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  1. Article ; Online: Is a tiered restrictions system an effective intervention for COVID-19 control? Results from Portugal, November-December 2020.

    Moniz, Marta / Soares, Patrícia / Nunes, Baltazar / Leite, Andreia

    BMC public health

    2024  Volume 24, Issue 1, Page(s) 956

    Abstract: Background: In November 2020, similar to other European countries, Portugal implemented a tiered restrictions system to control the COVID-19 pandemic. We aimed to compare the COVID-19 growth rate across tiers to assess the effect of a tiered ... ...

    Abstract Background: In November 2020, similar to other European countries, Portugal implemented a tiered restrictions system to control the COVID-19 pandemic. We aimed to compare the COVID-19 growth rate across tiers to assess the effect of a tiered restrictions system in Portugal, using models with different times between tiers assessment. Our hypothesis was that being in a higher tier brings a faster deceleration in the growth rate than being in a lower tier.
    Methods: The national database of notified COVID-19 cases and publicly available data were used to analyse the effect of the tiered restrictions system on the COVID-19 incidence growth rate. The tiers were based on the European Centre for Disease Control risk classification: moderate, high, very and extremely high. We used a generalised mixed-effects regression model to estimate the growth rate ratio (GRR) for each tier, comparing the growth rates of higher tiers using moderate tier as reference. Three models were fitted using different times between tiers assessment, separated by 14 days.
    Results: We included 156 034 cases. Very high tier was the most frequent combination in all the three moments assessed (21.2%), and almost 50% of the municipalities never changed tier during the study period. Immediately after the tiers implementation, a reduction was identified in the municipalities in high tier (GRR high tier: 0.90 [95%CI: 0.79; 1.02]) and very high tier (GRR very high tier: 0.68 [95%CI: 0.61; 0.77]), however with some imprecision in the 95% confidence interval for the high tier. A reduction in very high tier growth rate was identified two weeks (GRR: 0.79 [95%CI: 0.71; 0.88]) and four weeks (GRR: 0.77 [95%CI: 0.74; 0.82]) after the implementation, compared to moderate tier. In high tier, a reduction was also identified in both times, although smaller.
    Conclusions: We observed a reduction in the growth rate in very high tier after the tiered restriction system was implemented, but we also observed a lag between tiered restriction system implementation and the onset of consequent effects. This could suggest the importance of early implementation of stricter measures for pandemic control. Thus, studies analysing a broader period of time are needed.
    MeSH term(s) Humans ; Portugal/epidemiology ; Pandemics/prevention & control ; COVID-19/epidemiology ; Europe
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-024-18369-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Does CDHR3 gene polymorphism affect paediatric asthma and its treatment response?

    Carneiro, Joana / Tavendale, Roger / Mukhopadhyay, Somnath / Soares, Patrícia

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2023  Volume 54, Issue 2, Page(s) 159–161

    MeSH term(s) Child ; Humans ; Asthma/genetics ; Asthma/therapy ; Membrane Proteins/genetics ; Polymorphism, Genetic ; Cadherin Related Proteins
    Chemical Substances Membrane Proteins ; CDHR3 protein, human ; Cadherin Related Proteins
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.14430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Thio-Induced Organophosphate Breakdown Promoted by Methimazole: an Experimental and Theoretical Study.

    Campos, Renan B / Capato, Lucas A / Soares, Patrícia M / Tantillo, Dean J / Orth, Elisa S

    ChemPlusChem

    2024  , Page(s) e202300756

    Abstract: Investigating the reactivity of small nucleophilic scaffolds is a strategic approach for the design of new catalysts aiming at effective detoxification processes of organophosphorus compounds. The drug methimazole (MMZ) is an interesting candidate ... ...

    Abstract Investigating the reactivity of small nucleophilic scaffolds is a strategic approach for the design of new catalysts aiming at effective detoxification processes of organophosphorus compounds. The drug methimazole (MMZ) is an interesting candidate featuring two non-equivalent nucleophilic centers. Herein, phosphoryl transfer reactions mediated by MMZ were assessed by means of spectrophotometric kinetic studies, mass spectrometry (MS) analyses, and density functional theory (DFT) calculations using the multi-electrophilic compound O,O-diethyl 2,4-dinitrophenyl phosphate (DEDNPP). MMZ anion acts primarily as an S-nucleophile, exhibiting a nucleophilic activity comparable to that of certain oximes featuring alpha-effect. Selective nucleophilic aromatic substitution was observed, consistent with the DFT prediction of a low energy barrier. Overall, the results bring important advances regarding the mechanistic understanding of nucleophilic dephosphorylation reactions, which comprises a strategic tool for neutralizing toxic organophosphates, hence promoting chemical security.
    Language English
    Publishing date 2024-02-27
    Publishing country Germany
    Document type Journal Article
    ISSN 2192-6506
    ISSN (online) 2192-6506
    DOI 10.1002/cplu.202300756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tuberculosis amongst foreign-born and nationals: different delays, different risk factors.

    Moniz, Marta / Soares, Patrícia / Leite, Andreia / Nunes, Carla

    BMC infectious diseases

    2021  Volume 21, Issue 1, Page(s) 934

    Abstract: Background: Delay in Tuberculosis (TB) diagnosis affects foreign-born and nationals in different ways, especially in low-incidence countries. This study characterises total delay and its components amongst foreign-born individuals in Portugal. ... ...

    Abstract Background: Delay in Tuberculosis (TB) diagnosis affects foreign-born and nationals in different ways, especially in low-incidence countries. This study characterises total delay and its components amongst foreign-born individuals in Portugal. Additionally, we identify risk factors for each type of delay and compare their effects between foreign-born and nationals.
    Methods: We analysed data from the Portuguese TB surveillance system and included individuals with pulmonary TB (PTB), notified between 2008 and 2017. We described patient, healthcare, and total delays. Cox regression was used to identify factors associated with each type of delay. All analyses were stratified according to the origin country: nationals (those born in Portugal) and foreign-born.
    Results: Compared with nationals, foreign-born persons presented statistically significant and longer median total and patient delays (Total: 67 vs. 63; Patient: 44 vs. 36 days), and lower healthcare services delays (7 vs. 9 days). Risk factors for delayed diagnosis differed between foreign-born and nationals. Being unemployed, having drug addiction, and having comorbidities were identified as risk factors for delayed diagnosis in national individuals but not in foreigners. Alcohol addiction was the only factor identified for healthcare delay for both populations: foreign-born (Hazard Ratio 1.34 [95% confidence interval 1.17;1.53]); nationals (Hazard Ratio 1.20 [95% confidence interval 1.13;1.27]).
    Conclusions: Foreign-born individuals with PTB take longer to seek health care. While no specific risk factors were identified, more in-depth studies are required to identify barriers and support public health intervention to address PTB diagnosis delay in foreign-born individuals.
    MeSH term(s) Emigrants and Immigrants ; Humans ; Internationality ; Risk Factors ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology ; Tuberculosis, Pulmonary
    Language English
    Publishing date 2021-09-08
    Publishing country England
    Document type Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-021-06635-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Predicting Independence 6 and 18 Months after Ischemic Stroke Considering Differences in 12 Countries: A Secondary Analysis of the IST-3 Trial.

    Vieira, André / Soares, Patrícia / Nunes, Carla

    Stroke research and treatment

    2021  Volume 2021, Page(s) 5627868

    Abstract: Objectives: This study is aimed at identifying the best clinical model to predict poststroke independence at 6 and 18 months, considering sociodemographic and clinical characteristics, and then identifying differences between countries.: Methods: ... ...

    Abstract Objectives: This study is aimed at identifying the best clinical model to predict poststroke independence at 6 and 18 months, considering sociodemographic and clinical characteristics, and then identifying differences between countries.
    Methods: Data was retrieved from the International Stroke Trial 3 study. Nine clinical variables (age, gender, severity, rt-PA, living alone, atrial fibrillation, history of transient ischemic attack/stroke, and abilities to lift arms and walk) were measured immediately after the stroke and considered to predict independence at 6 and 18 months poststroke. Independence was measured using the Oxford Handicap Scale. The adequacy, predictive capacity, and discriminative capacity of the models were checked. Countries were added to the final models.
    Results: At 6 months poststroke, 35.8% (
    Language English
    Publishing date 2021-07-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573724-7
    ISSN 2042-0056 ; 2090-8105
    ISSN (online) 2042-0056
    ISSN 2090-8105
    DOI 10.1155/2021/5627868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correction to: a temporal analysis on patient and health service delays in pulmonary tuberculosis in Portugal: inter and intra‑regional differences and in(equalities) between gender and age.

    Chakma, Bhaswar / Gomes, Dulce / A Filipe, Patrícia / Soares, Patrícia / de Sousa, Bruno / Nunes, Carla

    BMC public health

    2023  Volume 23, Issue 1, Page(s) 491

    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-023-15406-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Pandemic-Related Factors Associated with Emergency Department Visits in Portugal throughout Two Years of the Pandemic: A Retrospective Population-Based Study.

    Kinaan, Walaa / Soares, Patrícia / Rocha, João Victor / Boto, Paulo / Santana, Rui / Lopes, Sílvia

    International journal of environmental research and public health

    2023  Volume 20, Issue 2

    Abstract: The COVID-19 pandemic has affected the use of emergency departments (ED) worldwide. This study identifies the pandemic-related factors associated with the number of ED visits in mainland Portugal and each of its regions. We collected data on ED visits ... ...

    Abstract The COVID-19 pandemic has affected the use of emergency departments (ED) worldwide. This study identifies the pandemic-related factors associated with the number of ED visits in mainland Portugal and each of its regions. We collected data on ED visits from March 2020 to March 2022. Data on incidence, vaccination, mobility, containment index, and Google search volume were retrieved from open online sources at different time points. We fitted a quasi-Poisson generalized linear regression model, and each variable was modeled separately and adjusted for time and month. There was a positive ED trend throughout the two years of the pandemic in mainland Portugal and each of its regions. In the mainland, during months with high workplace mobility, there were 10.5% more ED visits compared to months with average mobility. ED visits decreased in months with low mobility for retail and recreation, groceries and pharmacies, and transit compared to months of medium mobility. Portugal saw a reduction in ED utilization during the pandemic period, but with a positive trend from March 2020 to March 2022. The change in the population's behavior of seeking the ED throughout the pandemic might be associated with mobility, incidence, and pandemic fatigue.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Retrospective Studies ; Pandemics ; Portugal/epidemiology ; Emergency Service, Hospital
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20021207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Children with asthma and eczema carrying filaggrin loss-of-function mutations have increased antibiotic use through to adulthood.

    Holden, Ciara / Soares, Patrícia / Fidler, Katy / Tavendale, Roger / Felton, Jessie / Mukhopadhyay, Somnath

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2023  Volume 54, Issue 4, Page(s) 291–293

    MeSH term(s) Child ; Humans ; Filaggrin Proteins ; Eczema/genetics ; Asthma ; Mutation ; Intermediate Filament Proteins/genetics ; Genetic Predisposition to Disease ; Genotype
    Chemical Substances Filaggrin Proteins ; Intermediate Filament Proteins
    Language English
    Publishing date 2023-12-15
    Publishing country England
    Document type Letter
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.14440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Multi-Drug and β-Lactam Resistance in

    Costa, Miguel Mendes / Cardo, Miguel / Soares, Patricia / Cara d'Anjo, Maria / Leite, Andreia

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 1

    Abstract: Animal and food sources are seen as a potential transmission pathway of antimicrobial resistance (AMR) to humans. The aim of this study is to ... ...

    Abstract Animal and food sources are seen as a potential transmission pathway of antimicrobial resistance (AMR) to humans. The aim of this study is to describe
    Language English
    Publishing date 2022-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11010090
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  10. Article ; Online: A temporal analysis on patient and health service delays in pulmonary tuberculosis in Portugal: inter and intra‑regional differences and in(equalities) between gender and age.

    Chakma, Bhaswar / Gomes, Dulce / Filipe, Patrícia A / Soares, Patrícia / de Sousa, Bruno / Nunes, Carla

    BMC public health

    2022  Volume 22, Issue 1, Page(s) 1830

    Abstract: Background: Tuberculosis (TB) diagnosis and treatment delays increase the period of infectiousness, making TB control difficult and increasing the fatality rates. This study aimed to determine the evolution of health care service delay (time between the ...

    Abstract Background: Tuberculosis (TB) diagnosis and treatment delays increase the period of infectiousness, making TB control difficult and increasing the fatality rates. This study aimed to determine the evolution of health care service delay (time between the patient's first contact with the health service and the diagnosis/start of treatment) and patient delay (time between onset symptoms date and the date of first contact with health services) for Pulmonary Tuberculosis (PTB) in Portugal between 2008 and 2017 across different regions, age groups and gender.
    Methods: An exploratory analysis was performed, trends of both delays were studied, and 36 months forecasts were generated. We used the permutation test to test differences between groups and the Seasonal and Trend decomposition using Loess (STL) method and Autoregressive Integrated Moving Average (ARIMA) models for forecasting for both Health and Patient delays. We used data from notified PTB cases in mainland Portugal between 2008 and 2017, provided by the national surveillance system.
    Results: Health delays remained relatively constant while patient delays increased. Females had significantly higher health delays in some regions. Individuals older than 64 had higher health delays than younger individuals, while patient delay for working-age individuals between 15 and 64 years old, presents higher patient delay.
    Conclusions: Forecasts presage that the upward trend of the delays is unlikely to fall in the coming years. It is important to understand the evolution of the delays and predict how these will evolve. Our understanding of the delays behaviours will contribute to better health policies and resources allocation.
    MeSH term(s) Adolescent ; Adult ; Delayed Diagnosis ; Female ; Health Services ; Humans ; Middle Aged ; Portugal/epidemiology ; Time-to-Treatment ; Tuberculosis/epidemiology ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/epidemiology ; Tuberculosis, Pulmonary/therapy ; Young Adult
    Language English
    Publishing date 2022-09-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-022-14216-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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