LIVIVO - Search results -

Search results

Result 1 - 10 of total 137

Search options

Article ; Online: Examination of Effective Buccal Absorption of Salmon Calcitonin Using Cell-Penetrating Peptide-Conjugated Liposomal Drug Delivery System.

Keum, Taekwang / Noh, Gyubin / Seo, Jo-Eun / Bashyal, Santosh / Sohn, Dong Hwan / Lee, Sangkil

2022 Volume 17, Page(s) 697–710

Abstract: Introduction: The buccal route has been considered an attractive alternative delivery route for injectable formulations. Cell-penetrating peptides (CPPs) are gaining increased attention for their cellular uptake and tissue permeation effects. This study ...

Abstract	Introduction: The buccal route has been considered an attractive alternative delivery route for injectable formulations. Cell-penetrating peptides (CPPs) are gaining increased attention for their cellular uptake and tissue permeation effects. This study was aimed to evaluate the in vitro and ex vivo permeation-enhancing effect of penetratin-conjugated liposomes for salmon calcitonin (sCT) in TR146 human buccal cells and porcine buccal tissues. Methods: Penetratin was conjugated to phospholipids through a maleimide-thiol reaction. Liposomes were prepared and sCT was encapsulated using a thin-film hydration method. Physical properties such as particle size, zeta potential, encapsulation efficiency, and morphological images via transmission electron microscopy were obtained. Cellular uptake studies were conducted using flow cytometry (FACS) and confocal laser scanning microscopy (CLSM). A cell permeation study was performed using a Transwell Results: The particle size of penetratin-conjugated liposomes was approximately 123.0 nm, their zeta potential was +29.6 mV, and their calcitonin encapsulation efficiency was 18.0%. In the cellular uptake study using FACS and CLSM, stronger fluorescence was observed in penetratin-conjugated liposomes compared with the solution containing free sCT and control liposomes. Likewise, the amount of sCT permeated from penetratin-conjugated liposomes was higher than that from the free sCT solution and control liposomes by 5.8-fold across TR146 cells and 91.5-fold across porcine buccal tissues. Conclusion: Penetratin-conjugated liposomes are considered a good drug delivery strategy for sCT via the buccal route.
MeSH term(s)	Animals ; Calcitonin ; Cell-Penetrating Peptides/pharmacology ; Drug Delivery Systems/methods ; Humans ; Liposomes/chemistry ; Mouth Mucosa ; Oral Mucosal Absorption ; Swine
Chemical Substances	Cell-Penetrating Peptides ; Liposomes ; salmon calcitonin (7SFC6U2VI5) ; Calcitonin (9007-12-9)
Language	English
Publishing date	2022-02-15
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S335774
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6606: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Customized Novel Design of 3D Printed Pregabalin Tablets for Intra-Gastric Floating and Controlled Release Using Fused Deposition Modeling.

Lamichhane, Shrawani / Park, Jun-Bom / Sohn, Dong Hwan / Lee, Sangkil

Pharmaceutics

2019 Volume 11, Issue 11

Abstract: Three-dimensional (3D) printing has been recently employed in the design and formulation of various dosage forms with the aim of on-demand manufacturing and personalized medicine. In this study, we formulated a floating sustained release system using ... ...

Abstract	Three-dimensional (3D) printing has been recently employed in the design and formulation of various dosage forms with the aim of on-demand manufacturing and personalized medicine. In this study, we formulated a floating sustained release system using fused deposition modeling (FDM). Filaments were prepared using hypromellose acetate succinate (HPMCAS), polyethylene glycol (PEG 400) and pregabalin as the active ingredient. Cylindrical tablets with infill percentages of 25%, 50% and 75% were designed and printed with the FDM printer. An optimized formulation (F6) was designed with a closed bottom layer and a partially opened top layer. Filaments and tablets were characterized by means of fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), and thermogravimetric analysis (TGA). The results show that the processing condition did not have a significant effect on the stability of the drug and the crystallinity of the drug remained even after printing. A dissolution study revealed that drug release is faster in an open system with low infill percentage compared to closed systems and open systems with a high infill ratio. The optimized formulation (F6) with partially opened top layer showed zero-order drug release. The results show that FDM printing is suitable for the formulation of floating dosage form with the desired drug release profile.
Language	English
Publishing date	2019-10-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics11110564
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Isoliquiritigenin suppresses tumor necrosis factor-α-induced inflammation via peroxisome proliferator-activated receptor-γ in intestinal epithelial cells.

