LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Snider, Elizabeth"
  2. AU="Klein, J R"
  3. AU="Deslandes, K."
  4. AU="Xie, Dandan"
  5. AU=Ward Helen
  6. AU="Grace Deukmedjian"
  7. AU="Lindeman, Neal"
  8. AU="Okoli, Mary"
  9. AU="Mathew, Philip"
  10. AU=Staros Eric B

Suchergebnis

Treffer 1 - 6 von insgesamt 6

Suchoptionen

  1. Artikel ; Online: Identification of Genes Required for Swarming Motility in

    Sanchez, Sandra / Snider, Elizabeth V / Wang, Xindan / Kearns, Daniel B

    Journal of bacteriology

    2022  Band 204, Heft 6, Seite(n) e0008922

    Abstract: Bacillus subtilis exhibits swarming motility, a flagellar-mediated form of surface motility. Here, we use transposon mutagenesis and sequencing (TnSeq) to perform a high-throughput screen for candidate genes required for swarming. The TnSeq approach ... ...

    Abstract Bacillus subtilis exhibits swarming motility, a flagellar-mediated form of surface motility. Here, we use transposon mutagenesis and sequencing (TnSeq) to perform a high-throughput screen for candidate genes required for swarming. The TnSeq approach identified all of the known genes required for flagellar biosynthesis and nearly all of the previously reported regulators that promote swarming. Moreover, we identified an additional 36 genes that improve swarming and validated them individually. Among these, two mutants with severe defects were recovered, including
    Mesh-Begriff(e) Bacillus subtilis/genetics ; Bacterial Proteins/genetics ; Flagella/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Mutagenesis ; Mutagenesis, Insertional ; Mutation
    Chemische Substanzen Bacterial Proteins
    Sprache Englisch
    Erscheinungsdatum 2022-05-31
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/jb.00089-22
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  2. Artikel: The alternative sigma factor SigN of

    Burton, Aisha T / Kálalová, Debora / Snider, Elizabeth V / Burrage, Andrew M / Krásný, Libor / Kearns, Daniel B

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Sigma factors bind and direct the RNA polymerase core to specific promoter sequences and alternative sigma factors direct transcription of different regulons of genes. Here, we study the pBS32 plasmid-encoded sigma factor SigN of : Significance: ... ...

    Abstract Sigma factors bind and direct the RNA polymerase core to specific promoter sequences and alternative sigma factors direct transcription of different regulons of genes. Here, we study the pBS32 plasmid-encoded sigma factor SigN of
    Significance: Alternative sigma factors activate entire regulons of genes to improve viability in response to environmental stimuli. The pBS32 plasmid-encoded SigN of
    Sprache Englisch
    Erscheinungsdatum 2023-03-23
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.03.22.533896
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  3. Artikel ; Online: The alternative sigma factor SigN of

    Burton, Aisha T / Pospíšilová, Debora / Sudzinova, Petra / Snider, Elizabeth V / Burrage, Andrew M / Krásný, Libor / Kearns, Daniel B

    Journal of bacteriology

    2023  Band 205, Heft 10, Seite(n) e0011223

    Abstract: Sigma factors bind and direct the RNA polymerase core to specific promoter sequences, and alternative sigma factors direct transcription of different regulons of genes. Here, we study the pBS32 plasmid-encoded sigma factor SigN ... ...

    Abstract Sigma factors bind and direct the RNA polymerase core to specific promoter sequences, and alternative sigma factors direct transcription of different regulons of genes. Here, we study the pBS32 plasmid-encoded sigma factor SigN of
    Mesh-Begriff(e) Sigma Factor/metabolism ; Bacillus subtilis/genetics ; Bacillus subtilis/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; DNA-Directed RNA Polymerases/genetics ; DNA-Directed RNA Polymerases/metabolism ; Immunoglobulin A, Secretory/genetics ; Transcription, Genetic ; Gene Expression Regulation, Bacterial
    Chemische Substanzen Sigma Factor ; Bacterial Proteins ; DNA-Directed RNA Polymerases (EC 2.7.7.6) ; Immunoglobulin A, Secretory
    Sprache Englisch
    Erscheinungsdatum 2023-09-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/jb.00112-23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  4. Artikel ; Online: Identification of distinct capsule types associated with Serratia marcescens infection isolates.

    Anderson, Mark T / Himpsl, Stephanie D / Mitchell, Lindsay A / Kingsley, Leandra G / Snider, Elizabeth P / Mobley, Harry L T

    PLoS pathogens

    2022  Band 18, Heft 3, Seite(n) e1010423

    Abstract: Serratia marcescens is a versatile opportunistic pathogen that can cause a variety of infections, including bacteremia. Our previous work established that the capsule polysaccharide (CPS) biosynthesis and translocation locus contributes to the survival ... ...

    Abstract Serratia marcescens is a versatile opportunistic pathogen that can cause a variety of infections, including bacteremia. Our previous work established that the capsule polysaccharide (CPS) biosynthesis and translocation locus contributes to the survival of S. marcescens in a murine model of bacteremia and in human serum. In this study, we determined the degree of capsule genetic diversity among S. marcescens isolates. Capsule loci (KL) were extracted from >300 S. marcescens genome sequences and compared. A phylogenetic comparison of KL sequences demonstrated a substantial level of KL diversity within S. marcescens as a species and a strong delineation between KL sequences originating from infection isolates versus environmental isolates. Strains from five of the identified KL types were selected for further study and electrophoretic analysis of purified CPS indicated the production of distinct glycans. Polysaccharide composition analysis confirmed this observation and identified the constituent monosaccharides for each strain. Two predominant infection-associated clades, designated KL1 and KL2, emerged from the capsule phylogeny. Bacteremia strains from KL1 and KL2 were determined to produce ketodeoxynonulonic acid and N-acetylneuraminic acid, two sialic acids that were not found in strains from other clades. Further investigation of KL1 and KL2 sequences identified two genes, designated neuA and neuB, that were hypothesized to encode sialic acid biosynthesis functions. Disruption of neuB in a KL1 isolate resulted in the loss of sialic acid and CPS production. The absence of sialic acid and CPS production also led to increased susceptibility to internalization by a human monocytic cell line, demonstrating that S. marcescens phagocytosis resistance requires CPS. Together, these results establish the capsule genetic repertoire of S. marcescens and identify infection-associated clades with sialic acid CPS components.
    Mesh-Begriff(e) Animals ; Bacteremia ; Humans ; Mice ; N-Acetylneuraminic Acid ; Phylogeny ; Serratia Infections ; Serratia marcescens/genetics
    Chemische Substanzen N-Acetylneuraminic Acid (GZP2782OP0)
    Sprache Englisch
    Erscheinungsdatum 2022-03-30
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1010423
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  5. Artikel ; Online: Low costs of adaptation to dietary restriction.

    Moger-Reischer, Roy Z / Snider, Elizabeth V / McKenzie, Kelsey L / Lennon, Jay T

    Biology letters

    2020  Band 16, Heft 3, Seite(n) 20200008

    Abstract: Dietary restriction (DR) is the most successful and widespread means of extending organismal lifespan. However, the evolutionary basis of life extension under DR remains uncertain. The traditional evolutionary explanation is that when organisms ... ...

    Abstract Dietary restriction (DR) is the most successful and widespread means of extending organismal lifespan. However, the evolutionary basis of life extension under DR remains uncertain. The traditional evolutionary explanation is that when organisms experience DR, they allocate endogenous resources to survival and postpone reproduction until conditions improve. However, this life-extension strategy should be maladaptive if DR continues for multiple generations due to trade-offs between longevity and reproduction. To test this prediction, we subjected the budding yeast
    Mesh-Begriff(e) Acclimatization ; Adaptation, Physiological ; Caloric Restriction ; Longevity ; Reproduction
    Sprache Englisch
    Erscheinungsdatum 2020-03-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2135022-X
    ISSN 1744-957X ; 1744-9561
    ISSN (online) 1744-957X
    ISSN 1744-9561
    DOI 10.1098/rsbl.2020.0008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  6. Artikel ; Online: Analysis of Uncharacterized

    Snider, Paige L / Snider, Elizabeth / Simmons, Olga / Lilly, Brenda / Conway, Simon J

    Journal of cardiovascular development and disease

    2019  Band 6, Heft 2

    Abstract: ... ...

    Abstract Mammalian
    Sprache Englisch
    Erscheinungsdatum 2019-06-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd6020024
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang