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Article ; Online: Quality assessment of patient information on the management of gallstone disease in the internet - A systematic analysis using the modified ensuring quality information for patients tool.

Raptis, Dimitri A / Sinanyan, Milena / Ghani, Shahi / Soggiu, Fiammetta / Gilliland, Jack J / Imber, Charles

HPB : the official journal of the International Hepato Pancreato Biliary Association

2019 Volume 21, Issue 12, Page(s) 1632–1640

Abstract: Introduction: The internet has become a fundamental source of medical information for patients, however, little is known about the quality of patient information regarding the management of gallstone disease (GD).: Methods: A systematic review of ... ...

Abstract	Introduction: The internet has become a fundamental source of medical information for patients, however, little is known about the quality of patient information regarding the management of gallstone disease (GD). Methods: A systematic review of information on GD in the internet was performed. The top 100 websites for every different search term and search engine were assessed using the validated EQIP tool (Score 0-36). Results: A total of 2000 websites were identified and 212 (11%) were eligible for analysis. The overall median EQIP score of all websites was 15 (IQR 13-18). Of all websites, 63% originated from North America however, these represented the lowest median EQIP score of 15. Only 41% of the websites differentiated between clinical presentations and 19% provided emergency information. Only 3% of the websites reported complication rates, ranging from 3 to 36%. Conclusion: This is a comprehensive assessment of online patient information on GD using the EQIP tool. The assessment of the quality of websites concerning GD by the EQIP tool indicates that the majority of sites were of low-quality information. There is an immediate need for better informative and educational websites regarding GD that are compatible with international quality standards.
MeSH term(s)	Consumer Health Information ; Gallstones ; Humans ; Internet ; Quality Control
Language	English
Publishing date	2019-06-05
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	2131251-5
ISSN	1477-2574 ; 1365-182X
ISSN (online)	1477-2574
ISSN	1365-182X
DOI	10.1016/j.hpb.2019.03.355
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Article ; Online: Oncological outcomes after pancreatoduodenectomy for pancreatic ductal adenocarcinoma in octogenarians: case-control study.

Pande, Rupaly / Attard, Joseph A / Al-Sarireh, Bilal / Bhogal, Ricky Harminder / Farrugia, Alexia / Fusai, Giuseppe / Harper, Simon / Hidalgo-Salinas, Camila / Jah, Asif / Marangoni, Gabriele / Mortimer, Matthew / Pizanias, Michail / Prachialias, Andreas / Roberts, Keith J / Hee, Chloe Sew / Soggiu, Fiammetta / Srinivasan, Parthi / Chatzizacharias, Nikolaos A

BJS open

2023 Volume 7, Issue 4

Abstract: Background: By the end of this decade, 70 per cent of all diagnosed pancreatic ductal adenocarcinomas will be in the elderly. Surgical resection is the only curative option. In the elderly perioperative mortality is higher, while controversy still ... ...

Abstract	Background: By the end of this decade, 70 per cent of all diagnosed pancreatic ductal adenocarcinomas will be in the elderly. Surgical resection is the only curative option. In the elderly perioperative mortality is higher, while controversy still exists as to whether aggressive treatment offers any survival benefit. This study aimed to assess the oncological benefit of pancreatoduodenectomy in octogenarians with pancreatic ductal adenocarcinoma. Method: Retrospective multicentre case-control study of octogenarians and younger controls who underwent pancreatoduodenectomy for pancreatic ductal adenocarcinoma between 2008 and 2017. The primary endpoint was overall survival and the secondary endpoint was disease-free survival. Results: Overall, 220 patients were included. Although the Charlson co-morbidity index was higher in octogenerians, Eastern Cooperative Oncology Group performance status, ASA and pathological parameters were comparable. Adjuvant therapy was more frequently delivered in the younger group (n = 80, 73 per cent versus n = 58, 53 per cent, P = 0.006). There was no significant difference between octogenarians and controls in overall survival (20 versus 29 months, P = 0.095) or disease-free survival (19 versus 22 months, P = 0.742). On multivariable analysis, age was not an independent predictor of either oncological outcome measured. Conclusion: Octogenarians with pancreatic ductal adenocarcinoma of the head and uncinate process may benefit from comparable oncological outcomes to younger patients with surgical treatment. Due to the age- and disease-related frailty and co-morbidities, careful preoperative assessment and patient selection is of paramount importance.
MeSH term(s)	Aged ; Aged, 80 and over ; Humans ; Case-Control Studies ; Pancreaticoduodenectomy ; Octogenarians ; Pancreatic Neoplasms/surgery ; Carcinoma, Pancreatic Ductal/surgery ; Pancreatic Neoplasms
Language	English
Publishing date	2023-07-11
Publishing country	England
Document type	Multicenter Study ; Journal Article
ISSN	2474-9842
ISSN (online)	2474-9842
DOI	10.1093/bjsopen/zrad053
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Article ; Online: Ward based goal directed fluid therapy (GDFT) in acute pancreatitis (GAP) trial: A feasibility randomised controlled trial.

