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  1. Article ; Online: Colecistitis aguda en pacientes con fibrosis quística tras inicio de tratamiento con elexacaftor/tezacaftor/ivacaftor.

    Solís García, Marta / Madrid Carbajal, Claudia / Girón Moreno, Rosa María

    Medicina clinica

    2023  Volume 160, Issue 11, Page(s) e5–e6

    Title translation Acute cholecystitis in cystic fibrosis patients after initiation of treatment with elexacaftor/tezacaftor/ivacaftor.
    MeSH term(s) Humans ; Cystic Fibrosis/complications ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/genetics ; Pyrrolidines/therapeutic use ; Cholecystitis, Acute ; Mutation ; Drug Combinations
    Chemical Substances elexacaftor (RRN67GMB0V) ; ivacaftor (1Y740ILL1Z) ; tezacaftor ; Pyrrolidines ; Drug Combinations
    Language Spanish
    Publishing date 2023-03-21
    Publishing country Spain
    Document type Letter
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2023.01.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mounier-Kuhn syndrome in poorly controlled asthma.

    Solís García, Marta / Cisneros Serrano, Carolina / Martín Hernández, Ana Sofía / Eiros Bachiller, Jose María / Marcos, Celeste

    The Journal of asthma : official journal of the Association for the Care of Asthma

    2024  , Page(s) 1–4

    Abstract: Introduction: Mounier-Kuhn syndrome or tracheobronchomegaly, is a rare condition that consists of abnormal dilation of the trachea and main bronchi due to a pathological arrangement of smooth muscle fibers in this area.: Case report: We present the ... ...

    Abstract Introduction: Mounier-Kuhn syndrome or tracheobronchomegaly, is a rare condition that consists of abnormal dilation of the trachea and main bronchi due to a pathological arrangement of smooth muscle fibers in this area.
    Case report: We present the case of a 46-year-old woman with poorly controlled asthma and recurrent infections, who was diagnosed with Mounier-Kuhn syndrome through a computed tomography scan revealing an unusual enlargement of the trachea with associated bronchiectasis.
    Results: The diagnosis of Mounier-Kuhn syndrome is radiological, involving measurement of the trachea where a diameter >25 mm in men and >21 mm in women is observed. While diagnosis is sometimes incidental, there is an association with respiratory diseases such as asthma or COPD, hence clinical suspicion is important in patients with poorly controlled underlying conditions who present with recurrent infections, inadequate secretion management, or even hemoptysis.
    Conclusions: Despite its rarity, this syndrome significantly impacts patients' quality of life. Diagnosis and management involve comprehensive evaluations including computed tomography, with a multidisciplinary approach including pulmonologists and radiologists. Exploring its clinical features, associations with other respiratory diseases and treatment options is crucial in managing this rare respiratory condition.
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 603816-5
    ISSN 1532-4303 ; 0277-0903
    ISSN (online) 1532-4303
    ISSN 0277-0903
    DOI 10.1080/02770903.2024.2344168
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  3. Article ; Online: Secuestro pulmonar.

    Martínez-Besteiro, Elisa / Eiros Bachiller, José María / Solís García, Marta / Ruiz-Álvarez, Inés

    Medicina clinica

    2022  Volume 158, Issue 9, Page(s) 449

    Title translation Pulmonary sequestration.
    MeSH term(s) Bronchopulmonary Sequestration/diagnostic imaging ; Humans ; Tomography, X-Ray Computed
    Language Spanish
    Publishing date 2022-01-31
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2021.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cytologic features of a pleural effusion after silicone breast implant rupture.

    Jiménez-Heffernan, José A / Rosell, Alejandra / Vázquez-Espinosa, Emma / Idoate-Ortueta, Carmen / Solís-García, Marta / Pacios, Eduardo

    Virchows Archiv : an international journal of pathology

    2022  Volume 482, Issue 6, Page(s) 1065–1068

    Abstract: Pleural effusion is an extremely rare complication of ruptured breast silicone implants. Rupture may be related to a recent trauma or occur spontaneously, making its diagnosis more difficult. In the few reported cases, cytology did not play a relevant ... ...

    Abstract Pleural effusion is an extremely rare complication of ruptured breast silicone implants. Rupture may be related to a recent trauma or occur spontaneously, making its diagnosis more difficult. In the few reported cases, cytology did not play a relevant role in its diagnosis. We describe and illustrate a silicone foreign body reaction in a pleural effusion. Cytologic findings were so remarkable as to permit a specific diagnosis. The patient, a 37-year-old female with a history of previous bilateral breast implant surgery was admitted because of a pleural effusion. Computed tomography scan showed a left effusion with secondary atelectasis and bilateral breast rupture with lymph node "siliconomas." Cytologic analysis of the effusion showed well-defined droplets or globules of transparent material, in addition to a microvacuolized background. Where abundant silicone droplets induced a staining artifact of the smears. These were cellular with numerous macrophages containing large vacuoles displacing the nuclei to the periphery. Some had a signet cell ring appearance, while others showed multinucleation. Flow cytometry revealed a predominant macrophagic cell population. With the increasing use of silicone breast implants, rare complications such as pleural effusion may become more common. The pathologist must consider this possibility when extracellular transparent droplets or evidence of a foreign body-type reaction are present. The artifact appearance of the smears may help to suspect it. This rare complication must be always considered when evaluating effusions in patients with silicone breast implants.
    MeSH term(s) Female ; Humans ; Adult ; Breast Implants/adverse effects ; Silicones/adverse effects ; Pleural Effusion/etiology ; Breast ; Breast Implantation
    Chemical Substances Silicones
    Language English
    Publishing date 2022-10-13
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-022-03425-1
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  5. Article ; Online: COVID-19-Associated Pulmonary Aspergillosis in a Tertiary Hospital

    García-Clemente Marta / Forcelledo-Espina Lorena / Martínez-Vega Laura / Lanza-Martínez Angela / Leoz-Gordillo Blanca / Albillos-Almaraz Rodrigo / Solís-García Marta / Melón-García Santiago / Pérez-Martínez Liliana / Sánchez-Nuñez Maria Luisa / Peláez-García de la Rasilla Teresa

    Journal of Fungi, Vol 8, Iss 97, p

    2022  Volume 97

    Abstract: Our study aims to assess the prevalence of CAPA (COVID-19-associated pulmonary aspergillosis) and describe the associated risk factors and their impact on mortality. A prospective study was conducted. We included patients with COVID-19 disease who were ... ...

    Abstract Our study aims to assess the prevalence of CAPA (COVID-19-associated pulmonary aspergillosis) and describe the associated risk factors and their impact on mortality. A prospective study was conducted. We included patients with COVID-19 disease who were admitted to the ICU with a diagnosis of respiratory failur. Mycological culture and other biomarkers (calcofluor staining, LFD, LFA, PCR, GM, and B-D-glucan) were performed. A total of 300 patients were included in the study. Thirty-five patients were diagnosed with CAPA (prevalence 11.7%). During admission, 57 patients died (19%), and, in the group of CAPA patients, mortality was 31.4%. In multivariate analysis, independent risk factors associated with CAPA diagnosis were age (OR: 1.05; 95% CI 1.01–1.09; p = 0.037), chronic lung disease (OR: 3.85; 95% CI 1.02–14.9; p = 0.049) and treatment with tocilizumab during admission (OR: 14.5; 95% 6.1–34.9; p = 0.001). Factors independently associated with mortality were age (OR: 1.06; 95% CI 1.01–1.11; p = 0.014) and CAPA diagnosis during admission (OR: 3.34; 95% CI 1.38–8.08; p = 0.007). CAPA is an infection that appears in many patients with COVID-19 disease. CAPA is associated with high mortality rates, which may be reduced by early diagnosis and initiation of appropriate antifungal therapy, so screening of COVID-19 ARDS (acute respiratory distress syndrome) patients for CAPA is essential.
    Keywords COVID-19 ; Aspergillosis ; CAPA ; mortality ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Real Life With Tezacaftor and Ivacaftor in Adult Patients With Cystic Fibrosis: Spanish Multicenter Study.

