LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 3 of total 3

Search options

  1. Article ; Online: Age and Environment Influences on Mouse Prion Disease Progression: Behavioral Changes and Morphometry and Stereology of Hippocampal Astrocytes.

    Bento-Torres, J / Sobral, L L / Reis, R R / de Oliveira, R B / Anthony, D C / Vasconcelos, P F C / Picanço Diniz, Cristovam Wanderley

    Oxidative medicine and cellular longevity

    2017  Volume 2017, Page(s) 4504925

    Abstract: Because enriched environment (EE) and exercise increase and aging decreases immune response, we hypothesized that environmental enrichment and aging will, respectively, delay and increase prion disease progression. Mice dorsal striatum received bilateral ...

    Abstract Because enriched environment (EE) and exercise increase and aging decreases immune response, we hypothesized that environmental enrichment and aging will, respectively, delay and increase prion disease progression. Mice dorsal striatum received bilateral stereotaxic intracerebral injections of normal or ME7 prion infected mouse brain homogenates. After behavior analysis, animals were euthanized and their brains processed for astrocyte GFAP immunolabeling. Our analysis related to the environmental influence are limited to young adult mice, whereas age influence refers to aged mice raised on standard cages. Burrowing activity began to reduce in ME7-SE two weeks before ME7-EE, while no changes were apparent in ME7 aged mice (ME7-A). Object placement recognition was impaired in ME7-SE, NBH-A, and ME7-A but normal in all other groups. Object identity recognition was impaired in ME7-A. Cluster analysis revealed two morphological families of astrocytes in NBH-SE animals, three in NBH-A and ME7-A, and four in NBH-EE, ME7-SE, and ME7-EE. As compared with control groups, astrocytes from DG and CA3 prion-diseased animals show significant numerical and morphological differences and environmental enrichment did not reverse these changes but induced different morphological changes in GFAP+ hippocampal astroglia. We suggest that environmental enrichment and aging delayed hippocampal-dependent behavioral and neuropathological signs of disease progression.
    MeSH term(s) Aging/physiology ; Animals ; Astrocytes/pathology ; Behavior, Animal ; Brain/pathology ; Disease Models, Animal ; Disease Progression ; Environment ; Hippocampus/pathology ; Immunoenzyme Techniques ; Male ; Mice ; Prion Diseases/pathology ; Prion Diseases/psychology
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 1942-0994
    ISSN (online) 1942-0994
    DOI 10.1155/2017/4504925
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Estimulación eléctrica y natación en la fase aguda de la axonotmesis: influencia sobre la regeneración nerviosa y la recuperación funcional.

    Oliveira, L S / Sobral, L L / Takeda, S Y M / Betini, J / Guirro, R R J / Somazz, M C / Teodori, R M

    Revista de neurologia

    2008  Volume 47, Issue 1, Page(s) 11–15

    Abstract: Introduction: Little attention has been given to the influence of low-frequency phasic electrical stimulation (LFPES) and physical exercise on the quality of peripheral nerve regeneration and functional recovery. AIM. To evaluate the influence of LFPES, ...

    Title translation Electrical stimulation and swimming in the acute phase of axonotmesis: their influence on nerve regeneration and functional recovery.
    Abstract Introduction: Little attention has been given to the influence of low-frequency phasic electrical stimulation (LFPES) and physical exercise on the quality of peripheral nerve regeneration and functional recovery. AIM. To evaluate the influence of LFPES, swimming and the association between the two in terms of the morphology of the regenerated sciatic nerve following axonotmesis.
    Materials and methods: Thirty Wistar mice (222.05 +/- 42.2 g) were distributed into groups: control (C), denervated (D), denervated + swimming (DS), denervated + electrostimulation (DE) and denervated + swimming + electrostimulation (DSE). After 24 hours of axonotmesis, the soleus muscle of the DE and DSE groups was stimulated electrically. The DS and DSE groups swam over a period of 22 days. The number of axons, morphometric data on the nerve and the functional index of the sciatic nerve (FIS) were evaluated.
    Results: The number of axons in the denervated groups was higher than in the control group, and in the DE group the figure was higher than in the D group. The axonal diameter was smaller in the denervated groups, yet in the DS group it was higher than in the D group. The other morphometric parameters were quite similar to those of the C group. The FIS between days 7 and 14 of the post-operative period was different to the pre-operative index and that measured on day 21 of the post-operative period; the DSE group, however, differed from the pre-operative values.
    Conclusions: Swimming and LFPES, applied on an individual basis, do not affect the maturation of the regenerated fibres or functional recovery. LFPES favoured axonal regeneration and combining the treatments delayed functional recovery without having any influence on nerve regeneration.
    MeSH term(s) Animals ; Axons/physiology ; Denervation ; Electric Stimulation Therapy ; Exercise Therapy ; Male ; Mice ; Nerve Regeneration ; Peripheral Nerves/physiology ; Peripheral Nerves/surgery ; Recovery of Function ; Swimming
    Language Spanish
    Publishing date 2008-07
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 1468278-3
    ISSN 1576-6578 ; 0210-0010
    ISSN (online) 1576-6578
    ISSN 0210-0010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5003: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Regeneración nerviosa periférica en ratones expuestos a un ambiente enriquecido.

    Takeda, S Y M / de Oliveira, L S / Sobral, L L / Somazz, M C / Montebelo, M I L / Teodori, R M

    Revista de neurologia

    2008  Volume 47, Issue 4, Page(s) 185–190

    Abstract: Introduction: Taking into account the fact that the literature contains no studies on how an enriched environment influences peripheral nerve lesions, in this study we analysed the characteristics of the sciatic nerve in mice submitted to axonotmesis ... ...

    Title translation Peripheral nerve regeneration in mice exposed to an enriched environment.
    Abstract Introduction: Taking into account the fact that the literature contains no studies on how an enriched environment influences peripheral nerve lesions, in this study we analysed the characteristics of the sciatic nerve in mice submitted to axonotmesis and subsequent exposure to an enriched environment.
    Materials and methods: Twenty-four male Wistar mice (198.66 +/- 11.61 g) were distributed into the following groups: control, lesion, enriched environment grouping (EEG) and simple environment grouping (SEG). Following lesion to the nerve, the animals were placed in different cages according to the groups they had been allocated to. The enriched cage had an exercise wheel, a ladder, a ramp, and mobile food and water compartments, which were randomly changed every day. After 24 days, the sciatic nerve was analysed quantitatively, morphometrically and functionally.
    Results: The number of axons in the EEG and SEG groups was higher than that of the control group (p < 0.05). The SEG group had a higher number of axons than the lesion and EEG groups. The diameter of the axons in the experimental groups was smaller than that of the control group. The same occurred with the diameter of the nerve fibre. The thickness of the myelin sheath was inferior in the experimental groups compared to the control, and the value for the SEG group was lower than for the lesion group. The G ratio did not differ among groups. There were no differences in the values of the sciatic function index among the groups, while in the intragroup comparison there was a difference between postoperative days 7 and 14 and the preoperative values. Functioning was restored at postoperative day 21.
    Conclusions: The enriched environment did not have a negative effect on axonal regeneration and maturation, but neither did it favour the process. Functional recovery was not influenced by this form of intervention.
    MeSH term(s) Animals ; Male ; Mice ; Nerve Regeneration ; Peripheral Nerves/physiology
    Language Spanish
    Publishing date 2008-08
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 1468278-3
    ISSN 1576-6578 ; 0210-0010
    ISSN (online) 1576-6578
    ISSN 0210-0010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5003: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top