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Article ; Online: Longitudinal Cognitive Decline in Alzheimer Disease Prevention Trials: A Test of Time

Castilhos, Raphael M / Snitz, Beth E

2023 Volume 102, Issue 2, Page(s) e208067

Abstract: The landscape of clinical trials for Alzheimer disease (AD) has undergone significant evolution in the past decade, most notably by the inclusion of individuals at progressively earlier stages of the disease. Recent approvals by the Food and Drug ... ...

Abstract	The landscape of clinical trials for Alzheimer disease (AD) has undergone significant evolution in the past decade, most notably by the inclusion of individuals at progressively earlier stages of the disease. Recent approvals by the Food and Drug Administration have predominantly centered around individuals with prodromal and mild AD,
MeSH term(s)	United States ; Humans ; Alzheimer Disease/prevention & control ; Cognitive Dysfunction/prevention & control ; Neuropsychological Tests ; Research Design ; Signal Transduction
Language	English
Publishing date	2023-12-26
Publishing country	United States
Document type	Editorial
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000208067
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Article ; Online: Do subtle cognitive deficits precede amyloid accumulation? Cart before the horse.

Snitz, Beth E / Brickman, Adam M

Neurology

2019 Volume 94, Issue 4, Page(s) 151–152

MeSH term(s)	Amyloid ; Cognition ; Cognition Disorders ; Cognitive Dysfunction ; Humans
Chemical Substances	Amyloid
Language	English
Publishing date	2019-12-30
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000008835
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Article: Voxel-wise hemispheric Amyloid Asymmetry and its association with cerebral metabolism and grey matter density in cognitively normal older adults.

Jayaprakash, Hunsica J / Mizuno, Akiko / Snitz, Beth E / Cohen, Ann D / Klunk, Willian E / Aizenstein, Howard J / Karim, Helmet T

medRxiv : the preprint server for health sciences

2024

Abstract: Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by changes in beta amyloid (Aß) and tau as well as changes in cerebral glucose metabolism and gray matter volume. This has been categorized as three distinct stages of ... ...

Abstract	Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by changes in beta amyloid (Aß) and tau as well as changes in cerebral glucose metabolism and gray matter volume. This has been categorized as three distinct stages of amyloid, tau, and neurodegeneration. Past studies have shown asymmetric Aβ accumulation and its association with asymmetric cerebral metabolism in preclinical AD. We analyzed data to replicate these findings and extend them to associations with gray matter volume and cognitive function. Methods: We recruited 93 (mean age = 76.4±6.1 years) cognitively normal adults who underwent magnetic resonance imaging (MRI) and positron emission tomography (PET) with Pittsburgh compound B (PiB) and Fluorodeoxyglucose (FDG) tracers (to estimate Aβ and glucose metabolism, respectively). We conducted voxel-wise paired t-test on PiB (left vs. right hemispheres) to identify regions that differ in Aβ between the left and right cortex. We identified whether these regions showed asymmetry in FDG and gray matter volume using paired t-tests on each region. We then conducted correlations between asymmetry indices for each region that had significant asymmetry in PiB, FDG, and gray matter volume. We ran a group regression analysis on cognitive functions. Results: We found 26 regions that had significant rightward asymmetry in PiB including prefrontal cortex, temporal cortex, insula, parahippocampus, caudate, and putamen. All these regions showed significant gray matter rightward asymmetry, and most of these regions showed significant FDG asymmetry except the caudate, orbital cortex, medial frontal gyrus, and superior temporal gyrus. Only in the superior frontal gyrus, we found that greater rightward asymmetry in PiB was associated with greater rightward asymmetry in FDG, Discussion: AD has previously been modeled in three-stages: however, our results indicate that cerebral glucose metabolism may be dynamic throughout the disease progression and may serve as a compensatory pathway for maintaining cognitive functioning.
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.05.24303808
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Article ; Online: Predicting Dementia from Decline in Gait Speed: Are We There Yet?

Rosano, Caterina / Snitz, Beth E

Journal of the American Geriatrics Society

2018 Volume 66, Issue 9, Page(s) 1659–1660

MeSH term(s)	Brain ; Cognition ; Dementia ; Gait ; Humans ; Walking Speed
Language	English
Publishing date	2018-04-02
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.15368
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Article: Differences in Alzheimer's Disease and Related Dementias Pathology Among African American and Hispanic Women: A Qualitative Literature Review of Biomarker Studies.