Froghi, Farid / Soggiu, Fiammetta / Ricciardi, Federico / Vindrola-Padros, Cecilia / Floros, Lefteris / Martin, Daniel / Filipe, Helder / Varcada, Massimo / Gurusamy, Kurinchi / Bhattacharya, Satya / Fanshawe, Angela / Delcea, Bogdan / Mathur, Pawan / Davidson, Brian

International journal of surgery (London, England)

2022 Volume 104, Page(s) 106737

Abstract: Background: Goal-directed fluid therapy (GDFT) reduces complications in patients undergoing major general surgery. There are no reports of cardiac output evaluation being used to optimise the fluid administration for patients with acute pancreatitis (AP) ...

Abstract	Background: Goal-directed fluid therapy (GDFT) reduces complications in patients undergoing major general surgery. There are no reports of cardiac output evaluation being used to optimise the fluid administration for patients with acute pancreatitis (AP) in a general surgery ward. Method: 50 patients with AP were randomised to either ward-based GDFT (n = 25) with intravenous (IV) fluids administered based on stroke volume optimisation protocol or standard care (SC) (n = 25), but with blinded cardiac output evaluation, for 48-h following hospital admission. Primary outcome was feasibility. Results: 50 of 116 eligible patients (43.1%) were recruited over 20 months demonstrating feasibility. 36 (72%) completed the 48-h of GDFT; 10 (20%) discharged within 48-h and 4 withdrawals (3 GDFT, 1 SC). Baseline characteristics were similar with only 3 participants having severe disease (6%, 1 GDFT, 2 SC). Similar volumes of IV fluids were administered in both groups (GDFT 5465 (1839) ml, SC 5211 (1745) ml). GDFT group had a lower heart rate, blood pressure and respiratory rate and improved oxygen saturations. GDFT was not associated with any harms. There was no evidence of difference in complications of AP (GDFT 24%, SC 32%) or in the duration of stay in intensive care (GDFT 0 (0), SC 0.7 (3) days). Length of hospital stay was 5 (2.9) days in GDFT and 6.3 (7.6) in SC groups. Conclusion: Ward-based GDFT is feasible and shows a signal of possible efficacy in AP in this early-stage study. A larger multi-site RCT is required to confirm clinical and cost effectiveness.
MeSH term(s)	Acute Disease ; Feasibility Studies ; Fluid Therapy ; Goals ; Hospitals ; Humans ; Pancreatitis
Language	English
Publishing date	2022-07-12
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1016/j.ijsu.2022.106737
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Article: Intrahepatic pseudoaneurysm after radiofrequency ablation of liver metastases.

Soggiu, Fiammetta / Marescaux, Jacques / Pessaux, Patrick

Hepatobiliary surgery and nutrition

2014 Volume 3, Issue 4, Page(s) 207–208

Language	English
Publishing date	2014-08-25
Publishing country	China (Republic : 1949- )
Document type	Case Reports
ZDB-ID	2812398-0
ISSN	2304-389X ; 2304-3881
ISSN (online)	2304-389X
ISSN	2304-3881
DOI	10.3978/j.issn.2304-3881.2014.06.06
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Article: Monosegment ALPPS hepatectomy preserving segment 4 for colorectal liver metastases: literature review and our experience.

Soggiu, Fiammetta / Giovinazzo, Francesco / Straiton, Jack / Turri, Giulia / Phillips, Jim / Al-Kari, Bassam / Ahmed, Irfan / Habib, Mohammad

Hepatobiliary surgery and nutrition

2018 Volume 7, Issue 2, Page(s) 105–115

Abstract: Monosegment 4±1 Associating Liver Partition and Portal Vein ligation for Staged hepatectomy (ALPPS) for bilateral colorectal liver metastases decreases the risk of drop-out of two stage hepatectomy, triggering a rapid and significant increase in future ... ...

Abstract	Monosegment 4±1 Associating Liver Partition and Portal Vein ligation for Staged hepatectomy (ALPPS) for bilateral colorectal liver metastases decreases the risk of drop-out of two stage hepatectomy, triggering a rapid and significant increase in future liver remnant (FLR) with promising oncological outcomes. We report two cases of segment 4+1 monosegment ALPPS for multiple colorectal liver metastases performed at our institution. In the literature, seven similar cases have been reported. Short and long term outcomes of our two patients were reported along with a review of data from the literature. Our patients showed a FLR increase from 13% to 37% and from 14% to 41% of total liver volume, respectively. This was compared to a median growth from 19% at baseline to 34% before stage 2, in the literature. After 20 and 27 months since resection both patients are alive and disease-free. In the literature, median overall survival and disease free survival were 13 months (range, 5-24 months) and 5 months (range, 3-23 months), respectively. Segment 4±1 ALPPS is associated with promising oncological outcomes and a significant FLR growth. It may be safely performed in selected patients as a salvage procedure, reducing the risk of the dropout of two-stage hepatectomy.
Language	English
Publishing date	2018-04-25
Publishing country	China (Republic : 1949- )
Document type	Case Reports
ZDB-ID	2812398-0
ISSN	2304-389X ; 2304-3881
ISSN (online)	2304-389X
ISSN	2304-3881
DOI	10.21037/hbsn.2017.03.12
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Article ; Online: Short-term outcomes after pancreatoduodenectomy in octogenarians: multicentre case-control study.

Attard, Joseph A / Al-Sarireh, Bilal / Bhogal, Ricky Harminder / Farrugia, Alexia / Fusai, Giuseppe / Harper, Simon / Hidalgo-Salinas, Camila / Jah, Asif / Marangoni, Gabriele / Mortimer, Matthew / Pizanias, Michail / Prachialias, Andreas / Roberts, Keith J / Sew Hee, Chloe / Soggiu, Fiammetta / Srinivasan, Parthi / Chatzizacharias, Nikolaos A

The British journal of surgery

2021 Volume 109, Issue 1, Page(s) 89–95

Abstract: Background: Pancreatoduodenectomy (PD) is frequently the surgical treatment indicated for a number of pathologies. Elderly patients may be denied surgery because of concerns over poor perioperative outcomes. The aim of this study was to evaluate ... ...

Abstract	Background: Pancreatoduodenectomy (PD) is frequently the surgical treatment indicated for a number of pathologies. Elderly patients may be denied surgery because of concerns over poor perioperative outcomes. The aim of this study was to evaluate postoperative clinical outcomes and provide evidence on current UK practice in the elderly population after PD. Methods: This was a multicentre retrospective case-control study of octogenarians undergoing PD between January 2008 and December 2017, matched with younger controls from seven specialist centres in the UK. The primary endpoint was 90-day mortality. Secondary endpoints were index admission mortality, postoperative complications, and 30-day readmission rates. Results: In total, 235 octogenarians (median age 81 (range 80-90) years) and 235 controls (age 67 (31-79) years) were included in the study. Eastern Cooperative Oncology Group performance status (median 0 (range 0-3) versus 0 (0-2); P = 0.010) and Charlson Co-morbidity Index score (7 (6-11) versus 5 (2-9); P = 0.001) were higher for octogenarians than controls. Postoperative complication and 30-day readmission rates were comparable. The 90-day mortality rate was higher among octogenarians (9 versus 3 per cent; P = 0.030). Index admission mortality rates were comparable (4 versus 2 per cent; P = 0.160), indicating that the difference in mortality was related to deaths after hospital discharge. Despite the higher 90-day mortality rate in the octogenarian population, multivariable Cox regression analysis did not identify age as an independent predictor of postoperative mortality. Conclusion: Despite careful patient selection and comparable index admission mortality, 90-day and, particularly, out-of-hospital mortality rates were higher in octogenarians.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Pancreaticoduodenectomy/adverse effects ; Pancreaticoduodenectomy/mortality ; Pancreaticoduodenectomy/statistics & numerical data ; Patient Readmission/statistics & numerical data ; Retrospective Studies ; Risk Factors ; Sex Factors ; United Kingdom/epidemiology
Language	English
Publishing date	2021-11-08
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znab374
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Article: Gemcitabine-Based Neoadjuvant Treatment in Borderline Resectable Pancreatic Ductal Adenocarcinoma: A Meta-Analysis of Individual Patient Data.