Jin, Xing Yu / Sohn, Dong Hwan / Lee, Sung Hee

Archives of pharmacal research

2016 Volume 39, Issue 10, Page(s) 1465–1471

Abstract: Intestinal epithelial cells play an important role in the mucosal immune reaction in inflammatory bowel diseases via the expression of inflammatory mediators, such as cyclooxygenase-2 (COX-2) and intercellular adhesion molecule-1 (ICAM-1). ... ...

Abstract	Intestinal epithelial cells play an important role in the mucosal immune reaction in inflammatory bowel diseases via the expression of inflammatory mediators, such as cyclooxygenase-2 (COX-2) and intercellular adhesion molecule-1 (ICAM-1). Isoliquiritigenin (ISL; 4,2',4'-trihydroxychalcone) has been shown to exhibit anti-inflammatory properties in murine macrophage cells. In the present study, we evaluated the anti-inflammatory properties of ISL in intestinal epithelial cells and determined its mechanism of action. ISL suppressed the expression of COX-2 and ICAM-1 in tumor necrosis factor-α (TNF-α) stimulated intestinal epithelium HT-29 cells. It also induced peroxisome proliferator-activated receptor-γ (PPARγ) protein expression. Moreover, using a PPARγ antagonist, GW9662, we found that the regulation of COX-2 and ICAM-1 expression by ISL in TNF-α-stimulated HT-29 cells is mediated via PPARγ expression. A signal transduction study revealed that ISL significantly attenuates TNF-α-mediated JNK phosphorylation. ISL-induced ERK1/2 phosphorylation was associated with PPARγ expression. Additionally, both the inhibitory effect on COX-2 and ICAM-1 expression and the induction of PPARγ expression by ISL in TNF-α-stimulated HT-29 cells was abolished by the addition of U0126, a specific ERK1/2 inhibitor. Collectively, ISL-induced PPARγ mediated, at least partially, the suppression of intestinal inflammation. These results suggest that ISL may be beneficial for the treatment of mucosal inflammation.
MeSH term(s)	Cell Survival/drug effects ; Cell Survival/physiology ; Chalcones/pharmacology ; Chalcones/therapeutic use ; Dose-Response Relationship, Drug ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; HT29 Cells ; Humans ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/metabolism ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; PPAR gamma/biosynthesis ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/toxicity
Chemical Substances	Chalcones ; Inflammation Mediators ; PPAR gamma ; Tumor Necrosis Factor-alpha ; isoliquiritigenin (B9CTI9GB8F)
Language	English
Publishing date	2016-10
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	447623-2
ISSN	1976-3786 ; 0253-6269
ISSN (online)	1976-3786
ISSN	0253-6269
DOI	10.1007/s12272-016-0805-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 3229: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Ameliorative effect of Alnus japonica ethanol extract on colitis through the inhibition of inflammatory responses and attenuation of intestinal barrier disruption in vivo and in vitro.

Chi, Jin Hua / Kim, Young Ho / Sohn, Dong Hwan / Seo, Geom Seog / Lee, Sung Hee

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2018 Volume 108, Page(s) 1767–1774

Abstract: Inflammatory bowel disease (IBD) is chronic inflammation of the gastrointestinal tract caused by high levels of pro-inflammatory cytokines and epithelial barrier dysfunction. Alnus japonica Steud. (Betulaceae) has been used in traditional Asian medicine. ...

