inflammatory agents, therapeutic blockade of the mobilization and survival of myeloid cells, and immunostimulatory adjuvants. More recently, immune checkpoint molecules expressed on tumor-infiltrating myeloid cells have emerged as potential therapeutic targets to redirect these cells to eliminate tumor cells. In this review, we discuss the complex crosstalk between cancer-related inflammation and immunosuppressive myeloid cells and possible therapeutic strategies to harness antitumor immune responses.
    MeSH term(s) Animals ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immune Tolerance/drug effects ; Macrophages/immunology ; Myeloid-Derived Suppressor Cells/immunology ; Myeloid-Derived Suppressor Cells/pathology ; Myelopoiesis/immunology ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/pathology ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2019-10-14
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-019-0306-1
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  8. Article: 2018 Nobel Prize in physiology or medicine.

    Smyth, Mark J / Teng, Michele Wl

    Clinical & translational immunology

    2018  Volume 7, Issue 10, Page(s) e1041

    Language English
    Publishing date 2018-10-24
    Publishing country Australia
    Document type Editorial
    ZDB-ID 2694482-0
    ISSN 2050-0068
    ISSN 2050-0068
    DOI 10.1002/cti2.1041
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  9. Article ; Online: Aberrant erythropoiesis fuels tumor growth.

    Nakamura, Kyohei / Smyth, Mark J

    Cell research

    2018  Volume 28, Issue 6, Page(s) 611–612

    MeSH term(s) Erythroblasts ; Erythropoiesis ; Humans ; Neoplasms ; Spleen
    Language English
    Publishing date 2018-05-29
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-018-0047-1
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    Zs.A 5283: Show issues Location:
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  10. Article ; Online: TGFβ shuts the door on T cells.

    Bald, Tobias / Smyth, Mark J

    British journal of cancer

    2018  Volume 119, Issue 1, Page(s) 1–3

    Abstract: T cell exclusion from cancers is a major problem for a proportion of patients suffering poor outcomes. Two papers recently published in Nature highlight the negative role of cancer associated fibroblast TGFβ. These studies indicate that TGFβ enables T ... ...

    Abstract T cell exclusion from cancers is a major problem for a proportion of patients suffering poor outcomes. Two papers recently published in Nature highlight the negative role of cancer associated fibroblast TGFβ. These studies indicate that TGFβ enables T cell exclusion in a proportion of colorectal and urothelial cancers, and in the latter disease may reduce their response to anti-PD-L1 immunotherapy.
    MeSH term(s) Colonic Neoplasms ; Humans ; Immune Evasion ; Immunotherapy ; T-Lymphocytes ; Transforming Growth Factor beta
    Chemical Substances Transforming Growth Factor beta
    Language English
    Publishing date 2018-06-14
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-018-0122-x
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