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Article: Lectin-binding capacity of glycoconjugates in Escherichia coli 09:K103:NM, 987P+ST+-infected porcine lower small intestines.

Sohn, Y S / Chae, C

The Journal of veterinary medical science

2000 Volume 62, Issue 5, Page(s) 543–547

Abstract: Composition of glycoconjugates were investigated in Escherichia coli 09:K103:NM, 987P+ST+-infected lower small intestines of 1-week-old pigs by the use of twenty one biotinylated-labelled lectins with avidin-biotin-peroxidase complex method. Piglets with ...

Abstract	Composition of glycoconjugates were investigated in Escherichia coli 09:K103:NM, 987P+ST+-infected lower small intestines of 1-week-old pigs by the use of twenty one biotinylated-labelled lectins with avidin-biotin-peroxidase complex method. Piglets with experimental group were inoculated by feeding 5 ml of culture inoculum (5 x 10(9) colony-forming units/ml) with 15 ml of milk replacer. At the onset of diarrhea, experimental piglets and time-matched control piglets were euthanatized using electrocution, necropsied, and tested by lectin histochemistry. As compared with control, staining intensity of seven lectins altered in ileal villus brush border and goblet cells of pigs inoculated with the pathogen.
MeSH term(s)	Animals ; Animals, Newborn ; Diarrhea/veterinary ; Escherichia coli/chemistry ; Escherichia coli Infections/veterinary ; Fimbriae, Bacterial/chemistry ; Glycoconjugates/chemistry ; Histocytochemistry ; Ileum/chemistry ; Ileum/microbiology ; Intestinal Diseases/microbiology ; Intestinal Diseases/veterinary ; Intestinal Mucosa/chemistry ; Intestinal Mucosa/microbiology ; Jejunum/chemistry ; Jejunum/microbiology ; Lectins/chemistry ; Random Allocation ; Swine ; Swine Diseases/microbiology
Chemical Substances	Glycoconjugates ; Lectins
Language	English
Publishing date	2000-05
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1071753-5
ISSN	1347-7439 ; 0916-7250
ISSN (online)	1347-7439
ISSN	0916-7250
DOI	10.1292/jvms.62.543
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Article: Presentation of words to separate hemispheres prevents interword illusory conjunctions.

Liederman, J / Sohn, Y S

The International journal of neuroscience

1999 Volume 97, Issue 1-2, Page(s) 1–16

Abstract: We tested the hypothesis that division of inputs between the hemispheres could prevent interword letter migrations in the form of illusory conjunctions. The task was to decide whether a centrally-presented consonant-vowel-consonant (CVC) target word ... ...

Abstract	We tested the hypothesis that division of inputs between the hemispheres could prevent interword letter migrations in the form of illusory conjunctions. The task was to decide whether a centrally-presented consonant-vowel-consonant (CVC) target word matched one of four CVC words presented to a single hemisphere or divided between the hemispheres in a subsequent test display. During half of the target-absent trials, known as conjunction trials, letters from two separate words (e.g., "tag" and "cop") in the test display could be mistaken for a target word (e.g., "top"). For the other half of the target-absent trails, the test display did not match any target consonants (Experiment 1, N = 16) or it matched one target consonant (Experiment 2, N = 29), the latter constituting true "feature" trials. Bi- as compared to unihemispheric presentation significantly reduced the number of conjunction, but not feature, errors. Illusory conjunctions did not occur when the words were presented to separate hemispheres.
MeSH term(s)	Adult ; Brain/physiology ; Female ; Functional Laterality/physiology ; Humans ; Language ; Male ; Psychomotor Performance ; Speech Perception/physiology
Language	English
Publishing date	1999-12-01
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	3061-2
ISSN	1543-5245 ; 0020-7454
ISSN (online)	1543-5245
ISSN	0020-7454
DOI	10.3109/00207459908994299
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Article: Changes in Cellular Fatty Acid Composition of Cephalosporium acremonium during Cephalosporin C Production.

Sohn, Y S / Lee, K C / Koh, Y H / Gil, G H

Applied and environmental microbiology

2005 Volume 60, Issue 3, Page(s) 947–952

Abstract: Cephalosporium acremonium was cultivated in fermentation medium containing sucrose or methyl oleate as a carbon source for cephalosporin C production. The level of antibiotic production was 48 g of cephalosporin C per liter under optimum conditions when ... ...