Royse, Sarah K / Cohen, Ann D / Snitz, Beth E / Rosano, Caterina

Frontiers in systems neuroscience

2021 Volume 15, Page(s) 685957

Abstract: Introduction: The population of older adults with Alzheimer's disease and Related Dementias (ADRD) is growing larger and more diverse. Prevalence of ADRD is higher in African American (AA) and Hispanic populations relative to non-Hispanic whites (nHW), ... ...

Abstract	Introduction: The population of older adults with Alzheimer's disease and Related Dementias (ADRD) is growing larger and more diverse. Prevalence of ADRD is higher in African American (AA) and Hispanic populations relative to non-Hispanic whites (nHW), with larger differences for women compared to men of the same race. Given the public health importance of this issue, we sought to determine if AA and Hispanic women exhibit worse ADRD pathology compared to men of the same race and nHW women. We hypothesized that such differences may explain the discrepancy in ADRD prevalence. Methods: We evaluated 932 articles that measured at least one of the following biomarkers of ADRD pathology Results: We included 26 articles (Aß = 9, tau = 6, neurodegeneration = 16, cSVD = 18), with seven including sex-by-race comparisons. Studies differed by sampling source (e.g., clinic or population), multivariable analytical approach (e.g., adjusted for risk factors for AD), and cognitive status of participants. Aß burden did not differ by race or sex. Tau differed by race (AA < nHW), and by sex (women > men). Both severity of neurodegeneration and cSVD differed by race (AA > nHW; Hispanics < nHW) and sex (women < men). Among the studies that tested sex-by-race interactions, results were not significant. Conclusion: Few studies have examined the burden of ADRD pathology by both race and sex. The higher prevalence of ADRD in women compared to men of the same race may be due to both higher tau load and more vulnerability to cognitive decline in the presence of similar Aß and cSVD burden. AA women may also exhibit more neurodegeneration and cSVD relative to nHW populations. Studies suggest that between-group differences in ADRD pathology are complex, but they are too sparse to completely explain why minority women have the highest ADRD prevalence. Future work should recruit diverse cohorts, compare ADRD biomarkers by both race and sex, and collect relevant risk factor and cognitive data.
Language	English
Publishing date	2021-07-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2453005-0
ISSN	1662-5137
ISSN	1662-5137
DOI	10.3389/fnsys.2021.685957
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Article ; Online: Assessing Social Cognition in Older Adults: A Population-Based Study.

Lee, Soyoung / Jia, Yichen / Snitz, Beth E / Chang, Chung-Chou H / Ganguli, Mary

Alzheimer disease and associated disorders

2022 Volume 36, Issue 2, Page(s) 103–110

Abstract: Objectives: In a population-based study of mild cognitive impairment (MCI), to validate the assessment of social cognition in older adults.: Methods: Cross-sectional study of 902 adults aged 65+ with mean age 76.6 years (SD 8.06). We created a social ...

Abstract	Objectives: In a population-based study of mild cognitive impairment (MCI), to validate the assessment of social cognition in older adults. Methods: Cross-sectional study of 902 adults aged 65+ with mean age 76.6 years (SD 8.06). We created a social cognition composite comprising standardized z scores on the Social Norms Questionnaire and the 10-item Reading the Mind in the Eyes Test. We identified associated factors and compared sensitivity, specificity, and the area under the curve of social cognition, for MCI defined as Clinical Dementia Rating (CDR)=0.5, to those of other cognitive domains. We calculated the impact of including social cognition on the proportion neuropsychologically classified as MCI. Results: Better social cognition was associated with younger age, female sex, higher education, better general cognition (mini-mental state examination), fewer depressive symptoms, and lower CDR. Adjusting for demographics, associations with mini-mental state examination, depressive symptoms, anxiety symptoms, and subjective cognitive complaints remained significant. The sensitivity and specificity of social cognition for CDR=0.5 were comparable to those of the traditional 5 cognitive domains. Including social cognition as a sixth domain of cognition resulted in a 5% increase in the proportion classified as MCI. Conclusions: Brief objective assessment of social cognition may enhance cognitive assessment of older adults.
MeSH term(s)	Aged ; Cognition ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/psychology ; Cross-Sectional Studies ; Female ; Humans ; Neuropsychological Tests ; Sensitivity and Specificity ; Social Cognition
Language	English
Publishing date	2022-03-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1002700-2
ISSN	1546-4156 ; 0893-0341
ISSN (online)	1546-4156
ISSN	0893-0341
DOI	10.1097/WAD.0000000000000497
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Article ; Online: Predictors of Driving Cessation in Older Adults: A 12-year Population-based Study.

Wood, Isabella / Bhojak, Tejal / Jia, Yichen / Jacobsen, Erin / Snitz, Beth E / Chang, Chung-Chou H / Ganguli, Mary

Alzheimer disease and associated disorders

2023 Volume 37, Issue 1, Page(s) 13–19

Abstract: Background: Changes in physical health and cognition during aging can result in some older adults to stop driving. In this population-based longitudinal study, we describe potential predictors of driving cessation in older adults.: Methods: Age- ... ...

Abstract	Background: Changes in physical health and cognition during aging can result in some older adults to stop driving. In this population-based longitudinal study, we describe potential predictors of driving cessation in older adults. Methods: Age-stratified random population cohort of 1982 adults aged 65 years and older drawn from voter registration lists. Participant characteristics were measured using demographics, physical and self-rated health, sleeping habits, driving status, cognitive screening, modified Center for Epidemiologic Studies-Depression scale, clinical dementia rating, and mini-mental state examination. Results: Over 12 years of follow-up, 390 participants stopped driving. These individuals were older, more likely to be women and to have a clinical dementia rating score ≥1, had worse self-reported health, and more symptoms of depression, compared with those who were still driving. In addition, individuals with lower test performance in all cognitive domains, loss of visual acuity and fields, and bilateral hearing loss were more likely to stop driving. Conclusions: Age, sex, cognitive impairments, physical health, and depressive symptoms were associated with driving cessation in this cohort. By identifying potential driving cessation predictors, health care providers and families may better recognize these risk factors and begin the driving cessation discussion early.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Longitudinal Studies ; Automobile Driving/psychology ; Cognition ; Aging/psychology ; Cognitive Dysfunction
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1002700-2
ISSN	1546-4156 ; 0893-0341
ISSN (online)	1546-4156
ISSN	0893-0341
DOI	10.1097/WAD.0000000000000541
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Article ; Online: It goes both ways: The relationship between anxiety and mild cognitive impairment.

Jain, Neha / Wang, Yueting / Zhang, Yingjin / Jacobsen, Erin / Andreescu, Carmen / Snitz, Beth E / Chang, Chung-Chou H / Ganguli, Mary

International journal of geriatric psychiatry

2023 Volume 38, Issue 3, Page(s) e5899

Abstract: Objective: To investigate the relationship between anxiety and mild cognitive impairment (MCI), and whether it is mediated by perceived stress, at the population level.: Method and design: In a longitudinal study of 368 adults aged 65+ from a ... ...

Abstract	Objective: To investigate the relationship between anxiety and mild cognitive impairment (MCI), and whether it is mediated by perceived stress, at the population level. Method and design: In a longitudinal study of 368 adults aged 65+ from a population-based cohort, we annually assessed anxiety symptoms (GAD-7), perceived stress (PSS-4), and ratings on the Clinical Dementia Rating (CDR®), where CDR = 0.5 was operationalized as MCI. Examining data from three consecutive assessment waves, we first determined the associations between anxiety at the first wave with MCI at the third wave, and vice versa. We then used mediation analyses to determine whether the pathways in both directions were mediated by perceived stress at the second wave, adjusting for demographics and other relevant covariates. Results: We confirmed significant bidirectional longitudinal associations between anxiety and MCI. Perceived stress was detected as a significant mediator for both pathways between anxiety and MCI, explaining 37.1% of the total effect (TE) of anxiety on incident MCI while conversely explaining 27.1% of the TE of MCI on anxiety. Conclusions: A bidirectional relationship with a 2-year lag between anxiety and MCI was mediated through perceived stress. Clinicians should be sensitive both to potential consequent anxiety when patients present with cognitive impairment, and to potential incipient MCI when the presenting complaint is anxiety. Managing stress may help mitigate adverse outcomes.
MeSH term(s)	Humans ; Longitudinal Studies ; Anxiety/epidemiology ; Anxiety Disorders ; Cognitive Dysfunction/epidemiology ; Mental Status and Dementia Tests
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	806736-3
ISSN	1099-1166 ; 0885-6230
ISSN (online)	1099-1166
ISSN	0885-6230
DOI	10.1002/gps.5899
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Article ; Online: Identifying sex-specific risk architectures for predicting amyloid deposition using neural networks.

Wang, Linghai / Kolobaric, Antonija / Aizenstein, Howard / Lopresti, Brian / Tudorascu, Dana / Snitz, Beth / Klunk, William / Wu, Minjie

NeuroImage

2023 Volume 275, Page(s) 120147

Abstract: In older adults without dementia, White Matter Hyperintensities (WMH) in MRI have been shown to be highly associated with cerebral amyloid deposition, measured by the Pittsburgh compound B (PiB) PET. However, the relation to age, sex, and education in ... ...

Abstract	In older adults without dementia, White Matter Hyperintensities (WMH) in MRI have been shown to be highly associated with cerebral amyloid deposition, measured by the Pittsburgh compound B (PiB) PET. However, the relation to age, sex, and education in explaining this association is not well understood. We use the voxel counts of regional WMH, age, one-hot encoded sex, and education to predict the regional PiB using a multilayer perceptron with only rectilinear activations using mean squared error. We then develop a novel, robust metric to understand the relevance of each input variable for prediction. Our observations indicate that sex is the most relevant predictor of PiB and that WMH is not relevant for prediction. These results indicate that there is a sex-specific risk architecture for Aβ deposition.
MeSH term(s)	Male ; Female ; Humans ; Aged ; Positron-Emission Tomography/methods ; Magnetic Resonance Imaging ; Aniline Compounds ; Amyloid beta-Peptides/metabolism ; Alzheimer Disease ; Brain/diagnostic imaging ; Brain/metabolism
Chemical Substances	Aniline Compounds ; Amyloid beta-Peptides
Language	English
Publishing date	2023-05-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2023.120147
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Zs.A 3664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Meta-analysis of age-related cognitive decline reveals a novel locus for the attention domain and implicates a COVID-19-related gene for global cognitive function.

Acharya, Vibha / Fan, Kang-Hsien / Snitz, Beth E / Ganguli, Mary / DeKosky, Steven T / Lopez, Oscar L / Feingold, Eleanor / Kamboh, Mohammed Ilyas

Alzheimer's & dementia : the journal of the Alzheimer's Association

2023 Volume 19, Issue 11, Page(s) 5010–5022

Abstract: Introduction: Cognitive abilities have substantial heritability throughout life, as shown by twin- and population-based studies. However, there is limited understanding of the genetic factors related to cognitive decline in aging across neurocognitive ... ...

Abstract	Introduction: Cognitive abilities have substantial heritability throughout life, as shown by twin- and population-based studies. However, there is limited understanding of the genetic factors related to cognitive decline in aging across neurocognitive domains. Methods: We conducted a meta-analysis on 3045 individuals aged ≥65, derived from three population-based cohorts, to identify genetic variants associated with the decline of five neurocognitive domains (attention, memory, executive function, language, visuospatial function) and global cognitive decline. We also conducted gene-based and functional bioinformatics analyses. Results: Apolipoprotein E (APOE)4 was significantly associated with decline of memory (p = 5.58E-09) and global cognitive function (p = 1.84E-08). We identified a novel association with attention decline on chromosome 9, rs6559700 (p = 2.69E-08), near RASEF. Gene-based analysis also identified a novel gene, TMPRSS11D, involved in the activation of SARS-CoV-2, to be associated with the decline in global cognitive function (p = 4.28E-07). Discussion: Domain-specific genetic studies can aid in the identification of novel genes and pathways associated with decline across neurocognitive domains. Highlights: rs6559700 was associated with decline of attention. APOE4 was associated with decline of memory and global cognitive decline. TMPRSS11D, a gene involved in the activation of SARS-CoV-2, was implicated in global cognitive decline. Cognitive domain abilities had both unique and shared molecular pathways across the domains.
MeSH term(s)	Humans ; COVID-19/genetics ; SARS-CoV-2 ; Cognition/physiology ; Cognitive Dysfunction/genetics ; Attention ; Apolipoprotein E4/genetics ; Neuropsychological Tests
Chemical Substances	Apolipoprotein E4
Language	English
Publishing date	2023-04-23
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13064
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Zs.MO 540: Show issues

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