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  1. AU="So, Ronald"
  2. AU="deSouza, Ashwin L"
  3. AU="Härtlova, Anetta"
  4. AU="Ghanem, Ahmed I"
  5. AU="Yue Lu"
  6. AU="Pincus, Laura B"
  7. AU="Ibrahim, Nashwan"
  8. AU=Bray Molly S AU=Bray Molly S
  9. AU="Bregy, Amadé"
  10. AU=Kaper J B
  11. AU="León-Ramón, Susana"
  12. AU="Simpson, Andrew"
  13. AU="Peters, Wibke"
  14. AU="Malik, Sajid Ali"
  15. AU="V, Gomathi"

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  1. Artikel ; Online: Closed system production of serum eye drops using dockable saline.

    Kirwan, Susy / Kwan, Patrick S L / So, Ronald / Tuinukuafe, Alice

    Vox sanguinis

    2023  Band 118, Heft 9, Seite(n) 790–793

    Abstract: Background and objectives: A fully closed system solution to manufacture serum eye drops using diluted serum has remained elusive, necessitating production steps to mitigate bacterial contamination risks in a clean suite environment, hampering ... ...

    Abstract Background and objectives: A fully closed system solution to manufacture serum eye drops using diluted serum has remained elusive, necessitating production steps to mitigate bacterial contamination risks in a clean suite environment, hampering production efficiency amid growing demand. We describe our recent implementation of a fully closed manufacturing process at New Zealand Blood Service.
    Materials and methods: A dockable format for sterile saline manufactured to custom specifications configured with a 15-cm tubing to enable sterile connections was sourced from a local pharmaceutical manufacturer.
    Results: From a total of 30,168 eye drop vials manufactured since implementation, the average production time was reduced by up to 45% performed in the general laboratory environment, attributed to eliminating processes performed in a clean suite. No bacterial contamination was observed, demonstrating robust sterile connections.
    Conclusion: Dockable saline takes serum eye drops manufactured from a functionally closed system to a fully closed system, thereby enhancing patient safety, significantly reducing manufacturing time and cost and transforming production from a highly restrictive process into a portable workflow that is simple, practical and effective.
    Mesh-Begriff(e) Humans ; Ophthalmic Solutions ; Serum ; Drug Contamination/prevention & control ; New Zealand
    Chemische Substanzen Ophthalmic Solutions
    Sprache Englisch
    Erscheinungsdatum 2023-07-10
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.13494
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  2. Artikel ; Online: Learning-based multi-modal rigid image registration by using Bhattacharyya distances.

    So, Ronald W K / Chung, Albert C S

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2011  Band 2011, Seite(n) 2642–2645

    Abstract: Multi-modal image registration is a momentous technology in medical image processing and analysis. In order to improve the robustness and accuracy of multi-modal rigid image registration, a novel learning-based dissimilarity function is proposed in this ... ...

    Abstract Multi-modal image registration is a momentous technology in medical image processing and analysis. In order to improve the robustness and accuracy of multi-modal rigid image registration, a novel learning-based dissimilarity function is proposed in this paper. This novel dissimilarity function is based on measuring the dissimilarity between the joint intensity distribution of the testing image pair and the expected intensity distributions, which is learned from a registered image pair, with Bhattacharyya distances. Then, the aim of the registration process is to minimize the dissimilarity function. Eight hundred randomized CT - T1 registrations were performed and evaluated by the Retrospective Image Registration Evaluation (RIRE) project. The experimental results demonstrate that the proposed method can achieve higher robustness and accuracy, as compared with a closely related approach and a state-of-the-art method.
    Mesh-Begriff(e) Learning ; Models, Theoretical ; Tomography, X-Ray Computed/methods
    Sprache Englisch
    Erscheinungsdatum 2011-12-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/IEMBS.2011.6090514
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: International Forum on Management of Blood Donors with Culture-Positive Platelet Donations: Summary.