    Carrasco Hernández, Laura / Girón Moreno, Rosa M / Peláez, Adrián / Gómez Bonilla, Ainhoa / Gómez Crespo, Beatriz / Diab Cáceres, Layla / Tejedor Ortiz, Mª Teresa / García Clemente, Marta / Solís García, Marta / González Torres, Lucia / Blanco Aparicio, Marina / Olveira Fuster, Casilda / Girón Fernández, Mª Victoria / Zamarrón de Lucas, Esther / Prados Sanchez, Concha / Quintana Gallego, Esther

    Archivos de bronconeumologia

    2022  Volume 58, Issue 9, Page(s) 672–674

    MeSH term(s) Adult ; Aminophenols/therapeutic use ; Benzodioxoles/therapeutic use ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Drug Combinations ; Humans ; Indoles ; Mutation ; Quinolones
    Chemical Substances Aminophenols ; Benzodioxoles ; Drug Combinations ; Indoles ; Quinolones ; tezacaftor, ivacaftor drug combination ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language Spanish
    Publishing date 2022-06-20
    Publishing country Spain
    Document type Case Reports ; Multicenter Study
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2022.06.003
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  7. Article ; Online: Experience With Elexacaftor/Tezacaftor/Ivacaftor in Patients With Cystic Fibrosis and Advanced Disease.

    Carrasco Hernández, Laura / Girón Moreno, Rosa Mª / Balaguer Cartagena, Mari Nieves / Peláez, Adrián / Sole, Amparo / Álvarez Fernández, Antonio / Felipe Montiel, Almudena / Olveira, Casilda / Olveira, Gabriel / Gómez Bonilla, Ainhoa / Gómez Crespo, Beatriz / García Clemente, Marta / Solís García, Marta / Quaresma Vázquez, Joana / Blitz Castro, Enrique / Rodríguez González, Jesús / Expósito Marrero, Andrea / Diab-Cáceres, Laila / Ramos Hernández, Cristina /
    Zamarrón de Lucas, Ester / Prados Sanchez, Concha / Blanco Aparicio, Marina / López Neyra, Alejandro / Sanz Santiago, Verónica / Luna Paredes, Carmen / Delgado Pecellín, Isabel / Asensio de la Cruz, Óscar / Quintana Gallego, Esther

    Archivos de bronconeumologia

    2023  Volume 59, Issue 9, Page(s) 556–565

    Abstract: Introduction: Elexacaftor/tezacaftor/ivacaftor (ETI) was used through the early access programme in Spain from December 2019 in cystic fibrosis (CF) patients with homozygous or heterozygous F508del mutation with advanced lung disease.: Methodology: ... ...

    Abstract Introduction: Elexacaftor/tezacaftor/ivacaftor (ETI) was used through the early access programme in Spain from December 2019 in cystic fibrosis (CF) patients with homozygous or heterozygous F508del mutation with advanced lung disease.
    Methodology: Multicentre, ambispective, observational, study in which 114 patients in follow-up in 16 national CF units were recruited. Clinical data, functional tests, nutritional parameters, quality of life questionnaires, microbiological isolates, number of exacerbations, antibiotic treatments and side effects were collected. The study also compared patients with homozygous and heterozygous F508del mutations.
    Results: Of the 114 patients, 85 (74.6%) were heterozygous for F508del mutation, and the mean age was 32.2±9.96 years. After 30 months of treatment, lung function measured by FEV
    Conclusions: ETI decreases the number of exacerbations, increases lung function and nutritional parameters, decrease in all isolated microorganisms, for 30 months of treatment. There is an improvement in the CFQ-R questionnaire score except for the digestive item. It is a safe and well-tolerated drug.
    MeSH term(s) Adult ; Humans ; Young Adult ; Aminophenols/therapeutic use ; Aminophenols/adverse effects ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/adverse effects ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/therapeutic use ; Mutation ; Quality of Life
    Chemical Substances Aminophenols ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; elexacaftor (RRN67GMB0V) ; ivacaftor (1Y740ILL1Z) ; tezacaftor
    Language Spanish
    Publishing date 2023-06-09
    Publishing country Spain
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2023.05.017
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