Abstract	Inflammatory bowel disease (IBD) is chronic inflammation of the gastrointestinal tract caused by high levels of pro-inflammatory cytokines and epithelial barrier dysfunction. Alnus japonica Steud. (Betulaceae) has been used in traditional Asian medicine. However, the potential of A. japonica for the treatment of intestinal inflammation has not been investigated. This study investigated the effects of ethanol extract from A. japonica bark (AJE) on colonic mucosa injury in mice with dextran sodium sulfate (DSS)-induced colitis. Treatment with AJE ameliorated pathological damage and the histopathologic features of DSS-induced colitis. The administration of AJE also inhibits DSS-induced pro-inflammatory cytokines expression, including interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and cyclooxygenase (COX)-2. Notably, AJE administration attenuated the reduction of tight junction proteins, zonula occludens (ZO)-1 and occludin, in DSS-induced colitis. In addition, AJE increased heme oxygenase (HO)-1 expression and prevented DSS-induced apoptosis in colonic epithelial cells. Furthermore, in vitro studies demonstrated that AJE inhibits TNF-α-induced IL-8, IL-1β, and COX-2 expression in human intestinal epithelial HT-29 cells and tert-butyl hydroperoxide-induced reduction of ZO-1 and occludin expression in human intestinal epithelial Caco-2 cells. AJE-induced HO-1 protein expression was also found in both HT-29 and Caco-2 cells. Taken together, our findings demonstrated that AJE inhibits intestinal inflammation and protects against intestinal barrier disruption in mice with DSS-induced colitis in vivo and human intestinal epithelial cells in vitro. These results suggest that AJE might have beneficial effects for the treatment of IBD.
MeSH term(s)	Alnus/chemistry ; Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Caco-2 Cells ; Colitis/drug therapy ; Colitis/pathology ; Dextran Sulfate ; Ethanol/chemistry ; HT29 Cells ; Humans ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Intestines/drug effects ; Intestines/pathology ; Male ; Mice, Inbred C57BL ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use
Chemical Substances	Anti-Inflammatory Agents ; Inflammation Mediators ; Plant Extracts ; Ethanol (3K9958V90M) ; Dextran Sulfate (9042-14-2)
Language	English
Publishing date	2018-10-16
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2018.10.050
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ud II Zs.198: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Complex formulations, simple techniques: Can 3D printing technology be the Midas touch in pharmaceutical industry?

Lamichhane, Shrawani / Bashyal, Santosh / Keum, Taekwang / Noh, Gyubin / Seo, Jo Eun / Bastola, Rakesh / Choi, Jaewoong / Sohn, Dong Hwan / Lee, Sangkil

Asian journal of pharmaceutical sciences

2019 Volume 14, Issue 5, Page(s) 465–479

Abstract: 3D printing is a method of rapid prototyping and manufacturing in which materials are deposited onto one another in layers to produce a three-dimensional object. Although 3D printing was developed in the 1980s and the technology has found widespread ... ...

Abstract	3D printing is a method of rapid prototyping and manufacturing in which materials are deposited onto one another in layers to produce a three-dimensional object. Although 3D printing was developed in the 1980s and the technology has found widespread industrial applications for production from automotive parts to machine tools, its application in pharmaceutical area is still limited. However, the potential of 3D printing in the pharmaceutical industry is now being recognized. The ability of 3D printing to produce medications to exact specifications tailored to the needs of individual patients has indicated the possibility of developing personalized medicines. The technology allows dosage forms to be precisely printed in various shapes, sizes and textures that are difficult to produce using traditional techniques. However, there are various challenges associated with the proper application of 3D printing in the pharmaceutical sector which should be overcome to exploit the scope of this technology. In this review, an overview is provided on the various 3D printing technologies used in fabrication of complex dosage forms along with their feasibility and limitations.
Language	English
Publishing date	2019-02-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2650931-3
ISSN	2221-285X ; 1818-0876 ; 1818-0876
ISSN (online)	2221-285X ; 1818-0876
ISSN	1818-0876
DOI	10.1016/j.ajps.2018.11.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Iontophoretic Transdermal Delivery of Human Growth Hormone (hGH) and the Combination Effect of a New Type Microneedle, Tappy Tok Tok

Noh, Gyubin / Keum, Taekwang / Seo, Jo-Eun / Bashyal, Santosh / Eum, Nyeon-Sik / Kweon, Min Jung / Lee, Sooyeun / Sohn, Dong Hwan / Lee, Sangkil

Pharmaceutics

2018 Volume 10, Issue 3

Abstract: Transdermal drug administration presents several advantages and it is therefore favorable as an alternative drug delivery route. However, transdermal delivery of biopharmaceutical drugs is made difficult by the skin barrier. Microneedle application and ... ...

Abstract	Transdermal drug administration presents several advantages and it is therefore favorable as an alternative drug delivery route. However, transdermal delivery of biopharmaceutical drugs is made difficult by the skin barrier. Microneedle application and iontophoresis are strategies which can be used to overcome this barrier. Therefore, recombinant human growth hormone (rhGH) was used as a model macromolecular drug and was transdermally delivered using microneedle application and iontophoresis. Methylene blue staining, stereomicroscopy and scanning electron microscope (SEM) imaging were used to characterize the microchannels produced. To optimize the iontophoresis protocol, the effects of molecular charge and current density on transdermal delivery were evaluated in an in vitro permeation study using excised rat skin tissues. Using the optimized iontophoresis protocol, the combination effects of iontophoretic delivery via microchannels were evaluated in three different experimental designs. The flux obtained with anodal iontophoresis in citrate buffer was approximately 10-fold higher that that with cathodal iontophoresis in phosphate buffered saline (PBS). Flux also increased with current density in anodal iontophoresis. The combination of iontophoresis and microneedle application produced higher flux than single application. These results suggest that anodal iontophoresis with higher current density enhances the permeation of macromolecules through microchannels created by microneedles. In conclusion, the combination of iontophoresis and microneedles is a potential strategy for the enhancement of transdermal delivery of macromolecular drugs.
Language	English
Publishing date	2018-09-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics10030153
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Correction: Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: Involvement of p53/FoxO3A axis.

