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  1. Article ; Online: Altered liver function test after Covid-19 vaccines: A retrospective control group study.

    Jabif, Fernando Ezequiel / Vallone, Marcelo Gabriel / Stanek, Vanina Cecilia / Lopez, Marlene Padilla / Sobenko, Natalia / Villamil, Alejandra Maria / Ratti, Maria Florencia Grande

    Pharmacoepidemiology and drug safety

    2023  Volume 33, Issue 1, Page(s) e5696

    Abstract: Background and purpose: Liver injury after Covid-19 vaccine has been described, although the incidence was not well established. We aimed to compare cumulative incidence of new onset liver test alteration after Covid-19 vaccination, and to compare with ... ...

    Abstract Background and purpose: Liver injury after Covid-19 vaccine has been described, although the incidence was not well established. We aimed to compare cumulative incidence of new onset liver test alteration after Covid-19 vaccination, and to compare with an historical control of influenza vaccination.
    Methods: We conducted a retrospective cohort study which included adults who received at least one dose of Covid-19 vaccine from January 1 to May 30, 2021 and a control group who received a single dose of influenza vaccine during 2019, in a tertiary medical center from Argentina.
    Results: We included 29 798 patients in Covid-19 vaccine group and 24 605 in influenza vaccine group. Liver function tests were performed in 7833 (26.9%) in Covid-19 vaccine group and 8459 (34.37%) in influenza vaccine group. Cumulative incidence at 90 days of new onset liver enzyme test alteration was 4.7 per 1000 (95% 4.0-5.5) for Covid-19 group, and 5.1 per 1000 (95% 4.3-6.1) for the influenza vaccine group (p value = 0.489). Two patients in the Covid-19 vaccine group developed immune mediated liver injury.
    Conclusions: We found no difference in liver test alteration between groups. These findings support the safety of Covid-19 vaccines. While we have identified two cases that are consistent with immune mediated liver injury following COVID-19 vaccination, we believe that the available data is insufficient to attribute them solely to the vaccination.
    MeSH term(s) Adult ; Humans ; Control Groups ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Influenza Vaccines/administration & dosage ; Liver Function Tests ; Retrospective Studies ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines ; Influenza Vaccines
    Language English
    Publishing date 2023-09-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1099748-9
    ISSN 1099-1557 ; 1053-8569
    ISSN (online) 1099-1557
    ISSN 1053-8569
    DOI 10.1002/pds.5696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3395: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Evaluation of the humoral response to the third dose of SARS-COV-2 vaccines in liver transplant recipients.

    Ducasa, Nicolás / Benencio, Paula / Mauro, Ezequiel / Anders, Margarita / Mazzitelli, Bianca / Bleichmar, Lucía / Quiroga, Maria Florencia / Barbero, Manuel / Cairo, Fernando / Alter, Adriana / Etcheves, Patricia / Scarton, Giampaolo / Sobenko, Natalia / Biglione, Mirna / Mendizabal, Manuel

    Vaccine

    2023  Volume 41, Issue 52, Page(s) 7663–7670

    Abstract: Solid organ transplant recipients (SOTR) commonly develop an unsatisfactory humoral response to vaccines compared to immunocompetent individuals (IC). We have previously evaluated the humoral response in liver transplant recipients (LTR) who received two- ...

    Abstract Solid organ transplant recipients (SOTR) commonly develop an unsatisfactory humoral response to vaccines compared to immunocompetent individuals (IC). We have previously evaluated the humoral response in liver transplant recipients (LTR) who received two-dose vaccines against SARS-CoV-2 and reported that 38 % of LTR did not produce anti-Spike antibodies. Thus, we set out to evaluate the humoral response after the third dose of SARS-CoV-2 vaccines. For this purpose, samples from a cohort of 81 LTR and 27 IC were extracted between 21 and 90 days after the third dose. Serology for anti-Spike IgG antibodies and neutralizing antibodies against Wuhan, Delta and Omicron variants were evaluated. We found that 73.5 % of LTR were responders for anti-Spike IgG, while all the IC mounted a measurable response. LTR who responded to the third dose showed significantly lower anti-Spike IgG levels and neutralizing antibodies than IC. We found that there is less neutralization in LTR compared to IC across all variants. Specifically, the neutralization titers in both groups decrease when encountering the Delta variant, and this decline is even more pronounced with the Omicron variant, compared to the Wuhan variant. Furthermore, we identified that the use of high doses of mycophenolate and advanced age were factors that negatively affected the development of anti-Spike IgG antibodies. Regarding vaccine regimes, the regime viral vector/mRNA/mRNA elicited significantly higher responses in LTR compared to other vaccine schemes. In addition to the recommended and necessary booster doses in this population, strategies that achieve adequate immunization should be evaluated.
    MeSH term(s) Humans ; COVID-19 Vaccines ; Liver Transplantation ; COVID-19/prevention & control ; SARS-CoV-2 ; Antibodies, Neutralizing ; RNA, Messenger ; Transplant Recipients ; Immunoglobulin G ; Antibodies, Viral
    Chemical Substances COVID-19 Vaccines ; Antibodies, Neutralizing ; RNA, Messenger ; Immunoglobulin G ; Antibodies, Viral
    Language English
    Publishing date 2023-11-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.11.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1930: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.MO 458: Show issues

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  3. Article ; Online: Spontaneous bacteremia and spontaneous bacterial peritonitis share similar prognosis in patients with cirrhosis: a cohort study.

    Marciano, Sebastián / Dirchwolf, Melisa / Bermudez, Carla S / Sobenko, Natalia / Haddad, Leila / Genre Bert, Federico / Barcán, Laura / Smud, Astrid / Posadas-Martínez, Maria Lourdes / Giunta, Diego / Gadano, Adrián

    Hepatology international

    2017  Volume 12, Issue 2, Page(s) 181–190

    Abstract: Background and aims: Spontaneous bacteremia is a poorly characterized infection in patients with cirrhosis. We compared the incidence of mortality and acute kidney injury in patients with spontaneous bacterial peritonitis and spontaneous bacteremia, and ...

    Abstract Background and aims: Spontaneous bacteremia is a poorly characterized infection in patients with cirrhosis. We compared the incidence of mortality and acute kidney injury in patients with spontaneous bacterial peritonitis and spontaneous bacteremia, and identified risk factors for mortality and acute kidney injury in patients with spontaneous bacteremia.
    Methods: We performed a retrospective cohort study of patients with cirrhosis and spontaneous bacteremia or spontaneous bacterial peritonitis from 2008 to 2016 at Hospital Italiano, Buenos Aires. We compared the cumulative incidence of acute kidney injury and death between the two infections, and identified risk factors for these outcomes in patients with spontaneous bacteremia.
    Results: Seventy-one patients with spontaneous bacteremia and 55 patients with spontaneous bacterial peritonitis were included. Most infections were nosocomial. Overall, 26% of bacteria were resistant and 11% multi-resistant. We found no significant association between acute kidney injury [subhazard ratio (sHR) 1.05 (95% confidence interval, CI 0.67-1.63, p = 0.83)] or death [sHR 1.15 (95% CI 0.60-2.20, p = 0.68)] and type of spontaneous infection in multivariate analyses adjusting for basal Model for End-Stage Liver Disease (MELD) score. In patients with spontaneous bacteremia, baseline MELD score was independently associated with acute kidney injury [sHR 1.07 (95% CI 1.03-1.11, p = 0.001)] and death [sHR 1.07 (95% CI 1.02-1.15, p = 0.03)].
    Conclusions: Short-term acute kidney injury and mortality rates were similar in patients with spontaneous bacteremia and spontaneous bacterial peritonitis. Risk assessment of patients with spontaneous bacteremia can be performed with baseline MELD score.
    MeSH term(s) Acute Kidney Injury/mortality ; Aged ; Argentina/epidemiology ; Bacteremia/mortality ; Female ; Gram-Negative Bacterial Infections/mortality ; Gram-Positive Bacterial Infections/mortality ; Humans ; Incidence ; Liver Cirrhosis/mortality ; Male ; Middle Aged ; Peritonitis/mortality ; Prognosis ; Retrospective Studies ; Risk Factors
    Keywords covid19
    Language English
    Publishing date 2017-12-09
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2270316-0
    ISSN 1936-0541 ; 1936-0533
    ISSN (online) 1936-0541
    ISSN 1936-0533
    DOI 10.1007/s12072-017-9837-7
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  4. Article ; Online: Adequate versus deep response to ursodeoxycholic acid in primary biliary cholangitis: To what extent and under what conditions is normal alkaline phosphatase level associated with complication-free survival gain?

    Corpechot, Christophe / Lemoinne, Sara / Soret, Pierre-Antoine / Hansen, Bettina / Hirschfield, Gideon / Gulamhusein, Aliya / Montano-Loza, Aldo J / Lytvyak, Ellina / Pares, Albert / Olivas, Ignasi / Eaton, John E / Osman, Karim T / Schramm, Christoph / Sebode, Marcial / Lohse, Ansgar W / Dalekos, George / Gatselis, Nikolaos / Nevens, Frederik / Cazzagon, Nora /
    Zago, Alessandra / Russo, Francesco Paolo / Floreani, Annarosa / Abbas, Nadir / Trivedi, Palak / Thorburn, Douglas / Saffioti, Francesca / Barkai, Laszlo / Roccarina, Davide / Calvaruso, Vicenza / Fichera, Anna / Delamarre, Adèle / Sobenko, Natalia / Villamil, Alejandra Maria / Medina-Morales, Esli / Bonder, Alan / Patwardhan, Vilas / Rigamonti, Cristina / Carbone, Marco / Invernizzi, Pietro / Cristoferi, Laura / van der Meer, Adriaan / de Veer, Rozanne / Zigmond, Ehud / Yehezkel, Eyal / Kremer, Andreas E / Deibel, Ansgar / Bruns, Tony / Große, Karsten / Wetten, Aaron / Dyson, Jessica Katharine / Jones, David / Dumortier, Jérôme / Pageaux, Georges-Philippe / de Lédinghen, Victor / Chazouillères, Olivier / Carrat, Fabrice

    Hepatology (Baltimore, Md.)

    2023  Volume 79, Issue 1, Page(s) 39–48

    Abstract: Background and aims: Normal alkaline phosphatase (ALP) levels in ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC) are associated with better long-term outcome. However, second-line therapies are currently recommended ... ...

    Abstract Background and aims: Normal alkaline phosphatase (ALP) levels in ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC) are associated with better long-term outcome. However, second-line therapies are currently recommended only when ALP levels remain above 1.5 times the upper limit of normal (×ULN) after 12-month UDCA. We assessed whether, in patients considered good responders to UDCA, normal ALP levels were associated with significant survival gains.
    Approach and results: We performed a retrospective cohort study of 1047 patients with PBC who attained an adequate response to UDCA according to Paris-2 criteria. Time to liver-related complications, liver transplantation, or death was assessed using adjusted restricted mean survival time (RMST) analysis. The overall incidence rate of events was 17.0 (95% CI: 13.7-21.1) per 1000 out of 4763.2 patient-years. On the whole population, normal serum ALP values (but not normal gamma-glutamyl transpeptidase (GGT), alanine aminotransferase (ALT), or aspartate aminotransferase (AST); or total bilirubin < 0.6 ×ULN) were associated with a significant absolute complication-free survival gain at 10 years (mean 7.6 months, 95% CI: 2.7 - 12.6 mo.; p = 0.003). In subgroup analysis, this association was significant in patients with a liver stiffness measurement ≥ 10 kPa and/or age ≤ 62 years, with a 10-year absolute complication-free survival gain of 52.8 months (95% CI: 45.7-59.9, p < 0.001) when these 2 conditions were met.
    Conclusions: PBC patients with an adequate response to UDCA and persistent ALP elevation between 1.1 and 1.5 ×ULN, particularly those with advanced fibrosis and/or who are sufficiently young, remain at risk of poor outcome. Further therapeutic efforts should be considered for these patients.
    MeSH term(s) Humans ; Middle Aged ; Ursodeoxycholic Acid/therapeutic use ; Liver Cirrhosis, Biliary/complications ; Liver Cirrhosis, Biliary/drug therapy ; Alkaline Phosphatase ; Cholagogues and Choleretics/therapeutic use ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Ursodeoxycholic Acid (724L30Y2QR) ; Alkaline Phosphatase (EC 3.1.3.1) ; Cholagogues and Choleretics
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Acute loss of vision as the initial symptom of multiple myeloma.

    Vázquez, Fernando Javier / Sobenko, Natalia / Schutz, Natalia / Altszul, Moira / Lagruta, Inés / Mateos, Maria Victoria / Fantl, Dorotea

    Clinical lymphoma, myeloma & leukemia

    2012  Volume 12, Issue 2, Page(s) 148–150

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Blindness/diagnosis ; Blindness/etiology ; Humans ; Male ; Middle Aged ; Multiple Myeloma/complications ; Multiple Myeloma/diagnosis ; Multiple Myeloma/drug therapy ; Radiography ; Retinal Artery/diagnostic imaging ; Treatment Outcome
    Language English
    Publishing date 2012-04
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2011.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5903: Show issues Location:
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