Abstract	Cephalosporium acremonium was cultivated in fermentation medium containing sucrose or methyl oleate as a carbon source for cephalosporin C production. The level of antibiotic production was 48 g of cephalosporin C per liter under optimum conditions when methyl oleate was used. The C(18:1) (oleic acid) methyl ester appeared to be utilized faster than the C(18:2) (linoleic acid) methyl ester in fermentation broth. Physiological characteristics of C. acremonium were investigated by determining the fatty acid composition of the total cellular free lipid. Significant changes in cellular fatty acid composition occurred during inoculum cultivation and fermentation. The percentage of C(18:1) increased from 19.1 to 38.5%, but the percentage of C(18:2) decreased from 56.7 to 36.1%, and there was an increase in pH during inoculum cultivation. The cellular fatty acid composition of C. acremonium grown in fermentation medium containing methyl oleate (methyl oleate medium) was significantly different from that in fermentation medium containing sucrose (sucrose medium). The major fatty acids detected were C(16:0) (palmitic acid), C(18:1), and C(18:2). In methyl oleate medium, the ratio of C(18:1) to C(18:2) increased from 0.34 to 1.37, while the cell morphology changed from hyphae to arthrospores and conidia. In contrast, in sucrose medium, the ratio of C(18:1) to C(18:2) decreased from 0.70 to 0.43, and most of the cells remained hyphal at the end of fermentation. We observed that hyphae contained a higher proportion of C(18:2) but arthrospores and conidia contained a higher proportion of C(18:1).
Language	English
Publishing date	2005-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/aem.60.3.947-952.1994
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Article: Biosynthetic pathway of cephabacins in Lysobacter lactamgenus: molecular and biochemical characterization of the upstream region of the gene clusters for engineering of novel antibiotics.

Sohn, Y S / Nam, D H / Ryu, D D

Metabolic engineering

2001 Volume 3, Issue 4, Page(s) 380–392

Abstract: The cephabacins, one of the beta-lactam antibiotics, are produced by Lysobacter lactamgenus. The previous studies the cephabacin biosynthesis were limited to a gene cluster that encodes the gene products responsible for the biosynthesis of the cephem ... ...

Abstract	The cephabacins, one of the beta-lactam antibiotics, are produced by Lysobacter lactamgenus. The previous studies the cephabacin biosynthesis were limited to a gene cluster that encodes the gene products responsible for the biosynthesis of the cephem nucleus. The long-term goal of this research is to elucidate the metabolic diversity and biosynthetic pathway of cephabacins and to design and/or discover new pharmacologically active compounds by engineering the cephabacin biosynthetic pathway in L. lactamgenus. In this study, we have cloned and sequenced a 24-kb fragment of a DNA locus upstream of the previously reported but incomplete putative ORF9 of L. lactamgenus. This contains three putative ORFs (the complete ORF9, ORF10, and ORF11) transcribed in the same direction and one putative ORF (ORF12) in the opposite direction. The isolated DNA locus extends the previously cloned part of the DNA locus containing the genes responsible for biosynthesis of the cephem nucleus up to 45 kb. The 42-kb fragment of the 45-kb gene cluster is located between a potential TATA box just upstream of the ORF11 and a termination loop just downstream of the previously reported bla gene. The complete ORF9 contains three nonribosomal peptide synthetase (NRPS) modules and one polyketide synthase (PKS) module and the ORF11 contains one NRPS module. The complete ORF9 also contains a putative thioesterase domain at the C-terminal end. We predicted the amino acid specificity of the four NRPSs by generating specificity binding pockets and expressed one of the NRPSs to confirm the amino acid specificity. The adenylation domain of the NRPS1, which is the last module of the NRPSs, showed significant amino acid specificity for L-arginine. These findings are in perfect agreement with the composition that was expected for the structure of cephabacins which contain an acetate residue, an L-arginine, and one to three L-alanines at the C-3' position of the cephem nucleus of cephabacins. The ORF10, encoding a putative ABC transporter which might be involved in conferring resistance against cephabacins, was identified between the complete ORF9 and the ORF11. Therefore, the complete ORF9, ORF10, ORF11 reported here and the other genes previously reported constitute an operon for the biosynthesis of cephabacins in L. lactamgenus. Based on our results, the biosynthetic pathways of acetate and elongated peptide moieties and a mechanism by which cephabacins are assembled by connecting the peptide moiety synthesized by the gene products of the complete ORF9 and the ORF11 to the C-3' position of the cephem nucleus synthesized by the gene products of pcbAB, pcbC, cefE, cefF, and cefD have been elucidated.
MeSH term(s)	Amino Acid Sequence ; Cephalosporins/biosynthesis ; Chromosome Walking ; Cloning, Molecular ; Genetic Engineering ; Gram-Negative Bacteria/genetics ; Gram-Negative Bacteria/metabolism ; Molecular Sequence Data ; Multigene Family ; Open Reading Frames
Chemical Substances	Cephalosporins ; cephabacins (94947-55-4)
Language	English
Publishing date	2001-10-17
Publishing country	Belgium
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1470383-x
ISSN	1096-7184 ; 1096-7176
ISSN (online)	1096-7184
ISSN	1096-7176
DOI	10.1006/mben.2001.0200
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Article: Effect of Oryza sativa extract on the progression of airway inflammation and remodeling in an experimental animal model of asthma

Lee, S.H / Choi, S.M / Sohn, Y.S / Kang, K.K / Yoo, M

Planta medica. 2006 Apr., v. 72, no. 5

2006

Keywords	Oryza sativa ; rice ; plant extracts ; inflammation ; asthma ; human health ; animal disease models ; mice ; lungs ; histopathology ; eosinophils ; immunoglobulin E ; cytokines ; pneumonia
Language	English
Dates of publication	2006-04
Size	p. 405-410.
Document type	Article
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
Database	NAL-Catalogue (AGRICOLA)

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Article: Synthesis, structures and antitumor activity of the first crown ester-linked bipyridyl platinum complexes.

Yoo, J / Sohn, Y S / Do, Y

Journal of inorganic biochemistry

1999 Volume 73, Issue 3, Page(s) 187–193

Abstract: Three new crown ester-linked bipyridine homologs with three, four or five ethylene glycol units, which are bulky and soluble in both hydrophilic and lipophilic media, were synthesized. The reaction of the appropriate macrocycles with K2PtCl4 in water ... ...

Abstract	Three new crown ester-linked bipyridine homologs with three, four or five ethylene glycol units, which are bulky and soluble in both hydrophilic and lipophilic media, were synthesized. The reaction of the appropriate macrocycles with K2PtCl4 in water gave yellow cisplatin analogs in good yield. These complexes were converted to carboplatin analogs by exchange of the leaving group. All the compounds were characterized by elemental analysis and various spectroscopic methods. Carboplatin analogs showed good solubility in both hydrophilic and lipophilic media. The crystal structure of 2c, the carboplatin analog with macrocycles containing five ethylene glycol units, was determined by X-ray diffraction: space group P1, a = 9.798(1), b = 12.580(3), c = 13.945(2) A, alpha = 108.61(2), beta = 94.59(1), gamma = 97.42(2) degrees, Z = 2, R = 0.0618. Some of platinum complexes showed a moderate cytotoxic effect on both murine leukemia L1210 and P388 even though they do not have any NH proton.
MeSH term(s)	2,2'-Dipyridyl/chemical synthesis ; 2,2'-Dipyridyl/chemistry ; 2,2'-Dipyridyl/pharmacology ; Animals ; Carboplatin/analogs & derivatives ; Carboplatin/chemical synthesis ; Carboplatin/pharmacology ; Cisplatin/analogs & derivatives ; Cisplatin/chemical synthesis ; Cisplatin/pharmacology ; Crystallography, X-Ray ; Drug Screening Assays, Antitumor ; Ethers, Cyclic/chemical synthesis ; Ethers, Cyclic/chemistry ; Ethers, Cyclic/pharmacology ; Leukemia L1210/drug therapy ; Leukemia P388/drug therapy ; Mice ; Molecular Structure ; Organoplatinum Compounds/chemical synthesis ; Organoplatinum Compounds/chemistry ; Organoplatinum Compounds/pharmacology
Chemical Substances	Ethers, Cyclic ; Organoplatinum Compounds ; 2,2'-Dipyridyl (551W113ZEP) ; Carboplatin (BG3F62OND5) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	1999-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/s0162-0134(99)00016-1
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Article: Synthesis and antitumor activity of (diamine)platinum(II) complexes of benzylmalonate derivatives.

Lee, Y A / Chung, Y K / Sohn, Y S

Journal of inorganic biochemistry

1997 Volume 68, Issue 4, Page(s) 289–294

Abstract: Diamine)platinum(II) complexes of benzylmalonate derivatives as a leaving group designed in a wide range of lipophilicity and water-solubility were prepared and their antitumor activities were attempted to correlate to their lipophilicity or solubility. ...

Abstract	(Diamine)platinum(II) complexes of benzylmalonate derivatives as a leaving group designed in a wide range of lipophilicity and water-solubility were prepared and their antitumor activities were attempted to correlate to their lipophilicity or solubility. A good relationship was observed between their in vitro toxicity and solubility of the title complexes with the same carrier ligand, DACH (trans-(+/-)-1,2-diaminocyclohexane): The most soluble complexes are most cytotoxic whereas the least soluble complexes are least cytotoxic. However, no relationship could be established between their in vivo activity and their lipophilicity or solubility presumably due to other pharmacokinetic factors involved in vivo. The molecular structure of (IPA)2Pt(DBM).2CH3OH (IPA = isopropylamine; DBM = dibenzylmalonate) was determined by X-ray diffraction: space group P2(1)/n, a = 11.433 (3), b = 14.461 (4), c = 17.478 (4) A, beta = 97.25 (3) degrees, z = 4, R = 0.0437.
MeSH term(s)	Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Leukemia L1210/drug therapy ; Lipid Metabolism ; Magnetic Resonance Spectroscopy ; Malonates/chemistry ; Mice ; Models, Molecular ; Molecular Structure ; Organoplatinum Compounds/chemical synthesis ; Organoplatinum Compounds/chemistry ; Organoplatinum Compounds/therapeutic use ; Platinum Compounds/chemical synthesis ; Platinum Compounds/chemistry ; Platinum Compounds/therapeutic use ; Solubility ; Structure-Activity Relationship ; X-Ray Diffraction
Chemical Substances	(dibenzylmalonate)diisopropylamineplatinum(II) ; Antineoplastic Agents ; Malonates ; Organoplatinum Compounds ; Platinum Compounds
Language	English
Publishing date	1997-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/s0162-0134(97)00109-8
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Article: Division of inputs between hemispheres eliminates illusory conjunctions.

Sohn, Y S / Liederman, J / Reinitz, M T

Neuropsychologia

1996 Volume 34, Issue 11, Page(s) 1057–1068

Abstract: We demonstrate that division of inputs between the hemispheres does not just generally improve performance but specifically reduces inter-item perceptual interference relative to single hemisphere presentation. Subjects verified the presence of colored ... ...

Abstract	We demonstrate that division of inputs between the hemispheres does not just generally improve performance but specifically reduces inter-item perceptual interference relative to single hemisphere presentation. Subjects verified the presence of colored letter targets in briefly presented letter pairs presented to the same (unihemispheric condition) or different (bihemispheric condition) sides of space. Four experiments showed consistently that although illusory conjunctions (i.e. perceptual miscombinations of stimulus features) occurred commonly during unihemispheric presentations, they never occurred during bihemispheric presentations, even though accuracy of detecting individual stimulus features was held constant across the conditions. Increasing inter-item similarity resulted in a general interference effect based in discrimination difficulty that was sufficient to eliminate illusory conjunctions even in the unihemispheric condition. However, when inter-item interference was manipulated using perceptual grouping by movement the bihemispheric illusory conjunction advantage increased with increasing interference. Our findings suggest that the two cerebral hemispheres can operate as relatively independent work stations during visual perceptual processing, thereby maximizing the efficiency of information processing.
MeSH term(s)	Adult ; Attention/physiology ; Cerebral Cortex/physiology ; Color Perception/physiology ; Corpus Callosum/physiology ; Discrimination Learning/physiology ; Dominance, Cerebral/physiology ; Female ; Humans ; Male ; Optical Illusions/physiology ; Orientation/physiology ; Pattern Recognition, Visual/physiology ; Vision, Binocular/physiology ; Vision, Monocular/physiology
Language	English
Publishing date	1996-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	207151-4
ISSN	1873-3514 ; 0028-3932
ISSN (online)	1873-3514
ISSN	0028-3932
DOI	10.1016/0028-3932(96)00030-9
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Article: Synthesis and antitumor activity of cyclotriphosphazene-(diamine)platinum(II) conjugates.

Baek, H / Cho, Y / Lee, C O / Sohn, Y S

Anti-cancer drugs

2000 Volume 11, Issue 9, Page(s) 715–725

Abstract: A new class of water-soluble cyclotriphosphazene-(diamine)platinum(II) conjugate drugs [NP(Am-Li2)(Am.PtA2)]3 (Am: dicarboxylic amino acid; A2: diamine) has been synthesized and characterized by means of elemental analysis, multinuclear (1H, 31P, 13C, ... ...

Abstract	A new class of water-soluble cyclotriphosphazene-(diamine)platinum(II) conjugate drugs [NP(Am-Li2)(Am.PtA2)]3 (Am: dicarboxylic amino acid; A2: diamine) has been synthesized and characterized by means of elemental analysis, multinuclear (1H, 31P, 13C, 195Pt) NMR and IR spectroscopies. All the title compounds were subjected to both in vitro and in vivo assays against the murine leukemia L1210 cell line and selected human tumor cells. Most of the title compounds have shown higher in vivo antitumor activity than cisplatin and carboplatin, and, in particular, [NP(L-Glu-Li2)(L-Glu.Pt(-dach)]3 (Glu=glutamate, dach=trans(+/-)-1,2-diaminocyclohexane) showed extraordinary high activity (ILS>500%) equally against both parent and cisplatin-resistant leukemia L1210 cell lines. Furthermore, this candidate compound (KI 60606) exhibited a wider spectrum of in vitro activity by showing higher cytotoxicity against all the selected human tumor cells than cisplatin and, therefore, was subjected to preclinical studies which are now near completion.
MeSH term(s)	Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Drug Screening Assays, Antitumor ; Humans ; Leukemia L1210/drug therapy ; Magnetic Resonance Spectroscopy ; Mice ; Nitriles/chemical synthesis ; Nitriles/pharmacology ; Organoplatinum Compounds/chemical synthesis ; Organoplatinum Compounds/pharmacology ; Phosphorus Compounds/chemical synthesis ; Phosphorus Compounds/pharmacology ; Tumor Cells, Cultured/drug effects
Chemical Substances	Antineoplastic Agents ; KI 60606 ; Nitriles ; Organoplatinum Compounds ; Phosphorus Compounds ; cyclotriphosphazene ester (291-37-2)
Language	English
Publishing date	2000-11-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1065301-6
ISSN	1473-5741 ; 0959-4973
ISSN (online)	1473-5741
ISSN	0959-4973
DOI	10.1097/00001813-200010000-00008
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Article: Electrophilic substitution of (diamine)tetrahydroxoplatinum(IV) with carboxylic anhydrides. Synthesis and characterization of (diamine)platinum(IV) complexes of mixed carboxylates.

Song, R / Kim, K M / Lee, S S / Sohn, Y S

Inorganic chemistry

2000 Volume 39, Issue 16, Page(s) 3567–3571

Abstract: A novel series of (diamine)platinum(IV) complexes of mixed carboxylates have been synthesized by electrophilic substitution of the tetrahydroxoplatinum(IV) complex (dach)Pt(OH)4 (dach = trans-(+/-)-1,2-diaminocyclohexane) with three different carboxylic ... ...

Abstract	A novel series of (diamine)platinum(IV) complexes of mixed carboxylates have been synthesized by electrophilic substitution of the tetrahydroxoplatinum(IV) complex (dach)Pt(OH)4 (dach = trans-(+/-)-1,2-diaminocyclohexane) with three different carboxylic anhydrides, pivalic, acetic, and trifluoroacetic anhydrides. Consecutive two-step acylations with two different carboxylic anhydrides in acetone or dichloromethane gave the mixed carboxylate complexes (dach)Pt(O2CR)x(O2CR')4 - x (R = C(CH3)3 or CF3, R' = CH3, x = 1-4) including all the possible stereoisomers, which could be separated and identified by means of HPLC, column chromatography, 1H NMR, and X-ray crystallography. From analysis of the reaction products we have found that the positions of electrophilic substitution of (dach)Pt(OH)4 were influenced by the kinds of carboxylic anhydrides exhibiting different electrophilicity or steric effects. The initial substitution by the first reactant occurs more favorably on axial OH, but in the case of pivalic anhydride, equatorial substitution is favored probably because of the bulkiness of the pivalate group. Such a result seems to be related to their stereochemical factors rather than to differences in electrophilicity. The lipophilicity of the title complexes was affected not only by the carbon numbers of substituents but also by the conformation of the resulting compound.
Language	English
Publishing date	2000-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/ic9913886
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