Nepal, Saroj / Kim, Mi Jin / Hong, Jin Tae / Kim, Sang Hyun / Sohn, Dong-Hwan / Lee, Sung Hee / Song, Kyung / Choi, Dong Young / Lee, Eung Seok / Park, Pil-Hoon

Oncotarget

2020 Volume 11, Issue 30, Page(s) 2956–2957

Abstract: This corrects the article DOI: 10.18632/oncotarget.3347.]. ...

Abstract	[This corrects the article DOI: 10.18632/oncotarget.3347.].
Language	English
Publishing date	2020-07-28
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.27467
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: PF2405, standardized fraction of Scutellaria baicalensis, ameliorates colitis in vitro and in vivo.

Jiang, Wen-Yi / Seo, Geom Seog / Kim, Youn-Chul / Sohn, Dong Hwan / Lee, Sung Hee

Archives of pharmacal research

2015 Volume 38, Issue 6, Page(s) 1127–1137

Abstract: Standardized extraction procedures for herb are as important as their authentication to maintain their quality and ensure their safe use. We had prepared a standardized and purified Scutellaria baicalensis Georgi extract, PF2405, which was enriched with ... ...

Abstract	Standardized extraction procedures for herb are as important as their authentication to maintain their quality and ensure their safe use. We had prepared a standardized and purified Scutellaria baicalensis Georgi extract, PF2405, which was enriched with three major components, baicalein, oroxylin A and wogonin. In the present study, we investigated the potential anti-inflammatory effects of PF2405 in vitro and in two different experimental animal models of inflammatory bowel disease. Effect of PF2405 studied in tumor necrosis factor (TNF)-α-induced HT-29 cells in vitro. In vivo experimental colitis models were induced by administration of trinitrobenzene sulfonic acid (TNBS) or dextran sulfate sodium (DSS). PF2405 (50 μg/ml) decreased TNF-α-induced cyclooxygenase (COX)-2 expressions through inhibition of phosphorylation of c-Jun N-terminal kinases and p38 mitogen-activated protein kinase in HT-29 cells. Combination of baicalein (20 μg/ml), oroxylin A (8 μg/ml), and wogonin (2 μg/ml) markedly inhibits TNF-α-induced COX-2 expression when compared with individual components. PF2405 (25 mg/kg b.w.) treatment significantly reduced histopathological severity; suppressed expression of COX-2, TNF-α, and interleukin-1β in TNBS-induced mice. Moreover, PF2405 (25 mg/kg b.w.) has both potent preventive and therapeutic activities in DSS-induced colitis. Collectively, PF2405 shows prominent anti-inflammatory effect that can be used as a new therapeutic approach for intestinal inflammatory disorders.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/therapeutic use ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/pathology ; Cyclooxygenase 2 Inhibitors/pharmacology ; Dextran Sulfate ; Female ; HT29 Cells ; Humans ; Interleukin-1beta/metabolism ; MAP Kinase Kinase 4/antagonists & inhibitors ; Mice ; Mice, Inbred C57BL ; Phosphorylation ; Plant Extracts/therapeutic use ; Scutellaria baicalensis/chemistry ; Trinitrobenzenesulfonic Acid ; Tumor Necrosis Factor-alpha
Chemical Substances	Anti-Inflammatory Agents ; Cyclooxygenase 2 Inhibitors ; Interleukin-1beta ; PF-2405 ; Plant Extracts ; Scutellaria baicalensis extract ; Tumor Necrosis Factor-alpha ; Trinitrobenzenesulfonic Acid (8T3HQG2ZC4) ; Dextran Sulfate (9042-14-2) ; MAP Kinase Kinase 4 (EC 2.7.12.2)
Language	English
Publishing date	2015-06
Publishing country	Korea (South)
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	447623-2
ISSN	1976-3786 ; 0253-6269
ISSN (online)	1976-3786
ISSN	0253-6269
DOI	10.1007/s12272-015-0553-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 3229: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Polyozellin blocks tumor necrosis factor α-induced interleukin 8 and matrix metalloproteinase 7 production in the human intestinal epithelial cell line HT-29.