    Vassallo, Ralph / Kamel, Hany / Goel, Ruchika / Al-Riyami, Arwa Z / Al Muharrmi, Zakariya / Jacquot, Cyril / Ramirez-Arcos, Sandra / Khandelwal, Aditi / Goldman, Mindy / Hands, Katie / McLintock, Lorna / Mitchell, Heather / Wendel, Silvano / Scuracchio, Patrícia / Fachini, Roberta / Pettersson, Sandra M / Bengtsson, Jesper / Brailsford, Susan R / Tossell, Joanne /
    Amorim, Luiz / Lopes, Maria Esther / Pêcego, Margarida / Germain, Marc / Renaud, Christian / Morley, Sarah L / So, Ronald / Townsend, Mary / Hopkins, Courtney / Harritshoej, Lene H / Erikstrup, Christian / Gosbell, Iain B / Levin, Melanie H / Dennington, Peta M / Dunbar, Nancy

    Vox sanguinis

    2023  Band 118, Heft 11, Seite(n) 997–1003

    Mesh-Begriff(e) Humans ; Blood Donors ; Blood Donation
    Sprache Englisch
    Erscheinungsdatum 2023-09-29
    Erscheinungsland England
    Dokumenttyp Consensus Development Conference ; Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.13519
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  4. Artikel ; Online: International Forum on Management of Blood Donors with Culture-Positive Platelet Donations: Responses.

    Vassallo, Ralph / Kamel, Hany / Goel, Ruchika / Al-Riyami, Arwa Z / Al-Muharrmi, Zakariya / Jacquot, Cyril / Ramirez-Arcos, Sandra / Khandelwal, Aditi / Goldman, Mindy / Hands, Katie / McLintock, Lorna / Mitchell, Heather / Wendel, Silvano / Scuracchio, Patrícia / Fachini, Roberta / Pettersson, Sandra M / Bengtsson, Jesper / Brailsford, Susan R / Tossell, Joanne /
    Amorim, Luiz / Lopes, Maria Esther / Pêcego, Margarida / Germain, Marc / Renaud, Christian / Morley, Sarah L / So, Ronald / Townsend, Mary / Hopkins, Courtney / Harritshoej, Lene H / Erikstrup, Christian / Gosbell, Iain B / Levin, Melanie H / Dennington, Peta M / Dunbar, Nancy

    Vox sanguinis

    2023  Band 118, Heft 11, Seite(n) 1004–1023

    Mesh-Begriff(e) Humans ; Blood Donors ; Blood Donation
    Sprache Englisch
    Erscheinungsdatum 2023-09-29
    Erscheinungsland England
    Dokumenttyp Consensus Development Conference ; Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.13520
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  5. Artikel ; Online: Principal curves for lumen center extraction and flow channel width estimation in 3-D arterial networks: theory, algorithm, and validation.

    Wong, Wilbur C K / So, Ronald W K / Chung, Albert C S

    IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

    2012  Band 21, Heft 4, Seite(n) 1847–1862

    Abstract: We present an energy-minimization-based framework for locating the centerline and estimating the width of tubelike objects from their structural network with a nonparametric model. The nonparametric representation promotes simple modeling of nested ... ...

    Abstract We present an energy-minimization-based framework for locating the centerline and estimating the width of tubelike objects from their structural network with a nonparametric model. The nonparametric representation promotes simple modeling of nested branches and n -way furcations, i.e., structures that abound in an arterial network, e.g., a cerebrovascular circulation. Our method is capable of extracting the entire vascular tree from an angiogram in a single execution with a proper initialization. A succinct initial model from the user with arterial network inlets, outlets, and branching points is sufficient for complex vasculature. The novel method is based upon the theory of principal curves. In this paper, theoretical extension to grayscale angiography is discussed, and an algorithm to find an arterial network as principal curves is also described. Quantitative validation on a number of simulated data sets, synthetic volumes of 19 BrainWeb vascular models, and 32 Rotterdam Coronary Artery volumes was conducted. We compared the algorithm to a state-of-the-art method and further tested it on two clinical data sets. Our algorithmic outputs-lumen centers and flow channel widths-are important to various medical and clinical applications, e.g., vasculature segmentation, registration and visualization, virtual angioscopy, and vascular atlas formation and population study.
    Mesh-Begriff(e) Algorithms ; Angiography/methods ; Artificial Intelligence ; Computer Simulation ; Humans ; Image Enhancement/methods ; Image Interpretation, Computer-Assisted/methods ; Imaging, Three-Dimensional/methods ; Models, Cardiovascular ; Pattern Recognition, Automated/methods ; Principal Component Analysis ; Reproducibility of Results ; Sensitivity and Specificity ; Subtraction Technique
    Sprache Englisch
    Erscheinungsdatum 2012-04
    Erscheinungsland United States
    Dokumenttyp Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't ; Validation Studies
    ISSN 1941-0042
    ISSN (online) 1941-0042
    DOI 10.1109/TIP.2011.2179054
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Experimental verification of the Acuros XB and AAA dose calculation adjacent to heterogeneous media for IMRT and RapidArc of nasopharygeal carcinoma.

