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Article ; Online: Cyclic-NDGA Effectively Inhibits Human γ-Synuclein Fibrillation, Forms Nontoxic Off-Pathway Species, and Disintegrates Preformed Mature Fibrils.

Singh, Sneh Lata / Bhat, Rajiv

ACS chemical neuroscience

2024 Volume 15, Issue 9, Page(s) 1770–1786

Abstract: Parkinson's disease arises from protein misfolding, aggregation, and fibrillation and is characterized by LB (Lewy body) deposits, which contain the protein α-synuclein (α-syn) as their major component. Another synuclein, γ-synuclein (γ-syn), coexists ... ...

Abstract	Parkinson's disease arises from protein misfolding, aggregation, and fibrillation and is characterized by LB (Lewy body) deposits, which contain the protein α-synuclein (α-syn) as their major component. Another synuclein, γ-synuclein (γ-syn), coexists with α-syn in Lewy bodies and is also implicated in various types of cancers, especially breast cancer. It is known to seed α-syn fibrillation after its oxidation at methionine residue, thereby contributing in synucleinopathy. Despite its involvement in synucleinopathy, the search for small molecule inhibitors and modulators of γ-syn fibrillation remains largely unexplored. This work reveals the modulatory properties of cyclic-nordihydroguaiaretic acid (cNDGA), a natural polyphenol, on the structural and aggregational properties of human γ-syn employing various biophysical and structural tools, namely, thioflavin T (ThT) fluorescence, Rayleigh light scattering, 8-anilinonaphthalene-1-sulfonic acid binding, far-UV circular dichroism (CD), Fourier transform infrared spectroscopy (FTIR) spectroscopy, atomic force microscopy, ITC, molecular docking, and MTT-toxicity assay. cNDGA was observed to modulate the fibrillation of γ-syn to form off-pathway amorphous species that are nontoxic in nature at as low as 75 μM concentration. The modulation is dependent on oxidizing conditions, with cNDGA weakly interacting (
MeSH term(s)	Humans ; gamma-Synuclein/metabolism ; Masoprocol/pharmacology ; Protein Aggregates/drug effects ; Protein Aggregates/physiology ; Spectroscopy, Fourier Transform Infrared ; Protein Aggregation, Pathological/metabolism ; Protein Aggregation, Pathological/drug therapy
Chemical Substances	gamma-Synuclein ; Masoprocol (7BO8G1BYQU) ; Protein Aggregates
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1948-7193
ISSN (online)	1948-7193
DOI	10.1021/acschemneuro.3c00793
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Article: An Assessment of the Bivalent Vaccine as a Second Booster for COVID-19.

Gupta, Sneh Lata / Jaiswal, Rishi K

Vaccines

2022 Volume 11, Issue 1

Abstract: In the USA, two monovalent COVID-19 mRNA vaccines are primarily used for vaccination [ ... ]. ...

Abstract	In the USA, two monovalent COVID-19 mRNA vaccines are primarily used for vaccination [...].
Language	English
Publishing date	2022-12-29
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11010079
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Article ; Online: Neutralizing antibody: a savior in the Covid-19 disease.

Gupta, Sneh Lata / Jaiswal, Rishi Kumar

Molecular biology reports

2022 Volume 49, Issue 3, Page(s) 2465–2474

Abstract: Coronavirus outbreak was declared a pandemic by World Health Organization (WHO) in March 2020. The pandemic has led to a devastating loss of life. It has shown us how infectious diseases can cause human existence at stake, and community health is ... ...

Abstract	Coronavirus outbreak was declared a pandemic by World Health Organization (WHO) in March 2020. The pandemic has led to a devastating loss of life. It has shown us how infectious diseases can cause human existence at stake, and community health is important. The spike protein is the most immunogenic component of the virus. Most vaccine development strategies have focused on the receptor-binding domain (RBD) in the spike protein because it is the most specific target site that recognizes and interacts with human lung cells. Neutralizing antibodies are generated by the humoral immune system and reduce the viral load by binding to spike protein components. Neutralizing antibodies are the proteins secreted by plasma cells and serve as an important part of the defense mechanism. In the recent Covid-19 infection, neutralizing antibodies can be utilized for both diagnostic such as immune surveillance and therapeutic tools such as plasma therapy. So far, many monoclonal antibodies are in the clinical trial phase, and few of them are already in use. In this review, we have discussed details about neutralizing antibodies and their role in combating Covid-19 disease.
MeSH term(s)	Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Antibodies, Viral/therapeutic use ; Antigens, Viral/immunology ; B-Lymphocytes/immunology ; COVID-19/immunology ; COVID-19/therapy ; Clinical Trials as Topic ; Enzyme-Linked Immunosorbent Assay ; Epitopes/immunology ; Forecasting ; Germinal Center/immunology ; Humans ; Immunization, Passive ; Immunoglobulin Isotypes/immunology ; Immunologic Memory ; Immunologic Surveillance ; Macaca mulatta ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Spike Glycoprotein, Coronavirus/immunology
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; Antigens, Viral ; Epitopes ; Immunoglobulin Isotypes ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-01-06
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-021-07020-6
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Article ; Online: Relevant of neutralizing antibody during SARS-CoV-2 infection and their therapeutic usage.

Gupta, Sneh Lata / Jaiswal, Rishi K

Molecular biology reports

2022 Volume 49, Issue 10, Page(s) 10137–10140

MeSH term(s)	Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/therapeutic use ; COVID-19 ; Humans ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-05-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-022-07493-z
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Article ; Online: A glutathione-independent DJ-1/Pfp1 domain containing glyoxalase III, OsDJ-1C, functions in abiotic stress adaptation in rice.

Rathore, Ray Singh / Mishra, Manjari / Pareek, Ashwani / Singla-Pareek, Sneh Lata

Planta

2024 Volume 259, Issue 4, Page(s) 81

Abstract: Main conclusion: Overexpression of OsDJ-1C in rice improves root architecture, photosynthesis, yield and abiotic stress tolerance through modulating methylglyoxal levels, antioxidant defense, and redox homeostasis. Exposure to abiotic stresses leads to ... ...

Abstract	Main conclusion: Overexpression of OsDJ-1C in rice improves root architecture, photosynthesis, yield and abiotic stress tolerance through modulating methylglyoxal levels, antioxidant defense, and redox homeostasis. Exposure to abiotic stresses leads to elevated methylglyoxal (MG) levels in plants, impacting seed germination and root growth. In response, the activation of NADPH-dependent aldo-keto reductase and glutathione (GSH)-dependent glyoxalase enzymes helps to regulate MG levels and reduce its toxic effects. However, detoxification may not be carried out effectively due to the limitation of GSH and NADPH in plants under stress. Recently, a novel enzyme called glyoxalase III (GLY III) has been discovered which can detoxify MG in a single step without needing GSH. To understand the physiological importance of this pathway in rice, we overexpressed the gene encoding GLYIII enzyme (OsDJ-1C) in rice. It was observed that OsDJ-1C overexpression in rice regulated MG levels under stress conditions thus, linked well with plants' abiotic stress tolerance potential. The OsDJ-1C overexpression lines displayed better root architecture, improved photosynthesis, and reduced yield penalty compared to the WT plants under salinity, and drought stress conditions. These plants demonstrated an improved GSH/GSSG ratio, reduced level of reactive oxygen species, increased antioxidant capacity, and higher anti-glycation activity thereby indicating that the GLYIII mediated MG detoxification plays a significant role in plants' ability to reduce the impact of abiotic stress. Furthermore, these findings imply the potential of OsDJ-1C in crop improvement programs.
MeSH term(s)	Oryza/genetics ; Antioxidants ; NADP ; Pyruvaldehyde ; Glutathione ; Stress, Physiological ; Aldehyde Oxidoreductases
Chemical Substances	Antioxidants ; glyoxalase III (EC 1.2.-) ; NADP (53-59-8) ; Pyruvaldehyde (722KLD7415) ; Glutathione (GAN16C9B8O) ; Aldehyde Oxidoreductases (EC 1.2.-)
Language	English
Publishing date	2024-03-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	208909-9
ISSN	1432-2048 ; 0032-0935 ; 1866-2749
ISSN (online)	1432-2048
ISSN	0032-0935 ; 1866-2749
DOI	10.1007/s00425-023-04315-9
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Article ; Online: OsRR26, a type-B response regulator, modulates salinity tolerance in rice via phytohormone-mediated ROS accumulation in roots and influencing reproductive development.

Nongpiur, Ramsong Chantre / Rawat, Nishtha / Singla-Pareek, Sneh Lata / Pareek, Ashwani

Planta

2024 Volume 259, Issue 5, Page(s) 96

Abstract: Main conclusion: OsRR26 is a cytokinin-responsive response regulator that promotes phytohormone-mediated ROS accumulation in rice roots, regulates seedling growth, spikelet fertility, awn development, represses NADPH oxidases, and negatively affects ... ...