Lee, Sung Hee / Song, Kyung-Sik / Sohn, Dong Hwan / Seo, Geom Seog

Archives of pharmacal research

2011 Volume 34, Issue 1, Page(s) 91–97

Abstract: Polyozellin isolated from Polyozellus multiplex (Thelephoraceae) displays potent anti-inflammatory effects in murine macrophages. Here we evaluated whether polyozellin has the potential to ameliorate diseases characterized by mucosal inflammation in ... ...

Abstract	Polyozellin isolated from Polyozellus multiplex (Thelephoraceae) displays potent anti-inflammatory effects in murine macrophages. Here we evaluated whether polyozellin has the potential to ameliorate diseases characterized by mucosal inflammation in intestinal epithelial HT-29 cells. Polyozellin significantly inhibited tumor necrosis factor (TNF)-α-induced interleukin-8 secretion and mRNA expression. Moreover, polyozellin suppressed the expression of matrix metalloproteinase-7 mRNA and extracellular pro-matrix metalloproteinase-7 secretion. A signal transduction study revealed that polyozellin significantly attenuates TNF-α-mediated p38 phosphorylation, inhibitory factor κBα degradation, and nuclear factor-κB-mediated transcriptional activation. Collectively, these results suggest that polyozellin has the potential to attenuate intestinal inflammation and shed light on the novel signal pathway evoked by TNF-α during intestinal inflammation.
MeSH term(s)	Basidiomycota/chemistry ; Furans/isolation & purification ; Furans/pharmacology ; HT29 Cells ; Humans ; I-kappa B Proteins/drug effects ; I-kappa B Proteins/metabolism ; Inflammation/drug therapy ; Inflammation/physiopathology ; Interleukin-8/drug effects ; Interleukin-8/secretion ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/pathology ; Matrix Metalloproteinase 7/drug effects ; Matrix Metalloproteinase 7/secretion ; NF-KappaB Inhibitor alpha ; NF-kappa B/drug effects ; NF-kappa B/metabolism ; Phosphorylation/drug effects ; RNA, Messenger/metabolism ; Signal Transduction/drug effects ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases/drug effects ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Furans ; I-kappa B Proteins ; Interleukin-8 ; NF-kappa B ; NFKBIA protein, human ; RNA, Messenger ; Tumor Necrosis Factor-alpha ; polyozellin ; NF-KappaB Inhibitor alpha (139874-52-5) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Matrix Metalloproteinase 7 (EC 3.4.24.23)
Language	English
Publishing date	2011-01
Publishing country	Korea (South)
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	447623-2
ISSN	1976-3786 ; 0253-6269
ISSN (online)	1976-3786
ISSN	0253-6269
DOI	10.1007/s12272-011-0111-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 3229: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: A new diarylheptanoid from the bark of Alnus japonica.

Tung, Nguyen Huu / Ra, Jeong Chan / Sohn, Dong Hwan / Kim, Young Ho

Journal of Asian natural products research

2010 Volume 12, Issue 10, Page(s) 921–924

Abstract: A new diarylheptanoid, epihirsutanonol (1), was isolated from the bark of Alnus japonica, along with two known ones (2 and 3). Their structures were elucidated on the basis of extensive spectroscopic evidence. The new compound 1 showed significant ... ...

Abstract	A new diarylheptanoid, epihirsutanonol (1), was isolated from the bark of Alnus japonica, along with two known ones (2 and 3). Their structures were elucidated on the basis of extensive spectroscopic evidence. The new compound 1 showed significant hepatoprotective activity on the basis of t-butylhydroperoxide-induced hepatocyte injury in vitro assay.
MeSH term(s)	Alnus/chemistry ; Diarylheptanoids/chemistry ; Diarylheptanoids/isolation & purification ; Diarylheptanoids/pharmacology ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; Hepatocytes/drug effects ; Liver/drug effects ; Liver Diseases/drug therapy ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Plant Bark/chemistry ; Wounds and Injuries/chemically induced ; tert-Butylhydroperoxide/pharmacology
Chemical Substances	Diarylheptanoids ; Drugs, Chinese Herbal ; epihirsutanonol ; tert-Butylhydroperoxide (955VYL842B)
Language	English
Publishing date	2010-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2010.507196
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito