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  1. Article ; Online: Multimodality Imaging Features of a Misleading Sacral Giant Cell Tumor in 18F-FDG PET/CT, Bone Scan, and MRI.

    Dejust, Sebastien / Jallerat, Pascaline / Soibinet-Oudot, Pauline / Jouannaud, Christelle / Morland, David

    Clinical nuclear medicine

    2020  Volume 45, Issue 10, Page(s) 800–801

    Abstract: We report the case of an asymptomatic 66-year-old woman referred for initial staging of an invasive ductal breast carcinoma. Initial workup incidentally revealed a bone tumor of right sacral wing corresponding to a giant cell tumor (GCT). We present the ... ...

    Abstract We report the case of an asymptomatic 66-year-old woman referred for initial staging of an invasive ductal breast carcinoma. Initial workup incidentally revealed a bone tumor of right sacral wing corresponding to a giant cell tumor (GCT). We present the imaging characteristics of GCT on Tc-HDP bone scan (doughnut sign), F-FDG PET/CT (intense and heterogeneous uptake of a prominent geographic lytic lesion with partial rupture of cortical), and MRI (hyposignal with gadolinium enhancement on T1-weighted images and heterogeneous hypersignal on T2-weighted images). GCT is a benign but locally aggressive primary bone tumor, constituting a pitfall and diagnostic challenge.
    MeSH term(s) Aged ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/pathology ; Female ; Fluorodeoxyglucose F18 ; Giant Cell Tumors/diagnostic imaging ; Giant Cell Tumors/pathology ; Humans ; Magnetic Resonance Imaging ; Positron Emission Tomography Computed Tomography ; Sacrum/diagnostic imaging
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2020-06-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000003148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1276: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: PEC-PRO: A new prognostic score from a series of 87 patients with localized perivascular epithelioid cell neoplasms (PEComas) treated with curative intent.

    Gantzer, Justine / Toulmonde, Maud / Severac, François / Chamseddine, Ali N / Charon-Barra, Céline / Vinson, Charles / Hervieu, Alice / Bourgmayer, Agathe / Bertucci, François / Ryckewaert, Thomas / Valentin, Thibaud / Firmin, Nelly / Chaigneau, Loïc / Bompas, Emmanuelle / Follana, Philippe / Rioux-Leclercq, Nathalie / Soibinet-Oudot, Pauline / Bozec, Laurence / Le Loarer, François /
    Weingertner, Noëlle / Chevreau, Christine / Duffaud, Florence / Blay, Jean-Yves / Kurtz, Jean-Emmanuel / Schöffski, Patrick / Brahmi, Mehdi / Malouf, Gabriel G

    Cancer

    2024  

    Abstract: Background: Perivascular epithelioid cell neoplasms (PEComas) encompass a heterogeneous family of mesenchymal tumors. Previously described clinicopathologic features aimed at distinguishing benign from malignant variants but lacked prognostic value.: ... ...

    Abstract Background: Perivascular epithelioid cell neoplasms (PEComas) encompass a heterogeneous family of mesenchymal tumors. Previously described clinicopathologic features aimed at distinguishing benign from malignant variants but lacked prognostic value.
    Methods: This retrospective analysis examined clinicopathologic data from patients who had localized PEComa across French Sarcoma Network centers. The authors analyzed 12 clinicopathologic features in a Cox proportional hazard framework to derive a multivariate prognostic risk model for event-free survival (EFS). They built the PEComa prognostic score (PEC-PRO), in which scores ranged from 0 to 5, based on the coefficients of the multivariate model. Three groups were identified: low risk (score = 0), intermediate risk (score = 1), and high risk (score ≥ 2).
    Results: Analyzing 87 patients who had a median 46-month follow-up (interquartile range, 20-74 months), the median EFS was 96.5 months (95% confidence interval [CI], 47.1 months to not applicable), with 2-year and 5-year EFS rates of 64.7% and 58%, respectively. The median overall survival was unreached, with 2-year and 5-year overall survival rates of 82.3% and 69.3%, respectively. The simplified Folpe classification did not correlate with EFS. Multivariate analysis identified three factors affecting EFS: positive surgical margins (hazard ratio [HR], 5.17; 95% CI, 1.65-16.24; p = .008), necrosis (HR, 3.94; 95% CI, 1.16-13.43; p = .030), and male sex (HR, 3.13; 95% CI, 1.19-8.27; p = 0.023). Four variables were retained in the prognostic model. Patients with low-risk PEC-PRO scores had a 2-year EFS rate of 93.7% (95% CI, 83.8%-100.0%), those with intermediate-risk PEC-PRO scores had a 2-year EFS rate of 67.4% (95% CI, 53.9%-80.9%), and those with high-risk PEC-PRO scores had a 2-year EFS rate of 2.3% (95% CI, 0.0%-18.3%).
    Conclusions: The PEC-PRO score reliably predicts the risk of postoperative recurrence in patients with localized PEComa. It has the potential to improve follow-up strategies but requires validation in a prospective trial.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.35277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.146: Show issues Location:
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  3. Article: Factors Associated With the Discussion of Fertility Preservation in a Cohort of 1,357 Young Breast Cancer Patients Receiving Chemotherapy.