Giovinazzo, Francesco / Soggiu, Fiammetta / Jang, Jin-Young / Versteijne, Eva / van Tienhoven, Geertjan / van Eijck, Casper H / Han, Youngmin / Choi, Seong Ho / Kang, Chang Moo / Zalupski, Mark / Ahmad, Hasham / Yentz, Sarah / Helton, Scott / Rose, J Bart / Takishita, Chie / Nagakawa, Yuichi / Abu Hilal, Mohammad

Frontiers in oncology

2020 Volume 10, Page(s) 1112

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2020-08-11
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2020.01112
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Article ; Online: Ward-based Goal-Directed Fluid Therapy (GDFT) in Acute Pancreatitis (GAP) trial: study protocol for a feasibility randomised controlled trial.

Froghi, Farid / Soggiu, Fiammetta / Ricciardi, Federico / Gurusamy, Kurinchi / Martin, Daniel S / Singh, Jeshika / Siddique, Sulman / Eastgate, Christine / Ciaponi, Maria / McNeil, Margaret / Filipe, Helder / Schwalowsky-Monks, Otto / Asis, Gretchelle / Varcada, Massimo / Davidson, Brian R

BMJ open

2019 Volume 9, Issue 10, Page(s) e028783

Abstract: Introduction: Acute pancreatitis is an inflammatory disease of the pancreas with high risk of developing multiorgan failure and death. There are no effective pharmacological interventions used in current clinical practice. Maintaining fluid and ... ...

Abstract	Introduction: Acute pancreatitis is an inflammatory disease of the pancreas with high risk of developing multiorgan failure and death. There are no effective pharmacological interventions used in current clinical practice. Maintaining fluid and electrolyte balance is the mainstay of supportive management. Goal-directed fluid therapy (GDFT) has been shown to decrease morbidity and mortality in surgical conditions with systemic inflammatory response. There is currently no randomised controlled trial (RCT) investigating the role of GDFT based on cardiac output parameters in patients with acute pancreatitis in the ward setting. A feasibility trial was designed to determine patient and clinician support for recruitment into an RCT of ward-based GDFT in acute pancreatitis, adherence to a GDFT protocol, safety, participant withdrawal, and to determine appropriate endpoints for a subsequent larger trial to evaluate efficacy. Methods and analysis: The GDFT in Acute Pancreatitis trial is a prospective two-centre feasibility RCT. Eligible adults admitted with new onset of acute pancreatitis will be enrolled and randomised into ward-based GDFT (n=25) or standard fluid therapy (n=25) within 6 hours from the diagnosis and continuing for the following 48 hours. Cardiac output parameters will be monitored with a non-invasive device (Cheetah NICOM; Cheetah Medical). The intervention group will consist of a protocolised GDFT approach consisting of stroke volume optimisation with crystalloid fluid boluses, while the control group will receive standard care fluid therapy as advised by the clinical team. The primary endpoint is feasibility. Secondary endpoints will include safety of the intervention, complications, mortality, admission to intensive care unit, cost and quality of life. Ethics and dissemination: Ethics approval was granted by the London Central Research Ethics Committee (17/LO/1235, project ID: 221872). The results of this trial will be presented to international conference with interest in general surgery and acute care and published in a peer-reviewed journal. Trial registration number: ISRCTN36077283.
MeSH term(s)	Acute Disease ; Adult ; Feasibility Studies ; Fluid Therapy/methods ; Humans ; Multicenter Studies as Topic ; Pancreatitis/therapy ; Prospective Studies ; Randomized Controlled Trials as Topic/methods
Language	English
Publishing date	2019-10-09
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2018-028783
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Article ; Online: The cardiac output optimisation following liver transplant (COLT) trial: a feasibility randomised controlled trial.

Martin, Daniel / Koti, Rahul / Gurusamy, Kurinchi / Longworth, Louise / Singh, Jeshika / Froghi, Farid / Soggiu, Fiammetta / Mallett, Susan / Schofield, Nick / Selves, Linda / Thorburn, Douglas / Eastgate, Christine / Filipe, Helder / McNeil, Margaret / Anastasiou, Zacharias / Davidson, Brian

HPB : the official journal of the International Hepato Pancreato Biliary Association

2019 Volume 22, Issue 8, Page(s) 1112–1120

Abstract: Background: Perioperative goal directed fluid therapy (GDFT) has been shown to reduce postoperative complications following major surgery; this intervention has not been formally evaluated in the setting of liver transplantation.: Methods: We ... ...

Abstract	Background: Perioperative goal directed fluid therapy (GDFT) has been shown to reduce postoperative complications following major surgery; this intervention has not been formally evaluated in the setting of liver transplantation. Methods: We conducted a prospective trial of GDFT following liver transplantation randomising patients with liver cirrhosis to either 12 h of GDFT using non-invasive cardiac output monitoring or standard care (SC). The primary outcome was feasibility. Secondary outcomes included survival, postoperative complications (Clavien-Dindo), quality of life (by EQ-5D-5L) and resource use. Trial specific follow up occurred at 90 and 180 days after surgery. Results: The study was feasible. Of 224 eligible patients, 122 were approached, 114 consented to participate and 60 were enrolled into the trial. The mean (SD) volume of IV crystalloid administered to the GDFT group during the 12-h study period was 3968 (2073) ml for the GDFT group and 2510 (1026) ml for the SC group. As regards secondary outcomes there was no difference in survival or overall complication rates. There was no significant difference in quality of life scores and resource use between the groups. Conclusion: A randomised study of GDFT following liver transplantation is feasible. A post-trial stakeholder meeting supported proceeding with a full multi-centre trial.
MeSH term(s)	Cardiac Output ; Feasibility Studies ; Fluid Therapy ; Humans ; Liver Transplantation ; Prospective Studies ; Quality of Life
Language	English
Publishing date	2019-12-23
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2131251-5
ISSN	1477-2574 ; 1365-182X
ISSN (online)	1477-2574
ISSN	1365-182X
DOI	10.1016/j.hpb.2019.11.011
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Article ; Online: Sentinel lymph node biopsy in multicentric breast cancer: five-year results in a large series from a single institution.

Gentilini, Oreste / Veronesi, Paolo / Botteri, Edoardo / Soggiu, Fiammetta / Trifirò, Giuseppe / Lissidini, Germana / Galimberti, Viviana / Musmeci, Simona / Raviele, Paola Rafaniello / Toesca, Antonio / Ratini, Silvia / Del Castillo, Andres / Castillo, Andres Del / Colleoni, Marco / Talakhadze, Nina / Rotmensz, Nicole / Viale, Giuseppe / Veronesi, Umberto / Luini, Alberto

Annals of surgical oncology

2011 Volume 18, Issue 10, Page(s) 2879–2884

Abstract: Purpose: This study was designed to present the 5-year results of patients with multicentric breast cancer who underwent sentinel lymph node biopsy (SLNB) in a single institution.: Methods: Between June 1999 and December 2007, 337 patients with ... ...

Abstract	Purpose: This study was designed to present the 5-year results of patients with multicentric breast cancer who underwent sentinel lymph node biopsy (SLNB) in a single institution. Methods: Between June 1999 and December 2007, 337 patients with multicentric breast cancer and a clinically negative axilla underwent lymphatic mapping by a single periareolar/peritumoral (n = 306) or a double peritumoral or subdermal injection (n = 31) of (99m)Tc-HSA nanocolloids. The sentinel lymph node (SLN) was evaluated by intraoperative frozen section and axillary dissection was performed only in cases of positive SLNB. Results: The median age of the patients was 48 (range, 22-81) years. The mean number of hot spots identified was 1.4 in the whole series, 1.3 in patients who received a single injection, and 1.7 in those who received a double injection (P < 0.001). The mean number of removed SLNs was 1.7 (median, 1; range, 1-7) with an identification rate of 100%. A total of 138 patients with negative SLNB (n = 134) or isolated tumor cells in the SLN (n = 4) did not receive completion axillary lymph node dissection (CALND). In these latter patients, a total of 27 events (19.5%) occurred with 3 patients (2.2%) developing axillary recurrences after a median follow-up of 5 years (range, 17-134 months). Conclusions: Axillary lymph node reappearance was infrequent among patients with multicentric breast cancer, having negative SLNB and no CALND. We recommend SLNB as the standard procedure for nodal staging in patients with multicentric breast cancer and a clinically negative axilla.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Axilla ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Carcinoma, Ductal, Breast/mortality ; Carcinoma, Ductal, Breast/secondary ; Carcinoma, Ductal, Breast/surgery ; Carcinoma, Lobular/mortality ; Carcinoma, Lobular/secondary ; Carcinoma, Lobular/surgery ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Sentinel Lymph Node Biopsy ; Survival Rate ; Young Adult
Language	English
Publishing date	2011-10
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-011-1694-3
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