Abstract	Main conclusion: OsRR26 is a cytokinin-responsive response regulator that promotes phytohormone-mediated ROS accumulation in rice roots, regulates seedling growth, spikelet fertility, awn development, represses NADPH oxidases, and negatively affects salinity tolerance. Plant two-component systems (TCS) play a pivotal role in phytohormone signaling, stress responses, and circadian rhythm. However, a significant knowledge gap exists regarding TCS in rice. In this study, we utilized a functional genomics approach to elucidate the role of OsRR26, a type-B response regulator in rice. Our results demonstrate that OsRR26 is responsive to cytokinin, ABA, and salinity stress, serving as the ortholog of Arabidopsis ARR11. OsRR26 primarily localizes to the nucleus and plays a crucial role in seedling growth, spikelet fertility, and the suppression of awn development. Exogenous application of cytokinin led to distinct patterns of reactive oxygen species (ROS) accumulation in the roots of both WT and transgenic plants (OsRR26OE and OsRR26KD), indicating the potential involvement of OsRR26 in cytokinin-mediated ROS signaling in roots. The application of exogenous ABA resulted in varied cellular compartmentalization of ROS between the WT and transgenic lines. Stress tolerance assays of these plants revealed that OsRR26 functions as a negative regulator of salinity stress tolerance across different developmental stages in rice. Physiological and biochemical analyses unveiled that the knockdown of OsRR26 enhances salinity tolerance, characterized by improved chlorophyll retention and the accumulation of soluble sugars, K
MeSH term(s)	Oryza/physiology ; Plant Growth Regulators/metabolism ; Salt Tolerance/genetics ; Reactive Oxygen Species/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Stress, Physiological ; Plants, Genetically Modified/metabolism ; Cytokinins/metabolism ; Seedlings/genetics ; Seedlings/metabolism ; Arabidopsis/genetics ; Salinity ; Gene Expression Regulation, Plant
Chemical Substances	Plant Growth Regulators ; Reactive Oxygen Species ; Plant Proteins ; Cytokinins
Language	English
Publishing date	2024-03-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	208909-9
ISSN	1432-2048 ; 0032-0935 ; 1866-2749
ISSN (online)	1432-2048
ISSN	0032-0935 ; 1866-2749
DOI	10.1007/s00425-024-04366-6
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Article ; Online: Concurrent improvement of rice grain yield and abiotic stress tolerance by overexpression of cytokinin activating enzyme LONELY GUY (OsLOG).

Rathore, Ray Singh / Mishra, Manjari / Pareek, Ashwani / Singla-Pareek, Sneh Lata

Plant physiology and biochemistry : PPB

2024 Volume 211, Page(s) 108635

Abstract: Meristem activity is important for normal plant growth as well as adaptive plastic development under abiotic stresses. Cytokinin has been recognized to have a major role in regulating meristem function which is controlled by cytokinin activating enzymes ... ...

Abstract	Meristem activity is important for normal plant growth as well as adaptive plastic development under abiotic stresses. Cytokinin has been recognized to have a major role in regulating meristem function which is controlled by cytokinin activating enzymes by fine-tuning the concentrations and spatial distribution of its bioactive forms. It was previously reported that LONELY GUY (LOG) acts in the direct activation pathway of cytokinin in rice shoot meristems. LOG has a cytokinin specific phosphoribohydrolase activity, which transforms inactive cytokinin nucleotides into active free bases. Here, we explored the role of OsLOG in controlling meristem activity mediated by cytokinin and its effects on growth, development, and stress resilience of rice plants. Overexpression of OsLOG in rice led to significant alterations in cytokinin levels in the inflorescence meristem, leading to enhanced plant growth, biomass and grain yield under both non-stress as well as stress conditions such as drought and salinity. Moreover, our study provides insight into how overexpression of OsLOG improves the ability of plants to withstand stress. The OsLOG-overexpressing lines exhibit reduced accumulation of H
Language	English
Publishing date	2024-04-16
Publishing country	France
Document type	Journal Article
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2024.108635
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Article ; Online: Mycorrhizal fungus Serendipita indica-associated acid phosphatase rescues the phosphate nutrition with reduced arsenic uptake in the host plant under arsenic stress

Aparna Singh Kushwaha / Imran Ahmad / Sneh Lata / Kalpana Padalia / Akhilesh Kumar Yadav / Manoj Kumar

Ecotoxicology and Environmental Safety, Vol 269, Iss , Pp 115783- (2024)

1481

Abstract: Symbiotic interactions play a vital role in maintaining the phosphate (Pi) nutrient status of host plants and providing resilience during biotic and abiotic stresses. Serendipita indica, a mycorrhiza-like fungus, supports plant growth by transporting Pi ... ...