    Hours, Alice / Toussaint, Aullene / De Castelbajac, Victoire / Sautter, Camille / Borghese, Julie / Frank, Sophie / Coussy, Florence / Laas, Enora / Grandal, Beatriz / Dumas, Elise / Daoud, Eric / Guerin, Julien / Balezeau, Thomas / Feron, Jean-Guillaume / Fourchotte, Virginie / Kirova, Youlia / Lerebours, Florence / Pierga, Jean-Yves / Guillot, Eugénie /
    Santulli, Pietro / Grynberg, Michael / Sonigo, Charlotte / Reyrat, Emmanuel / Soibinet-Oudot, Pauline / Reyal, Fabien / Hamy, Anne-Sophie

    Frontiers in oncology

    2021  Volume 11, Page(s) 701620

    Abstract: Purpose: Female breast cancer (BC) patients exposed to gonadotoxic chemotherapy are at risk of future infertility. There is evidence of disparities in the discussion of fertility preservation for these patients. The aim of the study was to identify ... ...

    Abstract Purpose: Female breast cancer (BC) patients exposed to gonadotoxic chemotherapy are at risk of future infertility. There is evidence of disparities in the discussion of fertility preservation for these patients. The aim of the study was to identify factors influencing the discussion of fertility preservation (FP).
    Material and methods: We analyzed consecutive BC patients treated by chemotherapy at Institut Curie from 2011-2017 and aged 18-43 years at BC diagnosis. The discussion of FP was classified in a binary manner (discussion/no discussion), based on mentions present in the patient's electronic health record (EHR) before the initiation of chemotherapy. The associations between FP discussion and the characteristics of patients/tumors and healthcare practitioners were investigated by logistic regression analysis.
    Results: The median age of the 1357 patients included in the cohort was 38.7 years, and median tumor size was 30.3 mm. The distribution of BC subtypes was as follows: 702 luminal BCs (58%), 241 triple-negative breast cancers (TNBCs) (20%), 193 HER2
    Conclusion: FP discussion rates are low and are influenced by patient and physician characteristics. There is therefore room for improvement in the promotion and systematization of FP discussion.
    Language English
    Publishing date 2021-09-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.701620
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  4. Article ; Online: Treatment of 120 adult osteosarcoma patients with metachronous and synchronous metastases: A retrospective series of the French Sarcoma Group.

    Lavit, Elise / Aldea, Mihaela / Piperno-Neumann, Sophie / Firmin, Nelly / Italiano, Antoine / Isambert, Nicolas / Kurtz, Jean-Emmanuel / Delcambre, Corinne / Lebrun, Valérie / Soibinet-Oudot, Pauline / Chevreau, Christine / Bompas, Emmanuelle / Le Maignan, Christine / Boudou-Rouquette, Pascaline / Le Cesne, Axel / Mancini, Julien / Blay, Jean-Yves / Duffaud, Florence

    International journal of cancer

    2021  Volume 150, Issue 4, Page(s) 645–653

    Abstract: Treatment options for metastatic osteosarcomas are scarce. Following failure of standard first line therapy, patients who relapse present a challenging treatment dilemma, and have a poor prognosis. Surgical removal of all metastases is essential. A ... ...

    Abstract Treatment options for metastatic osteosarcomas are scarce. Following failure of standard first line therapy, patients who relapse present a challenging treatment dilemma, and have a poor prognosis. Surgical removal of all metastases is essential. A retrospective analysis of patients with metastatic osteosarcomas was conducted in 15 French Sarcoma Group centers. From January 2009 to December 2018, we identified 120 adult patients; 36 with synchronous and 84 with metachronous metastases with 74 males and 46 females. Mean age was 30 years (18-53). Metastatic sites were lung, bone and other in 91, 11 and 24 patients, respectively. Mean time to first metachronous metastases was 22 months (4-97). All patients except 13 (10.8%) with metachronous metastases received a first line systemic treatment for relapse, and 39 patients (32.5%) were included in a clinical trial. Eighty-one patients (67.5%) had local treatment of distant metastases. Median progression free survival (PFS) and overall survival (OS) were 5.5 (95% CI 4.6-6.4) and 20.5 months (95% CI 13.2-27.7) respectively for the overall group. In multivariate analysis, more than five metastases, time to first metastases <24 months, were statistically significant negative prognostic factors for OS and PFS (P = .002, ≤.001 and P = .006, ≤.001, respectively). Surgery of metastases was associated with better prognosis on OS and PFS (P = .001 and .037, respectively). The presence of bone metastases was a negative prognostic factor on OS but not on PFS (P = .021). In reference sarcoma centers, relapsed osteosarcoma patients with more than one metastasis commonly receive more than one line of systemic therapy, and are included in clinical trial if available.
    MeSH term(s) Adolescent ; Adult ; Bone Neoplasms/mortality ; Bone Neoplasms/pathology ; Bone Neoplasms/therapy ; Female ; Humans ; Male ; Middle Aged ; Neoplasms, Multiple Primary/secondary ; Neoplasms, Second Primary/secondary ; Osteosarcoma/mortality ; Osteosarcoma/pathology ; Osteosarcoma/therapy ; Retrospective Studies ; Young Adult
    Language English
    Publishing date 2021-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218257-9
    ISSN 1097-0215 ; 0020-7136
    ISSN (online) 1097-0215
    ISSN 0020-7136
    DOI 10.1002/ijc.33823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 478: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 576: Show issues

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  5. Article ; Online: Management and outcomes of adolescent and young adult sarcoma patients: results from the French nationwide database NETSARC.

    Kubicek, Pierre / Cesne, Axel Le / Lervat, Cyril / Toulmonde, Maud / Chevreau, Christine / Duffaud, Florence / Le Nail, Louis-Romée / Morelle, Magali / Gaspar, Nathalie / Vérité, Cécile / Castex, Marie-Pierre / Penel, Nicolas / Saada, Esma / Causeret, Sylvain / Bertucci, François / Perrin, Christophe / Bompas, Emmanuelle / Orbach, Daniel / Laurence, Valérie /
    Piperno-Neumann, Sophie / Anract, Philippe / Rios, Maria / Gentet, Jean-Claude / Mascard, Éric / Pannier, Stéphanie / Blouin, Pascale / Carrère, Sébastien / Chaigneau, Loïc / Soibinet-Oudot, Pauline / Corradini, Nadège / Boudou-Rouquette, Pascaline / Ruzic, Jean-Christophe / Lebrun-Ly, Valérie / Dubray-Longeras, Pascale / Varatharajah, Sharmini / Lebbe, Céleste / Ropars, Mickaël / Kurtz, Jean-Emmanuel / Guillemet, Cécile / Lotz, Jean-Pierre / Berchoud, Juliane / Cherrier, Grégory / Ducimetière, Françoise / Chemin, Claire / Italiano, Antoine / Honoré, Charles / Desandes, Emmanuel / Blay, Jean-Yves / Gouin, François / Marec-Bérard, Perrine

    BMC cancer

    2023  Volume 23, Issue 1, Page(s) 69

    Abstract: Background: The initial management of patients with sarcoma is a critical issue. We used the nationwide French National Cancer Institute-funded prospective sarcoma database NETSARC to report the management and oncologic outcomes in adolescents and young ...

    Abstract Background: The initial management of patients with sarcoma is a critical issue. We used the nationwide French National Cancer Institute-funded prospective sarcoma database NETSARC to report the management and oncologic outcomes in adolescents and young adults (AYAs) patients with sarcoma at the national level.
    Patients and methods: NETSARC database gathers regularly monitored and updated data from patients with sarcoma. NETSARC was queried for patients (15-30 years) with sarcoma diagnosed from 2010 to 2017 for whom tumor resection had been performed. We reported management, locoregional recurrence-free survival (LRFS), progression-free survival (PFS), and overall survival (OS) in AYA treated in French reference sarcoma centers (RSC) and outside RSC (non-RSC) and conducted multivariable survival analyses adjusted for classical prognostic factors.
    Results: Among 3,227 patients aged 15-30 years with sarcoma diagnosed between 2010 and 2017, the study included 2,227 patients with surgery data available, among whom 1,290 AYAs had been operated in RSC, and 937 AYAs in non-RSC. Significant differences in compliance to guidelines were observed including pre-treatment biopsy (RSC: 85.9%; non-RSC 48.1%), pre-treatment imaging (RSC: 86.8%; non-RSC: 56.5%) and R0 margins (RSC 57.6%; non-RSC: 20.2%) (p < 0.001). 3y-OS rates were 81.1% (95%CI 78.3-83.6) in AYA in RSC and 82.7% (95%CI 79.4-85.5) in AYA in non-RSC, respectively. Whereas no significant differences in OS was observed in AYAs treated in RSC and in non-RSC, LRFS and PFS were improved in AYAs treated in RSC compared to AYAs treated in non-RSC (Hazard Ratios (HR): 0.58 and 0.83, respectively).
    Conclusions: This study highlights the importance for AYA patients with sarcoma to be managed in national sarcoma reference centers involving multidisciplinary medical teams with paediatric and adult oncologists.
    MeSH term(s) Humans ; Adolescent ; Young Adult ; Child ; Prospective Studies ; Sarcoma/diagnosis ; Sarcoma/surgery ; Soft Tissue Neoplasms/surgery ; Databases, Factual ; Progression-Free Survival
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-10556-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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