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  1. Article ; Online: Biomarkers of Coagulation and Inflammation in COVID-19-Associated Ischemic Stroke.

    Esenwa, Charles / Cheng, Natalie T / Luna, Jorge / Willey, Joshua / Boehme, Amelia K / Kirchoff-Torres, Kathryn / Labovitz, Daniel / Liberman, Ava L / Mabie, Peter / Moncrieffe, Khadean / Soetanto, Ainie / Lendaris, Andrea / Seiden, Johanna / Goldman, Inessa / Altschul, David / Holland, Ryan / Benton, Joshua / Dardick, Joseph / Fernandez-Torres, Jenelys /
    Flomenbaum, David / Lu, Jenny / Malaviya, Avinash / Patel, Nikunj / Toma, Aureliana / Lord, Aaron / Ishida, Koto / Torres, Jose / Snyder, Thomas / Frontera, Jennifer / Yaghi, Shadi

    Stroke

    2021  Volume 52, Issue 11, Page(s) e706–e709

    Abstract: Figure: see text]. ...

    Abstract [Figure: see text].
    MeSH term(s) Aged ; Aged, 80 and over ; Blood Sedimentation ; C-Reactive Protein/metabolism ; COVID-19/complications ; COVID-19/metabolism ; Cluster Analysis ; Female ; Ferritins/metabolism ; Fibrin Fibrinogen Degradation Products/metabolism ; Fibrinogen/metabolism ; Hospital Mortality ; Humans ; Inflammation/metabolism ; Interleukin-6/metabolism ; Ischemic Stroke/complications ; Ischemic Stroke/metabolism ; L-Lactate Dehydrogenase/metabolism ; Leukocyte Count ; Logistic Models ; Machine Learning ; Male ; Middle Aged ; Myocardial Infarction/complications ; Myocardial Infarction/metabolism ; Partial Thromboplastin Time ; Pulmonary Embolism/complications ; Pulmonary Embolism/metabolism ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index ; Thrombophilia/metabolism ; Venous Thrombosis/complications ; Venous Thrombosis/metabolism
    Chemical Substances Fibrin Fibrinogen Degradation Products ; IL6 protein, human ; Interleukin-6 ; fibrin fragment D ; Fibrinogen (9001-32-5) ; C-Reactive Protein (9007-41-4) ; Ferritins (9007-73-2) ; L-Lactate Dehydrogenase (EC 1.1.1.27)
    Language English
    Publishing date 2021-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.121.035045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 448: Show issues Location:
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  2. Article ; Online: Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans.

    Soetanto, Ainie / Wilson, Robert S / Talbot, Konrad / Un, Ashley / Schneider, Julie A / Sobiesk, Mark / Kelly, Jeremiah / Leurgans, Sue / Bennett, David A / Arnold, Steven E

    Archives of general psychiatry

    2010  Volume 67, Issue 5, Page(s) 448–457

    Abstract: Context: Chronic psychological distress has deleterious effects on many of the body's physiological systems. In experimental animal models, chronic stress leads to neuroanatomic changes in the hippocampus, in particular a decrease in the length and ... ...

    Abstract Context: Chronic psychological distress has deleterious effects on many of the body's physiological systems. In experimental animal models, chronic stress leads to neuroanatomic changes in the hippocampus, in particular a decrease in the length and branching of dendrites as well as a decrease in the number of dendritic spines.
    Objectives: To examine whether analogous distress-related neuroanatomic changes occur in humans and whether such changes might also be related to cognitive dysfunction observed in older people who report greater psychological distress.
    Design: Postmortem study of brain tissues from participants of the Religious Orders Study, an ongoing population-based clinicopathological study of aging and cognition.
    Setting: The Rush University Religious Orders Study and the University of Pennsylvania Cellular and Molecular Neuropathology Program.
    Participants: Seventy-two deceased participants of the Religious Orders Study.
    Main outcome measures: Densities of microtubule-associated protein 2-immunolabeled dendrites and synaptopodin-immunolabeled dendritic spines in the CA3 subfield of the hippocampus, quantified using semiautomated image acquisition and analysis.
    Results: Higher levels of trait anxiety and longitudinal depression scores were associated with decreased densities of dendrites and spines in CA3. Dendrite and spine densities did not correlate with an index of global cognition or with densities of common age-related pathological changes.
    Conclusions: Regressive neuronal changes occur in humans who experience greater psychological distress. These changes are analogous to neuronal changes in animal models of chronic stress.
    MeSH term(s) Aged ; Aged, 80 and over ; Anxiety Disorders/pathology ; CA3 Region, Hippocampal/pathology ; Catholicism ; Cognition Disorders/pathology ; Dendrites/pathology ; Dendritic Spines/pathology ; Depressive Disorder/pathology ; Female ; Humans ; Longitudinal Studies ; Male ; Microtubule-Associated Proteins/analysis ; Religion and Psychology
    Chemical Substances Microtubule-Associated Proteins
    Language English
    Publishing date 2010-05-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 211589-x
    ISSN 1538-3636 ; 0003-990X
    ISSN (online) 1538-3636
    ISSN 0003-990X
    DOI 10.1001/archgenpsychiatry.2010.48
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui I Zs.235: Show issues Location:
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