Abstract	Symbiotic interactions play a vital role in maintaining the phosphate (Pi) nutrient status of host plants and providing resilience during biotic and abiotic stresses. Serendipita indica, a mycorrhiza-like fungus, supports plant growth by transporting Pi to the plant. Despite the competitive behaviour of arsenate (AsV) with Pi, the association with S. indica promotes plant growth under arsenic (As) stress by reducing As bioavailability through adsorption, accumulation, and precipitation within the fungus. However, the capacity of S. indica to enhance Pi accumulation and utilization under As stress remains unexplored. Axenic studies revealed that As supply significantly reduces intracellular ACPase activity in S. indica, while extracellular ACPase remains unaffected. Further investigations using Native PAGE and gene expression studies confirmed that intracellular ACPase (isoform2) is sensitive to As, whereas extracellular ACPase (isoform1) is As-insensitive. Biochemical analysis showed that ACPase (isoform1) has a Km of 0.5977 µM and Vmax of 0.1945 Unit/min. In hydroponically cultured tomato seedlings, simultaneous inoculation of S. indica with As on the 14thday after seed germination led to hyper-colonization, increased root/shoot length, biomass, and induction of ACPase expression and secretion under As stress. Arsenic-treated S. indica colonized groups (13.33 µM As+Si and 26.67 µM As+Si) exhibited 8.28–19.14 and 1.71–3.45-fold activation of ACPase in both rhizospheric media and root samples, respectively, thereby enhancing Pi availability in the surrounding medium under As stress. Moreover, S. indica (13.33 µM As+Si and 26.67 µM As+Si) significantly improved Pi accumulation in roots by 7.26 and 9.46 times and in shoots by 4.36 and 8.85 times compared to the control. Additionally, S. indica induced the expression of SiPT under As stress, further improving Pi mobilization. Notably, fungal colonization also restricted As mobilization from the hydroponic medium to the shoot, with a higher amount of As (191.01 ppm ...
Keywords	AMF ; Enzyme Kinetics ; Mineral nutrition ; Organic acid ; Phosphate transporter ; Solanum lycopersicum ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	580
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article: Editorial: Enhancing salinity tolerance in crops - molecular and practical perspectives.

Gautam, Raj Kumar / Singh, Rakesh Kumar / Krishnamurthy, S L / Singla-Pareek, Sneh Lata

Frontiers in plant science

2024 Volume 15, Page(s) 1367677

Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2024.1367677
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Article: Correlation of mandibular third molar orientation and available retromolar space with arch length discrepancy in subjects with different growth pattern.

Verma, Sneh Lata / Tikku, Tripti / Khanna, Rohit / Srivastava, Kamna / Maurya, Rana Pratap / Rai, Priyanka

National journal of maxillofacial surgery

2024 Volume 15, Issue 1, Page(s) 106–115

Abstract: Aim and objective: To evaluate, compare, and correlate the mandibular third molar orientation and available retromolar space with arch length discrepancy in subjects with skeletal class II malocclusion and different growth pattern.: Material and ... ...

Abstract	Aim and objective: To evaluate, compare, and correlate the mandibular third molar orientation and available retromolar space with arch length discrepancy in subjects with skeletal class II malocclusion and different growth pattern. Material and method: A total of 250 patients (age >18 yrs) having skeletal class II malocclusion (based on YEN angle and WITS appraisal) were divided into two groups. Both the groups (Group I with erupted mandibular third molars {N = 150} and Group II with impacted mandibular third molars {N = 100}) were subdivided into subgroups IA (n = 71), IB (n = 19), IC (n = 71) and Group IIA (n = 54), IIB (n = 30) and IIC (n = 16) for normo-, hypo- and hyperdivergent growth patterns, respectively (based on Jarabak ratio and Sn-Go-Gn angle). Four parameters, that is, retromolar space, width of third molar, third molar angulation, and mandibular incisor angulation were measured on orthopantomogram whereas arch length discrepancy was calculated with the help of lateral cephalogram and study model. Intragroup, intergroup comparisons (using unpaired Student's 't' test), and Pearson's correlation coefficient for assessed parameters were obtained. Result: Third molar angulation and retromolar space were significantly higher in Group I than in Group II (hyperdivergent pattern of Group II had highest value). The width of third molar was less than retromolar space in Group II and vice versa for Group I. Mandibular incisor angulation and arch length discrepancy were more in Group II than in Group I, but difference was statistically nonsignificant. Strong positive correlation was observed for mandibular third molar angulation and available retromolar space in normo- and hyperdivergent growth patterns. Conclusion: Lack of retromolar space along with increased amount of arch length discrepancy and mandibular incisor angulation is responsible for increased chances of third molar impaction in some subjects with class II malocclusion.
Language	English
Publishing date	2024-03-19
Publishing country	India
Document type	Journal Article
ZDB-ID	2653583-X
ISSN	2229-3418 ; 0975-5950
ISSN (online)	2229-3418
ISSN	0975-5950
DOI	10.4103/njms.njms_63_22
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