    Kan, Monica W K / Leung, Lucullus H T / So, Ronald W K / Yu, Peter K N

    Medical physics

    2013  Band 40, Heft 3, Seite(n) 31714

    Abstract: Purpose: To compare the doses calculated by the Acuros XB (AXB) algorithm and analytical anisotropic algorithm (AAA) with experimentally measured data adjacent to and within heterogeneous medium using intensity modulated radiation therapy (IMRT) and ... ...

    Abstract Purpose: To compare the doses calculated by the Acuros XB (AXB) algorithm and analytical anisotropic algorithm (AAA) with experimentally measured data adjacent to and within heterogeneous medium using intensity modulated radiation therapy (IMRT) and RapidArc(®) (RA) volumetric arc therapy plans for nasopharygeal carcinoma (NPC).
    Methods: Two-dimensional dose distribution immediately adjacent to both air and bone inserts of a rectangular tissue equivalent phantom irradiated using IMRT and RA plans for NPC cases were measured with GafChromic(®) EBT3 films. Doses near and within the nasopharygeal (NP) region of an anthropomorphic phantom containing heterogeneous medium were also measured with thermoluminescent dosimeters (TLD) and EBT3 films. The measured data were then compared with the data calculated by AAA and AXB. For AXB, dose calculations were performed using both dose-to-medium (AXB_Dm) and dose-to-water (AXB_Dw) options. Furthermore, target dose differences between AAA and AXB were analyzed for the corresponding real patients. The comparison of real patient plans was performed by stratifying the targets into components of different densities, including tissue, bone, and air.
    Results: For the verification of planar dose distribution adjacent to air and bone using the rectangular phantom, the percentages of pixels that passed the gamma analysis with the ± 3%/3mm criteria were 98.7%, 99.5%, and 97.7% on the axial plane for AAA, AXB_Dm, and AXB_Dw, respectively, averaged over all IMRT and RA plans, while they were 97.6%, 98.2%, and 97.7%, respectively, on the coronal plane. For the verification of planar dose distribution within the NP region of the anthropomorphic phantom, the percentages of pixels that passed the gamma analysis with the ± 3%/3mm criteria were 95.1%, 91.3%, and 99.0% for AAA, AXB_Dm, and AXB_Dw, respectively, averaged over all IMRT and RA plans. Within the NP region where air and bone were present, the film measurements represented the dose close to unit density water in a heterogeneous medium, produced the best agreement with the AXB_Dw. For the verification of point doses within the target using TLD in the anthropomorphic phantom, the absolute percentage deviations between the calculated and measured data when averaged over all IMRT and RA plans were 1.8%, 1.7%, and 1.8% for AAA, AXB_Dm and AXB_Dw, respectively. From all the verification results, no significant difference was found between the IMRT and RA plans. The target dose analysis of the real patient plans showed that the discrepancies in mean doses to the PTV component in tissue among the three dose calculation options were within 2%, but up to about 4% in the bone content, with AXB_Dm giving the lowest values and AXB_Dw giving the highest values.
    Conclusions: In general, the verification measurements demonstrated that both algorithms produced acceptable accuracy when compared to the measured data. GafChromic(®) film results indicated that AXB produced slightly better accuracy compared to AAA for dose calculation adjacent to and within the heterogeneous media. Users should be aware of the differences in calculated target doses between options AXB_Dm and AXB_Dw, especially in bone, for IMRT and RA in NPC cases.
    Mesh-Begriff(e) Carcinoma ; Humans ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms/radiotherapy ; Phantoms, Imaging ; Radiation Dosage ; Radiometry ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/instrumentation ; Radiotherapy, Intensity-Modulated/instrumentation
    Sprache Englisch
    Erscheinungsdatum 2013-03-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1118/1.4792308
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  7. Artikel ; Online: A comprehensive dosimetric evaluation of using RapidArc volumetric-modulated arc therapy for the treatment of early-stage nasopharyngeal carcinoma.

    Kan, Monica W K / Wong, Wicger / Leung, Lucullus H T / Yu, Peter K N / So, Ronald W K / Cheng, Ashley C K

    Journal of applied clinical medical physics

    2012  Band 13, Heft 6, Seite(n) 3887

    Abstract: The purpose of this study was to investigate the potential benefits of using triple-arc volumetric-intensity modulated arc radiotherapy (RapidArc (RA)) for the treatment of early-stage nasopharyngeal carcinoma (NPC). A comprehensive evaluation was ... ...

    Abstract The purpose of this study was to investigate the potential benefits of using triple-arc volumetric-intensity modulated arc radiotherapy (RapidArc (RA)) for the treatment of early-stage nasopharyngeal carcinoma (NPC). A comprehensive evaluation was performed including plan quality, integral doses, and peripheral doses. Twenty cases of stage I or II NPC were selected for this study. Nine-field sliding window IMRT, double-arc, and triple-arc RA treatment plans were compared with respect to target coverage, dose conformity, critical organ sparing, and integral doses. Measurement of peripheral doses was performed using thermoluminescent dosimeters in an anthropomorphic phantom. While similar conformity and target coverage were achieved by the three types of plans, triple-arc RA produced better sparing of parotid glands and spinal cord than double-arc RA or IMRT. Double-arc RA plans produced slightly inferior parotid sparing and dose homogeneity than the other two delivery methods. The monitor units (MU) required for triple-arc were about 50% less than those of IMRT plans, while there was no significant difference in the required MUs between triple-arc and double-arc RA plans. The peripheral dose in triple-arc RA was found to be 50% less compared to IMRT near abdominal and pelvic region. Triple-arc RA improves both the plan quality and treatment efficiency compared with IMRT for the treatment of early stage NPC. It has become the preferred choice of treatment delivery method for early stage NPC at our center.
    Mesh-Begriff(e) Carcinoma ; Film Dosimetry ; Humans ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/radiotherapy ; Neoplasm Staging ; Phantoms, Imaging ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Intensity-Modulated
    Sprache Englisch
    Erscheinungsdatum 2012-11-08
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Evaluation Study ; Journal Article
    ZDB-ID 2010347-5
    ISSN 1526-9914 ; 1526-9914
    ISSN (online) 1526-9914
    ISSN 1526-9914
    DOI 10.1120/jacmp.v13i6.3887
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Buch ; Konferenzbeitrag: Near-wall turbulent flows

    Launder, Brian E / So, Ronald M. C / Speziale, Charles G

    proceedings of the International Conference on Near-Wall Turbulent Flows, Tempe, Arizona, U.S.A., 15 - 17 March 1993

    1993  

    Körperschaft International Conference on Near Wall Turbulent Flows
    Veranstaltung/Kongress International Conference on Near-Wall Turbulent Flows (1993.03.15-17, TempeAriz.)
    Verfasserangabe ed. by Ronald M. C. So; Charles G. Speziale; Brian E. Launder
    Sprache Englisch
    Umfang XV, 1048 S, Ill., graph. Darst, 25 cm
    Verlag Elsevier
    Erscheinungsort Amsterdam u.a
    Dokumenttyp Buch ; Konferenzbeitrag
    Anmerkung Literaturangaben
    ISBN 0444896635 ; 9780444896636
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  9. Buch: An experimental investigation of turbulent boundary layers along curved surfaces

    So, Ronald M. C / Mellor, George L

    (ASM [i.e. AMS] / Princeton University ; 979 ; NASA contractor report ; 1940)

    1972  

    Verfasserangabe by Ronald M. C. So and George L. Mellor
    Serientitel ASM [i.e. AMS] / Princeton University ; 979
    NASA contractor report ; 1940
    Sprache Englisch
    Umfang X, 260 S, graph. Darst
    Verlag National Aeronautics and Space Administration
    Erscheinungsort Washington, DC
    Dokumenttyp Buch
    Anmerkung Prepared by Princeton University (Dep. of Aerospace and Mechanical Sciences) for Lewis Research Center
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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